This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use ... See more...

Aliases for HLTF Gene

Aliases for HLTF Gene

  • Helicase Like Transcription Factor 2 3 5
  • SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 3 2 3
  • SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3 3 4
  • RING-Type E3 Ubiquitin Transferase HLTF 3 4
  • Sucrose Nonfermenting Protein 2-Like 3 3 4
  • Helicase-Like Transcription Factor 3 4
  • RING Finger Protein 80 3 4
  • SMARCA3 3 4
  • HIP116A 3 4
  • SNF2L3 3 4
  • HIP116 3 4
  • RNF80 3 4
  • ZBU1 3 4
  • DNA-Binding Protein/Plasminogen Activator Inhibitor-1 Regulator 3
  • DNA-Binding Protein/Plasminogen Activator Inhibitor 1 Regulator 4
  • Sucrose Nonfermenting-Like 3 3
  • SNF2-Like 3 3
  • EC 2.3.2.27 4
  • EC 3.6.4.- 4
  • EC 3.6.1 52
  • HLTF1 3

External Ids for HLTF Gene

Previous HGNC Symbols for HLTF Gene

  • SNF2L3
  • SMARCA3

Previous GeneCards Identifiers for HLTF Gene

  • GC03M150231
  • GC03M148747
  • GC03M146119

Summaries for HLTF Gene

Entrez Gene Summary for HLTF Gene

  • This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLTF Gene

HLTF (Helicase Like Transcription Factor) is a Protein Coding gene. Diseases associated with HLTF include Schimke Immunoosseous Dysplasia and Colorectal Cancer. Among its related pathways are PEDF Induced Signaling and Retinoblastoma (RB) in Cancer. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ligase activity. An important paralog of this gene is TTF2.

UniProtKB/Swiss-Prot Summary for HLTF Gene

  • Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.

Gene Wiki entry for HLTF Gene

Additional gene information for HLTF Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLTF Gene

Genomics for HLTF Gene

GeneHancer (GH) Regulatory Elements for HLTF Gene

Promoters and enhancers for HLTF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J149085 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 517.6 +0.6 554 2.8 ZNF217 EP300 NRF1 MYC TCF12 POLR2G SP1 GTF2E2 PHF8 PHB2 HLTF HLTF-AS1 lnc-CP-2 PFN2 lnc-CP-3
GH03J148990 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 15 +94.7 94704 3.1 HNRNPK CTCF NRF1 MYC POLR2G USF1 PHF8 JUND FOS ZFX GYG1 lnc-GYG1-2 HLTF lnc-CPA3-2
GH03J149128 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -44.4 -44359 4.6 ZNF217 EP300 SIN3A NRF1 TCF12 USF1 POLR2G SP1 PHF8 ZFX HPS3 lnc-CP-5 HLTF TM4SF18 CPHL1P RF00994-690
GH03J149042 Enhancer 0.7 Ensembl ENCODE 28.7 +42.9 42881 2.5 FOS JUND PRDM1 ATF2 TBX21 JUNB HLF ATF7 ZNF384 FOXA1 HLTF HLTF-AS1 GYG1 UBQLN4P1 lnc-CP-4 piR-34822-233
GH03J149008 Enhancer 1.1 Ensembl ENCODE dbSUPER 16.6 +75.9 75932 3.6 FOS SKI TEAD1 ZKSCAN8 FOXA2 KAT7 GABPA SAP130 MXD4 CREM HLTF GYG1 piR-34822-233 piR-50443-272 lnc-CPA3-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLTF on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HLTF

Top Transcription factor binding sites by QIAGEN in the HLTF gene promoter:
  • C/EBPalpha
  • CHOP-10
  • NF-Y
  • NF-YA
  • NF-YB
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RP58
  • STAT5B

Genomic Locations for HLTF Gene

Genomic Locations for HLTF Gene
chr3:149,030,117-149,086,554
(GRCh38/hg38)
Size:
56,438 bases
Orientation:
Minus strand
chr3:148,747,904-148,804,341
(GRCh37/hg19)
Size:
56,438 bases
Orientation:
Minus strand

Genomic View for HLTF Gene

Genes around HLTF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLTF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLTF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HLTF Gene

Proteins for HLTF Gene

  • Protein details for HLTF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14527-HLTF_HUMAN
    Recommended name:
    Helicase-like transcription factor
    Protein Accession:
    Q14527
    Secondary Accessions:
    • D3DNH3
    • Q14536
    • Q16051
    • Q7KYJ6
    • Q86YA5
    • Q92652
    • Q96KM9

    Protein attributes for HLTF Gene

    Size:
    1009 amino acids
    Molecular mass:
    113929 Da
    Quaternary structure:
    • Interacts with SP1 and SP3 independently of DNA; the interaction with these transcriptional factors may be required for basal transcription of target genes. Interacts with EGR1; the interaction requires prior binding to DNA and represses c-Rel via a DNA looping mechanism (By similarity). Interacts with GATA4 (By similarity). Interacts with PCNA; the interaction promotes polyubiquitination of PCNA through association with the UBE2B-RAD18 and UBE2V2-UBE2N ubiquitin ligase complexes. Interacts with RAD18, SHPRH, UBE2V2 and UBE2N.
    Miscellaneous:
    • Subject to frequent epigenetic inactivation by promoter methylation in colon cancer.

    Three dimensional structures from OCA and Proteopedia for HLTF Gene

    Alternative splice isoforms for HLTF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HLTF Gene

Selected DME Specific Peptides for HLTF Gene

Q14527:
  • LADDMGLGKT
  • GGVGLNL
  • MGLGKTL
  • LRQICCH
  • HQKQALAW
  • LLLRLRQ

Post-translational modifications for HLTF Gene

  • Ubiquitination at Lys12, Lys158, Lys176, Lys216, Lys95, Lys258, Lys340, Lys349, Lys355, Lys433, Lys523, Lys571, Lys638, Lys662, Lys682, Lys952, and Lys959
  • Modification sites at PhosphoSitePlus

Domains & Families for HLTF Gene

Gene Families for HLTF Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HLTF Gene

Blocks:
  • Zn-finger, RING
  • SNF2 related domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HLTF Gene

GenScript: Design optimal peptide antigens:
  • Sucrose nonfermenting protein 2-like 3 (HLTF_HUMAN)
  • HLTF protein (Q05BZ6_HUMAN)
  • HLTF protein (Q05DF7_HUMAN)
  • HLTF protein (Q05DQ5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14527

UniProtKB/Swiss-Prot:

HLTF_HUMAN :
  • Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily.
Family:
  • Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily.
genes like me logo Genes that share domains with HLTF: view

Function for HLTF Gene

Molecular function for HLTF Gene

UniProtKB/Swiss-Prot Function:
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for HLTF Gene

Phenotypes From GWAS Catalog for HLTF Gene

Gene Ontology (GO) - Molecular Function for HLTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding TAS 7876228
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with HLTF: view
genes like me logo Genes that share phenotypes with HLTF: view

Animal Models for HLTF Gene

MGI Knock Outs for HLTF:
  • Hltf Hltf<tm1.2Geno>
  • Hltf Hltf<tm1.1Arte>
  • Hltf Hltf<tm1.1Hdin>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for HLTF

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HLTF Gene

Localization for HLTF Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLTF Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Nuclear localization is stimulated by progesterone. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLTF gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HLTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7876228
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with HLTF: view

Pathways & Interactions for HLTF Gene

PathCards logo

SuperPathways for HLTF Gene

SuperPathway Contained pathways
1 AMPK Enzyme Complex Pathway
.01
-
2 BRCA1 Pathway
-
3 PEDF Induced Signaling
.43
4 Retinoblastoma (RB) in Cancer
genes like me logo Genes that share pathways with HLTF: view

Pathways by source for HLTF Gene

1 BioSystems pathway for HLTF Gene
4 Qiagen pathways for HLTF Gene
  • AMPK Enzyme Complex Pathway
  • BRCA1 Pathway
  • Chromatin Remodeling
  • Glucocorticoid Receptor Signaling

UniProtKB/Swiss-Prot Q14527-HLTF_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for HLTF Gene

Activates:

Gene Ontology (GO) - Biological Process for HLTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 7876228
GO:0008152 metabolic process IEA --
GO:0016567 protein ubiquitination TAS --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with HLTF: view

Drugs & Compounds for HLTF Gene

(1) Drugs for HLTF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HLTF: view

Transcripts for HLTF Gene

mRNA/cDNA for HLTF Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for HLTF

Alternative Splicing Database (ASD) splice patterns (SP) for HLTF Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a ·
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6:

ExUns: 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for HLTF Gene

GeneLoc Exon Structure for
HLTF

Expression for HLTF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HLTF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HLTF Gene

This gene is overexpressed in Fetal testis (29.1), Testis (8.2), Fetal ovary (7.5), Tonsil (6.8), and Adrenal (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HLTF Gene



Protein tissue co-expression partners for HLTF Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLTF

SOURCE GeneReport for Unigene cluster for HLTF Gene:

Hs.3068

mRNA Expression by UniProt/SwissProt for HLTF Gene:

Q14527-HLTF_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.

Evidence on tissue expression from TISSUES for HLTF Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with HLTF: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLTF Gene

Orthologs for HLTF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HLTF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HLTF 31 30
  • 99.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HLTF 31 30
  • 93.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HLTF 31 30
  • 92.04 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hltf 30
  • 86.62 (n)
mouse
(Mus musculus)
Mammalia Hltf 17 31 30
  • 85.71 (n)
oppossum
(Monodelphis domestica)
Mammalia HLTF 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HLTF 31
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HLTF 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hltf 30
  • 66.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12354 30
zebrafish
(Danio rerio)
Actinopterygii hltf 31 30
  • 60.32 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10762 30
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD5 31
  • 23 (a)
OneToOne
RAD16 33
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05130 30
  • 50.21 (n)
rice
(Oryza sativa)
Liliopsida Os07g0642400 30
  • 47.52 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07975 30
  • 46.65 (n)
Species where no ortholog for HLTF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLTF Gene

ENSEMBL:
Gene Tree for HLTF (if available)
TreeFam:
Gene Tree for HLTF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HLTF: view image

Paralogs for HLTF Gene

(2) SIMAP similar genes for HLTF Gene using alignment to 5 proteins:

  • HLTF_HUMAN
  • H7C5K0_HUMAN
  • Q05BZ6_HUMAN
  • Q05DF7_HUMAN
  • Q05DQ5_HUMAN
genes like me logo Genes that share paralogs with HLTF: view

Variants for HLTF Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HLTF Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
775912 Benign: not provided 149,050,343(-) T/C SYNONYMOUS_VARIANT
777802 Likely Benign: not provided 149,063,459(-) A/T MISSENSE_VARIANT
780431 Benign: not provided 149,071,340(-) T/C MISSENSE_VARIANT
780432 Benign: not provided 149,084,826(-) G/A SYNONYMOUS_VARIANT
780897 Benign: not provided 149,063,507(-) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for HLTF Gene

Structural Variations from Database of Genomic Variants (DGV) for HLTF Gene

Variant ID Type Subtype PubMed ID
esv1349617 CNV deletion 17803354
esv2726035 CNV deletion 23290073
esv3041777 CNV deletion 24192839
nsv1127997 CNV deletion 24896259
nsv1131735 CNV deletion 24896259
nsv528849 CNV gain 19592680
nsv829752 CNV loss 17160897
nsv829753 CNV gain 17160897

Variation tolerance for HLTF Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HLTF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLTF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HLTF Gene

Disorders for HLTF Gene

MalaCards: The human disease database

(4) MalaCards diseases for HLTF Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search HLTF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HLTF

genes like me logo Genes that share disorders with HLTF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLTF Gene

Publications for HLTF Gene

  1. Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination. (PMID: 18316726) Unk I … Haracska L (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 23 54
  2. Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. (PMID: 18719106) Motegi A … Myung K (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 23 54
  3. HLTF gene silencing in human colon cancer. (PMID: 11904375) Moinova HR … Markowitz SD (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 4 23 54
  4. Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. (PMID: 10391891) Ding H … Belayew A (The Journal of biological chemistry 1999) 3 4 23 54
  5. Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family. (PMID: 9126292) Gong X … Rosenthal N (Developmental biology 1997) 3 4 23 54

Products for HLTF Gene

Sources for HLTF Gene