HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately ... See more...

Aliases for HLA-DRB1 Gene

Aliases for HLA-DRB1 Gene

  • Major Histocompatibility Complex, Class II, DR Beta 1 2 3 5
  • Major Histocompatibility Complex, Class II, DR Beta 1 Precursor 3
  • HLA Class II Histocompatibility Antigen, DR-1 Beta Chain 3
  • HLA Class II Histocompatibility Antigen, DRB1 Beta Chain 4
  • MHC Class II HLA-DR Beta 1 Chain 3
  • Human Leucocyte Antigen DRB1 3
  • Human Leukocyte Antigen DRB1 4
  • Lymphocyte Antigen DRB1 3
  • HLA-DR1B 3
  • HLA-DRB1 5
  • HLA-DRB 3
  • DRB1 3
  • SS1 3

External Ids for HLA-DRB1 Gene

Previous HGNC Symbols for HLA-DRB1 Gene

  • HLA-DR1B

Previous GeneCards Identifiers for HLA-DRB1 Gene

  • GC06U990049
  • GC06Md32547
  • GC06M032317
  • GC06Md32654
  • GC06M032656
  • GC06M032546
  • GC06M032552

Summaries for HLA-DRB1 Gene

Entrez Gene Summary for HLA-DRB1 Gene

  • HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]

GeneCards Summary for HLA-DRB1 Gene

HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) is a Protein Coding gene. Diseases associated with HLA-DRB1 include Sarcoidosis 1 and Multiple Sclerosis. Among its related pathways are TCR Signaling (Qiagen) and Tuberculosis. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRB5.

UniProtKB/Swiss-Prot Summary for HLA-DRB1 Gene

  • A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:22327072, PubMed:27591323, PubMed:8642306, PubMed:15265931, PubMed:31495665). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819).
  • Allele DRB1*01:01: Displays an immunodominant epitope derived from Bacillus anthracis pagA/protective antigen, PA (KLPLYISNPNYKVNVYAVT), to both naive and PA-specific memory CD4-positive T cells (PubMed:22327072). Presents immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (PHQFINLRSNNSATLIVPYV), contributing to viral clearance (PubMed:27591323). Displays IAV and H5N1 HA-derived peptides (PKYVKQNTLKLAT and SNGNFIAPEYAYKIVK) (PubMed:8145819, PubMed:9075930, PubMed:25413013). Presents a self-peptide derived from COL4A3 (GWISLWKGFSF) to TCR (TRAV14 biased) on CD4-positive, FOXP3-positive regulatory T cells and mediates immune tolerance to self (PubMed:28467828). Displays with low affinity a self-peptide derived from MBP (VHFFKNIVTPRTP) (PubMed:9075930).
  • Allele DRB1*03:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Displays self-peptides derived from retinal SAG (NRERRGIALDGKIKHE) and thyroid TG (LSSVVVDPSIRHFDV) (PubMed:25413013).
  • Allele DRB1*04:01: Presents an immunodominant bacterial epitope derived from M. tuberculosis esxB/culture filtrate antigen CFP-10 (EISTNIRQAGVQYSR), eliciting CD4-positive T cell effector functions such as IFNG production and cytotoxic activity (PubMed:15265931). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Presents tumor epitopes derived from melanoma-associated TYR antigen (QNILLSNAPLGPQFP and DYSYLQDSDPDSFQD), triggering CD4-positive T cell effector functions such as GMCSF production (PubMed:8642306). Displays preferentially citrullinated self-peptides derived from VIM (GVYATR/citSSAVR and SAVRAR/citSSVPGVR) and ACAN (VVLLVATEGR/ CitVRVNSAYQDK) (PubMed:24190431). Displays self-peptides derived from COL2A1 (PubMed:9354468).
  • Allele DRB1*04:02: Displays native or citrullinated self-peptides derived from VIM.
  • Allele DRB1*04:04: May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (HIVMQYMYVPPGAPIPTTRN) and VP2 (RGDSTITSQDVANAVVGYGV), contributing to viral clearance (PubMed:27591323). Displays preferentially citrullinated self-peptides derived from VIM (SAVRAR/citSSVPGVR) (PubMed:24190431).
  • Allele DRB1*05:01: Presents an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load.
  • Allele DRB1*07:01: May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (VPYVNAVPMDSMVRHNNWSL), contributing to viral clearance.
  • Allele DRB1*11:01: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SDRIIQITRGDSTITSQDVA), contributing to viral clearance (PubMed:27591323). In the context of tumor immunesurveillance, may present tumor-derived neoantigens to CD4-positive T cells and trigger anti-tumor helper functions (PubMed:31495665).
  • Allele DRB1*15:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SNNSATLIVPYVNAVPMDSM), contributing to viral clearance (PubMed:27591323). Displays a self-peptide derived from MBP (ENPVVHFFKNIVTPR) (PubMed:9782128, PubMed:25413013).
  • Allele DRB1*15:02: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load.
  • (Microbial infection) Acts as a receptor for Epstein-Barr virus on lymphocytes.

Gene Wiki entry for HLA-DRB1 Gene

Additional gene information for HLA-DRB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLA-DRB1 Gene

Genomics for HLA-DRB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HLA-DRB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLA-DRB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HLA-DRB1

Top Transcription factor binding sites by QIAGEN in the HLA-DRB1 gene promoter:
  • AML1a
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CUTL1
  • HOXA3
  • p53
  • YY1

Genomic Locations for HLA-DRB1 Gene

Genomic Locations for HLA-DRB1 Gene
chr6:32,578,769-32,589,848
(GRCh38/hg38)
Size:
11,080 bases
Orientation:
Minus strand
chr6:32,546,546-32,557,625
(GRCh37/hg19)
Size:
11,080 bases
Orientation:
Minus strand

Genomic View for HLA-DRB1 Gene

Genes around HLA-DRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HLA-DRB1 Gene

Proteins for HLA-DRB1 Gene

  • Protein details for HLA-DRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01911-DRB_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DRB1 beta chain
    Protein Accession:
    P01911
    Secondary Accessions:
    • A0MWF2
    • A0N0W1
    • A2ICT1
    • A2TGX3
    • A4F5N0
    • A4ZXA5
    • A4ZXA6
    • A4ZY86
    • A5H000
    • A5HKN8
    • A7DZP9
    • A7LA26
    • A7UHG2
    • A7X5B1
    • A7X5B7
    • A7X5E0
    • A7X5E6
    • A7X5H8
    • A7X5J4
    • A7X5K7
    • A8K098
    • A8YQE9
    • A9JPG0
    • B0BK85
    • B0LUZ6
    • B0UYW1
    • B1GWE7
    • B2CR03
    • B2LVF9
    • B2NJ29
    • B2ZCY1
    • B3VTP8
    • B3VTQ3
    • B5A8Y2
    • B5A8Y3
    • B5B8U0
    • B5B9V5
    • B5B9V6
    • B5LZ25
    • B5QSK8
    • B6VCX2
    • B6VEL9
    • B7UDB2
    • B9VRA4
    • B9X248
    • C0LAB5
    • O02876
    • O02930
    • O19585
    • O19717
    • O19718
    • O19739
    • O19788
    • O46699
    • O46793
    • O46872
    • O62869
    • O62889
    • O77969
    • O78047
    • O78210
    • O98212
    • P01912
    • P01914
    • P04229
    • P13758
    • P13759
    • P13760
    • P13761
    • P20039
    • P79545
    • Q06662
    • Q0PGR5
    • Q0PQ39
    • Q14280
    • Q14QT2
    • Q155F7
    • Q19AF2
    • Q19K86
    • Q1AP33
    • Q1G0Z9
    • Q1JRP3
    • Q1KLJ6
    • Q27PR6
    • Q27PR7
    • Q29673
    • Q29720
    • Q29722
    • Q29734
    • Q29770
    • Q29771
    • Q29772
    • Q29790
    • Q29792
    • Q29800
    • Q29806
    • Q29833
    • Q29874
    • Q29875
    • Q29886
    • Q29968
    • Q29974
    • Q29975
    • Q2A120
    • Q2HZE5
    • Q2L9H4
    • Q2LE76
    • Q2MF40
    • Q2MJA6
    • Q2MZ92
    • Q2VQU1
    • Q2YHQ2
    • Q30006
    • Q30108
    • Q30112
    • Q30115
    • Q30116
    • Q30117
    • Q30120
    • Q30134
    • Q30142
    • Q30145
    • Q30149
    • Q30159
    • Q30166
    • Q30167
    • Q30200
    • Q307W5
    • Q31636
    • Q32MY7
    • Q3HUP9
    • Q3KTM1
    • Q3LA84
    • Q3LA87
    • Q3LA88
    • Q3LA89
    • Q3LA90
    • Q3LA91
    • Q3LA92
    • Q3LA93
    • Q3LA94
    • Q3LA95
    • Q3LA96
    • Q3LA97
    • Q3LA98
    • Q3LA99
    • Q3LAA0
    • Q3LAA1
    • Q3LAA2
    • Q3MQ60
    • Q3T919
    • Q4PRC3
    • Q4PRC5
    • Q4VZY7
    • Q53IG1
    • Q56FN9
    • Q56FP1
    • Q56FP2
    • Q56FP3
    • Q58F52
    • Q5BM92
    • Q5EER6
    • Q5K3W2
    • Q5NDB9
    • Q5U9W6
    • Q5UBA2
    • Q5UT58
    • Q5W3L4
    • Q5Y7A7
    • Q5Y7B0
    • Q5Y7B9
    • Q5Y7E9
    • Q5Y7G0
    • Q683P7
    • Q6REE2
    • Q6T865
    • Q6U387
    • Q701T1
    • Q70GL2
    • Q70Q85
    • Q768U2
    • Q768U4
    • Q7M2H4
    • Q7YNY9
    • Q7YP03
    • Q7YP04
    • Q7YQ26
    • Q7YQA3
    • Q7YQA5
    • Q860D8
    • Q860D9
    • Q860E5
    • Q860H8
    • Q860S0
    • Q860Z3
    • Q861G6
    • Q861H0
    • Q861H4
    • Q861H5
    • Q861H7
    • Q861H8
    • Q8HWQ6
    • Q8MH59
    • Q8MH60
    • Q8WLU3
    • Q8WMA0
    • Q95348
    • Q95383
    • Q95389
    • Q95461
    • Q95HK1
    • Q95HL0
    • Q95HL1
    • Q95IE3
    • Q95IG2
    • Q95IT6
    • Q96HZ9
    • Q9BCL7
    • Q9BCP0
    • Q9BCP1
    • Q9BCP2
    • Q9BCP5
    • Q9BD21
    • Q9BD33
    • Q9BD40
    • Q9GIK5
    • Q9GIL5
    • Q9GIL6
    • Q9GIP3
    • Q9GIX8
    • Q9GIX9
    • Q9GIY0
    • Q9GIY1
    • Q9GIY2
    • Q9GIY3
    • Q9GIY4
    • Q9GJ25
    • Q9GJ56
    • Q9GJ57
    • Q9GJ58
    • Q9GJ60
    • Q9GJF8
    • Q9GJF9
    • Q9GJG0
    • Q9MXZ0
    • Q9MXZ5
    • Q9MY13
    • Q9MY45
    • Q9MY56
    • Q9MYF5
    • Q9TPB6
    • Q9TPW1
    • Q9TPW3
    • Q9TPW9
    • Q9TPX4
    • Q9TQ37
    • Q9TQ91
    • Q9TQE0
    • Q9UBY1
    • Q9UIM9
    • Q9UIN0
    • Q9XRX1
    • Q9XRY4
    • Q9XRY5
    • Q9Y453
    • Q9Y4H7

    Protein attributes for HLA-DRB1 Gene

    Size:
    266 amino acids
    Molecular mass:
    29966 Da
    Quaternary structure:
    • Heterotrimer that consists of an alpha chain HLA-DRA1, a beta chain HLA-DRB1 and a peptide (peptide-MHCII) (PubMed:7477400, PubMed:9354468, PubMed:9782128). Newly synthesized alpha and beta chains forms a heterodimer (MHCII) that associates with the CD74/invariant chain (Ii) in the endoplasmic reticulum (ER). Ii is a trimer composed of three subunits and each subunit interacts with one MHCII dimer, blocking the peptide-binding cleft. As a result, MHCII molecules can not bind peptides present in the ER (PubMed:7479981). The complex of MHCII and CD74/Ii is transported in vesicles from ER to Golgi to lysosomes, where it encounters antigenic peptides generated via proteolysis of endocytosed antigens. MHCII dimers are dissociated from CD74/Ii by the combined action of proteolysis and HLA-DM (PubMed:25413013). Lysosomal enzymes such as cathepsin, degrade CD74/Ii leaving a 24 amino acid remnant called class II-associated Ii or CLIP. Interacts (via the peptide binding cleft) with CLIP; this interaction inhibits antigen peptide binding before entry in the endosomal compartment (PubMed:7477400, PubMed:9075930). The displacement of CLIP and replacement by a high affinity peptide in lysosomes is performed by HLA-DM heterodimer. HLA-DM catalyzes CLIP dissociation from MHCII, stabilizes empty MHCII and mediates the selection of high affinity peptides (PubMed:23260142, PubMed:11070170, PubMed:9075930). Interacts with HLA-DM heterodimer; this interaction is direct (PubMed:25413013). Interacts with TCR (via CDR3) (PubMed:29884618). Interacts (via beta-2 domain) with CD4 coreceptor (via Ig-like C2-type 1 domain); this interaction is of exceptionally low affinity yet necessary for optimal recognition of antigenic peptides (PubMed:21900604).
    • (Microbial infection) Interacts with Staphylococcus aureus enterotoxin A/entA, enterotoxin B/entB, enterotoxin C1/entC1, enterotoxin D/entD and enterotoxin H/entH. Enterotoxins bind outside the peptide-binding cleft of MHCII: enterotoxin H/entH interacts via the beta-1 domain of MHCII and in a zinc-dependent way, whereas enterotoxin B/entB interacts primarily via the alpha-1 domain.
    • (Microbial infection) Interacts with Epstein-Barr virus gp42 protein.

    Three dimensional structures from OCA and Proteopedia for HLA-DRB1 Gene

neXtProt entry for HLA-DRB1 Gene

Post-translational modifications for HLA-DRB1 Gene

Other Protein References for HLA-DRB1 Gene

Antibody Products

No data available for DME Specific Peptides for HLA-DRB1 Gene

Domains & Families for HLA-DRB1 Gene

Gene Families for HLA-DRB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for HLA-DRB1 Gene

InterPro:
Blocks:
  • Immunoglobulin C-type
  • Class II histocompatibility antigen, beta chain, beta-1 domain
ProtoNet:

Suggested Antigen Peptide Sequences for HLA-DRB1 Gene

GenScript: Design optimal peptide antigens:
  • MHC class II antigen DRB1*1 (2B11_HUMAN)
  • MHC class II antigen DRB1*3 (2B13_HUMAN)
  • MHC class II antigen DRB1*4 (2B14_HUMAN)
  • MHC class II antigen DRB1*7 (2B17_HUMAN)
  • MHC class II antigen DRB1*8 (2B18_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01911

UniProtKB/Swiss-Prot:

DRB_HUMAN :
  • The beta-1 domain is a structural part of the peptide-binding cleft. It contains one alpha helix and 4 beta sheets, respectively forming part of the wall and the floor of the peptide-binding cleft. The other 4 beta sheets of the floor and the second alpha helix wall is formed by the alpha-1 domain of HLA-DRA. Forms hydrogen bonds with the peptide main chain via conserved amino acid in most HLA-DRB molecules. The polymorphic residues accomodate the side chains of the peptide conferring peptide specificity to distinct HLA-DRB1 alleles (PubMed:8145819, PubMed:28467828, PubMed:9782128, PubMed:9354468). The peptide-bound beta-1 domain forms hydrogen bonds with CDR2 and CDR3 alpha-domains of the T cell receptor (PubMed:19303388).
Domain:
  • The beta-1 domain is a structural part of the peptide-binding cleft. It contains one alpha helix and 4 beta sheets, respectively forming part of the wall and the floor of the peptide-binding cleft. The other 4 beta sheets of the floor and the second alpha helix wall is formed by the alpha-1 domain of HLA-DRA. Forms hydrogen bonds with the peptide main chain via conserved amino acid in most HLA-DRB molecules. The polymorphic residues accomodate the side chains of the peptide conferring peptide specificity to distinct HLA-DRB1 alleles (PubMed:8145819, PubMed:28467828, PubMed:9782128, PubMed:9354468). The peptide-bound beta-1 domain forms hydrogen bonds with CDR2 and CDR3 alpha-domains of the T cell receptor (PubMed:19303388).
  • The beta-2 Ig-like domain mediates the interaction with CD4 coreceptor.
genes like me logo Genes that share domains with HLA-DRB1: view

Function for HLA-DRB1 Gene

Molecular function for HLA-DRB1 Gene

UniProtKB/Swiss-Prot Function:
A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:22327072, PubMed:27591323, PubMed:8642306, PubMed:15265931, PubMed:31495665). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819).
UniProtKB/Swiss-Prot Function:
Allele DRB1*01:01: Displays an immunodominant epitope derived from Bacillus anthracis pagA/protective antigen, PA (KLPLYISNPNYKVNVYAVT), to both naive and PA-specific memory CD4-positive T cells (PubMed:22327072). Presents immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (PHQFINLRSNNSATLIVPYV), contributing to viral clearance (PubMed:27591323). Displays IAV and H5N1 HA-derived peptides (PKYVKQNTLKLAT and SNGNFIAPEYAYKIVK) (PubMed:8145819, PubMed:9075930, PubMed:25413013). Presents a self-peptide derived from COL4A3 (GWISLWKGFSF) to TCR (TRAV14 biased) on CD4-positive, FOXP3-positive regulatory T cells and mediates immune tolerance to self (PubMed:28467828). Displays with low affinity a self-peptide derived from MBP (VHFFKNIVTPRTP) (PubMed:9075930).
UniProtKB/Swiss-Prot Function:
Allele DRB1*03:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Displays self-peptides derived from retinal SAG (NRERRGIALDGKIKHE) and thyroid TG (LSSVVVDPSIRHFDV) (PubMed:25413013).
UniProtKB/Swiss-Prot Function:
Allele DRB1*04:01: Presents an immunodominant bacterial epitope derived from M. tuberculosis esxB/culture filtrate antigen CFP-10 (EISTNIRQAGVQYSR), eliciting CD4-positive T cell effector functions such as IFNG production and cytotoxic activity (PubMed:15265931). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Presents tumor epitopes derived from melanoma-associated TYR antigen (QNILLSNAPLGPQFP and DYSYLQDSDPDSFQD), triggering CD4-positive T cell effector functions such as GMCSF production (PubMed:8642306). Displays preferentially citrullinated self-peptides derived from VIM (GVYATR/citSSAVR and SAVRAR/citSSVPGVR) and ACAN (VVLLVATEGR/ CitVRVNSAYQDK) (PubMed:24190431). Displays self-peptides derived from COL2A1 (PubMed:9354468).
UniProtKB/Swiss-Prot Function:
Allele DRB1*04:02: Displays native or citrullinated self-peptides derived from VIM.
UniProtKB/Swiss-Prot Function:
Allele DRB1*04:04: May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (HIVMQYMYVPPGAPIPTTRN) and VP2 (RGDSTITSQDVANAVVGYGV), contributing to viral clearance (PubMed:27591323). Displays preferentially citrullinated self-peptides derived from VIM (SAVRAR/citSSVPGVR) (PubMed:24190431).
UniProtKB/Swiss-Prot Function:
Allele DRB1*05:01: Presents an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load.
UniProtKB/Swiss-Prot Function:
Allele DRB1*07:01: May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (VPYVNAVPMDSMVRHNNWSL), contributing to viral clearance.
UniProtKB/Swiss-Prot Function:
Allele DRB1*11:01: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SDRIIQITRGDSTITSQDVA), contributing to viral clearance (PubMed:27591323). In the context of tumor immunesurveillance, may present tumor-derived neoantigens to CD4-positive T cells and trigger anti-tumor helper functions (PubMed:31495665).
UniProtKB/Swiss-Prot Function:
Allele DRB1*15:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SNNSATLIVPYVNAVPMDSM), contributing to viral clearance (PubMed:27591323). Displays a self-peptide derived from MBP (ENPVVHFFKNIVTPR) (PubMed:9782128, PubMed:25413013).
UniProtKB/Swiss-Prot Function:
Allele DRB1*15:02: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Epstein-Barr virus on lymphocytes.
GENATLAS Biochemistry:
HLA-DR,beta 1 chain,determining DR1,3,4,5 etc

Phenotypes From GWAS Catalog for HLA-DRB1 Gene

Gene Ontology (GO) - Molecular Function for HLA-DRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS 1281771
GO:0005515 protein binding IPI 9354468
GO:0023026 MHC class II protein complex binding HDA 20458337
GO:0030247 polysaccharide binding IDA 21502329
GO:0032395 MHC class II receptor activity TAS 3456344
genes like me logo Genes that share ontologies with HLA-DRB1: view
genes like me logo Genes that share phenotypes with HLA-DRB1: view

Human Phenotype Ontology for HLA-DRB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DRB1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DRB1 Gene

Localization for HLA-DRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DRB1 Gene

Cell membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane. Single-pass type I membrane protein. Endosome membrane. Single-pass type I membrane protein. Lysosome membrane. Single-pass type I membrane protein. Late endosome membrane. Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Component of immunological synapses at the interface between T cell and APC. {ECO:0000269 PubMed:29884618}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-DRB1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
endosome 5
lysosome 5
extracellular 4
endoplasmic reticulum 4
golgi apparatus 4
nucleus 3
mitochondrion 2
cytosol 2
peroxisome 0

Gene Ontology (GO) - Cellular Components for HLA-DRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005615 extracellular space HDA 16502470
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane TAS --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with HLA-DRB1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HLA-DRB1 Gene

Pathways & Interactions for HLA-DRB1 Gene

PathCards logo

SuperPathways for HLA-DRB1 Gene

SuperPathway Contained pathways
1 Allograft rejection
.44
.39
.38
2 Th17 cell differentiation
.36
3 Translocation of ZAP-70 to Immunological synapse
4 ICos-ICosL Pathway in T-Helper Cell
.66
.66
.31
5 TCR Signaling (Qiagen)
.68
.68
.54
genes like me logo Genes that share pathways with HLA-DRB1: view

Pathways by source for HLA-DRB1 Gene

6 GeneGo (Thomson Reuters) pathways for HLA-DRB1 Gene
  • G-protein signaling N-RAS regulation pathway
  • Immune response Antigen presentation by MHC class II
  • Immune response ICOS pathway in T-helper cell
  • Immune response IL-22 signaling pathway
  • Immune response NFAT in immune response
12 Qiagen pathways for HLA-DRB1 Gene
  • Calcium Mediated T-Cell Apoptosis
  • CD28 Signaling in T-Helper Cell
  • CDC42 Pathway
  • CTL Mediated Apoptosis
  • CTLA4 Signaling
1 GeneTex pathway for HLA-DRB1 Gene

SIGNOR curated interactions for HLA-DRB1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HLA-DRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 24942581
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response IDA 17050030
GO:0002437 inflammatory response to antigenic stimulus IDA 15795121
genes like me logo Genes that share ontologies with HLA-DRB1: view

Drugs & Compounds for HLA-DRB1 Gene

(30) Drugs for HLA-DRB1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coccidioides immitis spherule Approved Pharma Target, Target, Target, Target, Target, Target, Target, Target, Target, Target, Target, Target, Target, binder 0
Glatiramer Approved, Investigational Pharma Target, binder 0
Allopurinol Approved Pharma 176
Atorvastatin Approved Pharma Inhibitor, Competitive 893
Azathioprine Approved Pharma 227

(9) Additional Compounds for HLA-DRB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HLA-DRB1: view

Transcripts for HLA-DRB1 Gene

mRNA/cDNA for HLA-DRB1 Gene

4 REFSEQ mRNAs :
110 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DRB1

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DRB1 Gene

No ASD Table

Relevant External Links for HLA-DRB1 Gene

GeneLoc Exon Structure for
HLA-DRB1

Expression for HLA-DRB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HLA-DRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DRB1 Gene

This gene is overexpressed in Lung (x4.1) and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for HLA-DRB1 Gene

This gene is overexpressed in Lymph node (13.4), Lung (13.2), Oral epithelium (7.6), and Nasal epithelium (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HLA-DRB1 Gene



Protein tissue co-expression partners for HLA-DRB1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-DRB1

SOURCE GeneReport for Unigene cluster for HLA-DRB1 Gene:

Hs.534322

mRNA Expression by UniProt/SwissProt for HLA-DRB1 Gene:

P01911-DRB_HUMAN
Tissue specificity: Expressed in professional APCs: macrophages, dendritic cells and B cells.

Evidence on tissue expression from TISSUES for HLA-DRB1 Gene

  • Nervous system(4.9)
  • Lung(4.9)
  • Blood(4.8)
  • Skin(4.6)
  • Intestine(4.4)
  • Stomach(4.4)
  • Pancreas(4.3)
  • Kidney(4)
  • Spleen(3.9)
  • Eye(3.4)
  • Thyroid gland(2.8)
  • Liver(2.8)
  • Lymph node(2.6)
  • Bone marrow(2.6)
  • Heart(2.5)
  • Muscle(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DRB1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • epiglottis
  • eye
  • head
  • jaw
  • lacrimal apparatus
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • salivary gland
  • skull
  • tongue
  • tooth
Thorax:
  • chest wall
  • clavicle
  • esophagus
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • duodenum
  • intestine
  • kidney
  • large intestine
  • pancreas
  • small intestine
  • spleen
  • stomach
Pelvis:
  • pelvis
  • rectum
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • lymph node
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with HLA-DRB1: view

Orthologs for HLA-DRB1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HLA-DRB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PATR-DQB1 30
  • 96.62 (n)
DRB1*0204 31
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia DLA-DRB1 31
  • 76 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia H2-Eb1 31
  • 75 (a)
ManyToMany
H2-Eb2 31
  • 60 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia DSB 31
  • 68 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 63 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 55 (a)
ManyToMany
Species where no ortholog for HLA-DRB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for HLA-DRB1 Gene

ENSEMBL:
Gene Tree for HLA-DRB1 (if available)
TreeFam:
Gene Tree for HLA-DRB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HLA-DRB1: view image

Paralogs for HLA-DRB1 Gene

(230) SIMAP similar genes for HLA-DRB1 Gene using alignment to 2155 proteins:

  • 2B11_HUMAN
  • 2B13_HUMAN
  • 2B14_HUMAN
  • 2B17_HUMAN
  • 2B18_HUMAN
  • 2B19_HUMAN
  • 2B1A_HUMAN
  • 2B1B_HUMAN
  • 2B1C_HUMAN
  • 2B1D_HUMAN
  • 2B1E_HUMAN
  • 2B1F_HUMAN
  • 2B1G_HUMAN
  • A0AQX7_HUMAN
  • A0AQX8_HUMAN
  • A0AQX9_HUMAN
  • A0AQY0_HUMAN
  • A0AQY1_HUMAN
  • A0AQY2_HUMAN
  • A0AQY3_HUMAN
  • A0AQY4_HUMAN
  • A0AQY5_HUMAN
  • A0AQY6_HUMAN
  • A0AQY7_HUMAN
  • A0AQY8_HUMAN
  • A0AQZ0_HUMAN
  • A0AQZ1_HUMAN
  • A0AQZ2_HUMAN
  • A0AQZ3_HUMAN
  • A0AQZ4_HUMAN
  • A0N0W0_HUMAN
  • A0N0W2_HUMAN
  • A0N0W3_HUMAN
  • A0N0W5_HUMAN
  • A0N9E2_HUMAN
  • A0PFK3_HUMAN
  • A0PFV9_HUMAN
  • A0T4C2_HUMAN
  • A0T4C3_HUMAN
  • A0ZXX2_HUMAN
  • A1A413_HUMAN
  • A1A414_HUMAN
  • A1A415_HUMAN
  • A1A416_HUMAN
  • A1A417_HUMAN
  • A1A418_HUMAN
  • A1A419_HUMAN
  • A1DS51_HUMAN
  • A1Z0K9_HUMAN
  • A1Z1P0_HUMAN
  • A2BFX2_HUMAN
  • A2VBX2_HUMAN
  • A2VBX3_HUMAN
  • A3F923_HUMAN
  • A3FP43_HUMAN
  • A3RM25_HUMAN
  • A3RM26_HUMAN
  • A4F5N1_HUMAN
  • A4Q970_HUMAN
  • A4URM3_HUMAN
  • A4UUM5_HUMAN
  • A4VAP8_HUMAN
  • A5HED9_HUMAN
  • A5HKN7_HUMAN
  • A5HMQ3_HUMAN
  • A5I885_HUMAN
  • A5I890_HUMAN
  • A5JNG9_HUMAN
  • A5PHT3_HUMAN
  • A5YP91_HUMAN
  • A5YVG9_HUMAN
  • A6MWD7_HUMAN
  • A6YQP1_HUMAN
  • A7DWG6_HUMAN
  • A7DZ90_HUMAN
  • A7DZ95_HUMAN
  • A7L3U7_HUMAN
  • A7UHF9_HUMAN
  • A7UHG0_HUMAN
  • A7UHG1_HUMAN
  • A7UHG3_HUMAN
  • A7UHG4_HUMAN
  • A7UHG5_HUMAN
  • A7UHG6_HUMAN
  • A7UHG7_HUMAN
  • A7UHG8_HUMAN
  • A7UHG9_HUMAN
  • A7UMH1_HUMAN
  • A7UMH2_HUMAN
  • A7UMH3_HUMAN
  • A7UMH4_HUMAN
  • A7UMH5_HUMAN
  • A7UMH6_HUMAN
  • A7UMH7_HUMAN
  • A7UNZ6_HUMAN
  • A7UNZ7_HUMAN
  • A7UNZ8_HUMAN
  • A7UNZ9_HUMAN
  • A7UP00_HUMAN
  • A7UP01_HUMAN
  • A7UP02_HUMAN
  • A7UP03_HUMAN
  • A7UP04_HUMAN
  • A7UP05_HUMAN
  • A7UP06_HUMAN
  • A7UP07_HUMAN
  • A7UP08_HUMAN
  • A7UP09_HUMAN
  • A7UP10_HUMAN
  • A7X5C2_HUMAN
  • A7X5C9_HUMAN
  • A7X5D5_HUMAN
  • A7X5F1_HUMAN
  • A7X5F9_HUMAN
  • A7X5G4_HUMAN
  • A7X5H1_HUMAN
  • A7X5I3_HUMAN
  • A7X5I8_HUMAN
  • A7X5K1_HUMAN
  • A7X5L2_HUMAN
  • A7XFV9_HUMAN
  • A7XPK7_HUMAN
  • A8C5I7_HUMAN
  • A8CKH4_HUMAN
  • A8D305_HUMAN
  • A8D9Y3_HUMAN
  • A8D9Y6_HUMAN
  • A8D9Z0_HUMAN
  • A8D9Z3_HUMAN
  • A8KQQ2_HUMAN
  • A8WDP0_HUMAN
  • A8YQE8_HUMAN
  • A9JJF6_HUMAN
  • A9JQM0_HUMAN
  • A9YQ96_HUMAN
  • A9YTA3_HUMAN
  • A9Z190_HUMAN
  • B0F9M7_HUMAN
  • B0L892_HUMAN
  • B0LUD6_HUMAN
  • B0LUU3_HUMAN
  • B0LUU4_HUMAN
  • B0LUU5_HUMAN
  • B0LUY9_HUMAN
  • B0RZ68_HUMAN
  • B1GVZ5_HUMAN
  • B1GVZ9_HUMAN
  • B1PL08_HUMAN
  • B1VJP6_HUMAN
  • B1VK37_HUMAN
  • B2CKL1_HUMAN
  • B2CR04_HUMAN
  • B2G3D1_HUMAN
  • B2G3E5_HUMAN
  • B2NJ27_HUMAN
  • B2NJ28_HUMAN
  • B2NJ32_HUMAN
  • B2NJ33_HUMAN
  • B2NJ34_HUMAN
  • B2NJ35_HUMAN
  • B2NJ36_HUMAN
  • B2NJ37_HUMAN
  • B2NJ38_HUMAN
  • B2NJ39_HUMAN
  • B2RG88_HUMAN
  • B2RG89_HUMAN
  • B2RG90_HUMAN
  • B2ZCX8_HUMAN
  • B2ZCX9_HUMAN
  • B2ZCY0_HUMAN
  • B2ZGJ0_HUMAN
  • B3CL08_HUMAN
  • B3GDG5_HUMAN
  • B3GDG6_HUMAN
  • B3GDG7_HUMAN
  • B3GDG8_HUMAN
  • B3GV29_HUMAN
  • B3GV30_HUMAN
  • B3GV31_HUMAN
  • B3KYW3_HUMAN
  • B3V8R3_HUMAN
  • B3V8R4_HUMAN
  • B3V8R5_HUMAN
  • B3V8R6_HUMAN
  • B3VTQ0_HUMAN
  • B3VTQ1_HUMAN
  • B3VTQ2_HUMAN
  • B3VTQ4_HUMAN
  • B3VTQ5_HUMAN
  • B3VTQ6_HUMAN
  • B3VTQ7_HUMAN
  • B3VTQ8_HUMAN
  • B5A8Y4_HUMAN
  • B5A8Y5_HUMAN
  • B5A8Y6_HUMAN
  • B5A8Y7_HUMAN
  • B5ABX7_HUMAN
  • B5B9V7_HUMAN
  • B5BLW4_HUMAN
  • B5D5S9_HUMAN
  • B5QSK7_HUMAN
  • B6DST2_HUMAN
  • B6E315_HUMAN
  • B6ET91_HUMAN
  • B6ETP3_HUMAN
  • B6ETR7_HUMAN
  • B6ZLV2_HUMAN
  • B7TXX6_HUMAN
  • B7U794_HUMAN
  • B7VF70_HUMAN
  • B7VU65_HUMAN
  • B8Y6B0_HUMAN
  • B8Y6B1_HUMAN
  • B8YM95_HUMAN
  • B8ZHC3_HUMAN
  • B9WPM1_HUMAN
  • B9WPM2_HUMAN
  • B9WPM3_HUMAN
  • B9WPM4_HUMAN
  • B9WPM5_HUMAN
  • B9WPM6_HUMAN
  • B9WPM7_HUMAN
  • B9WPM8_HUMAN
  • B9WPQ6_HUMAN
  • C0LAB6_HUMAN
  • C0LAB7_HUMAN
  • C0LAB8_HUMAN
  • C0LAB9_HUMAN
  • C0LAC0_HUMAN
  • C0LAC1_HUMAN
  • C0LAC2_HUMAN
  • C0MNB7_HUMAN
  • C0MP08_HUMAN
  • C0MP09_HUMAN
  • C0MP10_HUMAN
  • C0MQC3_HUMAN
  • C0MQV5_HUMAN
  • C0MQV9_HUMAN
  • C1JJS3_HUMAN
  • C1KBK0_HUMAN
  • C1KJK6_HUMAN
  • C1KJK8_HUMAN
  • C3VJ06_HUMAN
  • C3VN82_HUMAN
  • C3W973_HUMAN
  • C4PFX4_HUMAN
  • C4PJL5_HUMAN
  • C4PJL6_HUMAN
  • C4R9G8_HUMAN
  • C4RA90_HUMAN
  • C5E7P3_HUMAN
  • C5E7P4_HUMAN
  • C5IAX3_HUMAN
  • C5IZL0_HUMAN
  • C5J434_HUMAN
  • C5J8E6_HUMAN
  • C5J8E7_HUMAN
  • C5MRD8_HUMAN
  • C5NU25_HUMAN
  • C5NU26_HUMAN
  • C5NU45_HUMAN
  • C6GZ76_HUMAN
  • C6H0J8_HUMAN
  • C6H0Y3_HUMAN
  • C6L819_HUMAN
  • C6L820_HUMAN
  • C6L821_HUMAN
  • C6L822_HUMAN
  • C6L825_HUMAN
  • C6L826_HUMAN
  • C6L827_HUMAN
  • C6L828_HUMAN
  • C6L829_HUMAN
  • C7C5G1_HUMAN
  • C7DRS1_HUMAN
  • C7EX09_HUMAN
  • C7FDW4_HUMAN
  • C7FDW5_HUMAN
  • C7FDW6_HUMAN
  • C7FDW7_HUMAN
  • C7FDW8_HUMAN
  • C7FDW9_HUMAN
  • C7FDX0_HUMAN
  • C8C9V4_HUMAN
  • C8C9V5_HUMAN
  • C8C9V6_HUMAN
  • C8C9V7_HUMAN
  • C8C9V9_HUMAN
  • C8C9W0_HUMAN
  • C8C9W1_HUMAN
  • C8C9W2_HUMAN
  • C8CBI3_HUMAN
  • C8CHC3_HUMAN
  • C8CHC4_HUMAN
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genes like me logo Genes that share paralogs with HLA-DRB1: view

Variants for HLA-DRB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DRB1 Gene

DRB_HUMAN-P01911
Highly polymorphic. Polymorphic residues encode for the beta-1 domain of the peptide-binding cleft, where they contribute to variations in peptide binding and TCR recognition among different alleles. The sequence shown is that of DRB1*15:01. The sequences of common representative alleles of serologically distinct allele groups as defined in the catalog of common and well-documented HLA alleles, are described as variants of DRB1*15:01.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HLA-DRB1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
691505 Uncertain Significance: Peritoneal Gliomatosis 32,584,172(-) C/G MISSENSE_VARIANT,NO_SEQUENCE_ALTERATION
VAR_082703 - p.Lys5Arg
VAR_082704 - p.Leu6Phe
VAR_082705 - p.Thr13Ala
VAR_082706 - p.Ala14Val

Additional dbSNP identifiers (rs#s) for HLA-DRB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HLA-DRB1 Gene

Variant ID Type Subtype PubMed ID
dgv1013n67 CNV loss 20364138
dgv1018n67 CNV loss 20364138
dgv1024n67 CNV loss 20364138
dgv1025n67 CNV loss 20364138
dgv1026n67 CNV loss 20364138
dgv1027n67 CNV loss 20364138
dgv10463n54 CNV loss 21841781
dgv10472n54 CNV loss 21841781
dgv10488n54 CNV loss 21841781
dgv10489n54 CNV loss 21841781
dgv10490n54 CNV loss 21841781
dgv10492n54 CNV gain 21841781
dgv10494n54 CNV gain 21841781
dgv10497n54 CNV loss 21841781
dgv10504n54 CNV gain+loss 21841781
dgv10505n54 CNV gain 21841781
dgv10506n54 CNV loss 21841781
dgv10519n54 CNV gain+loss 21841781
dgv10523n54 CNV loss 21841781
dgv10529n54 CNV loss 21841781
dgv10530n54 CNV loss 21841781
dgv10534n54 CNV gain 21841781
dgv10538n54 CNV gain 21841781
dgv10541n54 CNV gain 21841781
dgv10542n54 CNV gain 21841781
dgv10549n54 CNV loss 21841781
dgv10550n54 CNV loss 21841781
dgv10554n54 CNV gain+loss 21841781
dgv10558n54 CNV loss 21841781
dgv10559n54 CNV loss 21841781
dgv10560n54 CNV loss 21841781
dgv10562n54 CNV loss 21841781
dgv10563n54 CNV gain 21841781
dgv10564n54 CNV loss 21841781
dgv10566n54 CNV loss 21841781
dgv10567n54 CNV loss 21841781
dgv10568n54 CNV loss 21841781
dgv10569n54 CNV gain 21841781
dgv10570n54 CNV loss 21841781
dgv10571n54 CNV loss 21841781
dgv10572n54 CNV loss 21841781
dgv10573n54 CNV loss 21841781
dgv10574n54 CNV gain+loss 21841781
dgv10575n54 CNV gain 21841781
dgv10576n54 CNV loss 21841781
dgv1100e199 CNV deletion 23128226
dgv1105e199 CNV deletion 23128226
dgv1106e199 CNV deletion 23128226
dgv1108e199 CNV deletion 23128226
dgv121e19 CNV loss 19470904
dgv5947n100 CNV gain 25217958
dgv5950n100 CNV gain+loss 25217958
dgv6e3 OTHER complex 18987735
dgv998e201 CNV deletion 23290073
esv1128844 CNV insertion 17803354
esv21985 CNV gain+loss 19812545
esv2421657 CNV deletion 20811451
esv2422111 CNV deletion 20811451
esv2459937 CNV loss 19546169
esv2731847 CNV deletion 23290073
esv2731848 CNV deletion 23290073
esv2759416 CNV gain+loss 17122850
esv2761046 CNV gain+loss 21179565
esv2763944 CNV gain+loss 21179565
esv33476 CNV gain+loss 17666407
esv3385535 CNV duplication