Aliases for HMG20A Gene
Aliases for HMG20A Gene
External Ids for HMG20A Gene
- HGNC: 5001
- Entrez Gene: 10363
- Ensembl: ENSG00000140382
- OMIM: 605534
- UniProtKB: Q9NP66
Previous GeneCards Identifiers for HMG20A Gene
- GC15P073605
- GC15P070803
- GC15P075289
- GC15P075429
- GC15P075500
- GC15P077712
- GC15P054470
Summaries for HMG20A Gene
GeneCards Summary for HMG20A Gene
HMG20A (High Mobility Group 20A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is HMG20B.
UniProtKB/Swiss-Prot for HMG20A Gene
-
Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).
Additional gene information for HMG20A Gene
- Monarch Initiative
- Search for HMG20A at DataMed
- Search for HMG20A at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMG20A Gene
Genomics for HMG20A Gene
GeneHancer (GH) Regulatory Elements for HMG20A Gene
Promoters and enhancers for HMG20A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HMG20A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HMG20A gene promoter:
-
- ATF-2
- HNF-3beta
- MEF-2A
- MEF-2
- aMEF-2
- HOXA9B
- CUTL1
- HOXA9
- Meis-1
- Meis-1a
Regulatory Element Products
Genomic Locations for HMG20A Gene
Genomic Locations for HMG20A Gene
- chr15:77,420,412-77,485,607
- (GRCh38/hg38)
- Size:
- 65,196 bases
- Orientation:
- Plus strand
- chr15:77,712,754-77,777,949
- (GRCh37/hg19)
- Size:
- 65,196 bases
- Orientation:
- Plus strand
Genomic View for HMG20A Gene
Genes around HMG20A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.3 by Entrez Gene
- 15q24.3 by HGNC
- 15q24.3 by Ensembl
HMG20A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMG20A Gene
Proteins for HMG20A Gene
-
Protein details for HMG20A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NP66-HM20A_HUMAN
- Recommended name:
- High mobility group protein 20A
- Protein Accession:
- Q9NP66
- A6NHY3
- D3DW78
- Q53G31
- Q9NSF6
Protein attributes for HMG20A Gene
- Size:
- 347 amino acids
- Molecular mass:
- 40144 Da
- Quaternary structure:
- No Data Available
Protein Expression for HMG20A Gene
Post-translational modifications for HMG20A Gene
Other Protein References for HMG20A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HMG20A
- Invitrogen Antibodies for HMG20A
- GeneTex HMG20A Antibody for HMG20A
-
Santa Cruz Biotechnology (SCBT) Antibodies for HMG20A
Protein Products
-
OriGene Purified Proteins for HMG20A
- Search Origene for MassSpec and Protein Over-expression Lysates for HMG20A
- Origene Custom Protein Services for HMG20A
- antibodies-online: Search results for 5 available HMG20A Proteins ranked by validation data
- Compare Top HMG20A Proteins
-
Quality Products:
- Search GeneTex for Proteins for HMG20A
Assay Products
No data available for DME Specific Peptides for HMG20A Gene
Domains & Families for HMG20A Gene
Gene Families for HMG20A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HMG20A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMG20A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HMG20A Gene
Function for HMG20A Gene
Molecular function for HMG20A Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).
Phenotypes From GWAS Catalog for HMG20A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS,IEA | 10773667 |
| GO:0003682 | chromatin binding | IBA | -- |
| GO:0003700 | DNA binding transcription factor activity | NAS | 10773667 |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0042802 | identical protein binding | IPI | 16189514 |
Phenotypes for HMG20A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HMG20A
-
CRISPR Products
-
OriGene CRISPR knockouts for HMG20A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMG20A
- genomics-online: gRNA clones - Search results for 122 available HMG20A gene related products
- Overview of 122 available HMG20A gene related products
- Applied Biological Materials CRISPR for HMG20A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMG20A
- GenScript: Design CRISPR guide RNA sequences for HMG20A
miRNA for HMG20A Gene
- miRTarBase miRNAs that target HMG20A
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HMG20A
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- genomics-online: shRNA clones - Search results for 122 available HMG20A gene related products
- Overview of 122 available HMG20A gene related products
Clone Products
- Sino Biological Human cDNA Clone for HMG20A
- VectorBuilder custom plasmid, inducible vectors for HMG20A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMG20A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HMG20A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMG20A
- Applied Biological Materials Clones for HMG20A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HMG20A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMG20A Gene
Localization for HMG20A Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMG20A Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 1 |
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,NAS | 10773667 |
Pathways & Interactions for HMG20A Gene
No Data Available
Interacting Proteins for HMG20A Gene
Selected Interacting proteins:
Q9NP66-HM20A_HUMAN
ENSP00000336856
for HMG20A Gene via
IID
UniProtKB
STRING
MINT
GPS-Prot Interaction Network for HMG20A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006325 | chromatin organization | NAS | 10773667 |
| GO:0006338 | chromatin remodeling | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 10773667 |
No data available for Pathways by source and SIGNOR curated interactions for HMG20A Gene
Transcripts for HMG20A Gene
mRNA/cDNA for HMG20A Gene
- (4) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (229) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000336216 4046 bps (uc002bcs.4)
- ENST00000381714 4112 bps (uc002bcr.4)
- ENST00000558176 479 bps (uc059lzk.1)
- ENST00000558288 3558 bps (uc059lzq.1)
- ENST00000558651 494 bps (uc059lzi.1)
Unigene Clusters for HMG20A Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMG20A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HMG20A
- genomics-online: gRNA clones - Search results for 122 available HMG20A gene related products
- Overview of 122 available HMG20A gene related products
- Applied Biological Materials CRISPR for HMG20A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMG20A
- GenScript: Design CRISPR guide RNA sequences for HMG20A
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HMG20A
- Browse OriGene Inhibitory RNA Products For HMG20A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HMG20A
- genomics-online: shRNA clones - Search results for 122 available HMG20A gene related products
- Overview of 122 available HMG20A gene related products
Clone Products
- Sino Biological Human cDNA Clone for HMG20A
- VectorBuilder custom plasmid, inducible vectors for HMG20A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMG20A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HMG20A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HMG20A
- Applied Biological Materials Clones for HMG20A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP3: | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for HMG20A Gene
This gene is overexpressed in Blymphocyte (12.3), Fetal ovary (11.2), and CD8 Tcells (11.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HMG20A Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HMG20A Gene:
HMG20ASOURCE GeneReport for Unigene cluster for HMG20A Gene:
Hs.69594mRNA Expression by UniProt/SwissProt for HMG20A Gene:
Q9NP66-HM20A_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for HMG20A Gene
- Nervous system(4.6)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for HMG20A
-
OriGene qPCR primer pairs for HMG20A
- genomics-online: primer clones - Search results for 122 available HMG20A gene related products
- Overview of 122 available HMG20A gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMG20A Gene
Orthologs for HMG20A Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMG20A 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HMG20A 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HMG20A 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HMG20A 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hmg20a 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hmg20a 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HMG20A 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| HMG20A 34 33 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | HMG20A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.8432 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7860 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hmg20a 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004791 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9418 34 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | hmg-20 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NHP6A 36 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for HMG20A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for HMG20A Gene
- ENSEMBL:
- Gene Tree for HMG20A (if available)
- TreeFam:
- Gene Tree for HMG20A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HMG20A: view image
Paralogs for HMG20A Gene
Variants for HMG20A Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005727 | -- | 77,519,033(+) | T/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000026812 | -- | 77,506,543(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000055606 | -- | 77,460,788(+) | C/A/G | intron_variant | |
| rs1000063169 | -- | 77,467,566(+) | A/C/G | intron_variant | |
| rs1000122216 | -- | 77,513,123(+) | C/A | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv570139 | CNV | loss | 21841781 |
| nsv1116463 | OTHER | inversion | 24896259 |
| nsv1043284 | CNV | gain | 25217958 |
| nsv1040852 | CNV | gain | 25217958 |
| esv3636966 | CNV | loss | 21293372 |
| esv3552706 | CNV | deletion | 23714750 |
| esv3362224 | CNV | insertion | 20981092 |
| esv3306898 | CNV | mobile element insertion | 20981092 |
| esv2749898 | CNV | deletion | 23290073 |
| esv2660058 | CNV | deletion | 23128226 |
Residual Variation Intolerance Score:
31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.58;
12.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HMG20A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMG20A Gene
Disorders for HMG20A Gene
Additional Disease Information for HMG20A
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for HMG20A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMG20A Gene
Publications for HMG20A Gene
- HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. (PMID: 10773667) Sumoy L … Peral B (Cytogenetics and cell genetics 2000) 2 3 4 58
- Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X … Tai ES (PLoS genetics 2011) 3 44 58
- Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PMID: 21874001) Kooner JS … Chambers JC (Nature genetics 2011) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for HMG20A Gene
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- GenScript: Design CRISPR guide RNA sequences for HMG20A
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- VectorBuilder custom plasmid, inducible vectors for HMG20A
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HMG20A
- antibodies-online: Search results for 72 available HMG20A Antibodies ranked by validation data
- Compare Top HMG20A Antibodies
- antibodies-online: Search results for available HMG20A related products ranked by validation data
- antibodies-online: Search results for 5 available HMG20A Proteins ranked by validation data
- Compare Top HMG20A Proteins
- Quality Products:
- GeneTex HMG20A Antibody for HMG20A
- Search GeneTex for Proteins for HMG20A
- Santa Cruz Biotechnology (SCBT) Antibodies for HMG20A
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- Santa Cruz Biotechnology (SCBT) CRISPR for HMG20A
- Horizon Cell Lines for HMG20A
- genomics-online: cdna clones - Search results for 122 available HMG20A gene related products
- Overview of 122 available HMG20A gene related products
- orf clones - Search results for 122 available HMG20A gene related products
- Overview of 122 available HMG20A gene related products
- genomics-online: gRNA clones - Search results for 122 available HMG20A gene related products
- Overview of 122 available HMG20A gene related products
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- Overview of 122 available HMG20A gene related products
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Sources for HMG20A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
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