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This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
HMGB2 (High Mobility Group Box 2) is a Protein Coding gene. Diseases associated with HMGB2 include Juvenile Rheumatoid Arthritis. Among its related pathways are Chromatin Regulation / Acetylation and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is HMGB1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000400 | four-way junction DNA binding | ISS | -- |
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 19965638 |
GO:0000987 | proximal promoter sequence-specific DNA binding | ISS | -- |
GO:0003677 | DNA binding | IEA,IMP | 11909973 |
GO:0003684 | damaged DNA binding | IDA | 8226934 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | ISS | -- |
GO:0000793 | condensed chromosome | IDA | 12925773 |
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA | 19811285 |
GO:0005634 | nucleus | IEA,IDA | 8339930 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptosis induced DNA fragmentation | ||
2 | CDK-mediated phosphorylation and removal of Cdc6 |
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3 | Chromatin Regulation / Acetylation | ||
4 | Granzyme Pathway |
Granzyme Pathway
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5 | Granzyme-A Pathway |
Granzyme-A Pathway
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001938 | positive regulation of endothelial cell proliferation | IDA | 19811285 |
GO:0002376 | immune system process | IEA | -- |
GO:0002437 | inflammatory response to antigenic stimulus | ISS | -- |
GO:0006265 | DNA topological change | ISS | -- |
GO:0006303 | double-strand break repair via nonhomologous end joining | ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HMGB2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
HMGB2 30 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | HMGB2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HMGB2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Hmgb2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HMGB2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HMGB2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HMGB2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | hmgb2a 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000005 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Dsp1 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | hmg-1.2 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
juvenile rheumatoid arthritis |
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