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Aliases for HLA-DPB2 Gene

Aliases for HLA-DPB2 Gene

  • Major Histocompatibility Complex, Class II, DP Beta 2 (Pseudogene) 2 3 5
  • HLA-DP2B 3
  • DPbeta2 3
  • DP2B 3
  • DPB2 3

External Ids for HLA-DPB2 Gene

Previous HGNC Symbols for HLA-DPB2 Gene

  • HLA-DP2B

Previous GeneCards Identifiers for HLA-DPB2 Gene

  • GC06U990045
  • GC06P033127
  • GC06P033188
  • GC06P032822

Summaries for HLA-DPB2 Gene

GeneCards Summary for HLA-DPB2 Gene

HLA-DPB2 (Major Histocompatibility Complex, Class II, DP Beta 2 (Pseudogene)) is a Pseudogene. Among its related pathways are Immune response NFAT in immune response and G-protein signaling N-RAS regulation pathway.

Additional gene information for HLA-DPB2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DPB2 Gene

Genomics for HLA-DPB2 Gene

GeneHancer (GH) Regulatory Elements for HLA-DPB2 Gene

Promoters and enhancers for HLA-DPB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J033111 Enhancer 0.9 Ensembl ENCODE 657.6 +1.3 1303 3.7 HDGF PKNOX1 ATF1 EBF1 ZBTB40 RFX5 RFXANK POLR2A EED ZNF143 HLA-DPB2 HLA-DPA1 HLA-DPB1 HSD17B8 COL11A2 RPS18 RPL32P1 HCG24 HLA-DPA3 HLA-DMA
GH06J033079 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 47.1 -31.7 -31709 2 PKNOX1 SIN3A GLI4 ZNF2 ZNF121 GLIS2 ZNF213 ZNF143 KLF13 SP3 HLA-DPA1 RPL32P1 GC06P033079 HLA-DPB1 HLA-DPB2 PHF1 RING1 RXRB HLA-DMA HLA-DPA3
GH06J033270 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 7.5 +162.7 162678 8.4 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 VPS52 RPS18 PIR43330 BRD2 LEMD2 DAXX RXRB WDR46 RING1 RGL2
GH06J033116 Enhancer 1 Ensembl ENCODE 15.1 +5.1 5109 2.5 HDGF ELF3 PKNOX1 RB1 SIN3A ZNF2 RAD21 RFX5 SCRT2 ZNF143 PIR46525 HLA-DPB1 HLA-DPA1 HLA-DPB2 HCG24 RPL32P1 COL11A2 HSD17B8 PIR47274 GC06M032900
GH06J033409 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.9 +298.6 298610 4.1 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 PHF1 DAXX BRD2 LEMD2 RXRB VPS52 RGL2 WDR46 RING1 HCG25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLA-DPB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HLA-DPB2 gene promoter:
  • Elk-1
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • CBF-B
  • CBF-A
  • CBF(2)
  • c-Ets-1
  • CBF-C

Genomic Locations for HLA-DPB2 Gene

Genomic Locations for HLA-DPB2 Gene
chr6:33,112,451-33,129,113
(GRCh38/hg38)
Size:
16,663 bases
Orientation:
Plus strand
chr6:33,080,228-33,102,442
(GRCh37/hg19)
Size:
22,215 bases
Orientation:
Plus strand

Genomic View for HLA-DPB2 Gene

Genes around HLA-DPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-DPB2 Gene

Post-translational modifications for HLA-DPB2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HLA-DPB2 Gene

Domains & Families for HLA-DPB2 Gene

Gene Families for HLA-DPB2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HLA-DPB2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HLA-DPB2 Gene

Function for HLA-DPB2 Gene

Molecular function for HLA-DPB2 Gene

GENATLAS Biochemistry:
HLA-DP,beta chain-related pseudogene

Phenotypes From GWAS Catalog for HLA-DPB2 Gene

Phenotypes for HLA-DPB2 Gene

genes like me logo Genes that share phenotypes with HLA-DPB2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HLA-DPB2 Gene

Localization for HLA-DPB2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HLA-DPB2 Gene

Pathways & Interactions for HLA-DPB2 Gene

genes like me logo Genes that share pathways with HLA-DPB2: view

Interacting Proteins for HLA-DPB2 Gene

Gene Ontology (GO) - Biological Process for HLA-DPB2 Gene

None

No data available for SIGNOR curated interactions for HLA-DPB2 Gene

Drugs & Compounds for HLA-DPB2 Gene

(1) Drugs for HLA-DPB2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker 1232
genes like me logo Genes that share compounds with HLA-DPB2: view

Transcripts for HLA-DPB2 Gene

mRNA/cDNA for HLA-DPB2 Gene

(3) Additional mRNA sequences :
(599) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HLA-DPB2 Gene

Major histocompatibility complex, class II, DP beta 2 (pseudogene):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DPB2 Gene

No ASD Table

Relevant External Links for HLA-DPB2 Gene

GeneLoc Exon Structure for
HLA-DPB2
ECgene alternative splicing isoforms for
HLA-DPB2

Expression for HLA-DPB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HLA-DPB2 Gene

mRNA differential expression in normal tissues according to GTEx for HLA-DPB2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.0) and Brain - Cerebellum (x4.6).

SOURCE GeneReport for Unigene cluster for HLA-DPB2 Gene:

Hs.665450
genes like me logo Genes that share expression patterns with HLA-DPB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DPB2 Gene

Orthologs for HLA-DPB2 Gene

Evolution for HLA-DPB2 Gene

ENSEMBL:
Gene Tree for HLA-DPB2 (if available)
TreeFam:
Gene Tree for HLA-DPB2 (if available)

No data available for Orthologs for HLA-DPB2 Gene

Paralogs for HLA-DPB2 Gene

No data available for Paralogs for HLA-DPB2 Gene

Variants for HLA-DPB2 Gene

Sequence variations from dbSNP and Humsavar for HLA-DPB2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000171545 -- 33,116,617(+) T/ intron_variant
rs1000365670 -- 33,126,424(+) C/T intron_variant
rs1000517215 -- 33,117,167(+) A/T non_coding_transcript_variant
rs1000867397 -- 33,117,352(+) A/G intron_variant
rs1001086430 -- 33,115,672(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HLA-DPB2 Gene

Variant ID Type Subtype PubMed ID
dgv1000e201 CNV deletion 23290073
dgv1760e212 CNV loss 25503493
esv2199795 CNV deletion 18987734
esv2650098 CNV deletion 19546169
esv2676552 CNV deletion 23128226
esv2731885 CNV deletion 23290073
esv3157 CNV loss 18987735
esv32606 CNV gain 17666407
esv33191 CNV gain 17666407
esv3567589 CNV deletion 23714750
esv7387 CNV loss 19470904
nsv1024429 CNV loss 25217958
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv516221 CNV loss 19592680
nsv602818 CNV loss 21841781

Additional Variant Information for HLA-DPB2 Gene

Human Gene Mutation Database (HGMD)
HLA-DPB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-DPB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HLA-DPB2 Gene

Disorders for HLA-DPB2 Gene

Additional Disease Information for HLA-DPB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HLA-DPB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HLA-DPB2 Gene

Publications for HLA-DPB2 Gene

  1. Genome-wide association study identifies susceptibility loci for IgA nephropathy. (PMID: 21399633) Gharavi AG … Lifton RP (Nature genetics 2011) 3 44 58
  2. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E … Dorak MT (Molecular human reproduction 2010) 3 44 58
  3. HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans. (PMID: 19950302) Zhou X … Lee EB (Arthritis and rheumatism 2009) 3 44 58
  4. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F … EUROSPAN Consortium (Circulation. Cardiovascular genetics 2009) 3 44 58
  5. Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction. (PMID: 18682748) Shiffman D … Devlin JJ (PloS one 2008) 3 44 58

Products for HLA-DPB2 Gene

Sources for HLA-DPB2 Gene

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