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Aliases for HLF Gene

Aliases for HLF Gene

  • HLF, PAR BZIP Transcription Factor 2 3 5
  • PAR BZIP Transcription Factor 2 3
  • Hepatic Leukemia Factor 2 3

External Ids for HLF Gene

Previous GeneCards Identifiers for HLF Gene

  • GC17P053073
  • GC17P055823
  • GC17P053684
  • GC17P053817
  • GC17P050697
  • GC17P053342
  • GC17P048701

Summaries for HLF Gene

Entrez Gene Summary for HLF Gene

  • This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLF Gene

HLF (HLF, PAR BZIP Transcription Factor) is a Protein Coding gene. Diseases associated with HLF include Leukemia, Acute Lymphoblastic 3 and Leukemia. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and double-stranded DNA binding. An important paralog of this gene is TEF.

Gene Wiki entry for HLF Gene

Additional gene information for HLF Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLF Gene

Genomics for HLF Gene

GeneHancer (GH) Regulatory Elements for HLF Gene

Promoters and enhancers for HLF Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J055264 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.3 1270 3.8 ATF1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ELK1 HLF PIR42816
GH17J055263 Enhancer 0.8 Ensembl ENCODE 650.7 -1.0 -1000 0.5 L3MBTL2 SUZ12 ZIC2 ZNF335 CBX8 GLIS2 GLIS1 ZNF341 ZKSCAN8 PATZ1 GC17P055263 HLF
GH17J055281 Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 22.3 +20.2 20221 6.8 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 PAF1 SP5 ZHX2 MXD4 HLF ENSG00000263096 MMD COX11 STXBP4 GC17P055297
GH17J055237 Enhancer 1.5 FANTOM5 Ensembl ENCODE 15.1 -26.7 -26714 2.3 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF213 FOS SP3 HLF GC17M055237 GC17P055167
GH17J055303 Enhancer 1.1 ENCODE dbSUPER 16.1 +39.9 39853 2.9 ATF1 FOXA2 MLX ARID4B ETS1 ATF7 NFKBIZ PAF1 RXRA ZHX2 HLF ENSG00000263096 GC17M055299 GC17M055312
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HLF gene promoter:
  • GATA-1
  • PPAR-gamma2
  • PPAR-gamma1
  • STAT3
  • HSF1short

Genomic Locations for HLF Gene

Genomic Locations for HLF Gene
60,106 bases
Plus strand
60,106 bases
Plus strand

Genomic View for HLF Gene

Genes around HLF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HLF Gene

Proteins for HLF Gene

  • Protein details for HLF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatic leukemia factor
    Protein Accession:
    Secondary Accessions:
    • A8K1X8
    • Q6FHS9

    Protein attributes for HLF Gene

    295 amino acids
    Molecular mass:
    33199 Da
    Quaternary structure:
    • Binds DNA specifically as homodimer or heterodimer with other PAR factors.
    • Sequence=AAA58445.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HLF Gene


neXtProt entry for HLF Gene

Post-translational modifications for HLF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HLF Gene

Domains & Families for HLF Gene

Gene Families for HLF Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HLF Gene


Suggested Antigen Peptide Sequences for HLF Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bZIP family. PAR subfamily.
  • Belongs to the bZIP family. PAR subfamily.
genes like me logo Genes that share domains with HLF: view

Function for HLF Gene

Molecular function for HLF Gene

UniProtKB/Swiss-Prot Induction:
Accumulates according to a robust circadian rhythm.
GENATLAS Biochemistry:
hepatic leukemia factor,rearranged in acute B-cell leukemia,with translocation t(17;19)

Phenotypes From GWAS Catalog for HLF Gene

Gene Ontology (GO) - Molecular Function for HLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP 8065331
GO:0003677 DNA binding IEA,TAS 8639829
genes like me logo Genes that share ontologies with HLF: view
genes like me logo Genes that share phenotypes with HLF: view

Animal Models for HLF Gene

MGI Knock Outs for HLF:
  • Hlf Hlf<tm1Schb>

Animal Model Products

Transcription Factor Targets for HLF Gene

Selected GeneGlobe predicted Target genes for HLF

Clone Products

  • Addgene plasmids for HLF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for HLF Gene

Localization for HLF Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLF Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLF gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with HLF: view

Pathways & Interactions for HLF Gene

No Data Available

Gene Ontology (GO) - Biological Process for HLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 8639829
GO:0007275 multicellular organism development TAS 1386162
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with HLF: view

No data available for Pathways by source and SIGNOR curated interactions for HLF Gene

Drugs & Compounds for HLF Gene

(1) Drugs for HLF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HLF: view

Transcripts for HLF Gene

mRNA/cDNA for HLF Gene

Unigene Clusters for HLF Gene

Hepatic leukemia factor:
Representative Sequences:

Clone Products

  • Addgene plasmids for HLF

Alternative Splicing Database (ASD) splice patterns (SP) for HLF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP11: - - - - - - - -

Relevant External Links for HLF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HLF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HLF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HLF Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HLF Gene

Protein tissue co-expression partners for HLF Gene

NURSA nuclear receptor signaling pathways regulating expression of HLF Gene:


SOURCE GeneReport for Unigene cluster for HLF Gene:


mRNA Expression by UniProt/SwissProt for HLF Gene:

Tissue specificity: Highly expressed in liver; lower levels in lung and kidney.

Evidence on tissue expression from TISSUES for HLF Gene

  • Nervous system(4.8)
  • Liver(2.7)
genes like me logo Genes that share expression patterns with HLF: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLF Gene

Orthologs for HLF Gene

This gene was present in the common ancestor of animals.

Orthologs for HLF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HLF 34 33
  • 99.77 (n)
(Canis familiaris)
Mammalia HLF 34 33
  • 95.25 (n)
(Monodelphis domestica)
Mammalia HLF 34
  • 92 (a)
(Rattus norvegicus)
Mammalia LOC690286 33
  • 91.75 (n)
(Mus musculus)
Mammalia Hlf 16 34 33
  • 91.64 (n)
(Bos Taurus)
Mammalia HLF 34 33
  • 89.94 (n)
(Ornithorhynchus anatinus)
Mammalia HLF 34
  • 83 (a)
(Gallus gallus)
Aves HLF 34 33
  • 83.33 (n)
(Anolis carolinensis)
Reptilia HLF 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hlf 33
  • 77.18 (n)
(Danio rerio)
Actinopterygii hlfa 33
  • 73.15 (n)
hlfb 34
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3939 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006376 33
  • 57.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pdp1 34 33
  • 54.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6834 34
  • 13 (a)
Species where no ortholog for HLF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLF Gene

Gene Tree for HLF (if available)
Gene Tree for HLF (if available)
Evolutionary constrained regions (ECRs) for HLF: view image

Paralogs for HLF Gene

Paralogs for HLF Gene

(2) SIMAP similar genes for HLF Gene using alignment to 3 proteins:

  • I3L386_HUMAN
  • I3L4R4_HUMAN Pseudogenes for HLF Gene

genes like me logo Genes that share paralogs with HLF: view

Variants for HLF Gene

Sequence variations from dbSNP and Humsavar for HLF Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs193920793 uncertain-significance, Malignant tumor of prostate 55,268,071(+) A/AA coding_sequence_variant, frameshift
rs1000024666 -- 55,274,669(+) C/A intron_variant
rs1000051616 -- 55,282,193(+) G/A intron_variant
rs1000089084 -- 55,296,349(+) A/G intron_variant
rs1000135236 -- 55,322,745(+) G/A/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for HLF Gene

Variant ID Type Subtype PubMed ID
esv3573742 CNV gain 25503493
esv3582824 CNV loss 25503493
esv3582825 CNV loss 25503493

Variation tolerance for HLF Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HLF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HLF Gene

Disorders for HLF Gene

MalaCards: The human disease database

(3) MalaCards diseases for HLF Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute lymphoblastic 3
  • leukemia, acute lymphoblastic, susceptibility to, 3
lymphoblastic leukemia
  • acute lymphocytic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search HLF in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3.

Genatlas disease for HLF Gene

acute lymphoblastic leukemia,preB-cell,with t(17;19)(q22;p13) translocation (see TCF3),associated with CDNK2A and/or CDKN2B deletion

Additional Disease Information for HLF

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HLF: view

Publications for HLF Gene

  1. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. (PMID: 1386162) Inaba T … Look AT (Science (New York, N.Y.) 1992) 2 3 4 22 58
  2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58
  3. Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor. (PMID: 18239067) Otto T … Fandrey J (Endocrinology 2008) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. E2A basic helix-loop-helix transcription factors in human leukemia. (PMID: 12700034) LeBrun DP (Frontiers in bioscience : a journal and virtual library 2003) 3 22 58

Products for HLF Gene

Sources for HLF Gene

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