HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 ... See more...

Aliases for HLA-G Gene

Aliases for HLA-G Gene

  • Major Histocompatibility Complex, Class I, G 2 3 5
  • HLA Class I Histocompatibility Antigen, Alpha Chain G 3 4
  • HLA-G Histocompatibility Antigen, Class I, G 2 3
  • MHC Class I Antigen G 3 4
  • B2 Microglobulin 2 3
  • HLA G Antigen 3 4
  • Mutant MHC Class Ib Antigen 3
  • Mutant MHC Class I Antigen 3
  • MHC Class Ib Antigen 3
  • HLA-6.0 4
  • MHC-G 3
  • HLA-G 5
  • HLAG 4

External Ids for HLA-G Gene

Previous GeneCards Identifiers for HLA-G Gene

  • GC06P029852
  • GC06P029565
  • GC06P029904
  • GC06P029906
  • GC06P029907
  • GC06P029913
  • GC06P029598
  • GC06P029794
  • GC06P030042
  • GC06P030088
  • GC06P032171
  • GC06P032416
  • GC06P032552
  • GC06P033174
  • GC06P030330
  • GC06P030482
  • GC06P030683
  • GC06P030845
  • GC06P031009
  • GC06P031168
  • GC06P031338
  • GC06P031586

Summaries for HLA-G Gene

Entrez Gene Summary for HLA-G Gene

  • HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-G Gene

HLA-G (Major Histocompatibility Complex, Class I, G) is a Protein Coding gene. Diseases associated with HLA-G include Asthma and Severe Pre-Eclampsia. Among its related pathways are Antigen processing-Cross presentation and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and peptide antigen binding. An important paralog of this gene is HLA-A.

UniProtKB/Swiss-Prot Summary for HLA-G Gene

  • [Isoform 1]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:27859042). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799). Through interaction with KIR2DL4 receptor on decidual macrophages induces proinflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:11290782, PubMed:24453251). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251). May induce immune activation/suppression via intercellular membrane transfer (trogocytosis), likely enabling interaction with KIR2DL4, which resides mostly in endosomes (PubMed:20179272, PubMed:26460007). Through interaction with the inhibitory receptor CD160 on endothelial cells may control angiogenesis in immune privileged sites (PubMed:16809620).
  • [Isoform 2]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).
  • [Isoform 3]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).
  • [Isoform 4]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).
  • [Isoform 5]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799). Through interaction with KIR2DL4 receptor on decidual macrophages induces proinflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251).
  • [Isoform 6]: Likely does not bind B2M and presents peptides.
  • [Isoform 7]: Likely does not bind B2M and presents peptides.

Gene Wiki entry for HLA-G Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLA-G Gene

Genomics for HLA-G Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HLA-G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J029827 Promoter 0.5 Ensembl 600.7 +1.3 1334 2.2 EZH2 CTCF HCG4P8 HLA-G NONHSAG043375.2 NONHSAG045848.2 piR-38512-001 HLA-W HCG4 HLA-K HLA-A ENSG00000230521
GH06J029940 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 60.9 +115.8 115834 5.2 SP1 HNRNPL CREB1 PRDM10 ZNF629 RFX5 ZNF692 POLR2A BACH1 LARP7 HLA-A ENSG00000227766 HCG4P5 lnc-RNF39-9 piR-38512-003 HLA-J HLA-T HLA-G HLA-H HLA-W
GH06J029946 Enhancer 0.4 ENCODE dbSUPER 58.5 +119.6 119571 0.3 POLR2A HLA-J HLA-G HLA-A ENSG00000227766 HLA-K POLR1H lnc-RNF39-9 HCG4P4 HCG4B
GH06J029952 Enhancer 0.7 Ensembl ENCODE 31.5 +127.1 127145 3 JUND SP1 NR3C1 FOSL1 FOSL2 NR2F1 NR2F6 ADNP ATF3 JUN HCG4P4 HLA-W HLA-J HLA-T HLA-K HLA-G HLA-A ENSG00000227766 ZFP57 ENSG00000237669
GH06J029907 Enhancer 0.9 Ensembl ENCODE 25.3 +81.9 81934 3 JUND FOXA1 RXRB SP1 GABPA CEBPA ETS1 FOXA2 FOS FOSL1 MCCD1P1 lnc-RNF39-10 HLA-J HCG4 HLA-G HLA-A ZFP57 ENSG00000230521 HLA-V MICD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLA-G on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HLA-G

Top Transcription factor binding sites by QIAGEN in the HLA-G gene promoter:
  • AP-1
  • AP-2gamma
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • IRF-1
  • p300
  • RREB-1

Genomic Locations for HLA-G Gene

Genomic Locations for HLA-G Gene
chr6:29,826,967-29,831,130
(GRCh38/hg38)
Size:
4,164 bases
Orientation:
Plus strand
chr6:29,794,744-29,798,902
(GRCh37/hg19)
Size:
4,159 bases
Orientation:
Plus strand

Genomic View for HLA-G Gene

Genes around HLA-G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-G Gene

  • Protein details for HLA-G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17693-HLAG_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, alpha chain G
    Protein Accession:
    P17693

    Protein attributes for HLA-G Gene

    Size:
    338 amino acids
    Molecular mass:
    38224 Da
    Quaternary structure:
    • Forms a heterotrimer with B2M and a self-peptide (peptide-bound HLA-G-B2M) (PubMed:7584149, PubMed:8805247). HLA-G-B2M complex interacts with components of the antigen processing machinery TAPBP and TAP1-TAP2 complex; this interaction is required for loading of high affinity peptides and heterotrimer translocation to the cell surface (PubMed:7584149). Interacts with CALCR; this interaction is required for appropriate folding (PubMed:9640257). Interacts with COPB1; this interaction mediates the endoplasmic reticulum (ER) retrieval of HLA-G-B2M complexes that bind low affinity peptides (PubMed:11520457, PubMed:12582157). On the cell surface, peptide-bound HLA-G-B2M molecules (referred to as monomers) can form disulfide-linked homomultimers, homodimers and homotrimers (PubMed:12454284, PubMed:12874224, PubMed:16455647). Interacts with KIR2DL4; this interaction is direct (PubMed:10190900, PubMed:16366734). Interacts with LILRB1 and LILRB2 receptors; this interaction is direct (PubMed:16455647, PubMed:16366734, PubMed:17056715, PubMed:12853576). Interacts with CD160; this interactions is direct (PubMed:16809620). Interacts with CD8A homodimer; this interaction is direct and might down-regulate T cell receptor signaling (PubMed:12853576). Isoform 2: Forms a non-disulfide-linked homodimer and interacts with LILRB2 (PubMed:28348268).

    Three dimensional structures from OCA and Proteopedia for HLA-G Gene

    Alternative splice isoforms for HLA-G Gene

neXtProt entry for HLA-G Gene

Post-translational modifications for HLA-G Gene

  • N-glycosylated.
  • [Soluble HLA class I histocompatibility antigen, alpha chain G]: Produced by proteolytic cleavage at the cell surface (shedding) by matrix metalloproteinase MMP2.
  • Glycosylation at Asn110
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for HLA-G

No data available for DME Specific Peptides for HLA-G Gene

Domains & Families for HLA-G Gene

Gene Families for HLA-G Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for HLA-G Gene

Suggested Antigen Peptide Sequences for HLA-G Gene

GenScript: Design optimal peptide antigens:
  • MHC class I antigen (A5HSK0_HUMAN)
  • MHC class I antigen (A6YB83_HUMAN)
  • MHC class Ib antigen (B0L3P8_HUMAN)
  • MHC class Ib antigen (B0L3P9_HUMAN)
  • MHC class Ib antigen (B0L3Q0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17693

UniProtKB/Swiss-Prot:

HLAG_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-G: view

Function for HLA-G Gene

Molecular function for HLA-G Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:27859042). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799). Through interaction with KIR2DL4 receptor on decidual macrophages induces proinflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:11290782, PubMed:24453251). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251). May induce immune activation/suppression via intercellular membrane transfer (trogocytosis), likely enabling interaction with KIR2DL4, which resides mostly in endosomes (PubMed:20179272, PubMed:26460007). Through interaction with the inhibitory receptor CD160 on endothelial cells may control angiogenesis in immune privileged sites (PubMed:16809620).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).
UniProtKB/Swiss-Prot Function:
[Isoform 3]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).
UniProtKB/Swiss-Prot Function:
[Isoform 4]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).
UniProtKB/Swiss-Prot Function:
[Isoform 5]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799). Through interaction with KIR2DL4 receptor on decidual macrophages induces proinflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251).
UniProtKB/Swiss-Prot Function:
[Isoform 6]: Likely does not bind B2M and presents peptides.
UniProtKB/Swiss-Prot Function:
[Isoform 7]: Likely does not bind B2M and presents peptides.
UniProtKB/Swiss-Prot Induction:
Up-regulated by immunosuppressive cytokine IL10 on dendritic cells and CD4+ T cells (PubMed:20448110). Up-regulated by progesterone in cytotrophoblasts (PubMed:16210391).
GENATLAS Biochemistry:
HLA class Ib ,6.0kb Hind III fragment,expressed in trophoblast (see MHC1),including a 5' locus control region (see LCR- HLA-G)

Phenotypes From GWAS Catalog for HLA-G Gene

Gene Ontology (GO) - Molecular Function for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 20702625
GO:0005515 protein binding IPI 9640257
GO:0042605 peptide antigen binding IDA 7584149
GO:0042610 CD8 receptor binding IDA 12853576
GO:0042802 identical protein binding IPI 16455647
genes like me logo Genes that share ontologies with HLA-G: view
genes like me logo Genes that share phenotypes with HLA-G: view

Human Phenotype Ontology for HLA-G Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HLA-G Gene

MGI Knock Outs for HLA-G:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-G

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HLA-G Gene

Localization for HLA-G Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-G Gene

[Isoform 1]: Cell membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Early endosome membrane.
[Soluble HLA class I histocompatibility antigen, alpha chain G]: Secreted.
[Isoform 2]: Cell membrane. Single-pass type I membrane protein.
[Isoform 3]: Cell membrane. Single-pass type I membrane protein.
[Isoform 4]: Cell membrane. Single-pass type I membrane protein.
[Isoform 5]: Secreted. Early endosome.
[Isoform 6]: Secreted.
[Isoform 7]: Secreted.
Cell projection, filopodium membrane. Note=HLA-G trogocytosis from extravillous trophoblast's filopodia occurs in the majority of decidual NK cells. {ECO:0000269 PubMed:26460007}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-G gene
Compartment Confidence
plasma membrane 5
endosome 5
golgi apparatus 5
extracellular 4
endoplasmic reticulum 4
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
lysosome 2

Gene Ontology (GO) - Cellular Components for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA,IDA 16366734
genes like me logo Genes that share ontologies with HLA-G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HLA-G Gene

Pathways & Interactions for HLA-G Gene

genes like me logo Genes that share pathways with HLA-G: view

Pathways by source for HLA-G Gene

1 GeneGo (Thomson Reuters) pathway for HLA-G Gene
  • Immune response Role of DAP12 receptors in NK cells
2 Qiagen pathways for HLA-G Gene
  • CDC42 Pathway
  • CTL Mediated Apoptosis

SIGNOR curated interactions for HLA-G Gene

Activates:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001915 negative regulation of T cell mediated cytotoxicity IDA 11290782
GO:0001916 positive regulation of T cell mediated cytotoxicity IBA 21873635
GO:0002376 immune system process IEA --
GO:0002451 peripheral B cell tolerance induction IDA 24453251
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with HLA-G: view

Drugs & Compounds for HLA-G Gene

(17) Drugs for HLA-G Gene - From: PharmGKB, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1825
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1669
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 2338
hmg coa reductase inhibitors Pharma 0
Pharmaceutical Solutions Pharma 11855

(14) Additional Compounds for HLA-G Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HLA-G: view

Transcripts for HLA-G Gene

mRNA/cDNA for HLA-G Gene

4 REFSEQ mRNAs :
32 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-G

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-G Gene

No ASD Table

Relevant External Links for HLA-G Gene

GeneLoc Exon Structure for
HLA-G

Expression for HLA-G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HLA-G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-G Gene

This gene is overexpressed in Pituitary (x12.0), Whole Blood (x6.7), Lung (x4.2), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for HLA-G Gene

This gene is overexpressed in Skin (29.9) and Blymphocyte (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HLA-G Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-G

SOURCE GeneReport for Unigene cluster for HLA-G Gene:

Hs.512152

mRNA Expression by UniProt/SwissProt for HLA-G Gene:

P17693-HLAG_HUMAN
Tissue specificity: Expressed in adult eye (PubMed:1570318). Expressed in immune cell subsets including monocytes, myeloid and plasmacytoid dendritic cells and regulatory T cells (Tr1)(at protein level) (PubMed:20448110). Secreted by follicular dendritic cell and follicular helper T cells (PubMed:24453251). Isoform 5: Detected in physiological fluids including amniotic fluid and serum (PubMed:11137219). Isoform 7: Expressed in placenta, amniotic membrane, skin cord blood and peripheral blood mononuclear cells (PubMed:11137219).

Evidence on tissue expression from TISSUES for HLA-G Gene

  • Eye(4.4)
  • Blood(3.3)
  • Heart(3.2)
  • Intestine(3.1)
  • Muscle(3.1)
  • Kidney(3.1)
  • Liver(3)
  • Nervous system(2.9)
  • Stomach(2.7)
  • Lymph node(2.4)
  • Spleen(2.4)
  • Lung(2.1)
  • Bone marrow(2.1)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with HLA-G: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-G Gene

Orthologs for HLA-G Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HLA-G Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PATR-G 30
  • 98.95 (n)
-- 31
  • 68 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia RT1-M3-1 30
  • 72.33 (n)
Mouse
(Mus musculus)
Mammalia H2-M3 30 17
  • 71.41 (n)
Species where no ortholog for HLA-G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for HLA-G Gene

ENSEMBL:
Gene Tree for HLA-G (if available)
TreeFam:
Gene Tree for HLA-G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HLA-G: view image

Paralogs for HLA-G Gene

(117) SIMAP similar genes for HLA-G Gene using alignment to 101 proteins:

  • HLAG_HUMAN
  • A5HSK0_HUMAN
  • A6YB83_HUMAN
  • B0L3P8_HUMAN
  • B0L3P9_HUMAN
  • B0L3Q0_HUMAN
  • B1P198_HUMAN
  • B5LFX8_HUMAN
  • B5LFX9_HUMAN
  • B5LFY0_HUMAN
  • B5LFY1_HUMAN
  • B5LFY2_HUMAN
  • B7SFZ2_HUMAN
  • B7SFZ3_HUMAN
  • C0JSV2_HUMAN
  • C0JSV3_HUMAN
  • C0JT28_HUMAN
  • C0JT29_HUMAN
  • C0JT30_HUMAN
  • C0JTC7_HUMAN
  • C7SJ32_HUMAN
  • D2KT86_HUMAN
  • E5DHS1_HUMAN
  • G0T3C4_HUMAN
  • J3JRT1_HUMAN
  • J7H084_HUMAN
  • M9TK49_HUMAN
  • O02923_HUMAN
  • O02924_HUMAN
  • O02925_HUMAN
  • O02926_HUMAN
  • O02927_HUMAN
  • O02928_HUMAN
  • O02929_HUMAN
  • O19588_HUMAN
  • O19684_HUMAN
  • O19766_HUMAN
  • O19767_HUMAN
  • O19805_HUMAN
  • O19806_HUMAN
  • O19807_HUMAN
  • O19808_HUMAN
  • O19809_HUMAN
  • O78131_HUMAN
  • O78132_HUMAN
  • O78133_HUMAN
  • O78134_HUMAN
  • O78135_HUMAN
  • O78136_HUMAN
  • Q30182_HUMAN
  • Q30213_HUMAN
  • Q5RJ85_HUMAN
  • Q68YR8_HUMAN
  • Q68YR9_HUMAN
  • Q68YS0_HUMAN
  • Q68YS1_HUMAN
  • Q68YS2_HUMAN
  • Q68YS3_HUMAN
  • Q68YS4_HUMAN
  • Q6B844_HUMAN
  • Q6B845_HUMAN
  • Q6B846_HUMAN
  • Q6B847_HUMAN
  • Q6B848_HUMAN
  • Q6B849_HUMAN
  • Q6B850_HUMAN
  • Q6B851_HUMAN
  • Q6B9Y0_HUMAN
  • Q6B9Y1_HUMAN
  • Q6B9Y2_HUMAN
  • Q6B9Y3_HUMAN
  • Q6B9Y4_HUMAN
  • Q6B9Y5_HUMAN
  • Q6B9Y6_HUMAN
  • Q6DL85_HUMAN
  • Q6DL86_HUMAN
  • Q6DL87_HUMAN
  • Q6DL88_HUMAN
  • Q6DL89_HUMAN
  • Q6DU08_HUMAN
  • Q6DU14_HUMAN
  • Q6UV35_HUMAN
  • Q7JFN0_HUMAN
  • Q8MGQ7_HUMAN
  • Q8MH47_HUMAN
  • Q8MH48_HUMAN
  • Q8WLS1_HUMAN
  • Q95370_HUMAN
  • Q95391_HUMAN
  • Q95HM6_HUMAN
  • Q9BCT7_HUMAN
  • Q9MYA2_HUMAN
  • Q9TP10_HUMAN
  • Q9TP11_HUMAN
  • Q9TP12_HUMAN
  • Q9TP13_HUMAN
  • Q9TP14_HUMAN
  • R9WWD4_HUMAN
  • R9WXB4_HUMAN
  • R9WYY4_HUMAN
  • R9X0X9_HUMAN

Pseudogenes.org Pseudogenes for HLA-G Gene

genes like me logo Genes that share paralogs with HLA-G: view

Variants for HLA-G Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HLA-G Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
727913 Likely Benign: not provided 29,828,078(+) C/G SYNONYMOUS_VARIANT
728223 Likely Benign: not provided 29,829,503(+) G/A SYNONYMOUS_VARIANT
774644 Benign: not provided 29,828,150(+) G/A SYNONYMOUS_VARIANT
776116 Benign: not provided 29,828,210(+) G/A SYNONYMOUS_VARIANT
782473 Benign: not provided 29,828,571(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for HLA-G Gene

Structural Variations from Database of Genomic Variants (DGV) for HLA-G Gene

Variant ID Type Subtype PubMed ID
dgv1086e199 CNV deletion 23128226
dgv3467e59 CNV duplication 20981092
dgv3468e59 CNV duplication 20981092
dgv992e201 CNV deletion 23290073
esv25966 CNV gain+loss 19812545
esv2665698 CNV deletion 23128226
esv2670487 CNV deletion 23128226
esv2731772 CNV deletion 23290073
esv2731775 CNV deletion 23290073
esv2759412 CNV gain+loss 17122850
esv3332677 CNV duplication 20981092
esv3420260 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv428139 CNV gain 18775914
nsv950149 CNV deletion 24416366
nsv965702 CNV duplication 23825009

Variation tolerance for HLA-G Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.44; 81.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HLA-G Gene

Human Gene Mutation Database (HGMD)
HLA-G
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-G

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-G Gene

Disorders for HLA-G Gene

MalaCards: The human disease database

(31) MalaCards diseases for HLA-G Gene - From: OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, susceptibility to
severe pre-eclampsia
  • antepartum severe pre-eclampsia
vaginal cancer
  • malignant neoplasm of vagina
cytomegalovirus infection
  • cytomegalovirus infections
choriocarcinoma
  • chorioepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search HLA-G in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HLA-G

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HLA-G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-G Gene

Publications for HLA-G Gene

  1. The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes. (PMID: 19798077) Castelli EC … Donadi EA (Genes and immunity 2010) 3 23 41
  2. A study of HLA-G polymorphism and linkage disequilibrium in renal transplant patients and their donors. (PMID: 18926911) Pirri A … Bicalho Mda G (Transplant immunology 2009) 3 23 41
  3. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PMID: 17971048) Burfoot RK … Rubio JP (Tissue antigens 2008) 3 23 41
  4. HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus. (PMID: 18380776) Rizzo R … Baricordi OR (Tissue antigens 2008) 3 23 41
  5. Association between novel HLA-G genotypes and risk of recurrent miscarriages: a case-control study in a South Indian population. (PMID: 18480096) Suryanarayana V … Singh L (Reproductive sciences (Thousand Oaks, Calif.) 2008) 3 23 41

Products for HLA-G Gene

Sources for HLA-G Gene