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HMG20A (High Mobility Group 20A) is a Protein Coding gene. Diseases associated with HMG20A include Autosomal Recessive Congenital Cerebellar Ataxia and Cowpox. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is HMG20B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0042802 | identical protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,NAS | 10773667 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006325 | chromatin organization | NAS | 10773667 |
GO:0006355 | regulation of transcription, DNA-templated | NAS | 10773667 |
GO:0010468 | regulation of gene expression | IBA | 21873635 |
GO:0033234 | negative regulation of protein sumoylation | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HMG20A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HMG20A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HMG20A 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HMG20A 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Hmg20a 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hmg20a 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | HMG20A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
HMG20A 30 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | HMG20A 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7860 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.8432 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | hmg20a 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004789 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9418 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | hmg-20 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NHP6A 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs61755712 | Likely Benign: not provided | 77,458,433(+) |
C/T NM_001304504.2(HMG20A):c.26C>T (p.Thr9Ile) |
MISSENSE_VARIANT,FIVE_PRIME_UTR |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2660058 | CNV | deletion | 23128226 |
esv2749898 | CNV | deletion | 23290073 |
esv3306898 | CNV | mobile element insertion | 20981092 |
esv3362224 | CNV | insertion | 20981092 |
esv3552706 | CNV | deletion | 23714750 |
esv3636966 | CNV | loss | 21293372 |
nsv1040852 | CNV | gain | 25217958 |
nsv1043284 | CNV | gain | 25217958 |
nsv1116463 | OTHER | inversion | 24896259 |
nsv570139 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
autosomal recessive congenital cerebellar ataxia |
|
|
cowpox |
|
|