Aliases for HLA-E Gene
External Ids for HLA-E Gene
Previous GeneCards Identifiers for HLA-E Gene
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-E Gene
HLA-E (Major Histocompatibility Complex, Class I, E) is a Protein Coding gene. Diseases associated with HLA-E include Hematopoietic Stem Cell Transplantation. Among its related pathways are Cytokine Signaling in Immune system and Allograft rejection. Gene Ontology (GO) annotations related to this gene include receptor binding and MHC class I protein binding. An important paralog of this gene is HLA-A.
UniProtKB/Swiss-Prot for HLA-E Gene
Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.