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HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dend... See more...
Aliases for HLA-DQB2 Gene
Aliases for HLA-DQB2 Gene
- Major Histocompatibility Complex, Class II, DQ Beta 2 2 3 5
- HLA Class II Histocompatibility Antigen, DQ Beta 2 Chain 3 4
- HLA Class II Histocompatibility Antigen, DX Beta Chain 3 4
- MHC Class II Antigen DQB2 3 4
- HLA-DXB 3 4
- DV19.1 (Major Histocompatibility Complex, Class II, DQ Beta 2 (HLA-DXB)) 3
- HLA-DQB1 3
- HLA-DQB2 5
- DQB2 3
External Ids for HLA-DQB2 Gene
- HGNC: 4945
- Entrez Gene: 3120
- Ensembl: ENSG00000232629
- OMIM: 615161
- UniProtKB: P05538
Previous HGNC Symbols for HLA-DQB2 Gene
- HLA-DXB
Previous GeneCards Identifiers for HLA-DQB2 Gene
- GC06U990047
- GC06M032721
- GC06M032676
- GC06M032077
- GC06M032831
- GC06M032725
- GC06M032728
Summaries for HLA-DQB2 Gene
-
HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus. [provided by RefSeq, Oct 2010]
GeneCards Summary for HLA-DQB2 Gene
HLA-DQB2 (Major Histocompatibility Complex, Class II, DQ Beta 2) is a Protein Coding gene. Diseases associated with HLA-DQB2 include Tomato Allergy. Among its related pathways are Th17 cell differentiation and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include MHC class II receptor activity. An important paralog of this gene is HLA-DQB1.
UniProtKB/Swiss-Prot Summary for HLA-DQB2 Gene
-
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
Additional gene information for HLA-DQB2 Gene
- HGNC(4945)
- Entrez Gene(3120)
- Ensembl(ENSG00000232629)
- OMIM(615161)
- UniProtKB(P05538)
- Open Targets Platform(ENSG00000232629)
- Monarch Initiative
- Search for HLA-DQB2 at DataMed
- Search for HLA-DQB2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLA-DQB2 Gene
Genomics for HLA-DQB2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HLA-DQB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HLA-DQB2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HLA-DQB2
- Top Transcription factor binding sites by QIAGEN in the HLA-DQB2 gene promoter:
-
- AML1a
- HNF-4alpha1
- HNF-4alpha2
- HOXA9
- HOXA9B
- HTF
- Meis-1
- Meis-1a
- Meis-1b
Genomic Locations for HLA-DQB2 Gene
Genomic Locations for HLA-DQB2 Gene
- chr6:32,756,094-32,763,553
- (GRCh38/hg38)
- Size:
- 7,460 bases
- Orientation:
- Minus strand
- chr6:32,723,875-32,731,330
- (GRCh37/hg19)
- Size:
- 7,456 bases
- Orientation:
- Minus strand
Genomic View for HLA-DQB2 Gene
Genes around HLA-DQB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.32 by HGNC
- 6p21.32 by Entrez Gene
- 6p21.32 by Ensembl
HLA-DQB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HLA-DQB2 Gene
Proteins for HLA-DQB2 Gene
-
Protein details for HLA-DQB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05538-DQB2_HUMAN
- Recommended name:
- HLA class II histocompatibility antigen, DQ beta 2 chain
- Protein Accession:
- P05538
- A6NIA5
- Q29826
- Q29870
- Q29871
- Q29872
- Q29873
- Q5SR06
Protein attributes for HLA-DQB2 Gene
- Size:
- 268 amino acids
- Molecular mass:
- 30387 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. Dimer formation with HLA-DQA2, but not with HLA-DQA1, is required for efficient exit from the endoplasmic reticulum (ER). In the ER, forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. Association with HLA-DMA also occurs in skin Langerhans cells, in post-Golgi compartments.
- SequenceCaution:
-
- Sequence=CAA60790.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for HLA-DQB2 Gene
Post-translational modifications for HLA-DQB2 Gene
Other Protein References for HLA-DQB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ HLA-DQB2 Antibody and Immunotag™ DQB2 Polyclonal Antibody
- Novus Biologicals Antibodies for HLA-DQB2
- Invitrogen Antibodies for HLA-DQB2 (AFLGC-HLA-DQB2)
-
Boster Bio Antibodies for HLA-DQB2
-
Santa Cruz Biotechnology (SCBT) Antibodies for HLA-DQB2
Protein Products
-
OriGene Purified Proteins for HLA-DQB2
- Search Origene for MassSpec and Protein Over-expression Lysates for HLA-DQB2
- Origene Custom Protein Services for HLA-DQB2
-
Signalway Proteins for HLA-DQB2
-
Abcam proteins for HLA-DQB2
No data available for DME Specific Peptides for HLA-DQB2 Gene
Domains & Families for HLA-DQB2 Gene
Gene Families for HLA-DQB2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for HLA-DQB2 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-type
- Class II histocompatibility antigen, beta chain, beta-1 domain
- MHC Class II alpha chain, alpha-1 domain
- ProtoNet:
Suggested Antigen Peptide Sequences for HLA-DQB2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ40688 fis, clone THYMU2024185, highly similar to HLA class II histocompatibility antigen, DX beta chain (A2ADX3_HUMAN)
- Major histocompatibility complex, class II, DQ beta 2 (A2AGX0_HUMAN)
- Major histocompatibility complex, class II, DQ beta 2 (B0S7X9_HUMAN)
- Major histocompatibility complex, class II, DQ beta 2 (B0UZ89_HUMAN)
- Major histocompatibility complex, class II, DQ beta 2 (B0V0E9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P05538- Family:
-
- Belongs to the MHC class II family.
Function for HLA-DQB2 Gene
Molecular function for HLA-DQB2 Gene
- UniProtKB/Swiss-Prot Function:
- Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
- GENATLAS Biochemistry:
- HLA-DQ,beta chain-related,not known to be expressed
Phenotypes From GWAS Catalog for HLA-DQB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032395 | MHC class II receptor activity | NAS | 2564844 |
Phenotypes for HLA-DQB2 Gene
- GenomeRNAi human phenotypes for HLA-DQB2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased G1 DNA content
- Increased gamma-H2AX phosphorylation
- Strongly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased cell number and increased metaphase cell number
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HLA-DQB2 - Select products 50% OFF >
- * HLA-DQB2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HLA-DQB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HLA-DQB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DQB2
miRNA for HLA-DQB2 Gene
- miRTarBase miRNAs that target HLA-DQB2
miRNA Products
Inhibitory RNA Products
- Origene shrna and sirna products in human, mouse, rat for HLA-DQB2
- Browse OriGene Inhibitory RNA Products For HLA-DQB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DQB2
Clone Products
- Applied Biological Materials (abm): Clones for HLA-DQB2 - Select products 50% OFF >
- * HLA-DQB2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene ORF clones in human for HLA-DQB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HLA-DQB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HLA-DQB2
Cell Line Products
-
Horizon Cell Lines for HLA-DQB2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DQB2 Gene
Localization for HLA-DQB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HLA-DQB2 Gene
- Cell membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane. Single-pass type I membrane protein. Endosome membrane. Single-pass type I membrane protein. Lysosome membrane. Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 4 |
| lysosome | 4 |
| golgi apparatus | 4 |
| extracellular | 3 |
| endosome | 3 |
| cytoskeleton | 1 |
| nucleus | 1 |
| cytosol | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HLA-DQB2 Gene
Pathways & Interactions for HLA-DQB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Translocation of ZAP-70 to Immunological synapse |
.71
|
|
| 2 | Immune response NFAT in immune response |
Immune response ICOS pathway in T-helper cell
.56
Immune response NFAT in immune response
.56
|
Immune response T cell receptor signaling pathway
.52
|
| 3 | TCR signaling (REACTOME) |
.83
|
|
| 4 | Interferon gamma signaling | ||
| 5 | G-protein signaling N-RAS regulation pathway |
G-protein signaling N-RAS regulation pathway
.52
|
Immune response Antigen presentation by MHC class II
.52
|
Pathways by source for HLA-DQB2 Gene
13 Reactome pathways for HLA-DQB2 Gene
6 GeneGo (Thomson Reuters) pathways for HLA-DQB2 Gene
- G-protein signaling N-RAS regulation pathway
- Immune response Antigen presentation by MHC class II
- Immune response ICOS pathway in T-helper cell
- Immune response IL-22 signaling pathway
- Immune response NFAT in immune response
Interacting Proteins for HLA-DQB2 Gene
GPS-Prot Interaction Network for HLA-DQB2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | IEA | -- |
| GO:0006955 | immune response | IEA,NAS | 2564844 |
| GO:0019882 | antigen processing and presentation | IEA | -- |
No data available for SIGNOR curated interactions for HLA-DQB2 Gene
Transcripts for HLA-DQB2 Gene
mRNA/cDNA for HLA-DQB2 Gene
- 3 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000411527 1059 nts (view in UCSC)
- ENST00000427449 721 nts (view in UCSC)
- ENST00000435145 2026 nts (view in UCSC)
- ENST00000437316 1212 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HLA-DQB2 - Select products 50% OFF >
- * HLA-DQB2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HLA-DQB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HLA-DQB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DQB2
miRNA Products
Inhibitory RNA Products
- Origene shrna and sirna products in human, mouse, rat for HLA-DQB2
- Browse OriGene Inhibitory RNA Products For HLA-DQB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DQB2
Clone Products
- Applied Biological Materials (abm): Clones for HLA-DQB2 - Select products 50% OFF >
- * HLA-DQB2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene ORF clones in human for HLA-DQB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HLA-DQB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HLA-DQB2
Relevant External Links for HLA-DQB2 Gene
- GeneLoc Exon Structure for
- HLA-DQB2
Expression for HLA-DQB2 Gene
mRNA differential expression in normal tissues according to GTEx for HLA-DQB2 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x14.7) and Skin - Sun Exposed (Lower leg) (x12.9).
This gene is overexpressed in NK cells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HLA-DQB2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-DQB2
SOURCE GeneReport for Unigene cluster for HLA-DQB2 Gene:
Hs.731563mRNA Expression by UniProt/SwissProt for HLA-DQB2 Gene:
P05538-DQB2_HUMAN
Tissue specificity:
Restricted to skin Langerhans cells (at protein level).
Evidence on tissue expression from TISSUES for HLA-DQB2 Gene
- Blood(2.3)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for HLA-DQB2
-
OriGene qPCR primer pairs and template standards for HLA-DQB2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DQB2 Gene
Orthologs for HLA-DQB2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HLA-DQB2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DLA-DQBC1 31 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | BOLA-DQB 31 31 |
|
ManyToMany | |
| Mouse (Mus musculus) |
Mammalia | H2-Ab1 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany |
- Species where no ortholog for HLA-DQB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for HLA-DQB2 Gene
- ENSEMBL:
- Gene Tree for HLA-DQB2 (if available)
- TreeFam:
- Gene Tree for HLA-DQB2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HLA-DQB2: view image
Paralogs for HLA-DQB2 Gene
Paralogs for HLA-DQB2 Gene
(112) SIMAP similar genes for HLA-DQB2 Gene using alignment to 6 proteins:
- DQB2_HUMAN
- A2ADX3_HUMAN
- H0Y7Y7_HUMAN
- I7H125_HUMAN
- Q5SQ91_HUMAN
- Q5SR05_HUMAN
- HLQ-DQB1
- HLA-DQ-beta
- HLA-DQB
- HLA-DQB1*06x
- HLA-DQ3
- HLA-DQB1*05
- HLA DRB4
- HLA DQB1
- HLA-DQ
- HLA-Dw12
- HLA-DRB4*0102
- HLA-DQB1
- HLA-DQB3
- HLA-DRB13
- MHC Class II HLA DRB1
- HLA-DQB1/DRB1
- DQB1-02
- HLA-DRB2
- MHC class II HLA-DRB1 Exon-2
- HLA-DRB14
- HLA-DRB1*1605
- HLA-DRB1*1327
- HLA-DR4/Dw13
- HLA-DR beta
- HLA-DRB1*1125
- HLA-DP
- HLA-D8.2V
- HLA-DPB
- HLA-DRB4
- HLA-DRB3*01
- HLA-DRB1*0801
- DQB1*0603
- HLA-DRB3
- HLA-DQB1*05
- HLA DRB1 gene
- HLA-DR-beta 1
- HLA-DQB1I
- DRB52
- HLADRB1
- MHC class II HLA DRB1
- MHC DPB1
- HLA-DRw12
- HLA-DRB1*1324
- HLA-DRB1*11
- HLA-DR-beta1
- HLA-DQB1*06new1
- DRB1 HAG
- DQB1
- HLA-DQB1*03
- HLA-DRB
- HLA DRB1
- HLA-DPB1
- HLA-DRBI*1303
- HLA-DRB1-11
- HLA-DRB7
- HLA DRB1*1202
- HLA-DRB5
- HLA-DR
- HLA-DBR1
- HLA-DOB
- MHC class II HLA-DRB1*1315
- HLA-DRB1-0811
- DRB1*13PL
- DRB1*08
- DQB1.SLE
- DRB1
- HLA-DRB1*
- HLA-DR4
- HLA-D
- HLA-DRBI
- HLA-DRB4* variant allele
- HLA-DRB1*04
- DRB1*1303
- DRB1*0405V3
- DRB4
- HLA-DRB1
- HLA-DR4I
- HLA-DRB11
- HLA-DRB1-1113
- HLA-DB1
- DRB1*11
- HLA-DRB1*08
- HLA-DR3
- MHC class II HLA DRB1-0305
- HLA-DRB52
- HLA-DRB1*1302Var
- HLA-DRB1*0818
- HLA-DR-beta
- DRB1*1116
- DRB1*LY10
- HLA-DR15
- HLA-DR08
- DPB1
- MHC-DPB1*6001
- HLA
- HLA-DPA1
- B2M
- HFE
- HLA-C
- HLA-DQA2
- HLA-A
- IGLC6
- HLA-DRB9
- HLA-A*0201V3
- HLA-B
- IGLC2
- IGLC1
- DKFZp667J0810
- C1 segment
- HLA-DMB
- IGKC
- IGLC7
Variants for HLA-DQB2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HLA-DQB2 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 785166 | Benign: not provided | 32,761,931(-) | G/A | INTRON_VARIANT | |
| rs1049110 | - | p.Arg161Gln | |||
| VAR_069446 | - | p.Ser232Gly | |||
| VAR_069447 | - | p.Ile234Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10472n54 | CNV | loss | 21841781 |
| dgv10490n54 | CNV | loss | 21841781 |
| dgv10549n54 | CNV | loss | 21841781 |
| dgv10586n54 | CNV | loss | 21841781 |
| dgv1113e199 | CNV | deletion | 23128226 |
| dgv999e201 | CNV | deletion | 23290073 |
| esv21985 | CNV | gain+loss | 19812545 |
| esv2670072 | CNV | deletion | 23128226 |
| esv3433181 | CNV | duplication | 20981092 |
| esv6650 | CNV | loss | 19470904 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1119076 | CNV | deletion | 24896259 |
| nsv428142 | CNV | gain+loss | 18775914 |
| nsv511120 | OTHER | complex | 20534489 |
| nsv602240 | CNV | gain | 21841781 |
| nsv602758 | CNV | gain+loss | 21841781 |
| nsv830632 | CNV | loss | 17160897 |
| nsv970107 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.22;
52.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HLA-DQB2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DQB2 Gene
Disorders for HLA-DQB2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tomato allergy |
|
|
Search HLA-DQB2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HLA-DQB2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DQB2 Gene
Publications for HLA-DQB2 Gene
- Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC. (PMID: 2564844) Berdoz J … Gorski J (Immunogenetics 1989) 2 3 4
- HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule. (PMID: 22407913) Lenormand C … Tourne S (Journal of immunology (Baltimore, Md. : 1950) 2012) 3 4
- A genome-wide association study identifies three new risk loci for Kawasaki disease. (PMID: 22446962) Onouchi Y … US Kawasaki Disease Genetics Consortium (Nature genetics 2012) 3 41
- Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PMID: 21408207) Chung SA … Criswell LA (PLoS genetics 2011) 3 41
- A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. (PMID: 21750111) Mbarek H … Matsuda K (Human molecular genetics 2011) 3 41
ExternalLinks
Products for HLA-DQB2 Gene
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- antibodies-online: Show 9 available HLA-DQB2 Antibodies ranked by validation data
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- antibodies-online: Show 5 available HLA-DQB2 Proteins ranked by validation data
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