Aliases for HMGA1 Gene
Aliases for HMGA1 Gene
External Ids for HMGA1 Gene
- HGNC: 5010
- Entrez Gene: 3159
- Ensembl: ENSG00000137309
- OMIM: 600701
- UniProtKB: P17096
Previous HGNC Symbols for HMGA1 Gene
- HMGIY
Previous GeneCards Identifiers for HMGA1 Gene
- GC06P034206
- GC06P034251
- GC06P034312
- GC06P034205
- GC06P033927
- GC06P034209
- GC06P034445
- GC06P035768
- GC06P036298
- GC06P037284
- GC06P034920
- GC06P035503
- GC06P037624
- GC06P038313
- GC06P038953
- GC06P039541
- GC06P040100
Summaries for HMGA1 Gene
-
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]
GeneCards Summary for HMGA1 Gene
HMGA1 (High Mobility Group AT-Hook 1) is a Protein Coding gene. Diseases associated with HMGA1 include Diabetes Mellitus, Noninsulin-Dependent and Ring Chromosome 1. Among its related pathways are HIV Life Cycle and Autointegration results in viral DNA circles. Gene Ontology (GO) annotations related to this gene include enzyme binding and ligand-dependent nuclear receptor transcription coactivator activity.
UniProtKB/Swiss-Prot for HMGA1 Gene
-
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Additional gene information for HMGA1 Gene
- Monarch Initiative
- Search for HMGA1 at DataMed
- Search for HMGA1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGA1 Gene
Genomics for HMGA1 Gene
GeneHancer (GH) Regulatory Elements for HMGA1 Gene
Promoters and enhancers for HMGA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HMGA1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HMGA1 gene promoter:
Regulatory Element Products
Genomic Locations for HMGA1 Gene
Genomic Locations for HMGA1 Gene
- chr6:34,236,800-34,246,231
- (GRCh38/hg38)
- Size:
- 9,432 bases
- Orientation:
- Plus strand
- chr6:34,204,577-34,214,008
- (GRCh37/hg19)
Genomic View for HMGA1 Gene
Genes around HMGA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.31 by Ensembl
- 6p21.31 by Entrez Gene
- 6p21.31 by HGNC
HMGA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGA1 Gene
Proteins for HMGA1 Gene
-
Protein details for HMGA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17096-HMGA1_HUMAN
- Recommended name:
- High mobility group protein HMG-I/HMG-Y
- Protein Accession:
- P17096
- P10910
- Q5T6U9
- Q9UKB0
Protein attributes for HMGA1 Gene
- Size:
- 107 amino acids
- Molecular mass:
- 11676 Da
- Quaternary structure:
-
- Interacts with HIPK2 (By similarity). Interacts with HIV-1 pre-integration complex.
Three dimensional structures from OCA and Proteopedia for HMGA1 Gene
Protein Expression for HMGA1 Gene
Post-translational modifications for HMGA1 Gene
- Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.
- HMG-Y is not methylated.
- Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for HMGA1 Gene
Antibody Products
- R&D Systems Antibodies for HMGA1 (HMGA1B)
-
Custom Antibody ServicesOriGene Antibodies for HMGA1
- Novus Biologicals Antibodies for HMGA1
-
Abcam antibodies for HMGA1
-
Cloud-Clone Corp. Antibodies for HMGA1
- Invitrogen Antibodies for HMGA1
- GeneTex HMGA1 antibody for HMGA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HMGA1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGA1
- Origene Custom Protein Services for HMGA1
- ProSpec Recombinant Proteins for HMGA1
-
Cloud-Clone Corp. Proteins for HMGA1
- Search GeneTex for Proteins for HMGA1
-
Abcam proteins for HMGA1
Assay Products
-
Cloud-Clone Corp. Assay Kits for HMGA1
No data available for DME Specific Peptides for HMGA1 Gene
Domains & Families for HMGA1 Gene
Gene Families for HMGA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HMGA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMGA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P17096- Family:
-
- Belongs to the HMGA family.
Function for HMGA1 Gene
Molecular function for HMGA1 Gene
- UniProtKB/Swiss-Prot Function:
- HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Phenotypes From GWAS Catalog for HMGA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001158 | enhancer sequence-specific DNA binding | IDA | 9253416 |
| GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | ISS | -- |
| GO:0003677 | DNA binding | TAS | 10871404 |
| GO:0003680 | AT DNA binding | TAS,IDA | 10428834 |
| GO:0003682 | chromatin binding | ISS | -- |
Phenotypes for HMGA1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HMGA1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGA1 gene
- Search ViGene Biosciences for HMGA1
CRISPR Products
-
OriGene CRISPR knockouts for HMGA1
- genomics-online: gRNA clones - Search results for available HMGA1 gene related products
- Applied Biological Materials CRISPR for HMGA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGA1
- GenScript: Design CRISPR guide RNA sequences for HMGA1
miRNA for HMGA1 Gene
- miRTarBase miRNAs that target HMGA1
-
- hsa-mir-26a-5p (MIRT000110)
- hsa-mir-16-5p (MIRT000270)
- hsa-mir-125b-5p (MIRT000349)
- hsa-let-7b-5p (MIRT001625)
- hsa-let-7a-5p (MIRT003152)
- hsa-mir-124-3p (MIRT006562)
- hsa-mir-15a-5p (MIRT006801)
- hsa-mir-196a-5p (MIRT006802)
- hsa-mir-335-5p (MIRT018872)
- hsa-mir-98-5p (MIRT027852)
- hsa-mir-1301-3p (MIRT035976)
- hsa-mir-877-3p (MIRT037176)
- hsa-mir-877-5p (MIRT037370)
- hsa-mir-744-5p (MIRT037580)
- hsa-mir-296-3p (MIRT038421)
- hsa-mir-671-5p (MIRT039276)
- hsa-mir-18a-3p (MIRT040930)
- hsa-mir-324-3p (MIRT042853)
- hsa-mir-331-3p (MIRT043495)
- hsa-mir-222-3p (MIRT046655)
- hsa-mir-30c-5p (MIRT047920)
- hsa-mir-142-3p (MIRT053121)
- hsa-mir-185-3p (MIRT122798)
- hsa-mir-4675 (MIRT122808)
- hsa-mir-4741 (MIRT122811)
- hsa-mir-6805-5p (MIRT122816)
- hsa-mir-6846-5p (MIRT122818)
- hsa-mir-6848-5p (MIRT122819)
- hsa-mir-138-5p (MIRT168540)
- hsa-mir-1184 (MIRT168546)
- hsa-mir-1233-3p (MIRT168549)
- hsa-mir-3173-5p (MIRT168553)
- hsa-mir-4286 (MIRT168556)
- hsa-mir-4641 (MIRT168563)
- hsa-mir-6779-3p (MIRT168574)
- hsa-mir-6783-5p (MIRT168575)
- hsa-mir-6799-3p (MIRT168576)
- hsa-mir-6827-5p (MIRT168577)
- hsa-mir-6871-5p (MIRT168578)
- hsa-mir-7978 (MIRT168580)
- hsa-let-7c-5p (MIRT168581)
- hsa-let-7d-5p (MIRT168582)
- hsa-let-7e-5p (MIRT168583)
- hsa-let-7f-5p (MIRT168584)
- hsa-let-7g-5p (MIRT168587)
- hsa-let-7i-5p (MIRT168588)
- hsa-mir-15b-5p (MIRT168589)
- hsa-mir-195-5p (MIRT168591)
- hsa-mir-196b-5p (MIRT168592)
- hsa-mir-520a-5p (MIRT168595)
- hsa-mir-525-5p (MIRT168596)
- hsa-mir-4257 (MIRT168601)
- hsa-mir-4458 (MIRT168607)
- hsa-mir-4500 (MIRT168608)
- hsa-mir-6847-5p (MIRT168616)
- hsa-mir-185-5p (MIRT437482)
- hsa-mir-218-5p (MIRT440493)
- hsa-mir-3611 (MIRT475617)
- hsa-mir-3148 (MIRT475618)
- hsa-mir-6859-5p (MIRT475619)
- hsa-mir-3916 (MIRT475620)
- hsa-mir-4694-3p (MIRT475621)
- hsa-mir-3125 (MIRT475622)
- hsa-mir-758-3p (MIRT475623)
- hsa-mir-7108-5p (MIRT475624)
- hsa-mir-588 (MIRT475625)
- hsa-mir-4701-5p (MIRT475626)
- hsa-mir-4709-3p (MIRT475627)
- hsa-mir-6824-5p (MIRT475628)
- hsa-mir-6802-3p (MIRT475629)
- hsa-mir-663b (MIRT475630)
- hsa-mir-7974 (MIRT475631)
- hsa-mir-6809-5p (MIRT475632)
- hsa-mir-6133 (MIRT475633)
- hsa-mir-6130 (MIRT475634)
- hsa-mir-6129 (MIRT475635)
- hsa-mir-6127 (MIRT475636)
- hsa-mir-4510 (MIRT475637)
- hsa-mir-4419a (MIRT475638)
- hsa-mir-6862-3p (MIRT475639)
- hsa-mir-3681-3p (MIRT475640)
- hsa-mir-6784-3p (MIRT475641)
- hsa-mir-216a-3p (MIRT475642)
- hsa-mir-128-3p (MIRT475643)
- hsa-mir-6873-5p (MIRT475644)
- hsa-mir-3650 (MIRT536819)
- hsa-mir-920 (MIRT536821)
- hsa-mir-6726-5p (MIRT536822)
- hsa-mir-5591-5p (MIRT536823)
- hsa-mir-4300 (MIRT536824)
- hsa-mir-6090 (MIRT536825)
- hsa-mir-4659b-5p (MIRT657373)
- hsa-mir-4659a-5p (MIRT657374)
- hsa-mir-2355-5p (MIRT657375)
- hsa-mir-4749-3p (MIRT657376)
- hsa-mir-3189-5p (MIRT657377)
- hsa-mir-4758-3p (MIRT657378)
- hsa-mir-5699-5p (MIRT657379)
- hsa-mir-1236-3p (MIRT657380)
- hsa-mir-6872-3p (MIRT657381)
- hsa-mir-6769a-3p (MIRT657382)
- hsa-mir-625-5p (MIRT732581)
- hsa-mir-296-5p (MIRT732722)
- hsa-mir-1297 (MIRT735426)
- hsa-mir-1207-5p (MIRT736024)
- hsa-mir-1224-3p (MIRT736083)
- hsa-mir-125a-3p (MIRT736627)
- hsa-mir-1273h-5p (MIRT736867)
- hsa-mir-1321 (MIRT737333)
- hsa-mir-1343-5p (MIRT737467)
- hsa-mir-1976 (MIRT738709)
- hsa-mir-30b-3p (MIRT739757)
- hsa-mir-30c-1-3p (MIRT739817)
- hsa-mir-30c-2-3p (MIRT739860)
- hsa-mir-3667-3p (MIRT742080)
- hsa-mir-3689a-3p (MIRT742259)
- hsa-mir-3689b-3p (MIRT742329)
- hsa-mir-3689c (MIRT742399)
- hsa-mir-3934-5p (MIRT743100)
- hsa-mir-4270 (MIRT743568)
- hsa-mir-4278 (MIRT743687)
- hsa-mir-4297 (MIRT743805)
- hsa-mir-4323 (MIRT744048)
- hsa-mir-4425 (MIRT744277)
- hsa-mir-4441 (MIRT744535)
- hsa-mir-4459 (MIRT744802)
- hsa-mir-4667-3p (MIRT746791)
- hsa-mir-4690-3p (MIRT747055)
- hsa-mir-4722-3p (MIRT747567)
- hsa-mir-4722-5p (MIRT747597)
- hsa-mir-4739 (MIRT748051)
- hsa-mir-4756-5p (MIRT748423)
- hsa-mir-4763-3p (MIRT748533)
- hsa-mir-4779 (MIRT748734)
- hsa-mir-486-3p (MIRT749107)
- hsa-mir-486-5p (MIRT749142)
- hsa-mir-5581-5p (MIRT750939)
- hsa-mir-5685 (MIRT751183)
- hsa-mir-6081 (MIRT751758)
- hsa-mir-6165 (MIRT752507)
- hsa-mir-660-3p (MIRT753539)
- hsa-mir-6721-5p (MIRT753798)
- hsa-mir-6727-3p (MIRT753933)
- hsa-mir-6747-3p (MIRT754501)
- hsa-mir-6754-5p (MIRT754710)
- hsa-mir-6779-5p (MIRT755498)
- hsa-mir-6780a-5p (MIRT755574)
- hsa-mir-6788-5p (MIRT755969)
- hsa-mir-6789-5p (MIRT756015)
- hsa-mir-6815-5p (MIRT756776)
- hsa-mir-6865-5p (MIRT757925)
- hsa-mir-6887-3p (MIRT758571)
- hsa-mir-7106-5p (MIRT758857)
- hsa-mir-7112-5p (MIRT759082)
- hsa-mir-7152-5p (MIRT759197)
- hsa-mir-764 (MIRT759532)
- hsa-mir-765 (MIRT759559)
- hsa-mir-887-5p (MIRT760408)
- hsa-mir-92a-1-5p (MIRT760520)
- hsa-mir-939-5p (MIRT760758)
miRNA Products
- Search ViGene Biosciences for HMGA1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HMGA1
- Browse OriGene Inhibitory RNA Products For HMGA1
- genomics-online: shRNA clones - Search results for available HMGA1 gene related products
- Search ViGene Biosciences for HMGA1
Clone Products
-
OriGene ORF clones in human for HMGA1
- RG217358
- RC217358L2
- RC217358L1
- RC217358
- RG217302
- RC217302L2
- RC217302L1
- RC217302
- RG204972
- RC204972L2
- RC204972L1
- RC204972
- RG213109
- RC213109L2
- RC213109L1
- RC213109
- RG217251
- RC217251L2
- RC217251L1
- RC217251
- RG202928
- RC202928L2
- RC202928L1
- RC202928
- RG201458
- RC201458L2
- RC201458L1
- RC201458
- RC217358L2V
- RC217358L1V
- RC217302L2V
- RC217302L1V
- RC204972L2V
- RC204972L1V
- RC213109L2V
- RC213109L1V
- RC217251L2V
- RC217251L1V
- RC202928L2V
- RC202928L1V
- RC201458L2V
- RC201458L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HMGA1
- VectorBuilder custom plasmid, inducible vectors for HMGA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMGA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HMGA1
- genomics-online: cdna clones - Search results for available HMGA1 gene related products
- orf clones - Search results for available HMGA1 gene related products
- Applied Biological Materials Clones for HMGA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HMGA1
-
ViGene Biosciences adenoviral particle packaged cDNA for HMGA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGA1 gene
- Search ViGene Biosciences for HMGA1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGA1 Gene
Localization for HMGA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGA1 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Nucleoli (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 16901784 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | TAS | 10428834 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for HMGA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.92
.65
.45
|
|
| 2 | Autointegration results in viral DNA circles | ||
| 3 | Cellular Senescence (REACTOME) | ||
| 4 | DNA Damage/Telomere Stress Induced Senescence | ||
| 5 | Transport of the SLBP independent Mature mRNA | ||
Pathways by source for HMGA1 Gene
5 BioSystems pathways for HMGA1 Gene
17 Reactome pathways for HMGA1 Gene
1 GeneGo (Thomson Reuters) pathway for HMGA1 Gene
1 Qiagen pathway for HMGA1 Gene
1 Cell Signaling Technology pathway for HMGA1 Gene
Interacting Proteins for HMGA1 Gene
Selected Interacting proteins:
ENSP00000308227
P17096-HMGA1_HUMAN
for HMGA1 Gene via
STRING
IID
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006268 | DNA unwinding involved in DNA replication | NAS | 10428834 |
| GO:0006284 | base-excision repair | IBA | -- |
| GO:0006337 | nucleosome disassembly | TAS | 10428834 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 10871404 |
Transcripts for HMGA1 Gene
mRNA/cDNA for HMGA1 Gene
- (13) REFSEQ mRNAs :
- (23) Additional mRNA sequences :
- (2021) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMGA1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMGA1
- genomics-online: gRNA clones - Search results for available HMGA1 gene related products
- Applied Biological Materials CRISPR for HMGA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGA1
- GenScript: Design CRISPR guide RNA sequences for HMGA1
miRNA Products
- Search ViGene Biosciences for HMGA1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HMGA1
- Browse OriGene Inhibitory RNA Products For HMGA1
- genomics-online: shRNA clones - Search results for available HMGA1 gene related products
- Search ViGene Biosciences for HMGA1
Clone Products
-
OriGene ORF clones in human for HMGA1
- RG217358
- RC217358L2
- RC217358L1
- RC217358
- RG217302
- RC217302L2
- RC217302L1
- RC217302
- RG204972
- RC204972L2
- RC204972L1
- RC204972
- RG213109
- RC213109L2
- RC213109L1
- RC213109
- RG217251
- RC217251L2
- RC217251L1
- RC217251
- RG202928
- RC202928L2
- RC202928L1
- RC202928
- RG201458
- RC201458L2
- RC201458L1
- RC201458
- RC217358L2V
- RC217358L1V
- RC217302L2V
- RC217302L1V
- RC204972L2V
- RC204972L1V
- RC213109L2V
- RC213109L1V
- RC217251L2V
- RC217251L1V
- RC202928L2V
- RC202928L1V
- RC201458L2V
- RC201458L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HMGA1
- VectorBuilder custom plasmid, inducible vectors for HMGA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMGA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HMGA1
- genomics-online: cdna clones - Search results for available HMGA1 gene related products
- orf clones - Search results for available HMGA1 gene related products
- Applied Biological Materials Clones for HMGA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · |
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| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | - | - |
| ExUns: | 13c | · | 13d |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: | |||
| SP13: | |||
| SP14: | |||
| SP15: | |||
| SP16: | |||
| SP17: | |||
| SP18: | |||
| SP19: | |||
| SP20: | |||
| SP21: | |||
| SP22: | |||
| SP23: | |||
| SP24: |
Expression for HMGA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- S-shaped Body Cells S-shaped Body
- S-shaped Body
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Lymph (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for HMGA1 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.6).
This gene is overexpressed in Peripheral blood mononuclear cells (9.6), Amniocyte (8.2), Tlymphocyte (7.7), Blymphocyte (6.7), and CD8 Tcells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMGA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HMGA1 Gene:
HMGA1SOURCE GeneReport for Unigene cluster for HMGA1 Gene:
Hs.518805Evidence on tissue expression from TISSUES for HMGA1 Gene
- Liver(4.9)
- Pancreas(4.9)
- Nervous system(4.9)
- Blood(4.8)
- Lung(4.8)
- Skin(4.8)
- Eye(4.7)
- Intestine(4.7)
- Muscle(4.7)
- Stomach(3.9)
- Kidney(3.2)
- Heart(2.9)
- Bone(2.8)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGA1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- ear
- eye
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- heart
- rib
- rib cage
- scapula
- sternum
Abdomen:
- kidney
- liver
- pancreas
Pelvis:
- ovary
- pelvis
- uterus
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for HMGA1
- genomics-online: primer clones - Search results for available HMGA1 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for HMGA1 Gene
Orthologs for HMGA1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMGA1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HMGA1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hmga1 34 |
|
OneToMany | |
| Hmga1-rs1 33 34 |
|
||||
| Hmga1b 16 |
|
||||
| dog (Canis familiaris) |
Mammalia | HMGA1 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HMGA1 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hmga1 33 |
|
||
| chicken (Gallus gallus) |
Aves | HMGA1 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HMGA1 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | hmga1b 34 |
|
OneToMany | |
| hmga1a 34 |
|
OneToMany |
- Species where no ortholog for HMGA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HMGA1 Gene
Pseudogenes.org Pseudogenes for HMGA1 Gene
No data available for Paralogs for HMGA1 Gene
Variants for HMGA1 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000055979 | -- | 34,236,150(+) | G/A | upstream_transcript_variant | |
| rs1000097676 | -- | 34,239,965(+) | C/A | intron_variant | |
| rs1000159077 | -- | 34,236,369(+) | A/AA | upstream_transcript_variant | |
| rs1000396258 | -- | 34,246,423(+) | A/G | downstream_transcript_variant | |
| rs1000947920 | -- | 34,236,759(+) | G/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10616n54 | CNV | gain | 21841781 |
| dgv10617n54 | CNV | gain | 21841781 |
| esv24915 | CNV | loss | 19812545 |
| nsv1137544 | CNV | deletion | 24896259 |
| nsv602863 | CNV | loss | 21841781 |
| nsv602865 | CNV | loss | 21841781 |
| nsv602866 | CNV | loss | 21841781 |
| nsv823666 | CNV | gain | 20364138 |
| nsv969388 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.81;
34.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HMGA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGA1 Gene
Disorders for HMGA1 Gene
(8) MalaCards diseases for HMGA1 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetes mellitus, noninsulin-dependent |
|
|
| ring chromosome 1 |
|
|
| pelvic lipomatosis |
|
|
| malignant ectomesenchymoma |
|
|
| lipomatosis, multiple |
|
Search HMGA1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HMGA1_HUMAN- Note=A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B. {ECO:0000269 PubMed:11978964}.
Additional Disease Information for HMGA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for HMGA1 Gene
Publications for HMGA1 Gene
- Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. (PMID: 8414980) Friedmann M … Reeves R (Nucleic acids research 1993) 2 3 4 22 58
- Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity. (PMID: 17960875) Zhang Q … Wang Y (Journal of proteome research 2007) 3 4 22 58
- Serine ADP-Ribosylation Depends on HPF1. (PMID: 28190768) Bonfiglio JJ … Matic I (Molecular cell 2017) 3 4 58
- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 44 58
- Functional variants of the HMGA1 gene and type 2 diabetes mellitus. (PMID: 21364139) Chiefari E … Brunetti A (JAMA 2011) 3 44 58
Products for HMGA1 Gene
- R&D Systems Antibodies for HMGA1 (HMGA1B)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HMGA1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGA1
- Origene Custom Protein Services for HMGA1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HMGA1
- Browse OriGene Inhibitory RNA Products For HMGA1
- OriGene qPCR primer pairs for HMGA1
- OriGene CRISPR knockouts for HMGA1
- OriGene ORF clones in human for HMGA1
- RC201458L1V
- RC201458L2V
- RC202928L1V
- RC202928L2V
- RC217251L1V
- RC217251L2V
- RC213109L1V
- RC213109L2V
- RC204972L1V
- RC204972L2V
- RC217302L1V
- RC217302L2V
- RC217358L1V
- RC217358L2V
- RC201458
- RC201458L1
- RC201458L2
- RG201458
- RC202928
- RC202928L1
- RC202928L2
- RG202928
- RC217251
- RC217251L1
- RC217251L2
- RG217251
- RC213109
- RC213109L1
- RC213109L2
- RG213109
- RC204972
- RC204972L1
- RC204972L2
- RG204972
- RC217302
- RC217302L1
- RC217302L2
- RG217302
- RC217358
- RC217358L1
- RC217358L2
- RG217358
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HMGA1
- GenScript: Next-day shipping of latest version cDNA ORF clones for HMGA1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HMGA1
- GenScript Custom Assay Services for HMGA1
- GenScript Custom overexpressing Cell Line Services for HMGA1
- GenScript: Design CRISPR guide RNA sequences for HMGA1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HMGA1
- Sino Biological Human cDNA Clone for HMGA1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for HMGA1
- Novus Biologicals lysates and proteins for HMGA1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for HMGA1
- Abcam proteins for HMGA1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for HMGA1
- Cloud-Clone Corp. Antibodies for HMGA1
- Cloud-Clone Corp. Proteins for HMGA1
- Cloud-Clone Corp. Assay Kits for HMGA1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for HMGA1
- VectorBuilder custom plasmid, inducible vectors for HMGA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMGA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HMGA1
- antibodies-online: Search results for 135 available HMGA1 Antibodies ranked by validation data
- Compare Top HMGA1 Antibodies
- antibodies-online: Search results for 14 available HMGA1 Elisa Kits ranked by validation data
- Compare Top HMGA1 Elisa Kits
- antibodies-online: Search results for 20 available HMGA1 Proteins ranked by validation data
- Compare Top HMGA1 Proteins
- GeneTex HMGA1 antibody for HMGA1
- Search GeneTex for Proteins for HMGA1
- ViGene Biosciences adenoviral particle packaged cDNA for HMGA1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HMGA1 gene
- Search ViGene Biosciences for HMGA1
- Santa Cruz Biotechnology (SCBT) Antibodies for HMGA1
- Search Santa Cruz Biotechnology (SCBT) for HMGA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HMGA1
- Horizon Cell Lines for HMGA1
- genomics-online: cdna clones - Search results for available HMGA1 gene related products
- orf clones - Search results for available HMGA1 gene related products
- genomics-online: gRNA clones - Search results for available HMGA1 gene related products
- genomics-online: primer clones - Search results for available HMGA1 gene related products
- genomics-online: shRNA clones - Search results for available HMGA1 gene related products
Sources for HMGA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127)