Aliases for HLA-DPB2 Gene

Aliases for HLA-DPB2 Gene

  • Major Histocompatibility Complex, Class II, DP Beta 2 (Pseudogene) 2 3 5
  • HLA-DP2B 3
  • DPbeta2 3
  • DP2B 3
  • DPB2 3

External Ids for HLA-DPB2 Gene

Previous HGNC Symbols for HLA-DPB2 Gene

  • HLA-DP2B

Previous GeneCards Identifiers for HLA-DPB2 Gene

  • GC06U990045
  • GC06P033127
  • GC06P033188
  • GC06P033080
  • GC06P032822
  • GC06P033139

Summaries for HLA-DPB2 Gene

GeneCards Summary for HLA-DPB2 Gene

HLA-DPB2 (Major Histocompatibility Complex, Class II, DP Beta 2 (Pseudogene)) is a Pseudogene. Diseases associated with HLA-DPB2 include Granulomatosis With Polyangiitis. Among its related pathways are G-protein signaling N-RAS regulation pathway and Th17 cell differentiation.

Additional gene information for HLA-DPB2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLA-DPB2 Gene

Genomics for HLA-DPB2 Gene

GeneHancer (GH) Regulatory Elements for HLA-DPB2 Gene

Promoters and enhancers for HLA-DPB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLA-DPB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HLA-DPB2 gene promoter:
  • c-Ets-1
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • Elk-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b

Genomic Locations for HLA-DPB2 Gene

Genomic Locations for HLA-DPB2 Gene
chr6:33,112,451-33,129,113
(GRCh38/hg38)
Size:
16,663 bases
Orientation:
Plus strand
chr6:33,080,228-33,102,442
(GRCh37/hg19)
Size:
22,215 bases
Orientation:
Plus strand

Genomic View for HLA-DPB2 Gene

Genes around HLA-DPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-DPB2 Gene

Post-translational modifications for HLA-DPB2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HLA-DPB2 Gene

Domains & Families for HLA-DPB2 Gene

Gene Families for HLA-DPB2 Gene

genes like me logo Genes that share domains with HLA-DPB2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HLA-DPB2 Gene

Function for HLA-DPB2 Gene

Molecular function for HLA-DPB2 Gene

GENATLAS Biochemistry:
HLA-DP,beta chain-related pseudogene

Phenotypes From GWAS Catalog for HLA-DPB2 Gene

Phenotypes for HLA-DPB2 Gene

genes like me logo Genes that share phenotypes with HLA-DPB2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HLA-DPB2 Gene

Localization for HLA-DPB2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HLA-DPB2 Gene

Pathways & Interactions for HLA-DPB2 Gene

PathCards logo

SuperPathways for HLA-DPB2 Gene

SuperPathway Contained pathways
1 Immune response NFAT in immune response
.56
.56
.52
2 G-protein signaling N-RAS regulation pathway
.52
.52
3 Th17 cell differentiation
.36
genes like me logo Genes that share pathways with HLA-DPB2: view

Pathways by source for HLA-DPB2 Gene

6 GeneGo (Thomson Reuters) pathways for HLA-DPB2 Gene
  • G-protein signaling N-RAS regulation pathway
  • Immune response Antigen presentation by MHC class II
  • Immune response ICOS pathway in T-helper cell
  • Immune response IL-22 signaling pathway
  • Immune response NFAT in immune response
;

Gene Ontology (GO) - Biological Process for HLA-DPB2 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for HLA-DPB2 Gene

Drugs & Compounds for HLA-DPB2 Gene

(1) Drugs for HLA-DPB2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker 1440
genes like me logo Genes that share compounds with HLA-DPB2: view

Transcripts for HLA-DPB2 Gene

mRNA/cDNA for HLA-DPB2 Gene

2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DPB2 Gene

No ASD Table

Relevant External Links for HLA-DPB2 Gene

GeneLoc Exon Structure for
HLA-DPB2

Expression for HLA-DPB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HLA-DPB2 Gene

mRNA differential expression in normal tissues according to GTEx for HLA-DPB2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.0) and Brain - Cerebellum (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-DPB2

SOURCE GeneReport for Unigene cluster for HLA-DPB2 Gene:

Hs.665450
genes like me logo Genes that share expression patterns with HLA-DPB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DPB2 Gene

Orthologs for HLA-DPB2 Gene

Evolution for HLA-DPB2 Gene

ENSEMBL:
Gene Tree for HLA-DPB2 (if available)
TreeFam:
Gene Tree for HLA-DPB2 (if available)

No data available for Orthologs for HLA-DPB2 Gene

Paralogs for HLA-DPB2 Gene

No data available for Paralogs for HLA-DPB2 Gene

Variants for HLA-DPB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for HLA-DPB2 Gene

Variant ID Type Subtype PubMed ID
dgv1000e201 CNV deletion 23290073
dgv1760e212 CNV loss 25503493
esv2199795 CNV deletion 18987734
esv2650098 CNV deletion 19546169
esv2676552 CNV deletion 23128226
esv2731885 CNV deletion 23290073
esv3157 CNV loss 18987735
esv32606 CNV gain 17666407
esv33191 CNV gain 17666407
esv3567589 CNV deletion 23714750
esv7387 CNV loss 19470904
nsv1024429 CNV loss 25217958
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv516221 CNV loss 19592680
nsv602818 CNV loss 21841781

Additional Variant Information for HLA-DPB2 Gene

Human Gene Mutation Database (HGMD)
HLA-DPB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-DPB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for HLA-DPB2 Gene

Disorders for HLA-DPB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HLA-DPB2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
granulomatosis with polyangiitis
  • gpa
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HLA-DPB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HLA-DPB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DPB2 Gene

Publications for HLA-DPB2 Gene

  1. Genome-wide association study identifies susceptibility loci for IgA nephropathy. (PMID: 21399633) Gharavi AG … Lifton RP (Nature genetics 2011) 3 41 54
  2. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E … Dorak MT (Molecular human reproduction 2010) 3 41 54
  3. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F … EUROSPAN Consortium (Circulation. Cardiovascular genetics 2009) 3 41 54
  4. HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans. (PMID: 19950302) Zhou X … Lee EB (Arthritis and rheumatism 2009) 3 41 54
  5. Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction. (PMID: 18682748) Shiffman D … Devlin JJ (PloS one 2008) 3 41 54

Products for HLA-DPB2 Gene

Sources for HLA-DPB2 Gene