Aliases for HLA-E Gene
External Ids for HLA-E Gene
Previous GeneCards Identifiers for HLA-E Gene
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-E Gene
HLA-E (Major Histocompatibility Complex, Class I, E) is a Protein Coding gene. Diseases associated with HLA-E include Hematopoietic Stem Cell Transplantation. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and HTLV-I infection. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and MHC class I protein binding. An important paralog of this gene is HLA-A.
UniProtKB/Swiss-Prot for HLA-E Gene
Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.