HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendriti... See more...

Aliases for HLA-DPA1 Gene

Aliases for HLA-DPA1 Gene

  • Major Histocompatibility Complex, Class II, DP Alpha 1 2 3 5
  • HLA Class II Histocompatibility Antigen, DP Alpha 1 Chain 3 4
  • MHC Class II DP3-Alpha 3 4
  • HLA-SB Alpha Chain 3 4
  • HLA-DP1A 3 4
  • DP(W3) 3 4
  • DP(W4) 3 4
  • HLASB 3 4
  • MHC Class II HLA-DPA1 Antigen 3
  • MHC Class II DP Alpha Chain 3
  • HLA-DPA1*01:03:01:New 3
  • HLA-DPA1*02:01:01:NEW 3
  • MHC Class II DPA1 4
  • HLA DPA1 3
  • HLA-DPB1 3
  • HLADP 3
  • DPA1 3
  • PLT1 3

External Ids for HLA-DPA1 Gene

Previous HGNC Symbols for HLA-DPA1 Gene

  • HLA-DP1A

Previous GeneCards Identifiers for HLA-DPA1 Gene

  • GC06U990043
  • GC06M033029
  • GC06M033079
  • GC06M033140
  • GC06M033032
  • GC06M032775

Summaries for HLA-DPA1 Gene

Entrez Gene Summary for HLA-DPA1 Gene

  • HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-DPA1 Gene

HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1) is a Protein Coding gene. Diseases associated with HLA-DPA1 include Berylliosis and Granulomatosis With Polyangiitis. Among its related pathways are Hematopoietic cell lineage and G-protein signaling N-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRA.

UniProtKB/Swiss-Prot Summary for HLA-DPA1 Gene

  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Additional gene information for HLA-DPA1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLA-DPA1 Gene

Genomics for HLA-DPA1 Gene

GeneHancer (GH) Regulatory Elements for HLA-DPA1 Gene

Promoters and enhancers for HLA-DPA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLA-DPA1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HLA-DPA1

Top Transcription factor binding sites by QIAGEN in the HLA-DPA1 gene promoter:
  • CUTL1
  • GR
  • GR-alpha
  • MIF-1
  • NRSF form 1
  • NRSF form 2
  • p300
  • Pax-4a
  • PPAR-alpha
  • STAT3

Genomic Locations for HLA-DPA1 Gene

Genomic Locations for HLA-DPA1 Gene
chr6:33,064,569-33,080,778
(GRCh38/hg38)
Size:
16,210 bases
Orientation:
Minus strand
chr6:33,032,346-33,048,555
(GRCh37/hg19)
Size:
16,210 bases
Orientation:
Minus strand

Genomic View for HLA-DPA1 Gene

Genes around HLA-DPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-DPA1 Gene

  • Protein details for HLA-DPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20036-DPA1_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DP alpha 1 chain
    Protein Accession:
    P20036
    Secondary Accessions:
    • A9YWH7
    • B9UKH4
    • O19722
    • O46883
    • P01905
    • P79554
    • Q2Q060
    • Q2Q061
    • Q5EY03
    • Q5STP1
    • Q6DQK4
    • Q9BCQ1
    • Q9TPX3
    • Q9XS10

    Protein attributes for HLA-DPA1 Gene

    Size:
    260 amino acids
    Molecular mass:
    29381 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
    SequenceCaution:
    • Sequence=AAC64233.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD42927.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HLA-DPA1 Gene

neXtProt entry for HLA-DPA1 Gene

Post-translational modifications for HLA-DPA1 Gene

  • Glycosylation at Asn109 and Asn149
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for HLA-DPA1 Gene

No data available for DME Specific Peptides for HLA-DPA1 Gene

Domains & Families for HLA-DPA1 Gene

Gene Families for HLA-DPA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for HLA-DPA1 Gene

Blocks:
  • Immunoglobulin C-type
  • MHC Class II alpha chain, alpha-1 domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HLA-DPA1 Gene

GenScript: Design optimal peptide antigens:
  • Major histocompatibility complex, class II, DP alpha 1 (A2ABA4_HUMAN)
  • Major histocompatibility complex, class II, DP alpha 1 (A2ABA5_HUMAN)
  • Major histocompatibility complex, class II, DP alpha 1 (A2ABA6_HUMAN)
  • Major histocompatibility complex, class II, DP alpha 1 (A2ALJ1_HUMAN)
  • Major histocompatibility complex, class II, DP alpha 1 (A2ALJ2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20036

UniProtKB/Swiss-Prot:

DPA1_HUMAN :
  • Belongs to the MHC class II family.
Family:
  • Belongs to the MHC class II family.
genes like me logo Genes that share domains with HLA-DPA1: view

Function for HLA-DPA1 Gene

Molecular function for HLA-DPA1 Gene

UniProtKB/Swiss-Prot Function:
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
GENATLAS Biochemistry:
HLA-DP,alpha chain

Phenotypes From GWAS Catalog for HLA-DPA1 Gene

Gene Ontology (GO) - Molecular Function for HLA-DPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032395 MHC class II receptor activity NAS 2461352
GO:0042605 peptide antigen binding IDA 20356827
genes like me logo Genes that share ontologies with HLA-DPA1: view
genes like me logo Genes that share phenotypes with HLA-DPA1: view

Human Phenotype Ontology for HLA-DPA1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for HLA-DPA1 Gene

miRTarBase miRNAs that target HLA-DPA1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DPA1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DPA1 Gene

Localization for HLA-DPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DPA1 Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-DPA1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
endosome 5
lysosome 5
golgi apparatus 5
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HLA-DPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane TAS --
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with HLA-DPA1: view

Pathways & Interactions for HLA-DPA1 Gene

PathCards logo

SuperPathways for HLA-DPA1 Gene

SuperPathway Contained pathways
1 Allograft rejection
.44
.39
.38
2 Th17 cell differentiation
.36
3 Translocation of ZAP-70 to Immunological synapse
4 ICos-ICosL Pathway in T-Helper Cell
.66
.66
.31
5 TCR Signaling (Qiagen)
.68
.68
.54
genes like me logo Genes that share pathways with HLA-DPA1: view

Pathways by source for HLA-DPA1 Gene

6 GeneGo (Thomson Reuters) pathways for HLA-DPA1 Gene
  • G-protein signaling N-RAS regulation pathway
  • Immune response Antigen presentation by MHC class II
  • Immune response ICOS pathway in T-helper cell
  • Immune response IL-22 signaling pathway
  • Immune response NFAT in immune response
12 Qiagen pathways for HLA-DPA1 Gene
  • Calcium Mediated T-Cell Apoptosis
  • CD28 Signaling in T-Helper Cell
  • CDC42 Pathway
  • CTL Mediated Apoptosis
  • CTLA4 Signaling

Gene Ontology (GO) - Biological Process for HLA-DPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA --
GO:0006955 immune response IEA,NAS 2461352
GO:0019882 antigen processing and presentation IEA --
genes like me logo Genes that share ontologies with HLA-DPA1: view

No data available for SIGNOR curated interactions for HLA-DPA1 Gene

Drugs & Compounds for HLA-DPA1 Gene

(1) Drugs for HLA-DPA1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2b Approved Pharma 321

(1) Additional Compounds for HLA-DPA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HLA-DPA1: view

Transcripts for HLA-DPA1 Gene

mRNA/cDNA for HLA-DPA1 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-DPA1

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DPA1 Gene

No ASD Table

Relevant External Links for HLA-DPA1 Gene

GeneLoc Exon Structure for
HLA-DPA1

Expression for HLA-DPA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HLA-DPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DPA1 Gene

This gene is overexpressed in Whole Blood (x4.2) and Spleen (x4.0).

Protein differential expression in normal tissues from HIPED for HLA-DPA1 Gene

This gene is overexpressed in Blymphocyte (12.0), Lymph node (10.2), and Lung (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HLA-DPA1 Gene



Protein tissue co-expression partners for HLA-DPA1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-DPA1

SOURCE GeneReport for Unigene cluster for HLA-DPA1 Gene:

Hs.347270

Evidence on tissue expression from TISSUES for HLA-DPA1 Gene

  • Liver(4.3)
  • Lung(4.1)
  • Nervous system(3.8)
  • Pancreas(3.1)
  • Spleen(2.6)
  • Kidney(2.3)
  • Intestine(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with HLA-DPA1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DPA1 Gene

Orthologs for HLA-DPA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-DPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PATR-DPA1 31 30
  • 97.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BOLA-DYA 31
  • 56 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 58 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100332204 30
  • 47.43 (n)
si:busm1-160c18.1 31
  • 30 (a)
ManyToMany
Species where no ortholog for HLA-DPA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLA-DPA1 Gene

ENSEMBL:
Gene Tree for HLA-DPA1 (if available)
TreeFam:
Gene Tree for HLA-DPA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HLA-DPA1: view image

Paralogs for HLA-DPA1 Gene

(31) SIMAP similar genes for HLA-DPA1 Gene using alignment to 79 proteins:

  • DPA1_HUMAN
  • D9YLZ6_HUMAN
  • F6V115_HUMAN
  • G3GJV6_HUMAN
  • H0Y6F8_HUMAN
  • H9BIJ2_HUMAN
  • I2G9G1_HUMAN
  • J3KQ99_HUMAN
  • J9UEA6_HUMAN
  • K4PDP4_HUMAN
  • N0A0E5_HUMAN
  • O78000_HUMAN
  • O98050_HUMAN
  • Q29ZM9_HUMAN
  • Q29ZN0_HUMAN
  • Q29ZN1_HUMAN
  • Q29ZN2_HUMAN
  • Q29ZN3_HUMAN
  • Q29ZN4_HUMAN
  • Q49U27_HUMAN
  • Q49U29_HUMAN
  • Q49U31_HUMAN
  • Q49U33_HUMAN
  • Q49U35_HUMAN
  • Q49U37_HUMAN
  • Q49U39_HUMAN
  • Q49U41_HUMAN
  • Q49U43_HUMAN
  • Q49U45_HUMAN
  • Q49U47_HUMAN
  • Q49U49_HUMAN
  • Q49U51_HUMAN
  • Q49U53_HUMAN
  • Q49U55_HUMAN
  • Q49U57_HUMAN
  • Q49U59_HUMAN
  • Q49U61_HUMAN
  • Q49U63_HUMAN
  • Q49U65_HUMAN
  • Q49U67_HUMAN
  • Q49U69_HUMAN
  • Q49U71_HUMAN
  • Q5EY04_HUMAN
  • Q67AL9_HUMAN
  • Q67AM0_HUMAN
  • Q67AM1_HUMAN
  • Q67AM2_HUMAN
  • Q67AM3_HUMAN
  • Q67AM4_HUMAN
  • Q67AM5_HUMAN
  • Q67AM6_HUMAN
  • Q67AM7_HUMAN
  • Q67AM8_HUMAN
  • Q67AM9_HUMAN
  • Q67AN0_HUMAN
  • Q67AN1_HUMAN
  • Q67AN2_HUMAN
  • Q67AR8_HUMAN
  • Q67AS2_HUMAN
  • Q67AS8_HUMAN
  • Q67AS9_HUMAN
  • Q67AT4_HUMAN
  • Q67AT8_HUMAN
  • Q67AT9_HUMAN
  • Q67AU0_HUMAN
  • Q67AU1_HUMAN
  • Q67AU2_HUMAN
  • Q67AU3_HUMAN
  • Q67AU4_HUMAN
  • Q67AU5_HUMAN
  • Q67AU6_HUMAN
  • Q67AU7_HUMAN
  • Q67AU8_HUMAN
  • Q67AU9_HUMAN
  • Q9TPP2_HUMAN
  • Q9TQA9_HUMAN
  • Q9TQB0_HUMAN
  • Q9XS09_HUMAN
  • V5N4B3_HUMAN
genes like me logo Genes that share paralogs with HLA-DPA1: view

Variants for HLA-DPA1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DPA1 Gene

DPA1_HUMAN-P20036
The following alleles of DPA1 are known: DPA1*01:03, DPA1*01:04, DPA1*01:05, DPA1*01:06, DPA1*01:07, DPA1*01:08, DPA1*01:09, DPA1*01:10, DPA1*02:01, DPA1*02:02, DPA1*02:03, DPA1*02:04, DPA1*03:01, DPA1*03:02, DPA1*03:03, DPA1*04:01 The sequence shown is that of DPA1*01:03.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HLA-DPA1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
709409 Benign: not provided 33,076,122(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
725736 Benign: not provided 33,076,065(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
725737 Benign: not provided 33,076,088(-) C/T MISSENSE_VARIANT,INTRON_VARIANT
725738 Benign: not provided 33,076,149(-) C/T INTRON_VARIANT
779334 Benign: not provided 33,068,771(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for HLA-DPA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HLA-DPA1 Gene

Variant ID Type Subtype PubMed ID
dgv1039n67 CNV loss 20364138
dgv1040n67 CNV loss 20364138
esv1006913 CNV gain 20482838
esv22467 CNV loss 19812545
esv2545651 CNV loss 19546169
esv2731879 CNV deletion 23290073
nsv1024429 CNV loss 25217958
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv602818 CNV loss 21841781
nsv602819 CNV loss 21841781
nsv602822 CNV loss 21841781
nsv819387 CNV loss 19587683
nsv823641 CNV loss 20364138
nsv823645 CNV loss 20364138
nsv823646 CNV loss 20364138
nsv823647 CNV loss 20364138
nsv823648 CNV loss 20364138
nsv823649 CNV loss 20364138
nsv823650 CNV loss 20364138
nsv970108 CNV duplication 23825009

Variation tolerance for HLA-DPA1 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.70; 98.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HLA-DPA1 Gene

Human Gene Mutation Database (HGMD)
HLA-DPA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-DPA1

Disorders for HLA-DPA1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for HLA-DPA1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
berylliosis
  • beryllium poisoning
granulomatosis with polyangiitis
  • gpa
leishmaniasis
  • post kala-azar dermal leishmaniasis
beryllium disease
  • acute berylliosis
chronic beryllium disease
  • berylliosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HLA-DPA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HLA-DPA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DPA1 Gene

Publications for HLA-DPA1 Gene

  1. Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. (PMID: 6584734) Auffray C … Strominger JL (Nature 1984) 2 3 4 54
  2. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. (PMID: 21779181) Gorlova O … Martin J (PLoS genetics 2011) 3 41 54
  3. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. (PMID: 21750111) Mbarek H … Matsuda K (Human molecular genetics 2011) 3 41 54
  4. Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. (PMID: 21814517) Noguchi E … Matsumoto K (PLoS genetics 2011) 3 41 54
  5. Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. (PMID: 21274863) Guo X … O'Brien SJ (Hepatology (Baltimore, Md.) 2011) 3 41 54

Products for HLA-DPA1 Gene

Sources for HLA-DPA1 Gene