HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. T... See more...

Aliases for HLA-B Gene

Aliases for HLA-B Gene

  • Major Histocompatibility Complex, Class I, B 2 3 5
  • HLA Class I Histocompatibility Antigen, B Alpha Chain 3 4
  • HLAB 3 4
  • MHC Class I Antigen HLA-B Alpha Chain 3
  • MHC Class I Antigen HLA-B Heavy Chain 3
  • MHC HLA-B Transmembrane Glycoprotein 3
  • MHC HLA-B Cell Surface Glycoprotein 3
  • Leukocyte Antigen Class I-B 3
  • HLA Class I Antigen HLA-B 3
  • MHC Class I Antigen SHCHA 3
  • Human Leukocyte Antigen B 4
  • Ankylosing Spondylitis 2
  • MHC Class I Molecule 3
  • MHC Class 1 Antigen 3
  • B-4901 3
  • AS 3

External Ids for HLA-B Gene

Previous HGNC Symbols for HLA-B Gene

  • AS

Previous GeneCards Identifiers for HLA-B Gene

  • GC06M031376
  • GC06M031426
  • GC06M031342
  • GC06M031429
  • GC06M031345
  • GC06M031321
  • GC06M031112
  • GC06M031354
  • GC06M031277
  • GC06M031279

Summaries for HLA-B Gene

Entrez Gene Summary for HLA-B Gene

  • HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-B Gene

HLA-B (Major Histocompatibility Complex, Class I, B) is a Protein Coding gene. Diseases associated with HLA-B include Severe Cutaneous Adverse Reaction and Spondyloarthropathy 1. Among its related pathways are Innate Immune System and Human cytomegalovirus infection. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and peptide antigen binding. An important paralog of this gene is HLA-C.

UniProtKB/Swiss-Prot Summary for HLA-B Gene

  • Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227, PubMed:9620674, PubMed:23209413). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7743181, PubMed:18991276). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:29531227, PubMed:9620674, PubMed:24600035). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227).
  • Allele B*07:02: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and mainly a Leu anchor residue at the C-terminus (PubMed:7743181). Presents a long peptide (APRGPHGGAASGL) derived from the cancer-testis antigen CTAG1A/NY-ESO-1, eliciting a polyclonal CD8-positive T cell response against tumor cells (PubMed:29531227). Presents viral epitopes derived from HIV-1 gag-pol (TPQDLNTML) and Nef (RPQVPLRPM) (PubMed:25808313). Displays self-peptides including a peptide derived from the signal sequence of HLA-DPB1 (APRTVALTA) (PubMed:7743181).
  • Allele B*08:01: Presents to CD8-positive T cells viral epitopes derived from EBV/HHV-4 EBNA3 (QAKWRLQTL), eliciting cytotoxic T cell response.
  • Allele B*13:02: Presents multiple HIV-1 epitopes derived from gag (RQANFLGKI, GQMREPRGSDI), nef (RQDILDLWI), gag-pol (RQYDQILIE, GQGQWTYQI) and rev (LQLPPLERL), all having in common a Gln residue at position 2 and mainly hydrophobic amino acids Leu, Ile or Val at the C-terminus. Associated with succesful control of HIV-1 infection.
  • Allele B*18:01: Preferentially presents octomeric and nonameric peptides sharing a common motif, namely a Glu at position 2 and Phe or Tyr anchor residues at the C-terminus (PubMed:14978097, PubMed:23749632, PubMed:18991276). Presents an EBV/HHV-4 epitope derived from BZLF1 (SELEIKRY) (PubMed:23749632). May present to CD8-positive T cells an antigenic peptide derived from MAGEA3 (MEVDPIGHLY), triggering an anti-tumor immune response (PubMed:12366779). May display a broad repertoire of self-peptides with a preference for peptides derived from RNA-binding proteins (PubMed:14978097).
  • Allele B*27:05: Presents to CD8-positive T cells immunodominant viral epitopes derived from HCV POLG (ARMILMTHF), HIV-1 gag (KRWIILGLNK), IAV NP (SRYWAIRTR), EBV/HHV-4 EBNA4 (HRCQAIRKK) and EBV/HHV-4 EBNA6 (RRIYDLIEL), confering longterm protection against viral infection (PubMed:19139562, PubMed:18385228, PubMed:15113903, PubMed:9620674). Can present self-peptides derived from cytosolic and nuclear proteins. All peptides carry an Arg at position 2 (PubMed:1922338). The peptide-bound form interacts with NK cell inhibitory receptor KIR3DL1 and inhibits NK cell activation in a peptide-specific way, being particularly sensitive to the nature of the amino acid side chain at position 8 of the antigenic peptide (PubMed:8879234, PubMed:15657948). KIR3DL1 fails to recognize HLA-B*27:05 in complex with B2M and EBV/HHV-4 EBNA6 (RRIYDLIEL) peptide, which can lead to increased activation of NK cells during infection (PubMed:15657948). May present an altered repertoire of peptides in the absence of TAP1-TAP2 and TAPBPL (PubMed:9620674).
  • Allele B*40:01: Presents an immunodominant viral epitope derived from EBV/HHV-4 LMP2 (IEDPPFNSL), triggering memory CD8-positive T cell response (PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and a Leu anchor residue at the C-terminus (PubMed:18991276).
  • Allele B*41:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
  • Allele B*44:02: Presents immunodominant viral epitopes derived from EBV/HHV-4 EBNA4 (VEITPYKPTW) and EBNA6 (AEGGVGWRHW, EENLLDFVRF), triggering memory CD8-positive T cell response (PubMed:9620674, PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Phe, Tyr or Trp anchor residues at the C-terminus (PubMed:18991276).
  • Allele B*45:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
  • Allele B*46:01: Preferentially presents nonameric peptides sharing a signature motif, namely Ala and Leu at position 2 and Tyr, Phe, Leu, or Met anchor residues at the C-terminus. The peptide-bound form interacts with KIR2DL3 and inhibits NK cell cytotoxic response in a peptide-specific way.
  • Allele B*47:01: Displays self-peptides sharing a signature motif, namely an Asp at position 2 and Leu or Met anchor residues at the C-terminus.
  • Allele B*49:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ile or Val anchor residues at the C-terminus.
  • Allele B*50:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
  • Allele B*51:01: Presents an octomeric HIV-1 epitope derived from gag-pol (TAFTIPSI) to the public TRAV17/TRBV7-3 TCR clonotype, strongly suppressing HIV-1 replication.
  • Allele B*54:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
  • Allele B*55:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
  • Allele B*56:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
  • Allele B*57:01: The peptide-bound form recognizes KIR3DL1 and inhibits NK cell cytotoxic response.
  • Allele B*67:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Leu anchor residue at the C-terminus.

Gene Wiki entry for HLA-B Gene

PharmGKB "VIP" Summary for HLA-B Gene

Additional gene information for HLA-B Gene

No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for HLA-B Gene

Genomics for HLA-B Gene

GeneHancer (GH) Regulatory Elements for HLA-B Gene

Promoters and enhancers for HLA-B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLA-B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HLA-B

Top Transcription factor binding sites by QIAGEN in the HLA-B gene promoter:
  • AML1a
  • AP-2gamma
  • ATF6
  • ISGF-3
  • p300
  • Pax-5
  • POU2F1
  • POU2F1a
  • USF1

Genomic Locations for HLA-B Gene

Genomic Locations for HLA-B Gene
chr6:31,269,491-31,357,212
(GRCh38/hg38)
Size:
87,722 bases
Orientation:
Minus strand
chr6:31,321,649-31,324,989
(GRCh37/hg19)
Size:
3,341 bases
Orientation:
Minus strand

Genomic View for HLA-B Gene

Genes around HLA-B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-B Gene

  • Protein details for HLA-B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01889-HLAB_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, B alpha chain
    Protein Accession:
    P01889
    Secondary Accessions:
    • A0A2I6Q7B5
    • B0V0B8
    • G3GN01
    • O02862
    • O02956
    • O02957
    • O02960
    • O19555
    • O19556
    • O19595
    • O19615
    • O19624
    • O19625
    • O19627
    • O19641
    • O19651
    • O19675
    • O19692
    • O19758
    • O19779
    • O19783
    • O46702
    • O62897
    • O62901
    • O62915
    • O62917
    • O62919
    • O77933
    • O77959
    • O78053
    • O78138
    • O78160
    • O78163
    • O78172
    • O78173
    • O78180
    • O78217
    • O95730
    • O98140
    • P01890
    • P03989
    • P10317
    • P10318
    • P10319
    • P10320
    • P18463
    • P18464
    • P18465
    • P19373
    • P30460
    • P30461
    • P30462
    • P30463
    • P30464
    • P30465
    • P30466
    • P30467
    • P30468
    • P30469
    • P30470
    • P30471
    • P30472
    • P30473
    • P30474
    • P30475
    • P30476
    • P30477
    • P30478
    • P30479
    • P30480
    • P30481
    • P30482
    • P30483
    • P30484
    • P30485
    • P30486
    • P30487
    • P30488
    • P30489
    • P30490
    • P30491
    • P30492
    • P30493
    • P30494
    • P30495
    • P30496
    • P30497
    • P30498
    • P30513
    • P30685
    • P79489
    • P79490
    • P79496
    • P79504
    • P79523
    • P79524
    • P79542
    • P79555
    • Q04826
    • Q08136
    • Q29633
    • Q29636
    • Q29638
    • Q29661
    • Q29665
    • Q29678
    • Q29679
    • Q29681
    • Q29693
    • Q29695
    • Q29697
    • Q29718
    • Q29742
    • Q29749
    • Q29762
    • Q29764
    • Q29829
    • Q29836
    • Q29842
    • Q29845
    • Q29846
    • Q29847
    • Q29848
    • Q29850
    • Q29851
    • Q29852
    • Q29854
    • Q29855
    • Q29857
    • Q29858
    • Q29861
    • Q29924
    • Q29925
    • Q29933
    • Q29935
    • Q29936
    • Q29940
    • Q29953
    • Q29961
    • Q29982
    • Q30173
    • Q30198
    • Q31603
    • Q31610
    • Q31612
    • Q31613
    • Q546L8
    • Q546M4
    • Q5JP37
    • Q5QT24
    • Q5RIP1
    • Q5SRJ2
    • Q5TK76
    • Q5TK77
    • Q860I4
    • Q861B5
    • Q8HWF0
    • Q8MGQ3
    • Q8MHN4
    • Q8SNC5
    • Q95343
    • Q95344
    • Q95365
    • Q95369
    • Q95392
    • Q95HA3
    • Q95HA8
    • Q95HM9
    • Q95IA6
    • Q95IB8
    • Q95IH5
    • Q95J00
    • Q96IT9
    • Q9BCM6
    • Q9BCM7
    • Q9BCM8
    • Q9BD06
    • Q9BD38
    • Q9BD43
    • Q9GIL3
    • Q9GIM3
    • Q9GIX1
    • Q9GIY5
    • Q9GIZ0
    • Q9GIZ9
    • Q9GJ00
    • Q9GJ17
    • Q9GJ20
    • Q9GJ23
    • Q9GJ31
    • Q9GJF0
    • Q9GJM7
    • Q9MX21
    • Q9MY37
    • Q9MY42
    • Q9MY43
    • Q9MY61
    • Q9MY75
    • Q9MY78
    • Q9MY79
    • Q9MY84
    • Q9MY92
    • Q9MY93
    • Q9MY94
    • Q9MYB8
    • Q9MYC3
    • Q9MYC7
    • Q9MYF4
    • Q9MYG1
    • Q9TP35
    • Q9TP36
    • Q9TP37
    • Q9TP95
    • Q9TPQ7
    • Q9TPQ9
    • Q9TPR2
    • Q9TPR4
    • Q9TPS6
    • Q9TPT2
    • Q9TPT4
    • Q9TPT6
    • Q9TPV2
    • Q9TQG1
    • Q9TQH3
    • Q9TQH6
    • Q9TQH7
    • Q9TQH8
    • Q9TQH9
    • Q9TQM2
    • Q9TQN4
    • Q9TQN6
    • Q9UQS8
    • Q9UQT0

    Protein attributes for HLA-B Gene

    Size:
    362 amino acids
    Molecular mass:
    40460 Da
    Quaternary structure:
    • Heterotrimer that consists of an alpha chain HLA-B, a beta chain B2M and a peptide (peptide-HLA-B-B2M) (PubMed:25808313, PubMed:29531227, PubMed:15657948, PubMed:17057332, PubMed:22020283, PubMed:24600035). Early in biogenesis, HLA-B-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR (PubMed:9036970, PubMed:9620674, PubMed:26439010, PubMed:26416272). Interacts with TAP1-TAP2 transporter via TAPBP; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:9036970, PubMed:9620674). Interacts with TAPBPL; TAPBPL binds peptide-free HLA-B-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange for higher affinity peptides (PubMed:26439010). Only optimally assembled peptide-HLA-B-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. HLA-B (via polymorphic alpha-1 and alpha-2 domains) interacts with antigen-specific TCR (via CDR1, CDR2 and CDR3 domains) (PubMed:29531227, PubMed:24600035). One HLA-B molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction insures peptide-HLA-B-B2M recognition by CD8-positive T cells only (PubMed:29531227). Allele B*57:01 interacts (via Bw4 motif) with KIR3DL1 (via Ig-like C2-type domain); this interaction may interfere with peptide binding (PubMed:22020283, PubMed:25480565). Allele B*46:01 interacts with KIR2DL3 (PubMed:28514659).
    • (Microbial infection) Interacts with HTLV-1 accessory protein p12I.

    Three dimensional structures from OCA and Proteopedia for HLA-B Gene

neXtProt entry for HLA-B Gene

Post-translational modifications for HLA-B Gene

Other Protein References for HLA-B Gene

Antibody Products

No data available for DME Specific Peptides for HLA-B Gene

Domains & Families for HLA-B Gene

Gene Families for HLA-B Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for HLA-B Gene

Blocks:
  • MHC class I signature
  • Immunoglobulin C-type
  • MHC_I, C-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HLA-B Gene

GenScript: Design optimal peptide antigens:
  • MHC class I antigen (E5G0Z4_HUMAN)
  • MHC class I antigen (E5G0Z5_HUMAN)
  • MHC class I antigen (E5G0Z6_HUMAN)
  • MHC class I antigen (E5G0Z7_HUMAN)
  • MHC class I antigen (E5G0Z8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01889

UniProtKB/Swiss-Prot:

HLAB_HUMAN :
  • The alpha-1 domain is a structural part of the peptide-binding cleft (PubMed:25808313). Residues 101-107 determine Bw4/Bw6 motifs, which serologically distinguish HLA-B alleles. Each HLA-B allele posseses either the Bw4 or Bw6 motif. Only HLA-B alleles bearing the Bw4 epitope are recognized by NK cell inhibitory receptor KIR3DL1 (PubMed:25480565, PubMed:22020283).
Domain:
  • The alpha-1 domain is a structural part of the peptide-binding cleft (PubMed:25808313). Residues 101-107 determine Bw4/Bw6 motifs, which serologically distinguish HLA-B alleles. Each HLA-B allele posseses either the Bw4 or Bw6 motif. Only HLA-B alleles bearing the Bw4 epitope are recognized by NK cell inhibitory receptor KIR3DL1 (PubMed:25480565, PubMed:22020283).
  • The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:25808313). Mediates the interaction with TAP1-TAP2 complex (By similarity).
  • The alpha-3 Ig-like domain mediates the interaction with CD8 coreceptor.
genes like me logo Genes that share domains with HLA-B: view

Function for HLA-B Gene

Molecular function for HLA-B Gene

UniProtKB/Swiss-Prot Function:
Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227, PubMed:9620674, PubMed:23209413). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7743181, PubMed:18991276). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:29531227, PubMed:9620674, PubMed:24600035). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227).
UniProtKB/Swiss-Prot Function:
Allele B*07:02: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and mainly a Leu anchor residue at the C-terminus (PubMed:7743181). Presents a long peptide (APRGPHGGAASGL) derived from the cancer-testis antigen CTAG1A/NY-ESO-1, eliciting a polyclonal CD8-positive T cell response against tumor cells (PubMed:29531227). Presents viral epitopes derived from HIV-1 gag-pol (TPQDLNTML) and Nef (RPQVPLRPM) (PubMed:25808313). Displays self-peptides including a peptide derived from the signal sequence of HLA-DPB1 (APRTVALTA) (PubMed:7743181).
UniProtKB/Swiss-Prot Function:
Allele B*08:01: Presents to CD8-positive T cells viral epitopes derived from EBV/HHV-4 EBNA3 (QAKWRLQTL), eliciting cytotoxic T cell response.
UniProtKB/Swiss-Prot Function:
Allele B*13:02: Presents multiple HIV-1 epitopes derived from gag (RQANFLGKI, GQMREPRGSDI), nef (RQDILDLWI), gag-pol (RQYDQILIE, GQGQWTYQI) and rev (LQLPPLERL), all having in common a Gln residue at position 2 and mainly hydrophobic amino acids Leu, Ile or Val at the C-terminus. Associated with succesful control of HIV-1 infection.
UniProtKB/Swiss-Prot Function:
Allele B*18:01: Preferentially presents octomeric and nonameric peptides sharing a common motif, namely a Glu at position 2 and Phe or Tyr anchor residues at the C-terminus (PubMed:14978097, PubMed:23749632, PubMed:18991276). Presents an EBV/HHV-4 epitope derived from BZLF1 (SELEIKRY) (PubMed:23749632). May present to CD8-positive T cells an antigenic peptide derived from MAGEA3 (MEVDPIGHLY), triggering an anti-tumor immune response (PubMed:12366779). May display a broad repertoire of self-peptides with a preference for peptides derived from RNA-binding proteins (PubMed:14978097).
UniProtKB/Swiss-Prot Function:
Allele B*27:05: Presents to CD8-positive T cells immunodominant viral epitopes derived from HCV POLG (ARMILMTHF), HIV-1 gag (KRWIILGLNK), IAV NP (SRYWAIRTR), EBV/HHV-4 EBNA4 (HRCQAIRKK) and EBV/HHV-4 EBNA6 (RRIYDLIEL), confering longterm protection against viral infection (PubMed:19139562, PubMed:18385228, PubMed:15113903, PubMed:9620674). Can present self-peptides derived from cytosolic and nuclear proteins. All peptides carry an Arg at position 2 (PubMed:1922338). The peptide-bound form interacts with NK cell inhibitory receptor KIR3DL1 and inhibits NK cell activation in a peptide-specific way, being particularly sensitive to the nature of the amino acid side chain at position 8 of the antigenic peptide (PubMed:8879234, PubMed:15657948). KIR3DL1 fails to recognize HLA-B*27:05 in complex with B2M and EBV/HHV-4 EBNA6 (RRIYDLIEL) peptide, which can lead to increased activation of NK cells during infection (PubMed:15657948). May present an altered repertoire of peptides in the absence of TAP1-TAP2 and TAPBPL (PubMed:9620674).
UniProtKB/Swiss-Prot Function:
Allele B*40:01: Presents an immunodominant viral epitope derived from EBV/HHV-4 LMP2 (IEDPPFNSL), triggering memory CD8-positive T cell response (PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and a Leu anchor residue at the C-terminus (PubMed:18991276).
UniProtKB/Swiss-Prot Function:
Allele B*41:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
UniProtKB/Swiss-Prot Function:
Allele B*44:02: Presents immunodominant viral epitopes derived from EBV/HHV-4 EBNA4 (VEITPYKPTW) and EBNA6 (AEGGVGWRHW, EENLLDFVRF), triggering memory CD8-positive T cell response (PubMed:9620674, PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Phe, Tyr or Trp anchor residues at the C-terminus (PubMed:18991276).
UniProtKB/Swiss-Prot Function:
Allele B*45:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
UniProtKB/Swiss-Prot Function:
Allele B*46:01: Preferentially presents nonameric peptides sharing a signature motif, namely Ala and Leu at position 2 and Tyr, Phe, Leu, or Met anchor residues at the C-terminus. The peptide-bound form interacts with KIR2DL3 and inhibits NK cell cytotoxic response in a peptide-specific way.
UniProtKB/Swiss-Prot Function:
Allele B*47:01: Displays self-peptides sharing a signature motif, namely an Asp at position 2 and Leu or Met anchor residues at the C-terminus.
UniProtKB/Swiss-Prot Function:
Allele B*49:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ile or Val anchor residues at the C-terminus.
UniProtKB/Swiss-Prot Function:
Allele B*50:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
UniProtKB/Swiss-Prot Function:
Allele B*51:01: Presents an octomeric HIV-1 epitope derived from gag-pol (TAFTIPSI) to the public TRAV17/TRBV7-3 TCR clonotype, strongly suppressing HIV-1 replication.
UniProtKB/Swiss-Prot Function:
Allele B*54:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
UniProtKB/Swiss-Prot Function:
Allele B*55:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
UniProtKB/Swiss-Prot Function:
Allele B*56:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
UniProtKB/Swiss-Prot Function:
Allele B*57:01: The peptide-bound form recognizes KIR3DL1 and inhibits NK cell cytotoxic response.
UniProtKB/Swiss-Prot Function:
Allele B*67:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Leu anchor residue at the C-terminus.
GENATLAS Biochemistry:
HLA-B,beta chain,44kDa,class Ia (see MHC1)

Phenotypes From GWAS Catalog for HLA-B Gene

Gene Ontology (GO) - Molecular Function for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA --
GO:0005515 protein binding IPI --
GO:0042605 peptide antigen binding IBA --
genes like me logo Genes that share ontologies with HLA-B: view
genes like me logo Genes that share phenotypes with HLA-B: view

Human Phenotype Ontology for HLA-B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

  • Addgene plasmids for HLA-B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-B Gene

Localization for HLA-B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-B Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 4
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
lysosome 2
peroxisome 0

Gene Ontology (GO) - Cellular Components for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005886 plasma membrane IBA --
GO:0005887 integral component of plasma membrane NAS --
genes like me logo Genes that share ontologies with HLA-B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HLA-B Gene

Pathways & Interactions for HLA-B Gene

genes like me logo Genes that share pathways with HLA-B: view

Pathways by source for HLA-B Gene

2 GeneGo (Thomson Reuters) pathways for HLA-B Gene
  • Immune response Antigen presentation by MHC class I
  • Immune response Role of DAP12 receptors in NK cells
2 Qiagen pathways for HLA-B Gene
  • CDC42 Pathway
  • CTL Mediated Apoptosis

SIGNOR curated interactions for HLA-B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IBA --
GO:0002376 immune system process IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA --
GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with HLA-B: view

Drugs & Compounds for HLA-B Gene

(69) Drugs for HLA-B Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abacavir Approved, Investigational Pharma Target 231
Carbamazepine Approved, Investigational Pharma Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant 103
Coccidioides immitis spherule Approved Pharma Target 0
Acetazolamide Approved, Vet_approved Pharma 111
Allopurinol Approved Pharma 198

(40) Additional Compounds for HLA-B Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
genes like me logo Genes that share compounds with HLA-B: view

Transcripts for HLA-B Gene

mRNA/cDNA for HLA-B Gene

1 REFSEQ mRNAs :
292 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for HLA-B

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-B Gene

No ASD Table

Relevant External Links for HLA-B Gene

GeneLoc Exon Structure for
HLA-B

Expression for HLA-B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HLA-B Gene

mRNA differential expression in normal tissues according to GTEx for HLA-B Gene

This gene is overexpressed in Whole Blood (x15.6).

Protein differential expression in normal tissues from HIPED for HLA-B Gene

This gene is overexpressed in Amniocyte (36.4) and Oral epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HLA-B Gene



Protein tissue co-expression partners for HLA-B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-B

SOURCE GeneReport for Unigene cluster for HLA-B Gene:

Hs.77961

Evidence on tissue expression from TISSUES for HLA-B Gene

  • Blood(5)
  • Nervous system(5)
  • Intestine(4.9)
  • Liver(4.9)
  • Lung(4.9)
  • Pancreas(4.8)
  • Spleen(4.8)
  • Stomach(4.7)
  • Skin(4.6)
  • Kidney(3.9)
  • Eye(3.8)
  • Thyroid gland(3.6)
  • Heart(3.3)
  • Muscle(3)
  • Bone(2.5)
  • Bone marrow(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-B Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • face
  • head
  • meninges
  • mouth
  • neck
  • salivary gland
Thorax:
  • aorta
  • esophagus
  • heart
  • heart valve
  • lung
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • penis
  • testicle
  • vagina
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal cord
  • sweat gland
  • white blood cell
genes like me logo Genes that share expression patterns with HLA-B: view