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HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately ... See more...
Aliases for HLA-DRB1 Gene
Aliases for HLA-DRB1 Gene
- Major Histocompatibility Complex, Class II, DR Beta 1 2 3 5
- Major Histocompatibility Complex, Class II, DR Beta 1 Precursor 3
- HLA Class II Histocompatibility Antigen, DR-1 Beta Chain 3
- HLA Class II Histocompatibility Antigen, DRB1 Beta Chain 4
- MHC Class II HLA-DR Beta 1 Chain 3
- Human Leucocyte Antigen DRB1 3
External Ids for HLA-DRB1 Gene
- HGNC: 4948
- NCBI Entrez Gene: 3123
- Ensembl: ENSG00000196126
- OMIM®: 142857
- UniProtKB/Swiss-Prot: P01911
Previous HGNC Symbols for HLA-DRB1 Gene
- HLA-DR1B
Previous GeneCards Identifiers for HLA-DRB1 Gene
- GC06U990049
- GC06Md32547
- GC06M032317
- GC06Md32654
- GC06M032656
- GC06M032546
- GC06M032552
Summaries for HLA-DRB1 Gene
-
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020]
GeneCards Summary for HLA-DRB1 Gene
HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) is a Protein Coding gene. Diseases associated with HLA-DRB1 include Sarcoidosis 1 and Multiple Sclerosis. Among its related pathways are Rheumatoid arthritis and Allograft rejection. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRB5.
UniProtKB/Swiss-Prot Summary for HLA-DRB1 Gene
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A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:22327072, PubMed:27591323, PubMed:8642306, PubMed:15265931, PubMed:31495665, PubMed:16148104). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819).
-
Allele DRB1*01:01: Displays an immunodominant epitope derived from Bacillus anthracis pagA/protective antigen, PA (KLPLYISNPNYKVNVYAVT), to both naive and PA-specific memory CD4-positive T cells (PubMed:22327072). Presents immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (PHQFINLRSNNSATLIVPYV), contributing to viral clearance (PubMed:27591323). Displays commonly recognized peptides derived from IAV external protein HA (PKYVKQNTLKLAT and SNGNFIAPEYAYKIVK) and from internal proteins M, NP and PB1, with M-derived epitope (GLIYNRMGAVTTEV) being the most immunogenic (PubMed:8145819, PubMed:9075930, PubMed:25413013, PubMed:32668259). Presents a self-peptide derived from COL4A3 (GWISLWKGFSF) to TCR (TRAV14 biased) on CD4-positive, FOXP3-positive regulatory T cells and mediates immune tolerance to self (PubMed:28467828). May present peptides derived from oncofetal trophoblast glycoprotein TPBG 5T4, known to be recognized by both T-helper 1 and regulatory T cells (PubMed:31619516). Displays with low affinity a self-peptide derived from MBP (VHFFKNIVTPRTP) (PubMed:9075930).
-
Allele DRB1*03:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Displays self-peptides derived from retinal SAG (NRERRGIALDGKIKHE) and thyroid TG (LSSVVVDPSIRHFDV) (PubMed:25413013). Presents viral epitopes derived from HHV-6B gH/U48 and U85 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). Presents several immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:19830726).
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Allele DRB1*04:01: Presents an immunodominant bacterial epitope derived from M. tuberculosis esxB/culture filtrate antigen CFP-10 (EISTNIRQAGVQYSR), eliciting CD4-positive T cell effector functions such as IFNG production and cytotoxic activity (PubMed:15265931). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Presents tumor epitopes derived from melanoma-associated TYR antigen (QNILLSNAPLGPQFP and DYSYLQDSDPDSFQD), triggering CD4-positive T cell effector functions such as GMCSF production (PubMed:8642306). Displays preferentially citrullinated self-peptides derived from VIM (GVYATR/citSSAVR and SAVRAR/citSSVPGVR) and ACAN (VVLLVATEGR/ CitVRVNSAYQDK) (PubMed:24190431). Displays self-peptides derived from COL2A1 (PubMed:9354468).
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Allele DRB1*04:02: Displays native or citrullinated self-peptides derived from VIM.
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Allele DRB1*04:04: May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (HIVMQYMYVPPGAPIPTTRN) and VP2 (RGDSTITSQDVANAVVGYGV), contributing to viral clearance (PubMed:27591323). Displays preferentially citrullinated self-peptides derived from VIM (SAVRAR/citSSVPGVR) (PubMed:24190431).
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Allele DRB1*04:05: May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies.
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Allele DRB1*05:01: Presents an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load.
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Allele DRB1*07:01: Upon EBV infection, presents latent antigen EBNA2 peptide (PRSPTVFYNIPPMPLPPSQL) to CD4-positive T cells, driving oligoclonal expansion and selection of a dominant virus-specific memory T cell subset with cytotoxic potential to directly eliminate virus-infected B cells (PubMed:31308093). May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (VPYVNAVPMDSMVRHNNWSL), contributing to viral clearance (PubMed:27591323). In the context of tumor immunesurveillance, may present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (MTEYKLVVVGAVGVGKSALTIQLI), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:22929521). In metastatic epithelial tumors, presents to intratumoral CD4-positive T cells a KRAS neoantigen (MTEYKLVVVGAVGVGKSALTIQLI) carrying G12V hotspot driver mutation and may mediate tumor regression (PubMed:30282837).
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Allele DRB1*11:01: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SDRIIQITRGDSTITSQDVA), contributing to viral clearance (PubMed:27591323). Presents several immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a role in immune recognition and longterm protection (PubMed:19830726). In the context of tumor immunesurveillance, may present tumor-derived neoantigens to CD4-positive T cells and trigger anti-tumor helper functions (PubMed:31495665).
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Allele DRB1*13:01: Presents viral epitopes derived from HHV-6B antigens to polyfunctional CD4-positive T cells implicated in control of HHV-6B infection.
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Allele DRB1*15:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SNNSATLIVPYVNAVPMDSM), contributing to viral clearance (PubMed:27591323). Displays a self-peptide derived from MBP (ENPVVHFFKNIVTPR) (PubMed:9782128, PubMed:25413013). May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies.
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Allele DRB1*15:02: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:19120973).
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(Microbial infection) Acts as a receptor for Epstein-Barr virus on lymphocytes.
Additional gene information for HLA-DRB1 Gene
- HGNC (4948)
- NCBI Entrez Gene (3123)
- Ensembl (ENSG00000196126)
- OMIM® (142857)
- UniProtKB/Swiss-Prot (P01911)
- Open Targets Platform(ENSG00000196126)
- Monarch Initiative
- Alliance of Genome Resources
- Search for HLA-DRB1 at DataMed
- Search for HLA-DRB1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLA-DRB1 Gene
Genomics for HLA-DRB1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HLA-DRB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HLA-DRB1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HLA-DRB1
- Top Transcription factor binding sites by QIAGEN in the HLA-DRB1 gene promoter:
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- AML1a
- CBF(2)
- CBF-A
- CBF-B
- CBF-C
- CP1A
- CUTL1
- HOXA3
- p53
- YY1
Genomic Locations for HLA-DRB1 Gene
Latest Assembly
- chr6:32,578,769-32,589,848
- (GRCh38/hg38)
- Size:
- 11,080 bases
- Orientation:
- Minus strand
Previous Assembly
- chr6:32,546,552-32,557,625
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 11,074 bases
- Orientation:
- Minus strand
Alternative Locations (GRCh38/hg38)
- chr6(ALT_REF_LOCI_2):3,998,045-4,011,447 (-)
- chr6(ALT_REF_LOCI_3):3,814,543-3,830,112 (-)
- chr6(ALT_REF_LOCI_4):3,988,951-4,004,510 (-)
- chr6(ALT_REF_LOCI_6):3,779,004-3,792,421 (-)
- chr6(ALT_REF_LOCI_7):3,979,128-3,993,841 (-)
Genomic View for HLA-DRB1 Gene
Genes around HLA-DRB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.32 by HGNC
- 6p21.32 by Entrez Gene
- 6p21.32 by Ensembl
HLA-DRB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HLA-DRB1 Gene
Proteins for HLA-DRB1 Gene
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Protein details for HLA-DRB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01911-DRB1_HUMAN
- Recommended name:
- HLA class II histocompatibility antigen, DRB1 beta chain
- Protein Accession:
- P01911
- A0MWF2
- A0N0W1
- A2ICT1
- A2TGX3
- A4F5N0
- A4ZXA5
- A4ZXA6
- A4ZY86
- A5H000
- A5HKN8
- A7DZP9
- A7LA26
- A7UHG2
- A7X5B1
- A7X5B7
- A7X5E0
- A7X5E6
- A7X5H8
- A7X5J4
- A7X5K7
- A8K098
- A8YQE9
- A9JPG0
- B0BK85
- B0LUZ6
- B0UYW1
- B1GWE7
- B2CR03
- B2LVF9
- B2NJ29
- B2ZCY1
- B3VTP8
- B3VTQ3
- B5A8Y2
- B5A8Y3
- B5B8U0
- B5B9V5
- B5B9V6
- B5LZ25
- B5QSK8
- B6VCX2
- B6VEL9
- B7UDB2
- B9VRA4
- B9X248
- C0LAB5
- O02876
- O02930
- O19585
- O19717
- O19718
- O19739
- O19788
- O46699
- O46793
- O46872
- O62869
- O62889
- O77969
- O78047
- O78210
- O98212
- P01912
- P01914
- P04229
- P13758
- P13759
- P13760
- P13761
- P20039
- P79545
- Q06662
- Q0PGR5
- Q0PQ39
- Q14280
- Q14QT2
- Q155F7
- Q19AF2
- Q19K86
- Q1AP33
- Q1G0Z9
- Q1JRP3
- Q1KLJ6
- Q27PR6
- Q27PR7
- Q29673
- Q29720
- Q29722
- Q29734
- Q29770
- Q29771
- Q29772
- Q29790
- Q29792
- Q29800
- Q29806
- Q29833
- Q29874
- Q29875
- Q29886
- Q29968
- Q29974
- Q29975
- Q2A120
- Q2HZE5
- Q2L9H4
- Q2LE76
- Q2MF40
- Q2MJA6
- Q2MZ92
- Q2VQU1
- Q2YHQ2
- Q30006
- Q30108
- Q30112
- Q30115
- Q30116
- Q30117
- Q30120
- Q30134
- Q30142
- Q30145
- Q30149
- Q30159
- Q30166
- Q30167
- Q30200
- Q307W5
- Q31636
- Q32MY7
- Q3HUP9
- Q3KTM1
- Q3LA84
- Q3LA87
- Q3LA88
- Q3LA89
- Q3LA90
- Q3LA91
- Q3LA92
- Q3LA93
- Q3LA94
- Q3LA95
- Q3LA96
- Q3LA97
- Q3LA98
- Q3LA99
- Q3LAA0
- Q3LAA1
- Q3LAA2
- Q3MQ60
- Q3T919
- Q4PRC3
- Q4PRC5
- Q4VZY7
- Q53IG1
- Q56FN9
- Q56FP1
- Q56FP2
- Q56FP3
- Q58F52
- Q5BM92
- Q5EER6
- Q5K3W2
- Q5NDB9
- Q5U9W6
- Q5UBA2
- Q5UT58
- Q5W3L4
- Q5Y7A7
- Q5Y7B0
- Q5Y7B9
- Q5Y7E9
- Q5Y7G0
- Q683P7
- Q6REE2
- Q6T865
- Q6U387
- Q701T1
- Q70GL2
- Q70Q85
- Q768U2
- Q768U4
- Q7M2H4
- Q7YNY9
- Q7YP03
- Q7YP04
- Q7YQ26
- Q7YQA3
- Q7YQA5
- Q860D8
- Q860D9
- Q860E5
- Q860H8
- Q860S0
- Q860Z3
- Q861G6
- Q861H0
- Q861H4
- Q861H5
- Q861H7
- Q861H8
- Q8HWQ6
- Q8MH59
- Q8MH60
- Q8WLU3
- Q8WMA0
- Q95348
- Q95383
- Q95389
- Q95461
- Q95HK1
- Q95HL0
- Q95HL1
- Q95IE3
- Q95IG2
- Q95IT6
- Q96HZ9
- Q9BCL7
- Q9BCP0
- Q9BCP1
- Q9BCP2
- Q9BCP5
- Q9BD21
- Q9BD33
- Q9BD40
- Q9GIK5
- Q9GIL5
- Q9GIL6
- Q9GIP3
- Q9GIX8
- Q9GIX9
- Q9GIY0
- Q9GIY1
- Q9GIY2
- Q9GIY3
- Q9GIY4
- Q9GJ25
- Q9GJ56
- Q9GJ57
- Q9GJ58
- Q9GJ60
- Q9GJF8
- Q9GJF9
- Q9GJG0
- Q9MXZ0
- Q9MXZ5
- Q9MY13
- Q9MY45
- Q9MY56
- Q9MYF5
- Q9TPB6
- Q9TPW1
- Q9TPW3
- Q9TPW9
- Q9TPX4
- Q9TQ37
- Q9TQ91
- Q9TQE0
- Q9UBY1
- Q9UIM9
- Q9UIN0
- Q9XRX1
- Q9XRY4
- Q9XRY5
- Q9Y453
- Q9Y4H7
Protein attributes for HLA-DRB1 Gene
- Size:
- 266 amino acids
- Molecular mass:
- 29966 Da
- Quaternary structure:
-
- Heterotrimer that consists of an alpha chain HLA-DRA, a beta chain HLA-DRB1 and a peptide (peptide-MHCII) (PubMed:7477400, PubMed:9354468, PubMed:9782128, PubMed:31619516, PubMed:32668259). Newly synthesized alpha and beta chains forms a heterodimer (MHCII) that associates with the CD74/invariant chain (Ii) in the endoplasmic reticulum (ER). Ii is a trimer composed of three subunits and each subunit interacts with one MHCII dimer, blocking the peptide-binding cleft. As a result, MHCII molecules can not bind peptides present in the ER (PubMed:7479981). The complex of MHCII and CD74/Ii is transported in vesicles from ER to Golgi to lysosomes, where it encounters antigenic peptides generated via proteolysis of endocytosed antigens. MHCII dimers are dissociated from CD74/Ii by the combined action of proteolysis and HLA-DM (PubMed:25413013). Lysosomal enzymes such as cathepsin, degrade CD74/Ii leaving a 24 amino acid remnant called class II-associated Ii or CLIP. Interacts (via the peptide binding cleft) with CLIP; this interaction inhibits antigen peptide binding before entry in the endosomal compartment (PubMed:7477400, PubMed:9075930). The displacement of CLIP and replacement by a high affinity peptide in lysosomes is performed by HLA-DM heterodimer. HLA-DM catalyzes CLIP dissociation from MHCII, stabilizes empty MHCII and mediates the selection of high affinity peptides (PubMed:23260142, PubMed:11070170, PubMed:9075930). Interacts with HLA-DM heterodimer; this interaction is direct (PubMed:25413013). Interacts with TCR (via CDR3) (PubMed:29884618). Interacts (via beta-2 domain) with CD4 coreceptor (via Ig-like V-type domain); this interaction is of exceptionally low affinity yet necessary for optimal recognition of antigenic peptides (PubMed:21900604, PubMed:27114505).
- (Microbial infection) Interacts with Staphylococcus aureus enterotoxin A/entA, enterotoxin B/entB, enterotoxin C1/entC1, enterotoxin D/entD and enterotoxin H/entH. Enterotoxins bind outside the peptide-binding cleft of MHCII: enterotoxin H/entH interacts via the beta-1 domain of MHCII and in a zinc-dependent way, whereas enterotoxin B/entB interacts primarily via the alpha-1 domain.
- (Microbial infection) Interacts with Epstein-Barr virus gp42 protein.
Protein Expression for HLA-DRB1 Gene
Post-translational modifications for HLA-DRB1 Gene
Other Protein References for HLA-DRB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences HLA-DRB1 Monoclonal Antibody
- G Biosciences Immunotag™ HLA-DRB1 Antibody
- NSJ Bioreagents HLA-DRB1 Antibody (MHC II) (Mouse Monoclonal)
-
Custom Antibody ServicesOriGene Antibodies for HLA-DRB1
- Novus Biologicals Antibodies for HLA-DRB1
-
Abcam antibodies for HLA-DRB1
- Invitrogen Antibodies for HLA-DRB1 (AFLGC-HLA-DRB1)
- antibodies-online: Show 21 available HLA-DRB1 Antibodies ranked by validation data
- Compare Top HLA-DRB1 Antibodies
-
Recommended
- 216 WB Antibodies (anti-human)
- 32 FACS Antibodies (anti-human)
- 25 IF Antibodies (anti-human)
- 19 IHC (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 1 ICFC Antibody (anti-human)
- 1 RIA Antibody (anti-human)
- 114 WB Antibodies (anti-monkey)
- 25 IF Antibodies (anti-monkey)
- 14 IHC (p) Antibodies (anti-monkey)
- 5 FACS Antibodies (anti-monkey)
- 3 IHC Antibodies (anti-monkey)
- 25 IF Antibodies (anti-baboon)
- 1 WB Antibody (anti-baboon)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HLA-DRB1
Protein products for research
-
OriGene Purified Proteins for HLA-DRB1
- Search Origene for MassSpec and Protein Over-expression Lysates for HLA-DRB1
- Origene Custom Protein Services for HLA-DRB1
- ProSpec Recombinant Proteins for HLA-DRB1
-
Abcam proteins for HLA-DRB1
Assay products for research
No data available for DME Specific Peptides for HLA-DRB1 Gene
Domains & Families for HLA-DRB1 Gene
Gene Families for HLA-DRB1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted membrane proteins
Protein Domains for HLA-DRB1 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-type
- Class II histocompatibility antigen, beta chain, beta-1 domain
Suggested Antigen Peptide Sequences for HLA-DRB1 Gene
- GenScript: Design optimal peptide antigens:
-
- MHC class II antigen DRB1*1 (2B11_HUMAN)
- MHC class II antigen DRB1*3 (2B13_HUMAN)
- MHC class II antigen DRB1*4 (2B14_HUMAN)
- MHC class II antigen DRB1*7 (2B17_HUMAN)
- MHC class II antigen DRB1*8 (2B18_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P01911UniProtKB/Swiss-Prot:
DRB1_HUMAN :- The beta-1 domain is a structural part of the peptide-binding cleft. It contains one alpha helix and 4 beta sheets, respectively forming part of the wall and the floor of the peptide-binding cleft. The other 4 beta sheets of the floor and the second alpha helix wall is formed by the alpha-1 domain of HLA-DRA. Forms hydrogen bonds with the peptide main chain via conserved amino acid in most HLA-DRB molecules. The polymorphic residues accomodate the side chains of the peptide conferring peptide specificity to distinct HLA-DRB1 alleles (PubMed:8145819, PubMed:28467828, PubMed:9782128, PubMed:9354468). The peptide-bound beta-1 domain forms hydrogen bonds with CDR2 and CDR3 alpha-domains of TCR (PubMed:19303388).
- Domain:
-
- The beta-1 domain is a structural part of the peptide-binding cleft. It contains one alpha helix and 4 beta sheets, respectively forming part of the wall and the floor of the peptide-binding cleft. The other 4 beta sheets of the floor and the second alpha helix wall is formed by the alpha-1 domain of HLA-DRA. Forms hydrogen bonds with the peptide main chain via conserved amino acid in most HLA-DRB molecules. The polymorphic residues accomodate the side chains of the peptide conferring peptide specificity to distinct HLA-DRB1 alleles (PubMed:8145819, PubMed:28467828, PubMed:9782128, PubMed:9354468). The peptide-bound beta-1 domain forms hydrogen bonds with CDR2 and CDR3 alpha-domains of TCR (PubMed:19303388).
- The beta-2 Ig-like domain mediates the interaction with CD4 coreceptor.
Function for HLA-DRB1 Gene
Molecular function for HLA-DRB1 Gene
- UniProtKB/Swiss-Prot Function:
- A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:22327072, PubMed:27591323, PubMed:8642306, PubMed:15265931, PubMed:31495665, PubMed:16148104). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819).
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*01:01: Displays an immunodominant epitope derived from Bacillus anthracis pagA/protective antigen, PA (KLPLYISNPNYKVNVYAVT), to both naive and PA-specific memory CD4-positive T cells (PubMed:22327072). Presents immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (PHQFINLRSNNSATLIVPYV), contributing to viral clearance (PubMed:27591323). Displays commonly recognized peptides derived from IAV external protein HA (PKYVKQNTLKLAT and SNGNFIAPEYAYKIVK) and from internal proteins M, NP and PB1, with M-derived epitope (GLIYNRMGAVTTEV) being the most immunogenic (PubMed:8145819, PubMed:9075930, PubMed:25413013, PubMed:32668259). Presents a self-peptide derived from COL4A3 (GWISLWKGFSF) to TCR (TRAV14 biased) on CD4-positive, FOXP3-positive regulatory T cells and mediates immune tolerance to self (PubMed:28467828). May present peptides derived from oncofetal trophoblast glycoprotein TPBG 5T4, known to be recognized by both T-helper 1 and regulatory T cells (PubMed:31619516). Displays with low affinity a self-peptide derived from MBP (VHFFKNIVTPRTP) (PubMed:9075930).
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*03:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Displays self-peptides derived from retinal SAG (NRERRGIALDGKIKHE) and thyroid TG (LSSVVVDPSIRHFDV) (PubMed:25413013). Presents viral epitopes derived from HHV-6B gH/U48 and U85 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). Presents several immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:19830726).
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*04:01: Presents an immunodominant bacterial epitope derived from M. tuberculosis esxB/culture filtrate antigen CFP-10 (EISTNIRQAGVQYSR), eliciting CD4-positive T cell effector functions such as IFNG production and cytotoxic activity (PubMed:15265931). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Presents tumor epitopes derived from melanoma-associated TYR antigen (QNILLSNAPLGPQFP and DYSYLQDSDPDSFQD), triggering CD4-positive T cell effector functions such as GMCSF production (PubMed:8642306). Displays preferentially citrullinated self-peptides derived from VIM (GVYATR/citSSAVR and SAVRAR/citSSVPGVR) and ACAN (VVLLVATEGR/ CitVRVNSAYQDK) (PubMed:24190431). Displays self-peptides derived from COL2A1 (PubMed:9354468).
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*04:02: Displays native or citrullinated self-peptides derived from VIM.
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*04:04: May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (HIVMQYMYVPPGAPIPTTRN) and VP2 (RGDSTITSQDVANAVVGYGV), contributing to viral clearance (PubMed:27591323). Displays preferentially citrullinated self-peptides derived from VIM (SAVRAR/citSSVPGVR) (PubMed:24190431).
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*04:05: May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies.
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*05:01: Presents an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load.
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*07:01: Upon EBV infection, presents latent antigen EBNA2 peptide (PRSPTVFYNIPPMPLPPSQL) to CD4-positive T cells, driving oligoclonal expansion and selection of a dominant virus-specific memory T cell subset with cytotoxic potential to directly eliminate virus-infected B cells (PubMed:31308093). May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (VPYVNAVPMDSMVRHNNWSL), contributing to viral clearance (PubMed:27591323). In the context of tumor immunesurveillance, may present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (MTEYKLVVVGAVGVGKSALTIQLI), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:22929521). In metastatic epithelial tumors, presents to intratumoral CD4-positive T cells a KRAS neoantigen (MTEYKLVVVGAVGVGKSALTIQLI) carrying G12V hotspot driver mutation and may mediate tumor regression (PubMed:30282837).
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*11:01: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SDRIIQITRGDSTITSQDVA), contributing to viral clearance (PubMed:27591323). Presents several immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a role in immune recognition and longterm protection (PubMed:19830726). In the context of tumor immunesurveillance, may present tumor-derived neoantigens to CD4-positive T cells and trigger anti-tumor helper functions (PubMed:31495665).
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*13:01: Presents viral epitopes derived from HHV-6B antigens to polyfunctional CD4-positive T cells implicated in control of HHV-6B infection.
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*15:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SNNSATLIVPYVNAVPMDSM), contributing to viral clearance (PubMed:27591323). Displays a self-peptide derived from MBP (ENPVVHFFKNIVTPR) (PubMed:9782128, PubMed:25413013). May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies.
- UniProtKB/Swiss-Prot Function:
- Allele DRB1*15:02: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:19120973).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for Epstein-Barr virus on lymphocytes.
- GENATLAS Biochemistry:
- HLA-DR,beta 1 chain,determining DR1,3,4,5 etc
Phenotypes From GWAS Catalog for HLA-DRB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005200 | structural constituent of cytoskeleton | TAS | 1281771 |
| GO:0005515 | protein binding | IPI | 9354468 |
| GO:0023026 | MHC class II protein complex binding | HDA | 20458337 |
| GO:0030247 | polysaccharide binding | IDA | 21502329 |
| GO:0032395 | MHC class II receptor activity | TAS | 3456344 |
Phenotypes for HLA-DRB1 Gene
- GenomeRNAi human phenotypes for HLA-DRB1:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability ratio
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in esophageal squamous lineage
- Increased nuclear migration distance, increased nuclear migration speed
- Decreased shRNA abundance (Z-score < -2)
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HLA-DRB1 - Starting at $85 >
- * HLA-DRB1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HLA-DRB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HLA-DRB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DRB1
miRNA for HLA-DRB1 Gene
- miRTarBase miRNAs that target HLA-DRB1
-
- hsa-miR-335-3p (MIRT646400)
- hsa-miR-5006-3p (MIRT646401)
- hsa-miR-4755-5p (MIRT646402)
- hsa-miR-3978 (MIRT646403)
- hsa-miR-211-5p (MIRT646404)
- hsa-miR-204-5p (MIRT646405)
- hsa-miR-623 (MIRT646406)
- hsa-miR-664b-3p (MIRT646407)
- hsa-miR-579-3p (MIRT646408)
- hsa-miR-5696 (MIRT646409)
- hsa-miR-6124 (MIRT646410)
- hsa-miR-3148 (MIRT646411)
- hsa-miR-627-3p (MIRT646412)
- hsa-miR-6832-3p (MIRT646413)
- hsa-miR-153-5p (MIRT646414)
- hsa-miR-1250-3p (MIRT646415)
- hsa-miR-141-5p (MIRT646416)
- hsa-miR-5692a (MIRT646417)
- hsa-miR-148a-5p (MIRT762753)
- hsa-miR-22-5p (MIRT763970)
- hsa-miR-502-5p (MIRT773023)
- hsa-miR-5584-3p (MIRT774732)
- hsa-miR-6875-3p (MIRT780736)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna and sirna products in human, mouse, rat for HLA-DRB1
- Browse OriGene Inhibitory RNA Products For HLA-DRB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DRB1
Clone products for research
- Applied Biological Materials (abm): Clones for HLA-DRB1 - Starting at $45 >
- * HLA-DRB1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for HLA-DRB1
- Addgene plasmids for HLA-DRB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HLA-DRB1
Cell Lines for research
-
Horizon Cell Lines for HLA-DRB1
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DRB1 Gene
Localization for HLA-DRB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HLA-DRB1 Gene
- Cell membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Single-pass type I membrane protein. Lysosome membrane. Single-pass type I membrane protein. Late endosome membrane. Single-pass type I membrane protein. Autolysosome membrane. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:18305173). Component of immunological synapses at the interface between T cell and APC (PubMed:29884618). {ECO:0000269 PubMed:18305173, ECO:0000269 PubMed:29884618}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| endosome | 5 |
| lysosome | 5 |
| golgi apparatus | 4 |
| nucleus | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0001772 | immunological synapse | IDA | 15322540 |
| GO:0005615 | extracellular space | HDA | 16502470 |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HLA-DRB1 Gene
Pathways & Interactions for HLA-DRB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Allograft rejection |
.44
|
THC Differentiation Pathway
.39
CTL Mediated Apoptosis
.38
|
| 2 | Th17 cell differentiation |
Immune response IL-22 signaling pathway
.36
|
|
| 3 | Translocation of ZAP-70 to Immunological synapse |
.71
|
|
| 4 | ICos-ICosL Pathway in T-Helper Cell |
CD28 Signaling in T-Helper Cell
.66
ICos-ICosL Pathway in T-Helper Cell
.66
|
Calcium Mediated T-Cell Apoptosis
.31
|
| 5 | TCR Signaling (Qiagen) |
PKC-Theta Pathway
.68
TCR Signaling
.68
|
ITK and TCR Signaling
.54
|
Pathways by source for HLA-DRB1 Gene
6 BioSystems pathways for HLA-DRB1 Gene
13 Reactome pathways for HLA-DRB1 Gene
24 KEGG pathways for HLA-DRB1 Gene
6 GeneGo (Thomson Reuters) pathways for HLA-DRB1 Gene
- G-protein signaling N-RAS regulation pathway
- Immune response Antigen presentation by MHC class II
- Immune response ICOS pathway in T-helper cell
- Immune response IL-22 signaling pathway
- Immune response NFAT in immune response
12 Qiagen pathways for HLA-DRB1 Gene
- Calcium Mediated T-Cell Apoptosis
- CD28 Signaling in T-Helper Cell
- CDC42 Pathway
- CTL Mediated Apoptosis
- CTLA4 Signaling
1 GeneTex pathway for HLA-DRB1 Gene
Interacting Proteins for HLA-DRB1 Gene
Selected Interacting proteins:
P01911-DRB1_HUMAN
ENSP00000353099
for HLA-DRB1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HLA-DRB1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001916 | positive regulation of T cell mediated cytotoxicity | IDA | 29884618 |
| GO:0001934 | positive regulation of protein phosphorylation | IDA | 24942581 |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002381 | immunoglobulin production involved in immunoglobulin mediated immune response | IDA | 17050030 |
Drugs & Compounds for HLA-DRB1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for HLA-DRB1 Gene
mRNA/cDNA for HLA-DRB1 Gene
- 4 REFSEQ mRNAs :
- 110 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000360004 1229 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HLA-DRB1 - Starting at $85 >
- * HLA-DRB1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HLA-DRB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HLA-DRB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DRB1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna and sirna products in human, mouse, rat for HLA-DRB1
- Browse OriGene Inhibitory RNA Products For HLA-DRB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DRB1
Clone products for research
- Applied Biological Materials (abm): Clones for HLA-DRB1 - Starting at $45 >
- * HLA-DRB1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for HLA-DRB1
- Addgene plasmids for HLA-DRB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HLA-DRB1
Relevant External Links for HLA-DRB1 Gene
- GeneLoc Exon Structure for
- HLA-DRB1
Expression for HLA-DRB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Conjunctival Epithelium
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Tonsil (Hematopoietic System)
-
Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HLA-DRB1 Gene
This gene is overexpressed in Lung (x4.1) and Whole Blood (x4.1).
This gene is overexpressed in Lymph node (13.4), Lung (13.2), Oral epithelium (7.6), and Nasal epithelium (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HLA-DRB1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-DRB1
SOURCE GeneReport for Unigene cluster for HLA-DRB1 Gene:
Hs.534322mRNA Expression by UniProt/SwissProt for HLA-DRB1 Gene:
P01911-DRB1_HUMAN
Tissue specificity:
Expressed in professional APCs: monocyte/macrophages, dendritic cells and B cells (at protein level) (PubMed:31495665, PubMed:23783831, PubMed:19830726). Expressed in thymic epithelial cells (at protein level) (PubMed:23783831).
Evidence on tissue expression from TISSUES for HLA-DRB1 Gene
- Nervous system(4.9)
- Lung(4.9)
- Blood(4.8)
- Skin(4.6)
- Intestine(4.3)
- Stomach(4.3)
- Pancreas(4.2)
- Kidney(3.9)
- Spleen(3.8)
- Eye(3.3)
- Thyroid gland(2.7)
- Liver(2.6)
- Lymph node(2.4)
- Heart(2.3)
- Bone marrow(2.3)
- Muscle(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DRB1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cranial nerve
- ear
- epiglottis
- eye
- head
- jaw
- lacrimal apparatus
- larynx
- mandible
- maxilla
- mouth
- neck
- pharynx
- salivary gland
- skull
- tongue
- tooth
Thorax:
- chest wall
- clavicle
- esophagus
- heart
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- duodenum
- intestine
- kidney
- large intestine
- pancreas
- small intestine
- spleen
- stomach
Pelvis:
- pelvis
- rectum
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- lymph node
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal column
- sweat gland
- vertebrae
- white blood cell
Primer products for research
-
OriGene qPCR primer pairs for HLA-DRB1
-
OriGene qPCR primer pairs and template standards for HLA-DRB1
Gene Expression Assays for research
Orthologs for HLA-DRB1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PATR-DQB1 29 |
|
||
| DRB1*0204 30 |
|
OneToOne | |||
| Dog (Canis familiaris) |
Mammalia | DLA-DRB1 30 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | H2-Eb1 30 |
|
ManyToMany | |
| H2-Eb2 30 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | DSB 30 |
|
ManyToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 30 |
|
ManyToMany |
- Species where no ortholog for HLA-DRB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for HLA-DRB1 Gene
- ENSEMBL:
- Gene Tree for HLA-DRB1 (if available)
- TreeFam:
- Gene Tree for HLA-DRB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HLA-DRB1: view image
- Alliance of Genome Resources:
- Additional Orthologs for HLA-DRB1
Paralogs for HLA-DRB1 Gene
Paralogs for HLA-DRB1 Gene
(230) SIMAP similar genes for HLA-DRB1 Gene using alignment to 2155 proteins:
- 2B11_HUMAN
- 2B13_HUMAN
- 2B14_HUMAN
- 2B17_HUMAN
- 2B18_HUMAN
- 2B19_HUMAN
- 2B1A_HUMAN
- 2B1B_HUMAN
- 2B1C_HUMAN
- 2B1D_HUMAN
- 2B1E_HUMAN
- 2B1F_HUMAN
- 2B1G_HUMAN
- A0AQX7_HUMAN
- A0AQX8_HUMAN
- A0AQX9_HUMAN
- A0AQY0_HUMAN
- A0AQY1_HUMAN
- A0AQY2_HUMAN
- A0AQY3_HUMAN
- A0AQY4_HUMAN
- A0AQY5_HUMAN
- A0AQY6_HUMAN
- A0AQY7_HUMAN
- A0AQY8_HUMAN
- A0AQZ0_HUMAN
- A0AQZ1_HUMAN
- A0AQZ2_HUMAN
- A0AQZ3_HUMAN
- A0AQZ4_HUMAN
- A0N0W0_HUMAN
- A0N0W2_HUMAN
- A0N0W3_HUMAN
- A0N0W5_HUMAN
- A0N9E2_HUMAN
- A0PFK3_HUMAN
- A0PFV9_HUMAN
- A0T4C2_HUMAN
- A0T4C3_HUMAN
- A0ZXX2_HUMAN
- A1A413_HUMAN
- A1A414_HUMAN
- A1A415_HUMAN
- A1A416_HUMAN
- A1A417_HUMAN
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- U5IQJ3_HUMAN
- U5IQQ1_HUMAN
- U5IRI6_HUMAN
- U5ISB2_HUMAN
- U5IT82_HUMAN
- U5XKZ8_HUMAN
- U5YLY3_HUMAN
- U5YQ41_HUMAN
- U6BZR3_HUMAN
- U6EFL1_HUMAN
- U6EFS4_HUMAN
- U6EFX2_HUMAN
- V5J9W1_HUMAN
- V5J9Z3_HUMAN
- V5JA18_HUMAN
- V5JA83_HUMAN
- V5JAA0_HUMAN
- V5JAC9_HUMAN
- V5JAP2_HUMAN
- V5JAR0_HUMAN
- V5NR41_HUMAN
- V5RNU3_HUMAN
- V6AQ63_HUMAN
- V6BNZ6_HUMAN
- V6BPA6_HUMAN
- V9N2U6_HUMAN
- V9N2Y1_HUMAN
- V9N336_HUMAN
- V9N379_HUMAN
- V9N3I1_HUMAN
- W0GCL0_HUMAN
- W0GCN6_HUMAN
- W0HE50_HUMAN
- W0HE86_HUMAN
- W0HE91_HUMAN
- W0HHN7_HUMAN
- W0HIJ7_HUMAN
- W0HIT3_HUMAN
- W0NT93_HUMAN
- W0NTG8_HUMAN
- W1I181_HUMAN
- W1I364_HUMAN
- W1I684_HUMAN
- W1I6D2_HUMAN
- W1I840_HUMAN
- W1I8Y2_HUMAN
- W1I9X3_HUMAN
- W1IA32_HUMAN
- HLA DRB4
- HLA-DRB1*1402
- HLA-DRB1*1302
- HLA-DRB1*1301
- HLA-DRB1*0407
- HLA-DRB1*0402
- HLA-All
- HLA-A*03
- HLA-A null
- HLA-DRB13
- HLA-B27
- HLA-DRB1*1605
- HLA-DRB1*1327
- HLA-DRB14
- HLA-Cw3
- HLA-D8.2V
- HLA-DRB4$0101
- DRB52
- HLA-DR4/Dw13
- MHC Class II HLA DRB1
- HLA-DR beta
- HLA-Cw*02023
- Cw
- DRB1*1303
- HLA-DRB1*0801
- MHC class II HLA-DRB1 Exon-2
- HLA-DRB1*1324
- HLA-DRBI*1303
- HLA-DRB1*1302Var
- DRB1 HAG
- HLADRB1
- MHC class II HLA-DRB1*1315
- DRB1*08
- DRB1*13PL
- HLA-DRB1*11
- DRB1*11
- HLA-DRB1*08
- MHC class II HLA DRB1-0305
- HLA-DRB11
- HLA-DRB1*1125
- HLA-A*33
- HLA-A*24
- HLA-A*0226
- HLA-A*02
- DRB1*1116
- HLA-DR3
- HLA-DRB
- HLA-DR
- HLA-DRB1-11
- HLA-D
- HLA DRB1 gene
- HLA DRB1
- HLA-DRB1*
- HLA-DR-beta
- HLA-DRB1*0818
- DRB1
- HLA-DRB1-1113
- HLA-DBR1
- HLA-DR-beta 1
- HLA-DR08
- MHC class II HLA DRB1
- HLA-DRB4*0102
- HLA-DRB52
- DRB1*0405V3
- DRB1*LY10
- HLA-DRBI
- MHC class I HLA-A
- HLAC
- HLA-G3
- HLA-G2.2
- HLA-Cw*07
- HLA-Cw*03MAC
- HLA-B35
- HLA-B1501V2
- HLA-B*5603
- HLA-B*15UL
- HLA-B*1522
- HLA-B*07ML
- HLA-B*0707
- HLA-A26
- HLA-A24AK
- HLA-A2
- HLA-A*0225
- HLA C*
- Cw*08
- HLA-DRB1*04
- HLA-DRB1-0811
- HLA-DR4I
- HLA-DR4
- HLA-DR-beta1
- HLA-DRw12
- HLA-Cw*15P
- HLA-B15
- HLA-DRB3$0301
- HLA
- HLC-C
- HLA-Cw*0707
- HLA-Cw*03
- HLA-Bw62.5
- HLA-Bw62.4
- HLA-Bw62.3
- HLA-Bw62.1
- HLA-B*5501 variant
- HLA-B*4202
- HLA-B*3531
- HLA-B*18 variant
- HLA-B*15IL
- B-1510
- HLA DRB1*1202
- HLA-DRB5
- HLA-CW
- HLA-B18
- HLA-B*47RG
- HLA-B*40
- HLA-B*35JAC
- HLA-DRB3
- HLA-DR15
- HLA-B52v
- HLA-B41
- HLA-B*4012
- HLA-B*35KM
- HLA-B*3512
- HLA-B*27
- HLA-B*1805
- HLA-A*2410
- HLA -B
- Cw*03
- B-3501
- B*35
- B*15
- HLA-DRB3*01
- LOC554223
- HLA-B*35SRE
- HLA-B*15MD
- HLA-B*1513
- HLA G locus
- EA1.2
- DKFZp686P19218
- HLA-DRB4
- HLA-B52
- HLA-B*13
- HLA-DRB4* variant allele
- DRB4
- HLA-DRB2
- HLA-B*58
- EA2.1
- HLA-C
- HLA-B57
- HLA-B51
- HLA-B*51IM
- HLA-B*5101 variant
- HLA-B gene
- HLA-Cw
- HLA-DRB7
- DQB1-02
- HLQ-DQB1
- HLA-J
- HLA-A
- HLA-DPB
- DPB1
- HLA-Dw12
- HLA-G
- HLA-DB1
- MHC-G
- FLJ45422
- MHC DPB1
- HLA-DPB1
- HLA-DP
- DQB1.SLE
- HLA-B*
- MHC-DPB1*6001
- HLA B
- HLA-E
- HLA-DQB1*03
- HLA-F
- HLA-DQ-beta
- HLA-DQ3
- HLA-DQB1*06x
- HLA-DQB3
- HLA-DQB1I
- HLA-DQB1*06new1
- DQB1*0603
- HLA-DQB1
- HLA-DQ
- HLA-DQB
- DQB1
- HLA-DQB1/DRB1
- HLA-A*01
- HLA DQB1
- HLA-DQB2
- HLA-DQB1*05
- HLA-DOB
- HLA-DQB1*05
- B*56
- HLA-B
- HLA-Cw*
- HLA-A*31
- MHC
- HLA-H
- DKFZp686N10220
- MR1
- HLA-DRB9
- IGLL5
- HLA-B*2712
- IGHM
- HLA-DOA
- FCGRT
- DKFZp781M0386
- AZGP1
- HLA-DQA1
- SIRPB1
- HLA-DPA1
- CD1E
- CD1C
- IGLC6
- HLA-DMB
- IGLC1
- C1 segment
- PTPNS1
- IGHG2
- DKFZp686E23209
- B2M
- IGLC2
- IGLC7
- IGLC3
- DKFZp667J0810
- HLA-DQA2
- HFE
- HLA-A*0201V3
- IgLC-rG
Variants for HLA-DRB1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DRB1 Gene
- DRB1_HUMAN-P01911
- Highly polymorphic. Polymorphic residues encode for the beta-1 domain of the peptide-binding cleft, where they contribute to variations in peptide binding and TCR recognition among different alleles. The sequence shown is that of DRB1*15:01. The sequences of common representative alleles of serologically distinct allele groups as defined in the catalog of common and well-documented HLA alleles, are described as variants of DRB1*15:01 (PubMed:23510415). In the context of hematological malignancy and T cell transplantation, alleles DRB1*03:01 and DRB1*13:01 present minor histocompatibility antigens derived respectively from host MTHFD1 and LY75 proteins, contributing to T cell-mediated graft-versus-leukemia effect and complete remission (PubMed:19706888).
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HLA-DRB1 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs16822805 | Uncertain Significance: Peritoneal Gliomatosis | 32,584,172(-) |
C/G NM_001243965.1(HLA-DRB1):c.307= (p.Arg103=) |
MISSENSE_VARIANT,NO_SEQUENCE_ALTERATION | |
| rs1059351 | -- |
p.Ser149Asn |
|||
| rs1059569 | -- |
p.Phe55Tyr |
|||
| rs1059572 | -- |
p.Phe55Leu |
|||
| rs1059575 | -- |
p.Asp57Glu |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).