Aliases for HLA-F Gene
External Ids for HLA-F Gene
Previous GeneCards Identifiers for HLA-F Gene
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-F Gene
HLA-F (Major Histocompatibility Complex, Class I, F) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Allograft rejection. Gene Ontology (GO) annotations related to this gene include receptor binding and TAP1 binding. An important paralog of this gene is HLA-A.
UniProtKB/Swiss-Prot for HLA-F Gene
Involved in the presentation of foreign antigens to the immune system.