HLA-DRA Gene (Protein Coding)

Major Histocompatibility Complex, Class II, DR Alpha

GC06P032439
GIFtS:
47
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macro... See more...

Aliases for HLA-DRA Gene

Aliases for HLA-DRA Gene

  • Major Histocompatibility Complex, Class II, DR Alpha 2 3 5
  • HLA Class II Histocompatibility Antigen, DR Alpha Chain 3 4
  • MHC Class II Antigen DRA 3 4
  • HLA-DRA1 3 4
  • Histocompatibility Antigen HLA-DR Alpha 3
  • HLA-DRA 5

External Ids for HLA-DRA Gene

Previous HGNC Symbols for HLA-DRA Gene

  • HLA-DRA1

Previous GeneCards Identifiers for HLA-DRA Gene

  • GC06P032434
  • GC06Pd32422
  • GC06P032178
  • GC06P032412

Summaries for HLA-DRA Gene

Entrez Gene Summary for HLA-DRA Gene

  • HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]

CIViC Summary for HLA-DRA Gene

GeneCards Summary for HLA-DRA Gene

HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha) is a Protein Coding gene. Diseases associated with HLA-DRA include Graham-Little-Piccardi-Lassueur Syndrome and Heart Lymphoma. Among its related pathways are TCR Signaling (Qiagen) and Tuberculosis. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and MHC class II receptor activity. An important paralog of this gene is HLA-DPA1.

UniProtKB/Swiss-Prot Summary for HLA-DRA Gene

  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Gene Wiki entry for HLA-DRA Gene

Additional gene information for HLA-DRA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLA-DRA Gene

Genomics for HLA-DRA Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for HLA-DRA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLA-DRA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HLA-DRA

Top Transcription factor binding sites by QIAGEN in the HLA-DRA gene promoter:
  • AML1a
  • AREB6
  • Arnt
  • CUTL1
  • GCNF
  • GCNF-1
  • GCNF-2
  • IRF-2
  • Pax-4a
  • Pax-5

Genomic Locations for HLA-DRA Gene

Genomic Locations for HLA-DRA Gene
chr6:32,439,878-32,445,046
(GRCh38/hg38)
Size:
5,169 bases
Orientation:
Plus strand
chr6:32,407,619-32,412,823
(GRCh37/hg19)
Size:
5,205 bases
Orientation:
Plus strand

Genomic View for HLA-DRA Gene

Genes around HLA-DRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DRA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

Proteins for HLA-DRA Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HLA-DRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01903-DRA_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DR alpha chain
    Protein Accession:
    P01903
    Secondary Accessions:
    • A2BET4
    • Q30160
    • Q6IAZ1
    • Q861I2
    • Q9TP70

    Protein attributes for HLA-DRA Gene

    Size:
    254 amino acids
    Molecular mass:
    28607 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
    • (Microbial infection) Interacts with Epstein-Barr virus BZLF2/gp42.
    • (Microbial infection) Interacts with Staphylococcus aureus enterotoxin A/entA, enterotoxin B/entB, enterotoxin C1/entC1, enterotoxin D/entD, and enterotoxin H/entH.
    SequenceCaution:
    • Sequence=CAA25076.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HLA-DRA Gene

neXtProt entry for HLA-DRA Gene

Protein Expression for HLA-DRA Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HLA-DRA Gene

  • Ubiquitinated by MARCH1 or MARCH8 at Lys-244 leading to down-regulation of MHC class II. When associated with ubiquitination of the beta subunit of HLA-DR: HLA-DRB4 'Lys-254', the down-regulation of MHC class II may be highly effective.
  • Glycosylation at Asn103 and Asn143
  • Ubiquitination at Lys244
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for HLA-DRA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HLA-DRA Gene

Domains & Families for HLA-DRA Gene

Gene Families for HLA-DRA Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for HLA-DRA Gene

InterPro:
Blocks:
  • Immunoglobulin C-type
  • MHC Class II alpha chain, alpha-1 domain
ProtoNet:

Suggested Antigen Peptide Sequences for HLA-DRA Gene

GenScript: Design optimal peptide antigens:
  • MHC class II antigen (A1A435_HUMAN)
  • MHC class II antigen (A1A436_HUMAN)
  • cDNA, FLJ93608, Homo sapiens major histocompatibility complex, class II, DR alpha(HLA-DRA), mRNA (B0UXD8_HUMAN)
  • cDNA FLJ57318, highly similar to HLA class II histocompatibility antigen, DRalpha chain (B4DLJ8_HUMAN)
  • cDNA FLJ51117, highly similar to HLA class II histocompatibility antigen, DRalpha chain (B4DW37_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01903

UniProtKB/Swiss-Prot:

DRA_HUMAN :
  • Belongs to the MHC class II family.
Family:
  • Belongs to the MHC class II family.
genes like me logo Genes that share domains with HLA-DRA: view

Function for HLA-DRA Gene

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  2. CRISPR
  3. miRNA
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  6. Cell Line

Molecular function for HLA-DRA Gene

UniProtKB/Swiss-Prot Function:
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
GENATLAS Biochemistry:
HLA-DR,alpha chain

Phenotypes From GWAS Catalog for HLA-DRA Gene

Gene Ontology (GO) - Molecular Function for HLA-DRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9354468
GO:0023026 MHC class II protein complex binding HDA 20458337
GO:0030247 polysaccharide binding IDA 21502329
GO:0032395 MHC class II receptor activity NAS 6304715
GO:0042605 peptide antigen binding IDA 1448172
genes like me logo Genes that share ontologies with HLA-DRA: view
genes like me logo Genes that share phenotypes with HLA-DRA: view

Human Phenotype Ontology for HLA-DRA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

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No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DRA Gene

Localization for HLA-DRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DRA Gene

Cell membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane. Single-pass type I membrane protein. Endosome membrane. Single-pass type I membrane protein. Lysosome membrane. Single-pass type I membrane protein. Late endosome membrane. Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-DRA gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
endosome 5
lysosome 5
golgi apparatus 5
cytoskeleton 2
nucleus 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HLA-DRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005764 lysosome IDA 8890155
GO:0005765 lysosomal membrane TAS --
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with HLA-DRA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HLA-DRA Gene

Pathways & Interactions for HLA-DRA Gene

PathCards logo

SuperPathways for HLA-DRA Gene

SuperPathway Contained pathways
1 Allograft rejection
Allograft rejection
.65
Type I diabetes mellitus
.65
Graft-versus-host disease
.60
Autoimmune thyroid disease
.60
Allograft Rejection
.46
Asthma
.44
THC Differentiation Pathway
.39
CTL Mediated Apoptosis
.38
Intestinal immune network for IgA production
.38
Viral myocarditis
.38
Antigen processing and presentation
.35
2 Th17 cell differentiation
Th1 and Th2 cell differentiation
.55
Th17 cell differentiation
.55
Inflammatory bowel disease (IBD)
.37
Immune response IL-22 signaling pathway
.36
3 Translocation of ZAP-70 to Immunological synapse
Phosphorylation of CD3 and TCR zeta chains
.81
Translocation of ZAP-70 to Immunological synapse
.81
PD-1 signaling
.71
Generation of second messenger molecules
.57
4 ICos-ICosL Pathway in T-Helper Cell
CD28 Signaling in T-Helper Cell
.66
ICos-ICosL Pathway in T-Helper Cell
.66
Calcium Mediated T-Cell Apoptosis
.31
5 TCR Signaling (Qiagen)
PKC-Theta Pathway
.68
TCR Signaling
.68
ITK and TCR Signaling
.54
genes like me logo Genes that share pathways with HLA-DRA: view

Pathways by source for HLA-DRA Gene

6 GeneGo (Thomson Reuters) pathways for HLA-DRA Gene
  • G-protein signaling N-RAS regulation pathway
  • Immune response Antigen presentation by MHC class II
  • Immune response ICOS pathway in T-helper cell
  • Immune response IL-22 signaling pathway
  • Immune response NFAT in immune response
12 Qiagen pathways for HLA-DRA Gene
  • Calcium Mediated T-Cell Apoptosis
  • CD28 Signaling in T-Helper Cell
  • CDC42 Pathway
  • CTL Mediated Apoptosis
  • CTLA4 Signaling

SIGNOR curated interactions for HLA-DRA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HLA-DRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002503 peptide antigen assembly with MHC class II protein complex IDA 1448172
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA,IDA 21502329
GO:0006955 immune response IEA,NAS 6304715
genes like me logo Genes that share ontologies with HLA-DRA: view

Drugs & Compounds for HLA-DRA Gene

Products:

  1. Drug

(3) Drugs for HLA-DRA Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coccidioides immitis spherule Approved Pharma Target, binder 0
1D09C3 Investigational Pharma Target 0
genes like me logo Genes that share compounds with HLA-DRA: view

Transcripts for HLA-DRA Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for HLA-DRA Gene

1 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DRA

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DRA Gene

No ASD Table

Relevant External Links for HLA-DRA Gene

GeneLoc Exon Structure for
HLA-DRA

Expression for HLA-DRA Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HLA-DRA Gene

mRNA expression in normal human tissues for HLA-DRA Gene
mRNA expression by GTEx for HLA-DRA GenemRNA expression by BioGPS for HLA-DRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DRA Gene

This gene is overexpressed in Whole Blood (x5.0) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for HLA-DRA Gene

This gene is overexpressed in Nasal epithelium (16.5), Lymph node (13.1), and Lung (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HLA-DRA Gene



Protein tissue co-expression partners for HLA-DRA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-DRA

SOURCE GeneReport for Unigene cluster for HLA-DRA Gene:

Hs.520048

Evidence on tissue expression from TISSUES for HLA-DRA Gene

  • Lung(4.9)
  • Blood(4.8)
  • Intestine(4.8)
  • Liver(4.7)
  • Pancreas(4.1)
  • Nervous system(4)
  • Skin(3.9)
  • Spleen(3.8)
  • Kidney(3.3)
  • Lymph node(3.3)
  • Heart(3.1)
  • Stomach(3.1)
  • Muscle(2.8)
  • Bone marrow(2.6)
  • Eye(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DRA Gene

Germ Layers:
  • ectoderm
Systems:
  • integumentary
Regions:
Limb:
  • nail
General:
  • hair
  • skin
genes like me logo Genes that share expression patterns with HLA-DRA: view

No data available for mRNA Expression by UniProt/SwissProt for HLA-DRA Gene

Orthologs for HLA-DRA Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-DRA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PATR-DRA 30 31
  • 98.95 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia DLA-DRA 30
  • 89.5 (n)
DLA-DRA1 31
  • 87 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia BOLA-DRA 30 31
  • 85.24 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia RT1-Da 30
  • 79.28 (n)
Mouse
(Mus musculus)
 Mammalia H2-Ea-ps 30
  • 76.75 (n)
H2-Ea 17
Oppossum
(Monodelphis domestica)
 Mammalia HLA-DRA 31
  • 68 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-1342 31
  • 63 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves BLA 30
  • 57.82 (n)
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 55 (a)
 ManyToMany
-- 31
  • 53 (a)
 ManyToMany
Zebrafish
(Danio rerio)
 Actinopterygii zgc:123107 31
  • 30 (a)
 ManyToMany
Species where no ortholog for HLA-DRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HLA-DRA Gene

ENSEMBL:
Gene Tree for HLA-DRA (if available)
TreeFam:
Gene Tree for HLA-DRA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HLA-DRA: view image

Paralogs for HLA-DRA Gene

Paralogs for HLA-DRA Gene

(9) SIMAP similar genes for HLA-DRA Gene using alignment to 6 proteins:

  • DRA_HUMAN
  • A1A435_HUMAN
  • A1A436_HUMAN
  • F5GZ59_HUMAN
  • Q30118_HUMAN
  • Q30125_HUMAN
genes like me logo Genes that share paralogs with HLA-DRA: view

Variants for HLA-DRA Gene

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Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DRA Gene

DRA_HUMAN-P01903
The following alleles of DRA are known: DRA*01:01 and DRA*01:02. The sequence shown is that of DRA*01:01.
DRA_HUMAN-P01903
Genetic variations in HLA-DRA influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HLA-DRA Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
743767 Benign: not provided 32,442,494(+) A/G SYNONYMOUS_VARIANT
789589 Benign: not provided 32,443,749(+) C/T INTRON_VARIANT
rs16822586 - p.Val16Leu
rs7192 - p.Val242Leu

Additional dbSNP identifiers (rs#s) for HLA-DRA Gene

Structural Variations from Database of Genomic Variants (DGV) for HLA-DRA Gene

Variant ID Type Subtype PubMed ID
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
dgv10472n54 CNV loss 21841781
dgv5945n100 CNV gain 25217958
esv21985 CNV gain+loss 19812545
esv2759416 CNV gain+loss 17122850
esv33476 CNV gain+loss 17666407
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv428142 CNV gain+loss 18775914
nsv602111 CNV loss 21841781
nsv830630 CNV loss 17160897
nsv830631 CNV gain 17160897

Variation tolerance for HLA-DRA Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HLA-DRA Gene

Human Gene Mutation Database (HGMD)
HLA-DRA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-DRA

Disorders for HLA-DRA Gene

MalaCards: The human disease database

(12) MalaCards diseases for HLA-DRA Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
graham-little-piccardi-lassueur syndrome
  • graham little syndrome
heart lymphoma
  • lymphoma of heart
penicillin allergy
  • allergy to penicillin
keshan disease
  • caused by deficiency of selenium in the diet
rheumatoid arthritis
  • ra
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HLA-DRA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HLA-DRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DRA Gene

Publications for HLA-DRA Gene

  1. The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes. (PMID: 12445311) Kralovicova J … Vorechovsky I (Tissue antigens 2002) 3 4 23
  2. A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia. (PMID: 22541561) Zhao H … Chen ZJ (American journal of human genetics 2012) 3 41
  3. Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. (PMID: 21804548) Hirota T … Tamari M (Nature genetics 2011) 3 41
  4. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. (PMID: 21779181) Gorlova O … Martin J (PLoS genetics 2011) 3 41
  5. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 41

ExternalLinks

View latest publications for HLA-DRA gene in Mastermind

Products for HLA-DRA Gene

Sources for HLA-DRA Gene