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This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this g... See more...
Aliases for HMGA1 Gene
Aliases for HMGA1 Gene
External Ids for HMGA1 Gene
- HGNC: 5010
- Entrez Gene: 3159
- Ensembl: ENSG00000137309
- OMIM: 600701
- UniProtKB: P17096
Previous HGNC Symbols for HMGA1 Gene
- HMGIY
Previous GeneCards Identifiers for HMGA1 Gene
- GC06P034206
- GC06P034251
- GC06P034312
- GC06P034205
- GC06P033927
- GC06P034209
- GC06P034445
- GC06P035768
- GC06P036298
- GC06P037284
- GC06P034920
- GC06P035503
- GC06P042758
- GC06P043092
- GC06P043313
- GC06P046013
- GC06P037624
- GC06P038313
- GC06P038953
- GC06P039541
- GC06P040100
- GC06P041163
- GC06P041845
- GC06P042493
Summaries for HMGA1 Gene
-
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]
GeneCards Summary for HMGA1 Gene
HMGA1 (High Mobility Group AT-Hook 1) is a Protein Coding gene. Diseases associated with HMGA1 include Diabetes Mellitus, Noninsulin-Dependent and Rare Diabetes Mellitus Type 2. Among its related pathways are Preimplantation Embryo and IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include enzyme binding and nuclear receptor transcription coactivator activity.
UniProtKB/Swiss-Prot Summary for HMGA1 Gene
-
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Additional gene information for HMGA1 Gene
- HGNC(5010)
- Entrez Gene(3159)
- Ensembl(ENSG00000137309)
- OMIM(600701)
- UniProtKB(P17096)
- Open Targets Platform(ENSG00000137309)
- Monarch Initiative
- Search for HMGA1 at DataMed
- Search for HMGA1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HMGA1 Gene
Genomics for HMGA1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HMGA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HMGA1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HMGA1
- Top Transcription factor binding sites by QIAGEN in the HMGA1 gene promoter:
-
- TBP
Genomic Locations for HMGA1 Gene
Genomic Locations for HMGA1 Gene
- chr6:34,236,873-34,246,231
- (GRCh38/hg38)
- Size:
- 9,359 bases
- Orientation:
- Plus strand
- chr6:34,204,577-34,214,008
- (GRCh37/hg19)
- Size:
- 9,432 bases
- Orientation:
- Plus strand
Genomic View for HMGA1 Gene
Genes around HMGA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.31 by HGNC
- 6p21.31 by Entrez Gene
- 6p21.31 by Ensembl
HMGA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGA1 Gene
Proteins for HMGA1 Gene
-
Protein details for HMGA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17096-HMGA1_HUMAN
- Recommended name:
- High mobility group protein HMG-I/HMG-Y
- Protein Accession:
- P17096
- P10910
- Q5T6U9
- Q9UKB0
Protein attributes for HMGA1 Gene
- Size:
- 107 amino acids
- Molecular mass:
- 11676 Da
- Quaternary structure:
-
- Interacts with HIPK2 (By similarity).
Three dimensional structures from OCA and Proteopedia for HMGA1 Gene
Protein Expression for HMGA1 Gene
Post-translational modifications for HMGA1 Gene
- Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.
- HMG-Y is not methylated.
- Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.
-
Ubiquitination at Lys7 and Lys46
- NX_P17096 (NX_P17096-1)
- Modification sites at PhosphoSitePlus
Other Protein References for HMGA1 Gene
Antibody Products
- G Biosciences Immunotag™ HMGA1 Antibody
- GeneTex Anti-HMGA1 antibody and Anti-HMGA1 antibody [N1N3]
- NSJ Bioreagents HMGA1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for HMGA1
- Novus Biologicals Antibodies for HMGA1
-
Abcam antibodies for HMGA1
- Invitrogen Antibodies for HMGA1 (AFLGC-HMGA1)
- antibodies-online: Show 36 available HMGA1 Antibodies ranked by validation data
- Compare Top HMGA1 Antibodies
-
Recommended
- 88 WB Antibodies (anti-human)
- 13 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 40 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 8 IHC (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 41 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 8 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HMGA1
Protein Products
-
OriGene Purified Proteins for HMGA1
- NM_002131
- NM_145899
- NM_145903
- NM_145902
- NM_145904
- NM_145905
- NM_145899
- NM_145901
- NM_145902
- NM_145903
- NM_145904
- NM_145905
- NM_002131
- NM_145901
- NM_145902
- NM_145905
- NM_145899
- NM_145901
- NM_145902
- NM_145903
- NM_145904
- NM_145905
- NM_002131
- NM_145901
- NM_145902
- NM_145905
- NM_001319077
- NM_001319077
- NM_002131
- NM_145899
- NM_145903
- NM_145902
- NM_145904
- NM_145905
- NM_001039356
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGA1
- Origene Custom Protein Services for HMGA1
- ProSpec Recombinant Proteins for HMGA1
-
Signalway Proteins for HMGA1
-
Abcam proteins for HMGA1
Assay Products
-
Signalway ELISA kits for HMGA1
No data available for DME Specific Peptides for HMGA1 Gene
Domains & Families for HMGA1 Gene
Gene Families for HMGA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HMGA1 Gene
- InterPro:
- Blocks:
-
- High mobility group protein (HMGY) signature
- ProtoNet:
Suggested Antigen Peptide Sequences for HMGA1 Gene
- GenScript: Design optimal peptide antigens:
-
- High mobility group protein R (HMGA1_HUMAN)
- High mobility group AT-hook 1 (Q5T6U8_HUMAN)
- HMGA1 protein (Q6IPL9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P17096- Family:
-
- Belongs to the HMGA family.
Function for HMGA1 Gene
Molecular function for HMGA1 Gene
- UniProtKB/Swiss-Prot Function:
- HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Phenotypes From GWAS Catalog for HMGA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000987 | proximal promoter sequence-specific DNA binding | IDA | 9253416 |
| GO:0003677 | DNA binding | ISS | -- |
| GO:0003680 | AT DNA binding | IDA,TAS | 10428834 |
| GO:0003682 | chromatin binding | ISS | -- |
| GO:0003713 | transcription coactivator activity | ISS | -- |
Phenotypes for HMGA1 Gene
- MGI mutant phenotypes for HMGA1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for HMGA1:
Animal Models for HMGA1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HMGA1 - Select products 50% OFF >
- * HMGA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HMGA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMGA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGA1
miRNA for HMGA1 Gene
- miRTarBase miRNAs that target HMGA1
-
- hsa-miR-26a-5p (MIRT000110)
- hsa-miR-16-5p (MIRT000270)
- hsa-miR-125b-5p (MIRT000349)
- hsa-let-7b-5p (MIRT001625)
- hsa-let-7a-5p (MIRT003152)
- hsa-miR-124-3p (MIRT006562)
- hsa-miR-15a-5p (MIRT006801)
- hsa-miR-196a-5p (MIRT006802)
- hsa-miR-335-5p (MIRT018872)
- hsa-miR-98-5p (MIRT027852)
- hsa-miR-1301-3p (MIRT035976)
- hsa-miR-877-3p (MIRT037176)
- hsa-miR-877-5p (MIRT037370)
- hsa-miR-744-5p (MIRT037580)
- hsa-miR-296-3p (MIRT038421)
- hsa-miR-671-5p (MIRT039276)
- hsa-miR-18a-3p (MIRT040930)
- hsa-miR-324-3p (MIRT042853)
- hsa-miR-331-3p (MIRT043495)
- hsa-miR-222-3p (MIRT046655)
- hsa-miR-30c-5p (MIRT047920)
- hsa-miR-142-3p (MIRT053121)
- hsa-miR-185-3p (MIRT122798)
- hsa-miR-4675 (MIRT122808)
- hsa-miR-4741 (MIRT122811)
- hsa-miR-6805-5p (MIRT122816)
- hsa-miR-6846-5p (MIRT122818)
- hsa-miR-6848-5p (MIRT122819)
- hsa-miR-138-5p (MIRT168540)
- hsa-miR-1184 (MIRT168546)
- hsa-miR-1233-3p (MIRT168549)
- hsa-miR-3173-5p (MIRT168553)
- hsa-miR-4286 (MIRT168556)
- hsa-miR-4641 (MIRT168563)
- hsa-miR-6779-3p (MIRT168574)
- hsa-miR-6783-5p (MIRT168575)
- hsa-miR-6799-3p (MIRT168576)
- hsa-miR-6827-5p (MIRT168577)
- hsa-miR-6871-5p (MIRT168578)
- hsa-miR-7978 (MIRT168580)
- hsa-let-7c-5p (MIRT168581)
- hsa-let-7d-5p (MIRT168582)
- hsa-let-7e-5p (MIRT168583)
- hsa-let-7f-5p (MIRT168584)
- hsa-let-7g-5p (MIRT168587)
- hsa-let-7i-5p (MIRT168588)
- hsa-miR-15b-5p (MIRT168589)
- hsa-miR-195-5p (MIRT168591)
- hsa-miR-196b-5p (MIRT168592)
- hsa-miR-520a-5p (MIRT168595)
- hsa-miR-525-5p (MIRT168596)
- hsa-miR-4257 (MIRT168601)
- hsa-miR-4458 (MIRT168607)
- hsa-miR-4500 (MIRT168608)
- hsa-miR-6847-5p (MIRT168616)
- hsa-miR-185-5p (MIRT437482)
- hsa-miR-218-5p (MIRT440493)
- hsa-miR-3611 (MIRT475617)
- hsa-miR-3148 (MIRT475618)
- hsa-miR-6859-5p (MIRT475619)
- hsa-miR-3916 (MIRT475620)
- hsa-miR-4694-3p (MIRT475621)
- hsa-miR-3125 (MIRT475622)
- hsa-miR-758-3p (MIRT475623)
- hsa-miR-7108-5p (MIRT475624)
- hsa-miR-588 (MIRT475625)
- hsa-miR-4701-5p (MIRT475626)
- hsa-miR-4709-3p (MIRT475627)
- hsa-miR-6824-5p (MIRT475628)
- hsa-miR-6802-3p (MIRT475629)
- hsa-miR-663b (MIRT475630)
- hsa-miR-7974 (MIRT475631)
- hsa-miR-6809-5p (MIRT475632)
- hsa-miR-6133 (MIRT475633)
- hsa-miR-6130 (MIRT475634)
- hsa-miR-6129 (MIRT475635)
- hsa-miR-6127 (MIRT475636)
- hsa-miR-4510 (MIRT475637)
- hsa-miR-4419a (MIRT475638)
- hsa-miR-6862-3p (MIRT475639)
- hsa-miR-3681-3p (MIRT475640)
- hsa-miR-6784-3p (MIRT475641)
- hsa-miR-216a-3p (MIRT475642)
- hsa-miR-128-3p (MIRT475643)
- hsa-miR-6873-5p (MIRT475644)
- hsa-miR-3650 (MIRT536819)
- hsa-miR-920 (MIRT536821)
- hsa-miR-6726-5p (MIRT536822)
- hsa-miR-5591-5p (MIRT536823)
- hsa-miR-4300 (MIRT536824)
- hsa-miR-6090 (MIRT536825)
- hsa-miR-4659b-5p (MIRT657373)
- hsa-miR-4659a-5p (MIRT657374)
- hsa-miR-2355-5p (MIRT657375)
- hsa-miR-4749-3p (MIRT657376)
- hsa-miR-3189-5p (MIRT657377)
- hsa-miR-4758-3p (MIRT657378)
- hsa-miR-5699-5p (MIRT657379)
- hsa-miR-1236-3p (MIRT657380)
- hsa-miR-6872-3p (MIRT657381)
- hsa-miR-6769a-3p (MIRT657382)
- hsa-miR-625-5p (MIRT732581)
- hsa-miR-296-5p (MIRT732722)
- mmu-let-7a-5p (MIRT733304)
- hsa-miR-1297 (MIRT735426)
- hsa-miR-1207-5p (MIRT736024)
- hsa-miR-1224-3p (MIRT736083)
- hsa-miR-125a-3p (MIRT736627)
- hsa-miR-1273h-5p (MIRT736867)
- hsa-miR-1321 (MIRT737333)
- hsa-miR-1343-5p (MIRT737467)
- hsa-miR-1976 (MIRT738709)
- hsa-miR-30b-3p (MIRT739757)
- hsa-miR-30c-1-3p (MIRT739817)
- hsa-miR-30c-2-3p (MIRT739860)
- hsa-miR-3667-3p (MIRT742080)
- hsa-miR-3689a-3p (MIRT742259)
- hsa-miR-3689b-3p (MIRT742329)
- hsa-miR-3689c (MIRT742399)
- hsa-miR-3934-5p (MIRT743100)
- hsa-miR-4270 (MIRT743568)
- hsa-miR-4278 (MIRT743687)
- hsa-miR-4297 (MIRT743805)
- hsa-miR-4323 (MIRT744048)
- hsa-miR-4425 (MIRT744277)
- hsa-miR-4441 (MIRT744535)
- hsa-miR-4459 (MIRT744802)
- hsa-miR-4667-3p (MIRT746791)
- hsa-miR-4690-3p (MIRT747055)
- hsa-miR-4722-3p (MIRT747567)
- hsa-miR-4722-5p (MIRT747597)
- hsa-miR-4739 (MIRT748051)
- hsa-miR-4756-5p (MIRT748423)
- hsa-miR-4763-3p (MIRT748533)
- hsa-miR-4779 (MIRT748734)
- hsa-miR-486-3p (MIRT749107)
- hsa-miR-486-5p (MIRT749142)
- hsa-miR-5581-5p (MIRT750939)
- hsa-miR-5685 (MIRT751183)
- hsa-miR-6081 (MIRT751758)
- hsa-miR-6165 (MIRT752507)
- hsa-miR-660-3p (MIRT753539)
- hsa-miR-6721-5p (MIRT753798)
- hsa-miR-6727-3p (MIRT753933)
- hsa-miR-6747-3p (MIRT754501)
- hsa-miR-6754-5p (MIRT754710)
- hsa-miR-6779-5p (MIRT755498)
- hsa-miR-6780a-5p (MIRT755574)
- hsa-miR-6788-5p (MIRT755969)
- hsa-miR-6789-5p (MIRT756015)
- hsa-miR-6815-5p (MIRT756776)
- hsa-miR-6865-5p (MIRT757925)
- hsa-miR-6887-3p (MIRT758571)
- hsa-miR-7106-5p (MIRT758857)
- hsa-miR-7112-5p (MIRT759082)
- hsa-miR-7152-5p (MIRT759197)
- hsa-miR-764 (MIRT759532)
- hsa-miR-765 (MIRT759559)
- hsa-miR-887-5p (MIRT760408)
- hsa-miR-92a-1-5p (MIRT760520)
- hsa-miR-939-5p (MIRT760758)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HMGA1
- Browse OriGene Inhibitory RNA Products For HMGA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMGA1
Clone Products
- Applied Biological Materials (abm): Clones for HMGA1 - Select products 50% OFF >
- * HMGA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG200266
- MG200385
- MG223279
- MG223478
- MG223482
- MG223873
- MG224258
- MG224266
- MG224273
- MG224287
- MG224685
- MG224689
- MG224692
- MR200266
- MR200266L3
- MR200266L4
- MR200385
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- MR200385L4
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- MR223279L4
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- MR223478L3
- MR223478L4
- MR223482
- MR223482L3
- MR223482L4
- MR223873
- MR223873L3
- MR223873L4
- MR224258
- MR224258L3
- MR224258L4
- MR224266
- MR224266L3
- MR224266L4
- MR224273
- MR224273L3
- MR224273L4
- MR224287
- MR224287L3
- MR224287L4
- MR224685
- MR224685L3
- MR224685L4
- MR224689
- MR224689L3
- MR224689L4
- MR224692
- MR224692L3
- MR224692L4
- MR227874
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- RC201458
- RC201458L1
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- RC202928
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- RC217251
- RC217251L3
- RC217251L4
- RC217302
- RC217302L3
- RC217302L4
- RC217358
- RC217358L3
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- RG201458
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- RR215173
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- MR223482L3V
- MR223482L4V
- MR223873L3V
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- MR224258L3V
- MR224258L4V
- MR224266L3V
- MR224266L4V
- MR224273L3V
- MR224273L4V
- MR224287L3V
- MR224287L4V
- MR224685L3V
- MR224685L4V
- MR224689L3V
- MR224689L4V
- MR224692L3V
- MR224692L4V
- RC201458L1V
- RC201458L2V
- RC201458L3V
- RC201458L4V
- RC202928L1V
- RC202928L2V
- RC202928L3V
- RC202928L4V
- RC204972L3V
- RC204972L4V
- RC213109L3V
- RC213109L4V
- RC217251L3V
- RC217251L4V
- RC217302L3V
- RC217302L4V
- RC217358L3V
- RC217358L4V
- RR215173L3V
- RR215173L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HMGA1
- Addgene plasmids for HMGA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMGA1
Cell Line Products
-
Horizon Cell Lines for HMGA1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HMGA1 Gene
Localization for HMGA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGA1 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
| endosome | 1 |
| lysosome | 1 |
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IEA | -- |
| GO:0005634 | nucleus | IBA,IDA | 16901784 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | TAS | 10428834 |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for HMGA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.91
.65
.45
|
|
| 2 | Autointegration results in viral DNA circles | ||
| 3 | Cellular Senescence (REACTOME) | ||
| 4 | DNA Damage/Telomere Stress Induced Senescence | ||
| 5 | Transport of the SLBP independent Mature mRNA | ||
Pathways by source for HMGA1 Gene
5 BioSystems pathways for HMGA1 Gene
17 Reactome pathways for HMGA1 Gene
1 GeneGo (Thomson Reuters) pathway for HMGA1 Gene
- Immune response IL-2 activation and signaling pathway
1 Qiagen pathway for HMGA1 Gene
- iNOS Signaling
1 Cell Signaling Technology pathway for HMGA1 Gene
Interacting Proteins for HMGA1 Gene
Selected Interacting proteins:
P17096-HMGA1_HUMAN
ENSP00000399888
for HMGA1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HMGA1
SIGNOR curated interactions for HMGA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006268 | DNA unwinding involved in DNA replication | NAS | 10428834 |
| GO:0006284 | base-excision repair | IBA | 21873635 |
| GO:0006337 | nucleosome disassembly | TAS | 10428834 |
| GO:0006355 | regulation of transcription, DNA-templated | TAS,IBA | 21873635 |
| GO:0008285 | negative regulation of cell proliferation | IMP | 16901784 |
Transcripts for HMGA1 Gene
mRNA/cDNA for HMGA1 Gene
- 13 REFSEQ mRNAs :
- 32 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000311487 1920 nts (view in UCSC)
- ENST00000347617 1773 nts (view in UCSC)
- ENST00000374116 1848 nts (view in UCSC)
- ENST00000401473 1887 nts (view in UCSC)
- ENST00000447654 2159 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HMGA1 - Select products 50% OFF >
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OriGene CRISPR knockouts for HMGA1
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-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HMGA1
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Clone Products
- Applied Biological Materials (abm): Clones for HMGA1 - Select products 50% OFF >
- * HMGA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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-
- MG200266
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- RC213109L3V
- RC213109L4V
- RC217251L3V
- RC217251L4V
- RC217302L3V
- RC217302L4V
- RC217358L3V
- RC217358L4V
- RR215173L3V
- RR215173L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HMGA1
- Addgene plasmids for HMGA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMGA1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | - | - |
| ExUns: | 13c | · | 13d |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: | |||
| SP13: | |||
| SP14: | |||
| SP15: | |||
| SP16: | |||
| SP17: | |||
| SP18: | |||
| SP19: | |||
| SP20: | |||
| SP21: | |||
| SP22: | |||
| SP23: | |||
| SP24: |
Relevant External Links for HMGA1 Gene
- GeneLoc Exon Structure for
- HMGA1
Expression for HMGA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- S-shaped Body Cells S-shaped Body
- S-shaped Body
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Lymph (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for HMGA1 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.6).
This gene is overexpressed in Peripheral blood mononuclear cells (9.6), Amniocyte (8.2), Tlymphocyte (7.7), Blymphocyte (6.7), and CD8 Tcells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HMGA1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HMGA1
SOURCE GeneReport for Unigene cluster for HMGA1 Gene:
Hs.518805Evidence on tissue expression from TISSUES for HMGA1 Gene
- Pancreas(5)
- Liver(4.9)
- Nervous system(4.9)
- Skin(4.9)
- Lung(4.8)
- Blood(4.8)
- Intestine(4.8)
- Muscle(4.8)
- Eye(4.7)
- Stomach(4.1)
- Kidney(3.8)
- Heart(3.4)
- Bone(3.2)
- Lymph node(2.5)
- Bone marrow(2.4)
- Thyroid gland(2.2)
- Spleen(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGA1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- ear
- eye
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- heart
- rib
- rib cage
- scapula
- sternum
Abdomen:
- kidney
- liver
- pancreas
Pelvis:
- ovary
- pelvis
- uterus
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for HMGA1
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for HMGA1 Gene
Orthologs for HMGA1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HMGA1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HMGA1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Hmga1 17 31 |
|
OneToMany | |
| Hmga1-rs1 30 31 |
|
OneToMany | |||
| Hmga1b 17 |
|
||||
| Dog (Canis familiaris) |
Mammalia | HMGA1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | HMGA1 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hmga1 30 |
|
||
| Chicken (Gallus gallus) |
Aves | HMGA1 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | HMGA1 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | hmga1b 31 |
|
OneToMany | |
| hmga1a 31 |
|
OneToMany |
- Species where no ortholog for HMGA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for HMGA1 Gene
- ENSEMBL:
- Gene Tree for HMGA1 (if available)
- TreeFam:
- Gene Tree for HMGA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HMGA1: view image
Paralogs for HMGA1 Gene
Pseudogenes.org Pseudogenes for HMGA1 Gene
No data available for Paralogs for HMGA1 Gene
Variants for HMGA1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HMGA1 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 783751 | Benign: not provided | 34,240,837(+) | C/T | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10616n54 | CNV | gain | 21841781 |
| dgv10617n54 | CNV | gain | 21841781 |
| esv24915 | CNV | loss | 19812545 |
| nsv1137544 | CNV | deletion | 24896259 |
| nsv602863 | CNV | loss | 21841781 |
| nsv602865 | CNV | loss | 21841781 |
| nsv602866 | CNV | loss | 21841781 |
| nsv823666 | CNV | gain | 20364138 |
| nsv969388 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.81;
34.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HMGA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGA1 Gene
Disorders for HMGA1 Gene
(13) MalaCards diseases for HMGA1 Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetes mellitus, noninsulin-dependent |
|
|
| rare diabetes mellitus type 2 |
|
|
| lipomatosis, multiple |
|
|
| ring chromosome 1 |
|
|
| pelvic lipomatosis |
|
|
Search HMGA1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HMGA1_HUMAN- Note=A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B. {ECO:0000269 PubMed:11978964}.
Additional Disease Information for HMGA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for HMGA1 Gene
Publications for HMGA1 Gene
- Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. (PMID: 8414980) Friedmann M … Reeves R (Nucleic acids research 1993) 2 3 4 23
- Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity. (PMID: 17960875) Zhang Q … Wang Y (Journal of proteome research 2007) 3 4 23
- Serine ADP-Ribosylation Depends on HPF1. (PMID: 28190768) Bonfiglio JJ … Matic I (Molecular cell 2017) 3 4
- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 41
- Functional variants of the HMGA1 gene and type 2 diabetes mellitus. (PMID: 21364139) Chiefari E … Brunetti A (JAMA 2011) 3 41
ExternalLinks
Products for HMGA1 Gene
- Custom Antibody ServicesOriGene Antibodies for HMGA1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HMGA1
- NM_002131
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