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This major histocompatibility complex gene represents a transcribed pseudogene, possibly derived from HLA-A. This gene displays extensive variation. [provided by RefSeq, May 2010] See more...
Aliases for HLA-H Gene
Aliases for HLA-H Gene
External Ids for HLA-H Gene
- HGNC: 4965
- NCBI Entrez Gene: 3136
- Ensembl: ENSG00000206341
- UniProtKB/Swiss-Prot: P01893
Previous GeneCards Identifiers for HLA-H Gene
- GC06P029926
- GC06M029910
- GC06P029962
- GC06P029963
- GC06P029912
- GC06Pf29990
- GC06P029858
- GC06P029655
- GC06P030063
- GC06P030178
- GC06P030087
- GC06P030099
- GC06P032184
- GC06P032420
- GC06P032554
- GC06P033180
- GC06P030340
- GC06P030485
- GC06P030686
- GC06P030850
- GC06P031013
- GC06P031170
- GC06P031342
- GC06P031599
- GC06P047258
Summaries for HLA-H Gene
-
This major histocompatibility complex gene represents a transcribed pseudogene, possibly derived from HLA-A. This gene displays extensive variation. [provided by RefSeq, May 2010]
GeneCards Summary for HLA-H Gene
HLA-H (Major Histocompatibility Complex, Class I, H (Pseudogene)) is a Pseudogene. Among its related pathways are Innate Immune System and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and beta-2-microglobulin binding.
UniProtKB/Swiss-Prot Summary for HLA-H Gene
-
Involved in the presentation of foreign antigens to the immune system.
Additional gene information for HLA-H Gene
- HGNC (4965)
- NCBI Entrez Gene (3136)
- Ensembl (ENSG00000206341)
- UniProtKB/Swiss-Prot (P01893)
- Open Targets Platform(ENSG00000206341)
- Search for HLA-H at DataMed
- Search for HLA-H at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLA-H Gene
Genomics for HLA-H Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HLA-H Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HLA-H on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the HLA-H gene promoter:
-
- AML1a
- AP-2gamma
- ATF6
- Egr-4
- En-1
- MyoD
- Nkx2-5
- Olf-1
- STAT1
- STAT5A
Genomic Locations for HLA-H Gene
Latest Assembly
- chr6:29,887,573-29,891,079
- (GRCh38/hg38)
- Size:
- 3,507 bases
- Orientation:
- Plus strand
Previous Assembly
- chr6:29,855,350-29,858,856
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 3,507 bases
- Orientation:
- Plus strand
- chr6:29,855,350-29,858,259
- (GRCh37/hg19 by Ensembl)
- Size:
- 2,910 bases
- Orientation:
- Plus strand
Genomic View for HLA-H Gene
Genes around HLA-H on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
HLA-H Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HLA-H Gene
Proteins for HLA-H Gene
-
Protein details for HLA-H Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01893-HLAH_HUMAN
- Recommended name:
- Putative HLA class I histocompatibility antigen, alpha chain H
- Protein Accession:
- P01893
Protein attributes for HLA-H Gene
- Size:
- 362 amino acids
- Molecular mass:
- 40892 Da
- Quaternary structure:
-
- Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
- SequenceCaution:
-
- Sequence=AAA36218.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for HLA-H Gene
Post-translational modifications for HLA-H Gene
Antibodies for research
- G Biosciences Immunotag™ HLA-H Polyclonal Antibody
- Invitrogen Antibodies for HLA-H (AFLGC-HLA-H)
- antibodies-online: Show 23 available HLA-H Antibodies ranked by validation data
-
Biorbyt antibodies for HLA-H
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HLA-H
- Origene Custom Protein Services for HLA-H
Assay products for research
No data available for DME Specific Peptides for HLA-H Gene
Domains & Families for HLA-H Gene
Gene Families for HLA-H Gene
Protein Domains for HLA-H Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-type
- MHC class I signature
- MHC_I, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for HLA-H Gene
- GenScript: Design optimal peptide antigens:
-
- MHC class I antigen H (HLAH_HUMAN)
- Hereditary haemochromatosis protein (Q9UM46_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P01893- Family:
-
- Belongs to the MHC class I family.
Function for HLA-H Gene
Molecular function for HLA-H Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the presentation of foreign antigens to the immune system.
- GENATLAS Biochemistry:
- HLA class I-like gene H,5.4 Hind III fragment,see HFEC@,MHC1
Phenotypes From GWAS Catalog for HLA-H Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 29764935 |
| GO:0030881 | beta-2-microglobulin binding | IMP | 9162021 |
| GO:0042605 | peptide antigen binding | IBA | 21873635 |
Phenotypes for HLA-H Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HLA-H - Starting at $85 >
- * HLA-H CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Browse CRISPR knockouts for HLA-H
miRNA products for research
Inhibitory RNAs for research
- Origene shrna and sirna products in human, mouse, rat for HLA-H
- Browse OriGene Inhibitory RNA Products For HLA-H
Clone products for research
- Applied Biological Materials (abm): Clones for HLA-H - Starting at $45 >
- * HLA-H as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HLA-H Gene
Localization for HLA-H Gene
Subcellular locations from UniProtKB/Swiss-Prot for HLA-H Gene
- Cell membrane. Single-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 6461010 |
| GO:0009897 | external side of plasma membrane | IBA | 21873635 |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HLA-H Gene
Pathways & Interactions for HLA-H Gene
Pathways by source for HLA-H Gene
1 BioSystems pathway for HLA-H Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001916 | positive regulation of T cell mediated cytotoxicity | IBA | 21873635 |
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | TAS | -- |
| GO:0002476 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib | IBA | 21873635 |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent | TAS | -- |
No data available for SIGNOR curated interactions for HLA-H Gene
Transcripts for HLA-H Gene
mRNA/cDNA for HLA-H Gene
- 7 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000383620 1096 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HLA-H - Starting at $85 >
- * HLA-H CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Browse CRISPR knockouts for HLA-H
miRNA products for research
Inhibitory RNAs for research
- Origene shrna and sirna products in human, mouse, rat for HLA-H
- Browse OriGene Inhibitory RNA Products For HLA-H
Clone products for research
- Applied Biological Materials (abm): Clones for HLA-H - Starting at $45 >
- * HLA-H as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for HLA-H Gene
- GeneLoc Exon Structure for
- HLA-H
Expression for HLA-H Gene
mRNA differential expression in normal tissues according to GTEx for HLA-H Gene
This gene is overexpressed in Whole Blood (x7.1).
This gene is overexpressed in Lavage (30.1), Blymphocyte (20.0), and Urine (13.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HLA-H Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-H
SOURCE GeneReport for Unigene cluster for HLA-H Gene:
Hs.728808Primer products for research
-
OriGene qPCR primer pairs for HLA-H
-
OriGene qPCR primer pairs and template standards for HLA-H
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-H Gene
Orthologs for HLA-H Gene
No data available for Orthologs for HLA-H Gene
Paralogs for HLA-H Gene
(113) SIMAP similar genes for HLA-H Gene using alignment to 2 proteins:
- HLAH_HUMAN
- Q9UM46_HUMAN
- HLA-A*0201V3
- HLA-ABC
- HLA-B*27
- HLA-A*01
- HLA-Cw3
- HLA-B41
- HLA-A24AK
- DKFZp686N10220
- B-1510
- HLA-B27
- HLA-B52
- MHC class I HLA-A
- HLA-Bw62.5
- HLA-Bw62.4
- HLA-Bw62.3
- HLA-Bw62.1
- HLA-B*51IM
- HLA-B*5101 variant
- HLA-B*1513
- HLA-B*07ML
- HLA-A*2410
- HLA-A*0226
- HLA-A*02
- HLA C*
- HLA B
- Cw
- B*56
- MHC
- HLA-Cw*
- HLA-B57
- HLA-B51
- HLA-B*5603
- HLA-B*4202
- HLA-B*40
- HLA-B*3531
- HLA-B*3512
- HLA-B*0707
- HLA-A*33
- B-3501
- HLA
- HLA-B
- HLA-B35
- HLA-B*47RG
- HLAC
- HLA-A*31
- HLA-Cw*02023
- HLA-B52v
- HLA-B1501V2
- HLA-B15
- HLA-B*5501 variant
- HLA-B*4012
- HLA-B*2712
- HLA-B*15UL
- HLA-B*15MD
- HLA-B*15IL
- HLA-B*1522
- HLA-B*13
- HLA-B gene
- HLA-All
- HLA-A
- HLA-Cw2
- HLA-Cw*15P
- HLA-Cw*03MAC
- HLA-B*58
- HLA-B*35SRE
- HLA-B*35KM
- HLA-B*18 variant
- HLA-A null
- HLA G locus
- B*35
- B*15
- HLA-Cw
- HLA-B18
- HLA-B*35JAC
- HLA-A*03
- HLA-C
- HLA-G
- HLA-F
- HLC-C
- HLA-Cw*03
- HLA-B*1805
- HLA -B
- EA2.1
- Cw*03
- HLA-E
- HLA-CW
- HLA-A*24
- MHC-G
- HLA-G3
- HLA-Cw*0707
- HLA-Cw*07
- HLA-A2
- HLA-A*0225
- Cw*08
- HLA-B*
- HLA-J
- DKFZp686P19218
- LOC554223
- HLA-A26
- EA1.2
- FLJ45422
- HLA-DQB1
- HLA-DRB1
- MR1
- HLA-G2.2
- HFE
- HLA-DMB
- MICA
- MICB
- HLA-MICA
- AZGP1
- HLA-DQB
- HLA-DRB4
No data available for Paralogs for HLA-H Gene
Variants for HLA-H Gene
Additional Variant Information for HLA-H Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Variation tolerance for HLA-H Gene
Disorders for HLA-H Gene
Additional Disease Information for HLA-H
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for HLA-H Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HLA-H Gene
Publications for HLA-H Gene
- Transcription analysis, physical mapping, and molecular characterization of a nonclassical human leukocyte antigen class I gene. (PMID: 2294403) Chorney MJ … Weissman SM (Molecular and cellular biology 1990) 2 3 23
- Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation. (PMID: 15350465) Kotzampasaki EM … Stavropoulos-Giokas C (Transplantation proceedings 2004) 3 41
- [Role of polymorphic adhesion molecules in the development of graft-versus-leukemia effect after HLA-matched allogeneic stem cell transplantation]. (PMID: 15359910) Shiobara S … Nakao S ([Rinsho ketsueki] The Japanese journal of clinical hematology 2004) 3 41
- HLA-H: a pseudogene with increased variation due to balancing selection at neighboring loci. (PMID: 9866194) Grimsley C … Ober C (Molecular biology and evolution 1998) 3 23
- Examination of four HLA class I pseudogenes. Common events in the evolution of HLA genes and pseudogenes. (PMID: 1517564) Geraghty DE … Hansen JA (Journal of immunology (Baltimore, Md. : 1950) 1992) 2 3
ExternalLinks
Products for HLA-H Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HLA-H
- Origene Custom Protein Services for HLA-H
- Origene shrna and sirna products in human, mouse, rat for HLA-H
- Browse OriGene Inhibitory RNA Products For HLA-H
- OriGene qPCR primer pairs for HLA-H
- OriGene qPCR primer pairs and template standards for HLA-H
- Browse CRISPR knockouts for HLA-H
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HLA-H
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for HLA-H (AFLGC-HLA-H)
- antibodies-online: Show 23 available HLA-H Antibodies ranked by validation data
- antibodies-online: Search results for available HLA-H related products ranked by validation data
- antibodies-online: Search results for available HLA-H related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for HLA-H
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for HLA-H
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HLA-H
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for HLA-H
- Biorbyt antibodies for HLA-H
Sources for HLA-H Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB