HLA-DRA Gene (Protein Coding)

Major Histocompatibility Complex, Class II, DR Alpha

GC06P032439
GIFtS:
48
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by pr... See more...

Aliases for HLA-DRA Gene

Aliases for HLA-DRA Gene

  • Major Histocompatibility Complex, Class II, DR Alpha 2 3 5
  • HLA Class II Histocompatibility Antigen, DR Alpha Chain 3 4
  • MHC Class II Antigen DRA 3 4
  • HLA-DRA1 3 4
  • Histocompatibility Antigen HLA-DR Alpha 3
  • HLA-DRA 5

External Ids for HLA-DRA Gene

Previous HGNC Symbols for HLA-DRA Gene

  • HLA-DRA1

Previous GeneCards Identifiers for HLA-DRA Gene

  • GC06P032434
  • GC06Pd32422
  • GC06P032178
  • GC06P032412

Summaries for HLA-DRA Gene

Entrez Gene Summary for HLA-DRA Gene

  • HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020]

CIViC Summary for HLA-DRA Gene

GeneCards Summary for HLA-DRA Gene

HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha) is a Protein Coding gene. Diseases associated with HLA-DRA include Graham-Little-Piccardi-Lassueur Syndrome and Penicillin Allergy. Among its related pathways are Rheumatoid arthritis and Allograft rejection. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and MHC class II receptor activity. An important paralog of this gene is HLA-DPA1.

UniProtKB/Swiss-Prot Summary for HLA-DRA Gene

  • An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:17334368, PubMed:8145819, PubMed:15322540, PubMed:22327072, PubMed:27591323, PubMed:31495665, PubMed:15265931, PubMed:9075930, PubMed:24190431). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819).

Gene Wiki entry for HLA-DRA Gene

Additional gene information for HLA-DRA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLA-DRA Gene

Genomics for HLA-DRA Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for HLA-DRA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLA-DRA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HLA-DRA

Top Transcription factor binding sites by QIAGEN in the HLA-DRA gene promoter:
  • AML1a
  • AREB6
  • Arnt
  • CUTL1
  • GCNF
  • GCNF-1
  • GCNF-2
  • IRF-2
  • Pax-4a
  • Pax-5

Genomic Locations for HLA-DRA Gene

Latest Assembly
chr6:32,439,878-32,445,046
(GRCh38/hg38)
Size:
5,169 bases
Orientation:
Plus strand

Previous Assembly
chr6:32,407,664-32,412,823
(GRCh37/hg19 by Entrez Gene)
Size:
5,160 bases
Orientation:
Plus strand

chr6:32,407,619-32,412,823
(GRCh37/hg19 by Ensembl)
Size:
5,205 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr6(ALT_REF_LOCI_2):3,878,013-3,883,135 (+)
  • chr6(ALT_REF_LOCI_3):3,680,192-3,685,357 (+)
  • chr6(ALT_REF_LOCI_4):3,744,104-3,749,270 (+)
  • chr6(ALT_REF_LOCI_5):3,780,853-3,786,018 (+)
  • chr6(ALT_REF_LOCI_6):3,662,936-3,668,101 (+)
  • chr6(ALT_REF_LOCI_7):3,755,030-3,760,195 (+)
  • chr6(ALT_REF_LOCI_8):9,687-14,846 (-)

Genomic View for HLA-DRA Gene

Genes around HLA-DRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DRA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

Proteins for HLA-DRA Gene

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  • Protein details for HLA-DRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01903-DRA_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DR alpha chain
    Protein Accession:
    P01903
    Secondary Accessions:
    • A2BET4
    • Q30160
    • Q6IAZ1
    • Q861I2
    • Q9TP70

    Protein attributes for HLA-DRA Gene

    Size:
    254 amino acids
    Molecular mass:
    28621 Da
    Quaternary structure:
    • Heterotrimer that consists of an alpha chain HLA-DRA, a beta chain HLA-DRB and a peptide (peptide-MHCII) (PubMed:7477400, PubMed:9354468, PubMed:9782128, PubMed:31619516, PubMed:32668259, PubMed:11080454, PubMed:11163233, PubMed:12244309, PubMed:16079912, PubMed:17583734, PubMed:18697946). Newly synthesized alpha and beta chains forms a heterodimer (MHCII) that associates with the CD74/invariant chain (Ii) in the endoplasmic reticulum (ER). Ii is a trimer composed of three subunits and each subunit interacts with one MHCII dimer, blocking the peptide-binding cleft (PubMed:7479981). As a result, MHCII molecules can not bind peptides present in the ER (PubMed:7479981). The complex of MHCII and CD74/Ii is transported in vesicles from ER to Golgi to lysosomes, where it encounters antigenic peptides generated via proteolysis of endocytosed antigens. MHCII dimers are dissociated from CD74/Ii by the combined action of proteolysis and HLA-DM (PubMed:25413013, PubMed:23260142, PubMed:21115828). Lysosomal enzymes such as cathepsin, degrade CD74/Ii leaving a 24 amino acid remnant called class II-associated Ii or CLIP. Interacts (via the peptide binding cleft) with CLIP; this interaction inhibits antigen peptide binding before entry in the endosomal compartment (PubMed:9075930, PubMed:7477400). The displacement of CLIP and replacement by a high affinity peptide in lysosomes is performed by HLA-DM heterodimer. HLA-DM catalyzes CLIP dissociation from MHCII, stabilizes empty MHCII and mediates the selection of high affinity peptides (PubMed:23260142, PubMed:11070170, PubMed:9075930). Interacts with HLA-DM heterodimer; this interaction is direct (PubMed:25413013). Interacts (via alpha-1 domain) with TCR (via CDRs) (PubMed:17334368, PubMed:29884618). Interacts (via alpha-2 domain) with CD4 (via Ig-like V-type domain); this interaction increases the affinity of TCR for peptide-MHCII (PubMed:27114505).
    • (Microbial infection) Interacts with Epstein-Barr virus BZLF2/gp42.
    • (Microbial infection) Interacts with Staphylococcus aureus enterotoxin A/entA, enterotoxin B/entB, enterotoxin C1/entC1, enterotoxin D/entD, and enterotoxin H/entH.
    SequenceCaution:
    • Sequence=CAA25076.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HLA-DRA Gene

neXtProt entry for HLA-DRA Gene

Protein Expression for HLA-DRA Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HLA-DRA Gene

  • Ubiquitinated by MARCHF1 or MARCHF8 at Lys-244 leading to down-regulation of MHCII. When associated with ubiquitination of the beta chain at 'Lys-254', the down-regulation of MHCII may be highly effective.
  • Glycosylation at Asn103 and Asn143
  • Ubiquitination at Lys244
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for HLA-DRA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for HLA-DRA Gene

Domains & Families for HLA-DRA Gene

Gene Families for HLA-DRA Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for HLA-DRA Gene

InterPro:
Blocks:
  • Immunoglobulin C-type
  • MHC Class II alpha chain, alpha-1 domain

Suggested Antigen Peptide Sequences for HLA-DRA Gene

GenScript: Design optimal peptide antigens:
  • MHC class II antigen (A1A435_HUMAN)
  • MHC class II antigen (A1A436_HUMAN)
  • cDNA, FLJ93608, Homo sapiens major histocompatibility complex, class II, DR alpha(HLA-DRA), mRNA (B0UXD8_HUMAN)
  • cDNA FLJ57318, highly similar to HLA class II histocompatibility antigen, DRalpha chain (B4DLJ8_HUMAN)
  • cDNA FLJ51117, highly similar to HLA class II histocompatibility antigen, DRalpha chain (B4DW37_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01903

UniProtKB/Swiss-Prot:

DRA_HUMAN :
  • The alpha-1 domain is a structural part of the peptide-binding cleft. It contains one alpha helix and 4 beta sheets, respectively forming part of the wall and the floor of the peptide-binding cleft. The other 4 beta sheets of the floor and the second alpha helix wall is formed by the beta-1 domain of HLA-DRB. Forms hydrogen bonds with the peptide main chain via conserved amino acids (PubMed:8145819, PubMed:9354468, PubMed:9782128, PubMed:17583734, PubMed:29884618). The peptide-bound alpha-1 domain forms hydrogen bonds with CDR2 and CDR3 alpha-domain of TCR (PubMed:29884618).
  • Belongs to the MHC class II family.
Domain:
  • The alpha-1 domain is a structural part of the peptide-binding cleft. It contains one alpha helix and 4 beta sheets, respectively forming part of the wall and the floor of the peptide-binding cleft. The other 4 beta sheets of the floor and the second alpha helix wall is formed by the beta-1 domain of HLA-DRB. Forms hydrogen bonds with the peptide main chain via conserved amino acids (PubMed:8145819, PubMed:9354468, PubMed:9782128, PubMed:17583734, PubMed:29884618). The peptide-bound alpha-1 domain forms hydrogen bonds with CDR2 and CDR3 alpha-domain of TCR (PubMed:29884618).
  • The alpha-2 Ig-like domain mediates the interaction with CD4 coreceptor.
Family:
  • Belongs to the MHC class II family.
genes like me logo Genes that share domains with HLA-DRA: view

Function for HLA-DRA Gene

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Molecular function for HLA-DRA Gene

UniProtKB/Swiss-Prot Function:
An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:17334368, PubMed:8145819, PubMed:15322540, PubMed:22327072, PubMed:27591323, PubMed:31495665, PubMed:15265931, PubMed:9075930, PubMed:24190431). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819).
UniProtKB/Swiss-Prot Induction:
Up-regulated in dendritic cells upon maturation.
GENATLAS Biochemistry:
HLA-DR,alpha chain

Phenotypes From GWAS Catalog for HLA-DRA Gene

Gene Ontology (GO) - Molecular Function for HLA-DRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9354468
GO:0023026 MHC class II protein complex binding HDA 20458337
GO:0030247 polysaccharide binding IDA 21502329
GO:0032395 MHC class II receptor activity NAS 6304715
GO:0042605 peptide antigen binding IDA 1448172
genes like me logo Genes that share ontologies with HLA-DRA: view
genes like me logo Genes that share phenotypes with HLA-DRA: view

Human Phenotype Ontology for HLA-DRA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for research

Inhibitory RNAs for research

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No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DRA Gene

Localization for HLA-DRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DRA Gene

Cell membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Single-pass type I membrane protein. Early endosome membrane. Single-pass type I membrane protein. Late endosome membrane. Single-pass type I membrane protein. Lysosome membrane. Single-pass type I membrane protein. Autolysosome membrane. Single-pass type I membrane protein. Note=The MHCII complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:9075930, PubMed:18305173). Component of immunological synapses at the interface between T cell and APC (PubMed:15322540, PubMed:29884618). {ECO:0000269 PubMed:15322540, ECO:0000269 PubMed:18305173, ECO:0000269 PubMed:29884618, ECO:0000269 PubMed:9075930}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-DRA gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
lysosome 5
golgi apparatus 4
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HLA-DRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0001772 immunological synapse IDA 15322540
GO:0005764 lysosome IDA 8890155
GO:0005765 lysosomal membrane TAS --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with HLA-DRA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HLA-DRA Gene

Pathways & Interactions for HLA-DRA Gene

PathCards logo

SuperPathways for HLA-DRA Gene

SuperPathway Contained pathways
1 Allograft rejection
Allograft rejection
.65
Type I diabetes mellitus
.65
Graft-versus-host disease
.60
Autoimmune thyroid disease
.60
Allograft Rejection
.46
Asthma
.44
THC Differentiation Pathway
.39
CTL Mediated Apoptosis
.38
Intestinal immune network for IgA production
.38
Viral myocarditis
.38
Antigen processing and presentation
.35
2 Th17 cell differentiation
Th1 and Th2 cell differentiation
.55
Th17 cell differentiation
.55
Inflammatory bowel disease
.37
Immune response IL-22 signaling pathway
.36
3 Translocation of ZAP-70 to Immunological synapse
Phosphorylation of CD3 and TCR zeta chains
.81
Translocation of ZAP-70 to Immunological synapse
.81
PD-1 signaling
.71
Generation of second messenger molecules
.57
4 ICos-ICosL Pathway in T-Helper Cell
CD28 Signaling in T-Helper Cell
.66
ICos-ICosL Pathway in T-Helper Cell
.66
Calcium Mediated T-Cell Apoptosis
.31
5 TCR Signaling (Qiagen)
PKC-Theta Pathway
.68
TCR Signaling
.68
ITK and TCR Signaling
.54
genes like me logo Genes that share pathways with HLA-DRA: view

Pathways by source for HLA-DRA Gene

6 GeneGo (Thomson Reuters) pathways for HLA-DRA Gene
  • G-protein signaling N-RAS regulation pathway
  • Immune response Antigen presentation by MHC class II
  • Immune response ICOS pathway in T-helper cell
  • Immune response IL-22 signaling pathway
  • Immune response NFAT in immune response
12 Qiagen pathways for HLA-DRA Gene
  • Calcium Mediated T-Cell Apoptosis
  • CD28 Signaling in T-Helper Cell
  • CDC42 Pathway
  • CTL Mediated Apoptosis
  • CTLA4 Signaling

SIGNOR curated interactions for HLA-DRA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HLA-DRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IDA 29884618
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002469 myeloid dendritic cell antigen processing and presentation IDA 29884618
GO:0002491 antigen processing and presentation of endogenous peptide antigen via MHC class II IDA 15322540
genes like me logo Genes that share ontologies with HLA-DRA: view

Drugs & Compounds for HLA-DRA Gene

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(3) Drugs for HLA-DRA Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coccidioides immitis spherule Approved Pharma Target, binder 0
1D09C3 Investigational Pharma Target 0
genes like me logo Genes that share compounds with HLA-DRA: view

Transcripts for HLA-DRA Gene

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mRNA/cDNA for HLA-DRA Gene

1 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DRA

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DRA Gene

No ASD Table

Relevant External Links for HLA-DRA Gene

GeneLoc Exon Structure for
HLA-DRA

Expression for HLA-DRA Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HLA-DRA Gene

mRNA expression in normal human tissues for HLA-DRA Gene
mRNA expression by GTEx for HLA-DRA GenemRNA expression by BioGPS for HLA-DRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DRA Gene

This gene is overexpressed in Whole Blood (x5.0) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for HLA-DRA Gene

This gene is overexpressed in Nasal epithelium (16.5), Lymph node (13.1), and Lung (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HLA-DRA Gene



Protein tissue co-expression partners for HLA-DRA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-DRA

SOURCE GeneReport for Unigene cluster for HLA-DRA Gene:

Hs.520048

mRNA Expression by UniProt/SwissProt for HLA-DRA Gene:

P01903-DRA_HUMAN
Tissue specificity: Expressed in professional APCs: macrophages, dendritic cells and B cells (at protein level) (PubMed:31495665, PubMed:15322540, PubMed:23783831). Expressed in thymic epithelial cells (at protein level) (PubMed:23783831).

Evidence on tissue expression from TISSUES for HLA-DRA Gene

  • Lung(4.9)
  • Blood(4.8)
  • Intestine(4.7)
  • Liver(4.6)
  • Pancreas(4)
  • Nervous system(3.9)
  • Skin(3.9)
  • Spleen(3.7)
  • Kidney(3.2)
  • Lymph node(3.2)
  • Heart(3)
  • Stomach(3)
  • Muscle(2.6)
  • Bone marrow(2.5)
  • Eye(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DRA Gene

Germ Layers:
  • ectoderm
Systems:
  • integumentary
Regions:
Limb:
  • nail
General:
  • hair
  • skin
genes like me logo Genes that share expression patterns with HLA-DRA: view

Primer products for research

Orthologs for HLA-DRA Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-DRA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PATR-DRA 29 30
  • 98.95 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia DLA-DRA 29
  • 89.5 (n)
DLA-DRA1 30
  • 87 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia BOLA-DRA 29 30
  • 85.24 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia RT1-Da 29
  • 79.28 (n)
Mouse
(Mus musculus)
 Mammalia H2-Ea-ps 29
  • 76.75 (n)
H2-Ea 16
Oppossum
(Monodelphis domestica)
 Mammalia HLA-DRA 30
  • 68 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-1342 30
  • 63 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves BLA 29
  • 57.82 (n)
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 55 (a)
 ManyToMany
-- 30
  • 53 (a)
 ManyToMany
Zebrafish
(Danio rerio)
 Actinopterygii zgc:123107 30
  • 30 (a)
 ManyToMany
Species where no ortholog for HLA-DRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HLA-DRA Gene

ENSEMBL:
Gene Tree for HLA-DRA (if available)
TreeFam:
Gene Tree for HLA-DRA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HLA-DRA: view image
Alliance of Genome Resources:
Additional Orthologs for HLA-DRA

Paralogs for HLA-DRA Gene

Paralogs for HLA-DRA Gene

(9) SIMAP similar genes for HLA-DRA Gene using alignment to 6 proteins:

  • DRA_HUMAN
  • A1A435_HUMAN
  • A1A436_HUMAN
  • F5GZ59_HUMAN
  • Q30118_HUMAN
  • Q30125_HUMAN
genes like me logo Genes that share paralogs with HLA-DRA: view

Variants for HLA-DRA Gene

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Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DRA Gene

DRA_HUMAN-P01903
The following alleles of DRA are known: DRA*01:01 and DRA*01:02. The sequence shown is that of DRA*01:02.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HLA-DRA Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs139677040 Benign: not provided 32,443,749(+) C/T
NM_019111.5(HLA-DRA):c.611-7C>T 		INTRON
rs766774047 Benign: not provided 32,442,494(+) A/G
NM_019111.5(HLA-DRA):c.129A>G (p.Gln43=) 		SYNONYMOUS
rs16822586 -- p.Val16Leu
rs7192 -- p.Leu242Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HLA-DRA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HLA-DRA Gene

Variant ID Type Subtype PubMed ID
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
dgv10472n54 CNV loss 21841781
dgv5945n100 CNV gain 25217958
esv21985 CNV gain+loss 19812545
esv2759416 CNV gain+loss 17122850
esv33476 CNV gain+loss 17666407
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv428142 CNV gain+loss 18775914
nsv602111 CNV loss 21841781
nsv830630 CNV loss 17160897
nsv830631 CNV gain 17160897

Variation tolerance for HLA-DRA Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HLA-DRA Gene

Human Gene Mutation Database (HGMD)
HLA-DRA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-DRA
Leiden Open Variation Database (LOVD)
HLA-DRA

SNP Genotyping and Copy Number Assays for research

Disorders for HLA-DRA Gene

MalaCards: The human disease database

(11) MalaCards diseases for HLA-DRA Gene - From: ORP, COP, and GCD

Disorder Aliases PubMed IDs
graham-little-piccardi-lassueur syndrome
  • graham little syndrome
penicillin allergy
  • allergy to penicillin
keshan disease
  • caused by deficiency of selenium in the diet
rheumatoid arthritis
  • ra
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HLA-DRA

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HLA-DRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DRA Gene

Publications for HLA-DRA Gene

  1. The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes. (PMID: 12445311) Kralovicova J … Vorechovsky I (Tissue antigens 2002) 3 4 22
  2. CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers. (PMID: 29884618) Galperin M … Gras S (Science immunology 2018) 3 4
  3. Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans. (PMID: 27591323) Muehling LM … Woodfolk JA (Journal of immunology (Baltimore, Md. : 1950) 2016) 3 4
  4. Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions. (PMID: 27114505) Jönsson P … Klenerman D (Proceedings of the National Academy of Sciences of the United States of America 2016) 3 4
  5. Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection. (PMID: 23260142) Pos W … Wucherpfennig KW (Cell 2012) 3 4

ExternalLinks

View latest publications for HLA-DRA gene in Mastermind

Products for HLA-DRA Gene

Sources for HLA-DRA Gene