Aliases for HLA-DOA Gene
External Ids for HLA-DOA Gene
Previous HGNC Symbols for HLA-DOA Gene
Previous GeneCards Identifiers for HLA-DOA Gene
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-DOA Gene
HLA-DOA (Major Histocompatibility Complex, Class II, DO Alpha) is a Protein Coding gene. Diseases associated with HLA-DOA include Keshan Disease and Alopecia Universalis Congenita. Among its related pathways are G-protein signaling N-RAS regulation pathway and Allograft rejection. Gene Ontology (GO) annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DPA1.
UniProtKB/Swiss-Prot for HLA-DOA Gene
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.