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Aliases for HMGCLL1 Gene
Aliases for HMGCLL1 Gene
- Endoplasmic Reticulum 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase 3
- 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase-Like Protein 1 3
- 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase, Cytoplasmic 3
- Probable 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase 2 3
- 3-Hydroxy-3-Methylglutaryl-CoA Lyase, Cytoplasmic 4
- BA418P12.1 3
External Ids for HMGCLL1 Gene
- HGNC: 21359
- Entrez Gene: 54511
- Ensembl: ENSG00000146151
- UniProtKB: Q8TB92
Previous GeneCards Identifiers for HMGCLL1 Gene
- GC06M055300
- GC06M055346
- GC06M055133
- GC06M055299
Summaries for HMGCLL1 Gene
GeneCards Summary for HMGCLL1 Gene
HMGCLL1 (3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase Like 1) is a Protein Coding gene. Diseases associated with HMGCLL1 include Breast Adenoid Cystic Carcinoma and Hepatic Infarction. Among its related pathways are Valine, leucine and isoleucine degradation and Ketone body metabolism. Gene Ontology (GO) annotations related to this gene include lyase activity and hydroxymethylglutaryl-CoA lyase activity. An important paralog of this gene is HMGCL.
UniProtKB/Swiss-Prot Summary for HMGCLL1 Gene
-
Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.
Additional gene information for HMGCLL1 Gene
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HMGCLL1 Gene
Genomics for HMGCLL1 Gene
GeneHancer (GH) Regulatory Elements for HMGCLL1 Gene
Promoters and enhancers for HMGCLL1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J055578 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE CraniofacialAtlas | 513.9 | +100.6 | 100567 | 1.4 | ZNF217 EP300 ZNF10 ZIC2 ZBTB10 ZNF423 ZBTB26 KLF4 KLF7 ZEB1 | HMGCLL1 piR-41880-024 HSALNG0050757 | |
| GH06J055678 | Enhancer | 0.6 | Ensembl | 500.7 | +0.8 | 767 | 1 | ATF2 ZNF335 IKZF3 POLR2A FOXP2 PRDM6 GLIS1 ZFP69B ZBTB21 TRIM28 | HMGCLL1 piR-41880-024 | |
| GH06J055680 | Enhancer | 0.3 | Ensembl | 500.7 | -1.1 | -1133 | 0.4 | ZNF335 ZBTB44 | ENSG00000220725 HMGCLL1 lnc-BMP5-1 | |
| GH06J055635 | Enhancer | 0.9 | Ensembl ENCODE | 10.9 | +43.0 | 43021 | 3.2 | ZNF217 TCF12 FOS CUX1 CHD1 CTBP1 MBD2 POLR2A FOSL2 CEBPB | HMGCLL1 ENSG00000224984 piR-41880-024 | |
| GH06J055704 | Enhancer | 0.6 | Ensembl ENCODE | 10.9 | -25.1 | -25133 | 1.6 | FOS JUN BATF JUND | HMGCLL1 piR-46002-485 BMP5 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HMGCLL1 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HMGCLL1
- Top Transcription factor binding sites by QIAGEN in the HMGCLL1 gene promoter:
-
- C/EBPalpha
- Gfi-1
- Hlf
- NF-1
- NF-1/L
- NF-kappaB
- NF-kappaB1
- Pax-5
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for HMGCLL1 Gene
Genomic Locations for HMGCLL1 Gene
- chr6:55,434,369-55,679,668
- (GRCh38/hg38)
- Size:
- 245,300 bases
- Orientation:
- Minus strand
- chr6:55,299,167-55,444,012
- (GRCh37/hg19)
- Size:
- 144,846 bases
- Orientation:
- Minus strand
Genomic View for HMGCLL1 Gene
Genes around HMGCLL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.1 by HGNC
- 6p12.1 by Entrez Gene
- 6p12.1 by Ensembl
HMGCLL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGCLL1 Gene
Proteins for HMGCLL1 Gene
-
Protein details for HMGCLL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TB92-HMGC2_HUMAN
- Recommended name:
- 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
- Protein Accession:
- Q8TB92
- B1AQ42
- B3KNV0
- B7Z1S7
- F8W793
- Q6ZSA9
Protein attributes for HMGCLL1 Gene
- Size:
- 370 amino acids
- Molecular mass:
- 39514 Da
- Cofactor:
- Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
- SequenceCaution:
-
- Sequence=BAC87045.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAG51462.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Protein Expression for HMGCLL1 Gene
Selected DME Specific Peptides for HMGCLL1 Gene
- Q8TB92:
-
- EVGPRDGLQNE
- NCSIEES
- ALAVHCHDTYGQAL
- GASGNVATEDL
- YPVLTPN
- MGCYEISLGDTIGVGTPG
Post-translational modifications for HMGCLL1 Gene
Other Protein References for HMGCLL1 Gene
Antibody Products
- Creative Diagnostics Anti-HMGCLL1 monoclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for HMGCLL1
- Novus Biologicals Antibodies for HMGCLL1
-
Abcam antibodies for HMGCLL1
- Invitrogen Antibodies for HMGCLL1 (AFLGC-HMGCLL1)
Protein Products
-
OriGene Purified Proteins for HMGCLL1
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGCLL1
- Origene Custom Protein Services for HMGCLL1
- antibodies-online: Show 5 available HMGCLL1 Proteins ranked by validation data
- Compare Top HMGCLL1 Proteins
-
Quality Products:
-
Abcam proteins for HMGCLL1
Assay Products
- antibodies-online: Show 4 available HMGCLL1 Elisa Kits ranked by validation data
- Compare Top HMGCLL1 Elisa Kits
-
Quality Products:
Domains & Families for HMGCLL1 Gene
Gene Families for HMGCLL1 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for HMGCLL1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMGCLL1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ57919 (B7Z212_HUMAN)
- cDNA FLJ57397 (B7Z4D4_HUMAN)
- 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1 (HMGC2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TB92- Family:
-
- Belongs to the HMG-CoA lyase family.
Function for HMGCLL1 Gene
Molecular function for HMGCLL1 Gene
- UniProtKB/Swiss-Prot Function:
- Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA; Xref=Rhea:RHEA:24404, ChEBI:CHEBI:13705, ChEBI:CHEBI:43074, ChEBI:CHEBI:57288; EC=4.1.3.4; Evidence={ECO:0000269 PubMed:22847177, ECO:0000269 PubMed:22865860};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=40 uM for (S)-3-hydroxy-3-methylglutaryl-CoA (at pH 9) {ECO:0000269 PubMed:22847177}; KM=75 uM for (S)-3-hydroxy-3-methylglutaryl-CoA (at pH 8) {ECO:0000269 PubMed:22847177}; KM=28 uM for (S)-3-hydroxy-3-methylglutaryl-CoA {ECO:0000269 PubMed:22865860}; KM=49 uM for (S)-3-hydroxy-3-methylglutaryl-CoA (in presence of magnesium) {ECO:0000269 PubMed:22865860}; KM=0.18 uM for (S)-3-hydroxy-3-methylglutaryl-CoA (in presence of manganese) {ECO:0000269 PubMed:22865860}; Vmax=12 nmol/min/mg enzyme with (S)-3-hydroxy-3-methylglutaryl- CoA as substrate at pH 9 {ECO:0000269 PubMed:22847177}; Vmax=25 nmol/min/mg enzyme with (S)-3-hydroxy-3-methylglutaryl- CoA as substrate at pH 8 {ECO:0000269 PubMed:22847177};
Enzyme Numbers (IUBMB) for HMGCLL1 Gene
Phenotypes From GWAS Catalog for HMGCLL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004419 | hydroxymethylglutaryl-CoA lyase activity | ISS,IEA | -- |
| GO:0016829 | lyase activity | IEA | -- |
| GO:0046872 | metal ion binding | TAS | 22865860 |
Phenotypes for HMGCLL1 Gene
- GenomeRNAi human phenotypes for HMGCLL1:
-
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Increased cell number in S
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HMGCLL1 - Select products 50% OFF >
- * HMGCLL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * HMGCLL1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for HMGCLL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMGCLL1
- genomics-online: gRNA clones - Search for available HMGCLL1 gRNA products
- Overview of 89 available HMGCLL1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGCLL1
miRNA for HMGCLL1 Gene
- miRTarBase miRNAs that target HMGCLL1
-
- hsa-mir-335-5p (MIRT019060)
- hsa-mir-4635 (MIRT447458)
- hsa-mir-5585-3p (MIRT447459)
- hsa-mir-6772-3p (MIRT724264)
- hsa-mir-670-5p (MIRT724265)
- hsa-mir-4448 (MIRT724266)
- hsa-mir-4268 (MIRT724267)
- hsa-mir-1976 (MIRT724268)
- hsa-mir-6870-3p (MIRT724269)
- hsa-mir-6893-3p (MIRT724270)
- hsa-mir-370-3p (MIRT724271)
- hsa-mir-660-3p (MIRT724272)
- hsa-mir-5193 (MIRT724273)
- hsa-mir-6891-3p (MIRT724274)
- hsa-mir-6072 (MIRT724275)
- hsa-mir-4319 (MIRT724276)
- hsa-mir-125b-5p (MIRT724277)
- hsa-mir-125a-5p (MIRT724278)
- hsa-mir-4732-3p (MIRT724279)
- hsa-mir-345-3p (MIRT724280)
- hsa-mir-6729-3p (MIRT724281)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HMGCLL1
- Browse OriGene Inhibitory RNA Products For HMGCLL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMGCLL1
- genomics-online: shRNA clones - Search for available HMGCLL1 shRNA products
- Overview of 89 available HMGCLL1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for HMGCLL1 - Select products 50% OFF >
- * HMGCLL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * HMGCLL1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for HMGCLL1
- Addgene plasmids for HMGCLL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMGCLL1
Cell Line Products
-
Horizon Cell Lines for HMGCLL1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGCLL1 Gene
Localization for HMGCLL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGCLL1 Gene
- Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| cytosol | 5 |
| mitochondrion | 3 |
| extracellular | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IBA,IDA | 22847177 |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IDA,IEA | 22865860 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HMGCLL1 Gene
Pathways & Interactions for HMGCLL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.40
|
|
| 2 | Butanoate metabolism | ||
| 3 | Valine, leucine and isoleucine degradation | ||
| 4 | Ketone body metabolism | ||
| 5 | Peroxisome | ||
Pathways by source for HMGCLL1 Gene
1 BioSystems pathway for HMGCLL1 Gene
5 Reactome pathways for HMGCLL1 Gene
5 KEGG pathways for HMGCLL1 Gene
UniProtKB/Swiss-Prot Q8TB92-HMGC2_HUMAN
- Pathway: Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.
Interacting Proteins for HMGCLL1 Gene
GPS-Prot Interaction Network for HMGCLL1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006552 | leucine catabolic process | IBA | 21873635 |
| GO:0006629 | lipid metabolic process | IBA | 21873635 |
| GO:0046951 | ketone body biosynthetic process | TAS,IEA | -- |
No data available for SIGNOR curated interactions for HMGCLL1 Gene
Drugs & Compounds for HMGCLL1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Acetoacetic acid | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coa |
|
1553-55-5 |
|
|||
| acetyl-coa |
|
72-89-9 |
|
Transcripts for HMGCLL1 Gene
mRNA/cDNA for HMGCLL1 Gene
- 5 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000274901 2475 bps (ENST00000274901.8)
- ENST00000308161 1314 bps (ENST00000308161.8)
- ENST00000370850 1171 bps (ENST00000370850.6)
- ENST00000370852 2445 bps (ENST00000370852.6)
- ENST00000398661 2532 bps (ENST00000398661.6)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HMGCLL1 - Select products 50% OFF >
- * HMGCLL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * HMGCLL1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for HMGCLL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMGCLL1
- genomics-online: gRNA clones - Search for available HMGCLL1 gRNA products
- Overview of 89 available HMGCLL1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGCLL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HMGCLL1
- Browse OriGene Inhibitory RNA Products For HMGCLL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMGCLL1
- genomics-online: shRNA clones - Search for available HMGCLL1 shRNA products
- Overview of 89 available HMGCLL1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for HMGCLL1 - Select products 50% OFF >
- * HMGCLL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * HMGCLL1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for HMGCLL1
- Addgene plasmids for HMGCLL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMGCLL1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for HMGCLL1 Gene
- GeneLoc Exon Structure for
- HMGCLL1
Expression for HMGCLL1 Gene
mRNA differential expression in normal tissues according to GTEx for HMGCLL1 Gene
This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.7), Brain - Frontal Cortex (BA9) (x4.5), and Brain - Hypothalamus (x4.3).
This gene is overexpressed in Heart (36.6) and Liver (32.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HMGCLL1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HMGCLL1
SOURCE GeneReport for Unigene cluster for HMGCLL1 Gene:
Hs.147054Evidence on tissue expression from TISSUES for HMGCLL1 Gene
- Nervous system(4.7)
Primer Products
-
OriGene qPCR primer pairs for HMGCLL1
-
OriGene qPCR primer pairs and template standards for HMGCLL1
- genomics-online: primer clones - Search for available HMGCLL1 Primer products
- Overview of 89 available HMGCLL1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGCLL1 Gene
Orthologs for HMGCLL1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMGCLL1 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HMGCLL1 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HMGCLL1 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hmgcll1 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hmgcll1 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HMGCLL1 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HMGCLL1 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HMGCLL1 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HMGCLL1 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hmgcll1 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hmgcll1 31 30 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG10399 31 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y71G12B.10 31 |
|
OneToMany | |
| rice (Oryza sativa) |
Liliopsida | Os12g0134000 30 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for HMGCLL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for HMGCLL1 Gene
- ENSEMBL:
- Gene Tree for HMGCLL1 (if available)
- TreeFam:
- Gene Tree for HMGCLL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HMGCLL1: view image
Paralogs for HMGCLL1 Gene
(2) SIMAP similar genes for HMGCLL1 Gene using alignment to 5 proteins:
- HMGC2_HUMAN
- B7Z212_HUMAN
- B7Z4D4_HUMAN
- D6RHJ2_HUMAN
- G5E9S9_HUMAN
Variants for HMGCLL1 Gene
Residual Variation Intolerance Score:
44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.35;
26.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HMGCLL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HMGCLL1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HMGCLL1 Gene
Disorders for HMGCLL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast adenoid cystic carcinoma |
|
|
| hepatic infarction |
|
|
Search HMGCLL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HMGCLL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HMGCLL1 Gene
Publications for HMGCLL1 Gene
- Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol. (PMID: 22847177) Arnedo M … Pié J (Journal of lipid research 2012) 3 4 54
- Identification and characterization of an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase. (PMID: 22865860) Montgomery C … Miziorko HM (The Journal of biological chemistry 2012) 3 4 54
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
- Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 54
ExternalLinks
Products for HMGCLL1 Gene
- Custom Antibody ServicesOriGene Antibodies for HMGCLL1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HMGCLL1
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGCLL1
- Origene Custom Protein Services for HMGCLL1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HMGCLL1
- Browse OriGene Inhibitory RNA Products For HMGCLL1
- OriGene qPCR primer pairs for HMGCLL1
- OriGene qPCR primer pairs and template standards for HMGCLL1
- OriGene CRISPR knockouts for HMGCLL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HMGCLL1
- Sino Biological Human cDNA Clone for HMGCLL1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HMGCLL1
- Novus Biologicals proteins and lysates for HMGCLL1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for HMGCLL1
- Abcam proteins for HMGCLL1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Invitrogen Antibodies for HMGCLL1 (AFLGC-HMGCLL1)
- Addgene plasmids for HMGCLL1
- antibodies-online: Show 17 available HMGCLL1 Antibodies ranked by validation data
- Compare Top HMGCLL1 Antibodies
- antibodies-online: Show 4 available HMGCLL1 Elisa Kits ranked by validation data
- Compare Top HMGCLL1 Elisa Kits
- Quality Products:
- antibodies-online: Show 5 available HMGCLL1 Proteins ranked by validation data
- Compare Top HMGCLL1 Proteins
- Quality Products:
- Horizon Cell Lines for HMGCLL1
- genomics-online: cdna clones - Search for available HMGCLL1 CDNA products
- Overview of 89 available HMGCLL1 gene related products
- orf clones - Search for available HMGCLL1 ORF products
- Overview of 89 available HMGCLL1 gene related products
- genomics-online: gRNA clones - Search for available HMGCLL1 gRNA products
- Overview of 89 available HMGCLL1 gene related products
- genomics-online: primer clones - Search for available HMGCLL1 Primer products
- Overview of 89 available HMGCLL1 gene related products
- genomics-online: shRNA clones - Search for available HMGCLL1 shRNA products
- Overview of 89 available HMGCLL1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMGCLL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMGCLL1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HMGCLL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMGCLL1
Sources for HMGCLL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource