Aliases for HLA-DRA Gene
Aliases for HLA-DRA Gene
External Ids for HLA-DRA Gene
- HGNC: 4947
- Entrez Gene: 3122
- Ensembl: ENSG00000204287
- OMIM: 142860
- UniProtKB: P01903
Previous HGNC Symbols for HLA-DRA Gene
- HLA-DRA1
Previous GeneCards Identifiers for HLA-DRA Gene
- GC06P032434
- GC06Pd32422
- GC06P032178
Summaries for HLA-DRA Gene
-
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-DRA Gene
HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha) is a Protein Coding gene. Diseases associated with HLA-DRA include Graham-Little-Piccardi-Lassueur Syndrome and Heart Lymphoma. Among its related pathways are Rheumatoid arthritis and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and MHC class II receptor activity. An important paralog of this gene is HLA-DPA1.
UniProtKB/Swiss-Prot for HLA-DRA Gene
-
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
Additional gene information for HLA-DRA Gene
- Monarch Initiative
- Search for HLA-DRA at DataMed
- Search for HLA-DRA at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DRA Gene
Genomics for HLA-DRA Gene
GeneHancer (GH) Regulatory Elements for HLA-DRA Gene
Promoters and enhancers for HLA-DRA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around HLA-DRA on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HLA-DRA gene promoter:
-
- AREB6
- CUTL1
- IRF-2
- Pax-4a
- AML1a
- GCNF
- GCNF-1
- GCNF-2
- Pax-5
- Arnt
Regulatory Element Products
Genomic Locations for HLA-DRA Gene
Genomic Locations for HLA-DRA Gene
- chr6:32,439,842-32,445,046
- (GRCh38/hg38)
- Size:
- 5,205 bases
- Orientation:
- Plus strand
- chr6:32,407,619-32,412,823
- (GRCh37/hg19)
- Size:
- 5,205 bases
- Orientation:
- Plus strand
Genomic View for HLA-DRA Gene
Genes around HLA-DRA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.32 by Entrez Gene
- 6p21.32 by HGNC
- 6p21.32 by Ensembl
HLA-DRA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HLA-DRA Gene
Proteins for HLA-DRA Gene
-
Protein details for HLA-DRA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01903-DRA_HUMAN
- Recommended name:
- HLA class II histocompatibility antigen, DR alpha chain
- Protein Accession:
- P01903
- A2BET4
- Q30160
- Q6IAZ1
- Q861I2
- Q9TP70
Protein attributes for HLA-DRA Gene
- Size:
- 254 amino acids
- Molecular mass:
- 28607 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. Interacts with Epstein-Barr virus BZLF2/gp42.
- SequenceCaution:
-
- Sequence=CAA25076.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for HLA-DRA Gene
Post-translational modifications for HLA-DRA Gene
- Ubiquitinated by MARCH1 or MARCH8 at Lys-244 leading to down-regulation of MHC class II. When associated with ubiquitination of the beta subunit of HLA-DR: HLA-DRB4 Lys-254, the down-regulation of MHC class II may be highly effective.
- Glycosylation at isoforms=143 and isoforms=103
- Ubiquitination at isoforms=244
- Modification sites at PhosphoSitePlus
Other Protein References for HLA-DRA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for HLA-DRA (HLA-DR)
- Novus Biologicals Antibodies for HLA-DRA
-
Abcam antibodies for HLA-DRA
- Invitrogen Antibodies for HLA-DRA (AFLGC-HLA-DRA)
- antibodies-online: Search results for 158 available HLA-DRA Antibodies ranked by validation data
- Compare Top HLA-DRA Antibodies
-
Recommended
- 61 WB Antibodies (anti-human)
- 42 FACS Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 5 IF Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 18 FACS Antibodies (anti-cow)
- 5 IF Antibodies (anti-cow)
- 5 WB Antibodies (anti-cow)
- 18 FACS Antibodies (anti-cat)
- 5 IF Antibodies (anti-cat)
- GeneTex HLA-DRA Antibody for HLA-DRA
-
Boster Bio Antibodies for HLA-DRA
-
Santa Cruz Biotechnology (SCBT) Antibodies for HLA-DRA
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HLA-DRA
- Origene Custom Protein Services for HLA-DRA
- ProSpec Recombinant Proteins for HLA-DRA
- Search GeneTex for Proteins for HLA-DRA
Assay Products
- antibodies-online: Search results for 1 available HLA-DRA Elisa Kits ranked by validation data
- Compare Top HLA-DRA Elisa Kits
-
Recommended
No data available for DME Specific Peptides for HLA-DRA Gene
Domains & Families for HLA-DRA Gene
Gene Families for HLA-DRA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted membrane proteins
Protein Domains for HLA-DRA Gene
Suggested Antigen Peptide Sequences for HLA-DRA Gene
- GenScript: Design optimal peptide antigens:
-
- MHC class II antigen (A1A435_HUMAN)
- MHC class II antigen (A1A436_HUMAN)
- cDNA, FLJ93608, Homo sapiens major histocompatibility complex, class II, DR alpha(HLA-DRA), mRNA (B0UXD8_HUMAN)
- cDNA FLJ57318, highly similar to HLA class II histocompatibility antigen, DRalpha chain (B4DLJ8_HUMAN)
- cDNA FLJ51117, highly similar to HLA class II histocompatibility antigen, DRalpha chain (B4DW37_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P01903- Family:
-
- Belongs to the MHC class II family.
Function for HLA-DRA Gene
Molecular function for HLA-DRA Gene
- UniProtKB/Swiss-Prot Function:
- Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
- GENATLAS Biochemistry:
- HLA-DR,alpha chain
Phenotypes From GWAS Catalog for HLA-DRA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9354468 |
| GO:0023026 | MHC class II protein complex binding | HDA | 20458337 |
| GO:0032395 | MHC class II receptor activity | NAS | 6304715 |
| GO:0042605 | peptide antigen binding | IDA | 1448172 |
Phenotypes for HLA-DRA Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for HLA-DRA
- Cyagen custom Knockout/knockin (KOKI) mouse models for HLA-DRA
-
CRISPR Products
- Browse CRISPR knockouts for HLA-DRA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HLA-DRA
- genomics-online: gRNA clones - Search results for available HLA-DRA gene related products
- Applied Biological Materials CRISPR for HLA-DRA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DRA
- GenScript: Design CRISPR guide RNA sequences for HLA-DRA
miRNA for HLA-DRA Gene
- miRTarBase miRNAs that target HLA-DRA
-
- hsa-mir-4496 (MIRT392159)
- hsa-mir-27a-3p (MIRT401738)
- hsa-mir-216a-3p (MIRT401739)
- hsa-mir-27b-3p (MIRT401740)
- hsa-mir-128-3p (MIRT401741)
- hsa-mir-548c-3p (MIRT401743)
- hsa-mir-3681-3p (MIRT401744)
- hsa-mir-3915 (MIRT401745)
- hsa-mir-1304-5p (MIRT487339)
- hsa-mir-6858-5p (MIRT487340)
- hsa-mir-4689 (MIRT487341)
- hsa-mir-1224-5p (MIRT487342)
- hsa-mir-124-5p (MIRT487343)
- hsa-mir-3928-3p (MIRT487344)
miRNA Products
Inhibitory RNA Products
- Origene shrna and sirna products in human, mouse, rat for HLA-DRA
- Browse OriGene Inhibitory RNA Products For HLA-DRA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DRA
- genomics-online: shRNA clones - Search results for available HLA-DRA gene related products
Clone Products
- Sino Biological Human cDNA Clone for HLA-DRA
- Addgene plasmids for HLA-DRA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HLA-DRA
- genomics-online: cdna clones - Search results for available HLA-DRA gene related products
- orf clones - Search results for available HLA-DRA gene related products
- Applied Biological Materials Clones for HLA-DRA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HLA-DRA
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DRA Gene
Localization for HLA-DRA Gene
Subcellular locations from UniProtKB/Swiss-Prot for HLA-DRA Gene
- Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| lysosome | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005764 | lysosome | IDA | 8890155 |
| GO:0005765 | lysosomal membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HLA-DRA Gene
Pathways & Interactions for HLA-DRA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Allograft rejection |
.44
|
|
| 2 | Th17 cell differentiation | ||
| 3 | Translocation of ZAP-70 to Immunological synapse |
.71
|
|
| 4 | ICos-ICosL Pathway in T-Helper Cell | ||
| 5 | TCR Signaling (Qiagen) |
.68
|
|
Pathways by source for HLA-DRA Gene
6 BioSystems pathways for HLA-DRA Gene
13 Reactome pathways for HLA-DRA Gene
24 KEGG pathways for HLA-DRA Gene
6 GeneGo (Thomson Reuters) pathways for HLA-DRA Gene
6 R&D Systems pathways for HLA-DRA Gene
12 Qiagen pathways for HLA-DRA Gene
Interacting Proteins for HLA-DRA Gene
Selected Interacting proteins:
P01903-DRA_HUMAN
ENSP00000378786
for HLA-DRA Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for HLA-DRA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0002503 | peptide antigen assembly with MHC class II protein complex | IDA | 1448172 |
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | IDA,IEA | 21502329 |
| GO:0002506 | polysaccharide assembly with MHC class II protein complex | IDA | 21502329 |
| GO:0006955 | immune response | NAS,IEA | 6304715 |
No data available for SIGNOR curated interactions for HLA-DRA Gene
Transcripts for HLA-DRA Gene
mRNA/cDNA for HLA-DRA Gene
- (1) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (1920) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000374982 1169 bps (uc003obi.5)
- ENST00000395388 1280 bps (uc003obh.5)
Unigene Clusters for HLA-DRA Gene
CRISPR Products
- Browse CRISPR knockouts for HLA-DRA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HLA-DRA
- genomics-online: gRNA clones - Search results for available HLA-DRA gene related products
- Applied Biological Materials CRISPR for HLA-DRA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DRA
- GenScript: Design CRISPR guide RNA sequences for HLA-DRA
miRNA Products
Inhibitory RNA Products
- Origene shrna and sirna products in human, mouse, rat for HLA-DRA
- Browse OriGene Inhibitory RNA Products For HLA-DRA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DRA
- genomics-online: shRNA clones - Search results for available HLA-DRA gene related products
Clone Products
- Sino Biological Human cDNA Clone for HLA-DRA
- Addgene plasmids for HLA-DRA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HLA-DRA
- genomics-online: cdna clones - Search results for available HLA-DRA gene related products
- orf clones - Search results for available HLA-DRA gene related products
- Applied Biological Materials Clones for HLA-DRA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HLA-DRA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
- T Helper Cells Thymus
- Facilitating cells
- Regulatory T cells
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Conjunctival Epithelium
- Inner Cell Mass (Early Embryonic Tissues)
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Umbilical Cord (Extraembryonic Tissues)
- Neural Tube (Nervous System)
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for HLA-DRA Gene
This gene is overexpressed in Whole Blood (x5.0) and Spleen (x4.4).
This gene is overexpressed in Nasal epithelium (16.5), Lymph node (13.1), and Lung (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HLA-DRA Gene
- Elite partner
SOURCE GeneReport for Unigene cluster for HLA-DRA Gene:
Hs.520048Evidence on tissue expression from TISSUES for HLA-DRA Gene
- Lung(4.8)
- Blood(4.7)
- Intestine(4.6)
- Liver(4.5)
- Pancreas(3.8)
- Nervous system(3.6)
- Skin(3.5)
- Spleen(3.4)
- Kidney(2.7)
- Stomach(2.7)
- Lymph node(2.6)
- Heart(2.3)
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DRA Gene
Germ Layers:
- ectoderm
Systems:
- integumentary
Regions:
Limb:
- nail
General:
- hair
- skin
Primer Products
-
OriGene qPCR primer pairs for HLA-DRA
-
OriGene qPCR primer pairs and template standards for HLA-DRA
- genomics-online: primer clones - Search results for available HLA-DRA gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for HLA-DRA Gene
Orthologs for HLA-DRA Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PATR-DRA 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DLA-DRA 33 |
|
||
| DLA-DRA1 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | BOLA-DRA 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | RT1-Da 33 |
|
||
| mouse (Mus musculus) |
Mammalia | H2-Ea-ps 16 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HLA-DRA 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-1342 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BLA 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:123107 34 |
|
ManyToMany |
- Species where no ortholog for HLA-DRA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for HLA-DRA Gene
- ENSEMBL:
- Gene Tree for HLA-DRA (if available)
- TreeFam:
- Gene Tree for HLA-DRA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HLA-DRA: view image
Paralogs for HLA-DRA Gene
(9) SIMAP similar genes for HLA-DRA Gene using alignment to 6 proteins:
- DRA_HUMAN
- A1A435_HUMAN
- A1A436_HUMAN
- F5GZ59_HUMAN
- Q30118_HUMAN
- Q30125_HUMAN
Variants for HLA-DRA Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DRA Gene
- DRA_HUMAN-P01903
- The following alleles of DRA are known: DRA*01:01 and DRA*01:02. The sequence shown is that of DRA*01:01.
- DRA_HUMAN-P01903
- Genetic variations in HLA-DRA influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000321440 | -- | 32,439,026(+) | T/C | upstream_transcript_variant | |
| rs1001105789 | -- | 32,442,921(+) | T/C | intron_variant | |
| rs1001627549 | -- | 32,443,916(+) | A/G | 3_prime_UTR_variant | |
| rs1002014506 | -- | 32,444,187(+) | A/G | intron_variant | |
| rs1004181694 | -- | 32,441,732(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10404n54 | CNV | loss | 21841781 |
| dgv10463n54 | CNV | loss | 21841781 |
| dgv10472n54 | CNV | loss | 21841781 |
| dgv5945n100 | CNV | gain | 25217958 |
| esv21985 | CNV | gain+loss | 19812545 |
| esv2759416 | CNV | gain+loss | 17122850 |
| esv33476 | CNV | gain+loss | 17666407 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1126749 | CNV | deletion | 24896259 |
| nsv428142 | CNV | gain+loss | 18775914 |
| nsv602111 | CNV | loss | 21841781 |
| nsv830630 | CNV | loss | 17160897 |
| nsv830631 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.35;
41.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HLA-DRA Gene
SNP Genotyping and Copy Number Assay Products
Disorders for HLA-DRA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| graham-little-piccardi-lassueur syndrome |
|
|
| heart lymphoma |
|
|
| penicillin allergy |
|
|
| keshan disease |
|
|
| ischemic fasciitis |
|
|
Search HLA-DRA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HLA-DRA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DRA Gene
Publications for HLA-DRA Gene
- The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes. (PMID: 12445311) Kralovicova J … Vorechovsky I (Tissue antigens 2002) 3 4 22 58
- A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia. (PMID: 22541561) Zhao H … Chen ZJ (American journal of human genetics 2012) 3 44 58
- Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. (PMID: 21804548) Hirota T … Tamari M (Nature genetics 2011) 3 44 58
- Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. (PMID: 21779181) Gorlova O … Martin J (PLoS genetics 2011) 3 44 58
- Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PMID: 20228798) Franke A … Schreiber S (Nature genetics 2010) 3 44 58
Products for HLA-DRA Gene
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Taconic Biosciences Mouse Models for HLA-DRA
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- Humanized Mice
- Invitrogen Antibodies for HLA-DRA (AFLGC-HLA-DRA)
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- antibodies-online: Search results for 158 available HLA-DRA Antibodies ranked by validation data
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- 61 WB Antibodies (anti-human)
- 42 FACS Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 5 IF Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 18 FACS Antibodies (anti-cow)
- 5 IF Antibodies (anti-cow)
- 5 WB Antibodies (anti-cow)
- 18 FACS Antibodies (anti-cat)
- 5 IF Antibodies (anti-cat)
- antibodies-online: Search results for 1 available HLA-DRA Elisa Kits ranked by validation data
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- antibodies-online: Search results for 14 available HLA-DRA Proteins ranked by validation data
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- GeneTex HLA-DRA Antibody for HLA-DRA
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- Santa Cruz Biotechnology (SCBT) Antibodies for HLA-DRA
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- Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DRA
- Horizon Cell Lines for HLA-DRA
- genomics-online: cdna clones - Search results for available HLA-DRA gene related products
- orf clones - Search results for available HLA-DRA gene related products
- genomics-online: gRNA clones - Search results for available HLA-DRA gene related products
- genomics-online: primer clones - Search results for available HLA-DRA gene related products
- genomics-online: shRNA clones - Search results for available HLA-DRA gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HLA-DRA
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- GeneCopoeia miRNA 3'UTR Target clone products for HLA-DRA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DRA
- Boster Bio Antibodies for HLA-DRA
- Browse Boster Bio ELISA Kits
Sources for HLA-DRA Gene
- (1) GeneCards
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