HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 ... See more...

Aliases for HLA-E Gene

Aliases for HLA-E Gene

  • Major Histocompatibility Complex, Class I, E 2 3 5
  • HLA Class I Histocompatibility Antigen, Alpha Chain E 3 4
  • MHC Class I Antigen E 3 4
  • HLA-6.2 3 4
  • MHC Class Ib Antigen 3
  • HLA-E 5
  • HLAE 4
  • QA1 3

External Ids for HLA-E Gene

Previous GeneCards Identifiers for HLA-E Gene

  • GC06P030513
  • GC06P030228
  • GC06P030563
  • GC06P030565
  • GC06P030457
  • GC06P030257
  • GC06P030491
  • GC06P032276
  • GC06P032449
  • GC06P032577
  • GC06P033358
  • GC06P030635
  • GC06P030657
  • GC06P030764
  • GC06P030896
  • GC06P031055
  • GC06P031203
  • GC06P031407
  • GC06P032050

Summaries for HLA-E Gene

Entrez Gene Summary for HLA-E Gene

  • HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-E Gene

HLA-E (Major Histocompatibility Complex, Class I, E) is a Protein Coding gene. Diseases associated with HLA-E include Bk-Virus Nephropathy and Cytomegalovirus Infection. Among its related pathways are Antigen processing-Cross presentation and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and MHC class I protein binding. An important paralog of this gene is HLA-A.

UniProtKB/Swiss-Prot Summary for HLA-E Gene

  • Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8+ cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:30087334).
  • (Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells.

Gene Wiki entry for HLA-E Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLA-E Gene

Genomics for HLA-E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HLA-E Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLA-E on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HLA-E

Top Transcription factor binding sites by QIAGEN in the HLA-E gene promoter:
  • aMEF-2
  • AP-1
  • MEF-2A
  • MyoD
  • NF-kappaB1
  • Nkx2-5
  • RSRFC4
  • STAT3

Genomic Locations for HLA-E Gene

Genomic Locations for HLA-E Gene
chr6:30,489,508-30,494,194
(GRCh38/hg38)
Size:
4,687 bases
Orientation:
Plus strand
chr6:30,457,183-30,461,982
(GRCh37/hg19)
Size:
4,800 bases
Orientation:
Plus strand

Genomic View for HLA-E Gene

Genes around HLA-E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-E Gene

  • Protein details for HLA-E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13747-HLAE_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, alpha chain E
    Protein Accession:
    P13747
    Secondary Accessions:
    • E2G051
    • Q30169
    • Q6DU44
    • Q9BT83
    • Q9GIY7
    • Q9GIY8

    Protein attributes for HLA-E Gene

    Size:
    358 amino acids
    Molecular mass:
    40058 Da
    Quaternary structure:
    • Forms a heterotrimer with B2M and a self- or a pathogen-derived peptide (peptide-bound HLA-E-B2M) (PubMed:18339401, PubMed:30087334). Similarly to MHC class Ia assembly, HLA-E-B2M heterodimer interacts with components of the antigen processing machinery TAPBP and TAP1-TAP2 complex; this interaction is required for peptide loading and translocation to the cell surface (PubMed:9427624). Interacts with CALCR; this interaction is required for appropriate folding (PubMed:9427624). The optimum binding peptide is a nonamer (VL9) that is primarily derived from amino-acid residues 3-11 of the signal sequences of most HLA-A, -B, -C and -G molecules (PubMed:9754572, PubMed:18083576, PubMed:9660937, PubMed:18339401). The VL9 peptide anchors to five main sites in the peptide-binding groove of HLA-E (PubMed:18339401). Peptide-bound HLA-E-B2M complex interacts with KLRD1-KLRC1 receptor on NK cells (PubMed:9486650, PubMed:18083576). Binds with lower affinity to activating KLRD1-KLRC2 (PubMed:18083576, PubMed:23335510). The common subunit KLRC1 plays a prominent role in directly interacting with HLA-E (PubMed:18083576). Peptide-bound HLA-E-B2M interacts with the alpha-beta TCR on unconventional CD8+ T cells (PubMed:16474394). Peptide-free HLA-E interacts with HLA-F-B2M complex; this interaction may regulate the intracellular trafficking and the stability of peptide-free MHC class I OCs.

    Three dimensional structures from OCA and Proteopedia for HLA-E Gene

neXtProt entry for HLA-E Gene

Post-translational modifications for HLA-E Gene

  • N-glycosylated.
  • The soluble form (sHLA-E) can be partly produced by proteolytic cleavage at the cell surface (shedding) by a matrix metalloproteinase. Alternative splicing is also suggested as a mechanism for generation of sHLA-E, although it remains to be proved.
  • Glycosylation at Asn107
  • Ubiquitination at Lys142, Lys167, Lys191, and Lys343
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for HLA-E Gene

Antibody Products

No data available for DME Specific Peptides for HLA-E Gene

Domains & Families for HLA-E Gene

Gene Families for HLA-E Gene

Protein Domains for HLA-E Gene

Suggested Antigen Peptide Sequences for HLA-E Gene

GenScript: Design optimal peptide antigens:
  • MHC class I antigen (E2G051_HUMAN)
  • MHC class I antigen E (HLAE_HUMAN)
  • HLA-E (O19682_HUMAN)
  • Major histocompatibility complex, class I, E (Q2L6I5_HUMAN)
  • Major histocompatibility complex, class I, E, isoform CRA_b (Q6DU50_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13747

UniProtKB/Swiss-Prot:

HLAE_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-E: view

Function for HLA-E Gene

Molecular function for HLA-E Gene

UniProtKB/Swiss-Prot Function:
Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8+ cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:30087334).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells.
UniProtKB/Swiss-Prot Induction:
Proinflammatory cytokines including TNF, IL1B and IFNG up-regulate membrane bound HLA-E expression on endothelial and NK cells and induce the release of soluble HLA-E (sHLA-E) in the extracellular compartment.
GENATLAS Biochemistry:
HLA class Ib,44kDa,6.2kb HindIII fragment,TAP and tapasin dependent,localized at the cell surface,harboring structural features conferring tight peptide binding specificity,correlating with the binding of an MHC class I leader peptide (see MHC1)

Phenotypes From GWAS Catalog for HLA-E Gene

Gene Ontology (GO) - Molecular Function for HLA-E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 18448674
GO:0005515 protein binding IPI 9427624
GO:0030881 beta-2-microglobulin binding IMP 12411439
GO:0042288 MHC class I protein binding IDA 9754572
GO:0042605 peptide antigen binding IMP 12411439
genes like me logo Genes that share ontologies with HLA-E: view
genes like me logo Genes that share phenotypes with HLA-E: view

Animal Models for HLA-E Gene

MGI Knock Outs for HLA-E:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-E

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HLA-E Gene

Localization for HLA-E Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-E Gene

Cell membrane. Single-pass type I membrane protein. Golgi apparatus membrane.
[Soluble HLA class I histocompatibility antigen, alpha chain E]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-E gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 4
endosome 4
golgi apparatus 4
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
lysosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HLA-E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with HLA-E: view

Pathways & Interactions for HLA-E Gene

genes like me logo Genes that share pathways with HLA-E: view

Pathways by source for HLA-E Gene

3 GeneGo (Thomson Reuters) pathways for HLA-E Gene
  • Immune response CD16 signaling in NK cells
  • Immune response Role of DAP12 receptors in NK cells
  • Immune response_Role of integrins in NK cells cytotoxicity
2 Qiagen pathways for HLA-E Gene
  • CDC42 Pathway
  • CTL Mediated Apoptosis

SIGNOR curated interactions for HLA-E Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HLA-E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001815 positive regulation of antibody-dependent cellular cytotoxicity IDA 30134159
GO:0001916 positive regulation of T cell mediated cytotoxicity IBA,IDA 25631937
GO:0002250 adaptive immune response IEA,IDA 25631937
GO:0002376 immune system process IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with HLA-E: view

Drugs & Compounds for HLA-E Gene

(6) Drugs for HLA-E Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved Pharma 602
Certolizumab pegol Approved Pharma 144
Etanercept Approved, Investigational Pharma 454
Infliximab Approved Pharma 469
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1825
genes like me logo Genes that share compounds with HLA-E: view

Transcripts for HLA-E Gene

mRNA/cDNA for HLA-E Gene

1 REFSEQ mRNAs :
28 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-E

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-E Gene

No ASD Table

Relevant External Links for HLA-E Gene

GeneLoc Exon Structure for
HLA-E

Expression for HLA-E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HLA-E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-E Gene

This gene is overexpressed in Whole Blood (x12.7).

Protein differential expression in normal tissues from HIPED for HLA-E Gene

This gene is overexpressed in Skin (26.3) and Peripheral blood mononuclear cells (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HLA-E Gene



Protein tissue co-expression partners for HLA-E Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-E

SOURCE GeneReport for Unigene cluster for HLA-E Gene:

Hs.650174

mRNA Expression by UniProt/SwissProt for HLA-E Gene:

P13747-HLAE_HUMAN
Tissue specificity: Expressed in secretory endometrial cells during pregnancy (at protein level). The expression in nonlymphoid tissues is restricted to endothelial cells from all types of vessels, including arteries, veins, capillaries, and lymphatics (at protein level). In lymphoid organs, it is mainly expressed in endothelial venules, B and T cells, monocytes, macrophages, NK cells and megakaryocytes (at protein level).

Evidence on tissue expression from TISSUES for HLA-E Gene

  • Lung(5)
  • Blood(4.9)
  • Pancreas(4.9)
  • Nervous system(4.8)
  • Intestine(4.5)
  • Spleen(4.4)
  • Skin(4)
  • Kidney(4)
  • Stomach(3.6)
  • Liver(3.5)
  • Heart(3.5)
  • Lymph node(3.3)
  • Muscle(3.1)
  • Bone marrow(2.8)
  • Eye(2.7)
  • Bone(2.7)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with HLA-E: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-E Gene

Orthologs for HLA-E Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HLA-E Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PATR-E 30 31
  • 98.67 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia H2-T23 30 17
  • 79.5 (n)
H2-T-ps 17
Rat
(Rattus norvegicus)
Mammalia RT1-S3 30
  • 77.97 (n)
Species where no ortholog for HLA-E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for HLA-E Gene

ENSEMBL:
Gene Tree for HLA-E (if available)
TreeFam:
Gene Tree for HLA-E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HLA-E: view image

Paralogs for HLA-E Gene

genes like me logo Genes that share paralogs with HLA-E: view

Variants for HLA-E Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-E Gene

HLAE_HUMAN-P13747
The following alleles are known: E*01:01 and E*01:03 (PubMed:3131426, PubMed:10064069, PubMed:16702430, PubMed:16570139, PubMed:28127896). The frequency of E*01:01 and E*01:03 alleles in the population is about equal suggesting balanced selection in diverse populations. Evolutionary studies suggest that E*01:03 is the original allele (PubMed:12445303). Two other alleles has been described E*01:02 and E*01:04 (PubMed:3260916, PubMed:1977695). Allele E*01:02 was found to be identical to HLA E*01:01 (PubMed:3260916, PubMed:22665232). The existence of allele E*01:04 is uncertain as it could not be confirmed in further studies (PubMed:1977695, PubMed:12445303). The sequence shown is that of E*01:03 (PubMed:10064069, PubMed:16702430, PubMed:16570139, PubMed:28127896).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HLA-E Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
708684 Likely Benign: not provided 30,491,353(+) A/C MISSENSE_VARIANT
rs1059510 - p.Asn98Lys
rs1264457 - p.Gly128Arg
rs41562314 - p.Arg178Gly

Additional dbSNP identifiers (rs#s) for HLA-E Gene

Structural Variations from Database of Genomic Variants (DGV) for HLA-E Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv5242 CNV insertion 18451855
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv970103 CNV duplication 23825009

Variation tolerance for HLA-E Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HLA-E Gene

Human Gene Mutation Database (HGMD)
HLA-E
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-E

SNP Genotyping and Copy Number Assay Products

Disorders for HLA-E Gene

MalaCards: The human disease database

(9) MalaCards diseases for HLA-E Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bk-virus nephropathy
  • bk virus nephropathy
cytomegalovirus infection
  • cytomegalovirus infections
choriocarcinoma
  • chorioepithelioma
ceftazidime allergy
  • fortaz allergy
rabies
  • lyssa
- elite association - COSMIC cancer census association via MalaCards
Search HLA-E in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HLA-E

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HLA-E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-E Gene

Publications for HLA-E Gene

  1. Ethnic variability in human leukocyte antigen-E haplotypes. (PMID: 19140831) Antoun A … Briggs D (Tissue antigens 2009) 3 23 41
  2. HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. (PMID: 19180512) Lin YJ … Tsai FJ (Arthritis and rheumatism 2009) 3 23 41
  3. Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation. (PMID: 17179229) Coupel S … Charreau B (Blood 2007) 3 4 23
  4. HLA-E*0101 and HLA-G*010101 reduce the risk of Behcet's disease. (PMID: 17257316) Park KS … Lee ES (Tissue antigens 2007) 3 23 41
  5. HLA-E*0101 allele in homozygous state favors severe bacterial infections in sickle cell anemia. (PMID: 17961774) Tamouza R … Charron D (Human immunology 2007) 3 23 41

Products for HLA-E Gene

Sources for HLA-E Gene