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HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. T... See more...
Aliases for HLA-B Gene
Aliases for HLA-B Gene
- Major Histocompatibility Complex, Class I, B 2 3 5
- HLA Class I Histocompatibility Antigen, B Alpha Chain 3 4
- HLAB 3 4
- MHC Class I Antigen HLA-B Alpha Chain 3
- MHC Class I Antigen HLA-B Heavy Chain 3
- MHC HLA-B Transmembrane Glycoprotein 3
- MHC HLA-B Cell Surface Glycoprotein 3
- Leukocyte Antigen Class I-B 3
External Ids for HLA-B Gene
- HGNC: 4932
- Entrez Gene: 3106
- Ensembl: ENSG00000234745
- OMIM: 142830
- UniProtKB: P01889
Previous HGNC Symbols for HLA-B Gene
- AS
Previous GeneCards Identifiers for HLA-B Gene
- GC06M031376
- GC06M031426
- GC06M031342
- GC06M031429
- GC06M031345
- GC06M031321
- GC06M031112
- GC06M031354
- GC06M031277
- GC06M031279
- GC06M031289
Summaries for HLA-B Gene
-
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-B Gene
HLA-B (Major Histocompatibility Complex, Class I, B) is a Protein Coding gene. Diseases associated with HLA-B include Severe Cutaneous Adverse Reaction and Spondyloarthropathy 1. Among its related pathways are Antigen processing-Cross presentation and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and peptide antigen binding. An important paralog of this gene is HLA-C.
UniProtKB/Swiss-Prot Summary for HLA-B Gene
-
Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227, PubMed:9620674, PubMed:23209413). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7743181, PubMed:18991276). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:29531227, PubMed:9620674, PubMed:24600035). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227).
-
Allele B*07:02: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and mainly a Leu anchor residue at the C-terminus (PubMed:7743181). Presents a long peptide (APRGPHGGAASGL) derived from the cancer-testis antigen CTAG1A/NY-ESO-1, eliciting a polyclonal CD8-positive T cell response against tumor cells (PubMed:29531227). Presents viral epitopes derived from HIV-1 gag-pol (TPQDLNTML) and Nef (RPQVPLRPM) (PubMed:25808313). Displays self-peptides including a peptide derived from the signal sequence of HLA-DPB1 (APRTVALTA) (PubMed:7743181).
-
Allele B*08:01: Presents to CD8-positive T cells viral epitopes derived from EBV/HHV-4 EBNA3 (QAKWRLQTL), eliciting cytotoxic T cell response.
-
Allele B*13:02: Presents multiple HIV-1 epitopes derived from gag (RQANFLGKI, GQMREPRGSDI), nef (RQDILDLWI), gag-pol (RQYDQILIE, GQGQWTYQI) and rev (LQLPPLERL), all having in common a Gln residue at position 2 and mainly hydrophobic amino acids Leu, Ile or Val at the C-terminus. Associated with succesful control of HIV-1 infection.
-
Allele B*18:01: Preferentially presents octomeric and nonameric peptides sharing a common motif, namely a Glu at position 2 and Phe or Tyr anchor residues at the C-terminus (PubMed:14978097, PubMed:23749632, PubMed:18991276). Presents an EBV/HHV-4 epitope derived from BZLF1 (SELEIKRY) (PubMed:23749632). May present to CD8-positive T cells an antigenic peptide derived from MAGEA3 (MEVDPIGHLY), triggering an anti-tumor immune response (PubMed:12366779). May display a broad repertoire of self-peptides with a preference for peptides derived from RNA-binding proteins (PubMed:14978097).
-
Allele B*27:05: Presents to CD8-positive T cells immunodominant viral epitopes derived from HCV POLG (ARMILMTHF), HIV-1 gag (KRWIILGLNK), IAV NP (SRYWAIRTR), EBV/HHV-4 EBNA4 (HRCQAIRKK) and EBV/HHV-4 EBNA6 (RRIYDLIEL), confering longterm protection against viral infection (PubMed:19139562, PubMed:18385228, PubMed:15113903, PubMed:9620674). Can present self-peptides derived from cytosolic and nuclear proteins. All peptides carry an Arg at position 2 (PubMed:1922338). The peptide-bound form interacts with NK cell inhibitory receptor KIR3DL1 and inhibits NK cell activation in a peptide-specific way, being particularly sensitive to the nature of the amino acid side chain at position 8 of the antigenic peptide (PubMed:8879234, PubMed:15657948). KIR3DL1 fails to recognize HLA-B*27:05 in complex with B2M and EBV/HHV-4 EBNA6 (RRIYDLIEL) peptide, which can lead to increased activation of NK cells during infection (PubMed:15657948). May present an altered repertoire of peptides in the absence of TAP1-TAP2 and TAPBPL (PubMed:9620674).
-
Allele B*40:01: Presents an immunodominant viral epitope derived from EBV/HHV-4 LMP2 (IEDPPFNSL), triggering memory CD8-positive T cell response (PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and a Leu anchor residue at the C-terminus (PubMed:18991276).
-
Allele B*41:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
-
Allele B*44:02: Presents immunodominant viral epitopes derived from EBV/HHV-4 EBNA4 (VEITPYKPTW) and EBNA6 (AEGGVGWRHW, EENLLDFVRF), triggering memory CD8-positive T cell response (PubMed:9620674, PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Phe, Tyr or Trp anchor residues at the C-terminus (PubMed:18991276).
-
Allele B*45:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
-
Allele B*46:01: Preferentially presents nonameric peptides sharing a signature motif, namely Ala and Leu at position 2 and Tyr, Phe, Leu, or Met anchor residues at the C-terminus. The peptide-bound form interacts with KIR2DL3 and inhibits NK cell cytotoxic response in a peptide-specific way.
-
Allele B*47:01: Displays self-peptides sharing a signature motif, namely an Asp at position 2 and Leu or Met anchor residues at the C-terminus.
-
Allele B*49:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ile or Val anchor residues at the C-terminus.
-
Allele B*50:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
-
Allele B*51:01: Presents an octomeric HIV-1 epitope derived from gag-pol (TAFTIPSI) to the public TRAV17/TRBV7-3 TCR clonotype, strongly suppressing HIV-1 replication.
-
Allele B*54:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
-
Allele B*55:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
-
Allele B*56:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
-
Allele B*57:01: The peptide-bound form recognizes KIR3DL1 and inhibits NK cell cytotoxic response.
-
Allele B*67:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Leu anchor residue at the C-terminus.
Additional gene information for HLA-B Gene
- HGNC(4932)
- Entrez Gene(3106)
- Ensembl(ENSG00000234745)
- OMIM(142830)
- UniProtKB(P01889)
- Open Targets Platform(ENSG00000234745)
- Monarch Initiative
- Search for HLA-B at DataMed
- Search for HLA-B at HumanCyc
No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for HLA-B Gene
Genomics for HLA-B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HLA-B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HLA-B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HLA-B
- Top Transcription factor binding sites by QIAGEN in the HLA-B gene promoter:
-
- AML1a
- AP-2gamma
- ATF6
- ISGF-3
- p300
- Pax-5
- POU2F1
- POU2F1a
- USF1
Genomic Locations for HLA-B Gene
Genomic Locations for HLA-B Gene
- chr6:31,269,491-31,357,188
- (GRCh38/hg38)
- Size:
- 87,698 bases
- Orientation:
- Minus strand
- chr6:31,321,649-31,324,989
- (GRCh37/hg19)
- Size:
- 3,341 bases
- Orientation:
- Minus strand
Genomic View for HLA-B Gene
Genes around HLA-B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by HGNC
- 6p21.33 by Entrez Gene
- 6p21.33 by Ensembl
HLA-B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HLA-B Gene
Proteins for HLA-B Gene
-
Protein details for HLA-B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01889-HLAB_HUMAN
- Recommended name:
- HLA class I histocompatibility antigen, B alpha chain
- Protein Accession:
- P01889
- A0A2I6Q7B5
- B0V0B8
- G3GN01
- O02862
- O02956
- O02957
- O02960
- O19555
- O19556
- O19595
- O19615
- O19624
- O19625
- O19627
- O19641
- O19651
- O19675
- O19692
- O19758
- O19779
- O19783
- O46702
- O62897
- O62901
- O62915
- O62917
- O62919
- O77933
- O77959
- O78053
- O78138
- O78160
- O78163
- O78172
- O78173
- O78180
- O78217
- O95730
- O98140
- P01890
- P03989
- P10317
- P10318
- P10319
- P10320
- P18463
- P18464
- P18465
- P19373
- P30460
- P30461
- P30462
- P30463
- P30464
- P30465
- P30466
- P30467
- P30468
- P30469
- P30470
- P30471
- P30472
- P30473
- P30474
- P30475
- P30476
- P30477
- P30478
- P30479
- P30480
- P30481
- P30482
- P30483
- P30484
- P30485
- P30486
- P30487
- P30488
- P30489
- P30490
- P30491
- P30492
- P30493
- P30494
- P30495
- P30496
- P30497
- P30498
- P30513
- P30685
- P79489
- P79490
- P79496
- P79504
- P79523
- P79524
- P79542
- P79555
- Q04826
- Q08136
- Q29633
- Q29636
- Q29638
- Q29661
- Q29665
- Q29678
- Q29679
- Q29681
- Q29693
- Q29695
- Q29697
- Q29718
- Q29742
- Q29749
- Q29762
- Q29764
- Q29829
- Q29836
- Q29842
- Q29845
- Q29846
- Q29847
- Q29848
- Q29850
- Q29851
- Q29852
- Q29854
- Q29855
- Q29857
- Q29858
- Q29861
- Q29924
- Q29925
- Q29933
- Q29935
- Q29936
- Q29940
- Q29953
- Q29961
- Q29982
- Q30173
- Q30198
- Q31603
- Q31610
- Q31612
- Q31613
- Q546L8
- Q546M4
- Q5JP37
- Q5QT24
- Q5RIP1
- Q5SRJ2
- Q5TK76
- Q5TK77
- Q860I4
- Q861B5
- Q8HWF0
- Q8MGQ3
- Q8MHN4
- Q8SNC5
- Q95343
- Q95344
- Q95365
- Q95369
- Q95392
- Q95HA3
- Q95HA8
- Q95HM9
- Q95IA6
- Q95IB8
- Q95IH5
- Q95J00
- Q96IT9
- Q9BCM6
- Q9BCM7
- Q9BCM8
- Q9BD06
- Q9BD38
- Q9BD43
- Q9GIL3
- Q9GIM3
- Q9GIX1
- Q9GIY5
- Q9GIZ0
- Q9GIZ9
- Q9GJ00
- Q9GJ17
- Q9GJ20
- Q9GJ23
- Q9GJ31
- Q9GJF0
- Q9GJM7
- Q9MX21
- Q9MY37
- Q9MY42
- Q9MY43
- Q9MY61
- Q9MY75
- Q9MY78
- Q9MY79
- Q9MY84
- Q9MY92
- Q9MY93
- Q9MY94
- Q9MYB8
- Q9MYC3
- Q9MYC7
- Q9MYF4
- Q9MYG1
- Q9TP35
- Q9TP36
- Q9TP37
- Q9TP95
- Q9TPQ7
- Q9TPQ9
- Q9TPR2
- Q9TPR4
- Q9TPS6
- Q9TPT2
- Q9TPT4
- Q9TPT6
- Q9TPV2
- Q9TQG1
- Q9TQH3
- Q9TQH6
- Q9TQH7
- Q9TQH8
- Q9TQH9
- Q9TQM2
- Q9TQN4
- Q9TQN6
- Q9UQS8
- Q9UQT0
Protein attributes for HLA-B Gene
- Size:
- 362 amino acids
- Molecular mass:
- 40460 Da
- Quaternary structure:
-
- Heterotrimer that consists of an alpha chain HLA-B, a beta chain B2M and a peptide (peptide-HLA-B-B2M) (PubMed:25808313, PubMed:29531227, PubMed:15657948, PubMed:17057332, PubMed:22020283, PubMed:24600035). Early in biogenesis, HLA-B-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR (PubMed:9036970, PubMed:9620674, PubMed:26439010, PubMed:26416272). Interacts with TAP1-TAP2 transporter via TAPBP; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:9036970, PubMed:9620674). Interacts with TAPBPL; TAPBPL binds peptide-free HLA-B-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange for higher affinity peptides (PubMed:26439010). Only optimally assembled peptide-HLA-B-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. HLA-B (via polymorphic alpha-1 and alpha-2 domains) interacts with antigen-specific TCR (via CDR1, CDR2 and CDR3 domains) (PubMed:29531227, PubMed:24600035). One HLA-B molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction insures peptide-HLA-B-B2M recognition by CD8-positive T cells only (PubMed:29531227). Allele B*57:01 interacts (via Bw4 motif) with KIR3DL1 (via Ig-like C2-type domain); this interaction may interfere with peptide binding (PubMed:22020283, PubMed:25480565). Allele B*46:01 interacts with KIR2DL3 (PubMed:28514659).
- (Microbial infection) Interacts with HTLV-1 accessory protein p12I.
Protein Expression for HLA-B Gene
Post-translational modifications for HLA-B Gene
Other Protein References for HLA-B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ HLA-B Antibody
- GeneTex Anti-HLA-B7 antibody [BB7.1] and Anti-HLA-B antibody
-
Custom Antibody ServicesOriGene Antibodies for HLA-B
- Novus Biologicals Antibodies for HLA-B
- Invitrogen Antibodies for HLA-B (AFLGC-HLA-B)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HLA-B
- Sino Biological Antibodies for HLA-B
Protein Products
-
OriGene Purified Proteins for HLA-B
- Search Origene for MassSpec and Protein Over-expression Lysates for HLA-B
- Origene Custom Protein Services for HLA-B
- Novus Biologicals lysates for HLA-B
Assay Products
-
Signalway ELISA kits for HLA-B
No data available for DME Specific Peptides for HLA-B Gene
Domains & Families for HLA-B Gene
Gene Families for HLA-B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for HLA-B Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-type
- MHC class I signature
- MHC_I, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for HLA-B Gene
- GenScript: Design optimal peptide antigens:
-
- MHC class I antigen (E5G0Z4_HUMAN)
- MHC class I antigen (E5G0Z5_HUMAN)
- MHC class I antigen (E5G0Z6_HUMAN)
- MHC class I antigen (E5G0Z7_HUMAN)
- MHC class I antigen (E5G0Z8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P01889UniProtKB/Swiss-Prot:
HLAB_HUMAN :- The alpha-1 domain is a structural part of the peptide-binding cleft (PubMed:25808313). Residues 101-107 determine Bw4/Bw6 motifs, which serologically distinguish HLA-B alleles. Each HLA-B allele posseses either the Bw4 or Bw6 motif. Only HLA-B alleles bearing the Bw4 epitope are recognized by NK cell inhibitory receptor KIR3DL1 (PubMed:25480565, PubMed:22020283).
- Domain:
-
- The alpha-1 domain is a structural part of the peptide-binding cleft (PubMed:25808313). Residues 101-107 determine Bw4/Bw6 motifs, which serologically distinguish HLA-B alleles. Each HLA-B allele posseses either the Bw4 or Bw6 motif. Only HLA-B alleles bearing the Bw4 epitope are recognized by NK cell inhibitory receptor KIR3DL1 (PubMed:25480565, PubMed:22020283).
- The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:25808313). Mediates the interaction with TAP1-TAP2 complex (By similarity).
- The alpha-3 Ig-like domain mediates the interaction with CD8 coreceptor.
Function for HLA-B Gene
Molecular function for HLA-B Gene
- UniProtKB/Swiss-Prot Function:
- Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227, PubMed:9620674, PubMed:23209413). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7743181, PubMed:18991276). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:29531227, PubMed:9620674, PubMed:24600035). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227).
- UniProtKB/Swiss-Prot Function:
- Allele B*07:02: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and mainly a Leu anchor residue at the C-terminus (PubMed:7743181). Presents a long peptide (APRGPHGGAASGL) derived from the cancer-testis antigen CTAG1A/NY-ESO-1, eliciting a polyclonal CD8-positive T cell response against tumor cells (PubMed:29531227). Presents viral epitopes derived from HIV-1 gag-pol (TPQDLNTML) and Nef (RPQVPLRPM) (PubMed:25808313). Displays self-peptides including a peptide derived from the signal sequence of HLA-DPB1 (APRTVALTA) (PubMed:7743181).
- UniProtKB/Swiss-Prot Function:
- Allele B*08:01: Presents to CD8-positive T cells viral epitopes derived from EBV/HHV-4 EBNA3 (QAKWRLQTL), eliciting cytotoxic T cell response.
- UniProtKB/Swiss-Prot Function:
- Allele B*13:02: Presents multiple HIV-1 epitopes derived from gag (RQANFLGKI, GQMREPRGSDI), nef (RQDILDLWI), gag-pol (RQYDQILIE, GQGQWTYQI) and rev (LQLPPLERL), all having in common a Gln residue at position 2 and mainly hydrophobic amino acids Leu, Ile or Val at the C-terminus. Associated with succesful control of HIV-1 infection.
- UniProtKB/Swiss-Prot Function:
- Allele B*18:01: Preferentially presents octomeric and nonameric peptides sharing a common motif, namely a Glu at position 2 and Phe or Tyr anchor residues at the C-terminus (PubMed:14978097, PubMed:23749632, PubMed:18991276). Presents an EBV/HHV-4 epitope derived from BZLF1 (SELEIKRY) (PubMed:23749632). May present to CD8-positive T cells an antigenic peptide derived from MAGEA3 (MEVDPIGHLY), triggering an anti-tumor immune response (PubMed:12366779). May display a broad repertoire of self-peptides with a preference for peptides derived from RNA-binding proteins (PubMed:14978097).
- UniProtKB/Swiss-Prot Function:
- Allele B*27:05: Presents to CD8-positive T cells immunodominant viral epitopes derived from HCV POLG (ARMILMTHF), HIV-1 gag (KRWIILGLNK), IAV NP (SRYWAIRTR), EBV/HHV-4 EBNA4 (HRCQAIRKK) and EBV/HHV-4 EBNA6 (RRIYDLIEL), confering longterm protection against viral infection (PubMed:19139562, PubMed:18385228, PubMed:15113903, PubMed:9620674). Can present self-peptides derived from cytosolic and nuclear proteins. All peptides carry an Arg at position 2 (PubMed:1922338). The peptide-bound form interacts with NK cell inhibitory receptor KIR3DL1 and inhibits NK cell activation in a peptide-specific way, being particularly sensitive to the nature of the amino acid side chain at position 8 of the antigenic peptide (PubMed:8879234, PubMed:15657948). KIR3DL1 fails to recognize HLA-B*27:05 in complex with B2M and EBV/HHV-4 EBNA6 (RRIYDLIEL) peptide, which can lead to increased activation of NK cells during infection (PubMed:15657948). May present an altered repertoire of peptides in the absence of TAP1-TAP2 and TAPBPL (PubMed:9620674).
- UniProtKB/Swiss-Prot Function:
- Allele B*40:01: Presents an immunodominant viral epitope derived from EBV/HHV-4 LMP2 (IEDPPFNSL), triggering memory CD8-positive T cell response (PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and a Leu anchor residue at the C-terminus (PubMed:18991276).
- UniProtKB/Swiss-Prot Function:
- Allele B*41:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
- UniProtKB/Swiss-Prot Function:
- Allele B*44:02: Presents immunodominant viral epitopes derived from EBV/HHV-4 EBNA4 (VEITPYKPTW) and EBNA6 (AEGGVGWRHW, EENLLDFVRF), triggering memory CD8-positive T cell response (PubMed:9620674, PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Phe, Tyr or Trp anchor residues at the C-terminus (PubMed:18991276).
- UniProtKB/Swiss-Prot Function:
- Allele B*45:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
- UniProtKB/Swiss-Prot Function:
- Allele B*46:01: Preferentially presents nonameric peptides sharing a signature motif, namely Ala and Leu at position 2 and Tyr, Phe, Leu, or Met anchor residues at the C-terminus. The peptide-bound form interacts with KIR2DL3 and inhibits NK cell cytotoxic response in a peptide-specific way.
- UniProtKB/Swiss-Prot Function:
- Allele B*47:01: Displays self-peptides sharing a signature motif, namely an Asp at position 2 and Leu or Met anchor residues at the C-terminus.
- UniProtKB/Swiss-Prot Function:
- Allele B*49:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ile or Val anchor residues at the C-terminus.
- UniProtKB/Swiss-Prot Function:
- Allele B*50:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.
- UniProtKB/Swiss-Prot Function:
- Allele B*51:01: Presents an octomeric HIV-1 epitope derived from gag-pol (TAFTIPSI) to the public TRAV17/TRBV7-3 TCR clonotype, strongly suppressing HIV-1 replication.
- UniProtKB/Swiss-Prot Function:
- Allele B*54:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
- UniProtKB/Swiss-Prot Function:
- Allele B*55:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
- UniProtKB/Swiss-Prot Function:
- Allele B*56:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.
- UniProtKB/Swiss-Prot Function:
- Allele B*57:01: The peptide-bound form recognizes KIR3DL1 and inhibits NK cell cytotoxic response.
- UniProtKB/Swiss-Prot Function:
- Allele B*67:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Leu anchor residue at the C-terminus.
- GENATLAS Biochemistry:
- HLA-B,beta chain,44kDa,class Ia (see MHC1)
Phenotypes From GWAS Catalog for HLA-B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IPI | 8046333 |
| GO:0005515 | protein binding | IPI | 19858347 |
| GO:0042605 | peptide antigen binding | IDA | 22031944 |
| GO:0046977 | NOT TAP binding | IDA | 8617941 |
| GO:0051087 | chaperone binding | IPI | 15056662 |
Phenotypes for HLA-B Gene
- GenomeRNAi human phenotypes for HLA-B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HLA-B - Select products 50% OFF >
- * HLA-B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HLA-B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HLA-B
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-B
miRNA for HLA-B Gene
- miRTarBase miRNAs that target HLA-B
-
- hsa-miR-615-3p (MIRT039965)
- hsa-miR-3653-3p (MIRT392124)
- hsa-miR-30e-3p (MIRT486949)
- hsa-miR-30d-3p (MIRT486950)
- hsa-miR-30a-3p (MIRT486951)
- hsa-miR-5047 (MIRT486952)
- hsa-miR-1301-3p (MIRT486953)
- hsa-miR-7156-3p (MIRT486954)
- hsa-miR-222-5p (MIRT486955)
- hsa-miR-4660 (MIRT486956)
- hsa-miR-548ax (MIRT486957)
- hsa-miR-548ao-5p (MIRT486958)
- hsa-miR-3129-5p (MIRT486959)
- hsa-miR-199b-3p (MIRT486960)
- hsa-miR-199a-3p (MIRT486961)
- hsa-miR-936 (MIRT486962)
- hsa-miR-10b-3p (MIRT486963)
- hsa-miR-9500 (MIRT486964)
- hsa-miR-6822-5p (MIRT486965)
- hsa-miR-5584-5p (MIRT486966)
- hsa-miR-6750-5p (MIRT486967)
- hsa-miR-495-5p (MIRT486968)
- hsa-miR-6818-3p (MIRT716680)
- hsa-miR-3620-5p (MIRT716681)
- hsa-miR-1587 (MIRT716682)
- hsa-miR-4417 (MIRT716683)
- hsa-miR-593-3p (MIRT716684)
- hsa-miR-6895-3p (MIRT716685)
- hsa-miR-654-5p (MIRT716686)
- hsa-miR-541-3p (MIRT716687)
- hsa-miR-6766-5p (MIRT716688)
- hsa-miR-6756-5p (MIRT716689)
- hsa-miR-4741 (MIRT716690)
- hsa-miR-4675 (MIRT716691)
- hsa-miR-762 (MIRT716692)
- hsa-miR-5001-5p (MIRT716693)
- hsa-miR-4498 (MIRT716694)
- hsa-miR-4492 (MIRT716695)
- hsa-miR-6829-5p (MIRT716696)
- hsa-miR-4656 (MIRT716697)
- hsa-miR-6876-3p (MIRT716698)
- hsa-miR-626 (MIRT716699)
- hsa-miR-6845-3p (MIRT716700)
- hsa-miR-1306-5p (MIRT716701)
miRNA Products
Inhibitory RNA Products
- Origene shrna and sirna products in human, mouse, rat for HLA-B
- Browse OriGene Inhibitory RNA Products For HLA-B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-B
Clone Products
- Applied Biological Materials (abm): Clones for HLA-B - Select products 50% OFF >
- * HLA-B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HLA-B
- Addgene plasmids for HLA-B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HLA-B
Cell Line Products
-
Horizon Cell Lines for HLA-B
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-B Gene
Localization for HLA-B Gene
Subcellular locations from UniProtKB/Swiss-Prot for HLA-B Gene
- Cell membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| golgi apparatus | 5 |
| endosome | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005783 | endoplasmic reticulum | IEA,IDA | 20946353 |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | 20946353 |
| GO:0005886 | plasma membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HLA-B Gene
Pathways & Interactions for HLA-B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Allograft rejection |
CTL Mediated Apoptosis
.38
|
|
| 2 | Antigen processing-Cross presentation |
Immune response Antigen presentation by MHC class I
.51
|
|
| 3 | Human cytomegalovirus infection | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | Immune response Role of DAP12 receptors in NK cells |
Immune response Role of DAP12 receptors in NK cells
.32
|
|
Pathways by source for HLA-B Gene
3 BioSystems pathways for HLA-B Gene
15 Reactome pathways for HLA-B Gene
19 KEGG pathways for HLA-B Gene
2 GeneGo (Thomson Reuters) pathways for HLA-B Gene
- Immune response Antigen presentation by MHC class I
- Immune response Role of DAP12 receptors in NK cells
2 Qiagen pathways for HLA-B Gene
- CDC42 Pathway
- CTL Mediated Apoptosis
Interacting Proteins for HLA-B Gene
Selected Interacting proteins:
P01889-HLAB_HUMAN
ENSP00000399168
for HLA-B Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HLA-B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001916 | positive regulation of T cell mediated cytotoxicity | IDA | 2420472 |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
Drugs & Compounds for HLA-B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Abacavir | Approved, Investigational | Pharma | Target | 231 | ||
| Carbamazepine | Approved, Investigational | Pharma | Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant | 104 | ||
| Coccidioides immitis spherule | Approved | Pharma | Target | 0 | ||
| Acetazolamide | Approved, Vet_approved | Pharma | 114 | |||
| Allopurinol | Approved | Pharma | 176 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Glycerylphosphorylethanolamine |
|
1190-00-7 |
|
Transcripts for HLA-B Gene
mRNA/cDNA for HLA-B Gene
- 1 REFSEQ mRNAs :
- 292 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000412585 1536 nts (view in UCSC)
- ENST00000434333 863 nts (view in UCSC)
- ENST00000463574 588 nts (view in UCSC)
- ENST00000474381 1139 nts (view in UCSC)
- ENST00000481849 753 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HLA-B - Select products 50% OFF >
- * HLA-B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HLA-B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HLA-B
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-B
miRNA Products
Inhibitory RNA Products
- Origene shrna and sirna products in human, mouse, rat for HLA-B
- Browse OriGene Inhibitory RNA Products For HLA-B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HLA-B
Clone Products
- Applied Biological Materials (abm): Clones for HLA-B - Select products 50% OFF >
- * HLA-B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HLA-B
- Addgene plasmids for HLA-B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HLA-B
Relevant External Links for HLA-B Gene
- GeneLoc Exon Structure for
- HLA-B
Expression for HLA-B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- Double Positive Thymocytes Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- Double Positive Thymocytes Thymus
- Adipose (Muscoskeletal System)
- Mesenchymal Stem Cells
- Umbilical Cord (Extraembryonic Tissues)
-
Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HLA-B Gene
This gene is overexpressed in Whole Blood (x15.6).
This gene is overexpressed in Amniocyte (36.4) and Oral epithelium (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HLA-B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HLA-B
SOURCE GeneReport for Unigene cluster for HLA-B Gene:
Hs.77961Evidence on tissue expression from TISSUES for HLA-B Gene
- Nervous system(5)
- Blood(5)
- Intestine(5)
- Liver(5)
- Lung(5)
- Spleen(4.9)
- Pancreas(4.8)
- Stomach(4.8)
- Skin(4.7)
- Thyroid gland(4)
- Eye(4)
- Kidney(4)
- Heart(3.7)
- Muscle(3.6)
- Bone(3.1)
- Bone marrow(2.5)
- Lymph node(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-B Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cranial nerve
- ear
- eye
- face
- head
- meninges
- mouth
- neck
- salivary gland
Thorax:
- aorta
- esophagus
- heart
- heart valve
- lung
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Pelvis:
- penis
- testicle
- vagina
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- hair
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal cord
- sweat gland
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for HLA-B
-
OriGene qPCR primer pairs and template standards for HLA-B
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for HLA-B Gene
Orthologs for HLA-B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PATR-B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BOLA-A 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | DLA88 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100217322 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC796419 30 |
|
- Species where no ortholog for HLA-B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for HLA-B Gene
Paralogs for HLA-B Gene
(147) SIMAP similar genes for HLA-B Gene using alignment to 6308 proteins:
- 1B07_HUMAN
- 1B08_HUMAN
- 1B13_HUMAN
- 1B14_HUMAN
- 1B15_HUMAN
- 1B18_HUMAN
- 1B27_HUMAN
- 1B35_HUMAN
- 1B37_HUMAN
- 1B38_HUMAN
- 1B39_HUMAN
- 1B40_HUMAN
- 1B41_HUMAN
- 1B42_HUMAN
- 1B44_HUMAN
- 1B45_HUMAN
- 1B46_HUMAN
- 1B47_HUMAN
- 1B48_HUMAN
- 1B49_HUMAN
- 1B50_HUMAN
- 1B51_HUMAN
- 1B52_HUMAN
- 1B53_HUMAN
- 1B54_HUMAN
- 1B55_HUMAN
- 1B56_HUMAN
- 1B57_HUMAN
- 1B58_HUMAN
- 1B59_HUMAN
- 1B67_HUMAN
- 1B73_HUMAN
- 1B78_HUMAN
- 1B81_HUMAN
- 1B82_HUMAN
- A0FIZ3_HUMAN
- A0FIZ4_HUMAN
- A0FKC4_HUMAN
- A0FKC5_HUMAN
- A0JCS1_HUMAN
- A0JKD1_HUMAN
- A0MNW2_HUMAN
- A0MVW9_HUMAN
- A0N001_HUMAN
- A0N0V9_HUMAN
- A0N0W4_HUMAN
- A0PCH6_HUMAN
- A0PCH7_HUMAN
- A1DS52_HUMAN
- A1DZT3_HUMAN
- A1DZT9_HUMAN
- A1DZU0_HUMAN
- A1DZU1_HUMAN
- A1E2C1_HUMAN
- A1E2R4_HUMAN
- A1EAG1_HUMAN
- A1EC34_HUMAN
- A1IVL5_HUMAN
- A1KQY2_HUMAN
- A1KR26_HUMAN
- A1KWR0_HUMAN
- A1XAM5_HUMAN
- A1YRJ1_HUMAN
- A1YWK4_HUMAN
- A1Z0L0_HUMAN
- A1Z0L1_HUMAN
- A1Z0L2_HUMAN
- A1Z0L3_HUMAN
- A1Z0L5_HUMAN
- A1Z0L8_HUMAN
- A1Z0M3_HUMAN
- A1Z1N9_HUMAN
- A1Z288_HUMAN
- A1Z289_HUMAN
- A1Z290_HUMAN
- A1Z291_HUMAN
- A1Z3E0_HUMAN
- A2IAT8_HUMAN
- A2ICZ8_HUMAN
- A2Q118_HUMAN
- A2Q119_HUMAN
- A2RQE1_HUMAN
- A2TDT1_HUMAN
- A2TEL9_HUMAN
- A2TEM0_HUMAN
- A2TEM1_HUMAN
- A2TEM2_HUMAN
- A2TEM6_HUMAN
- A2TEM7_HUMAN
- A2TEM8_HUMAN
- A2TJS3_HUMAN
- A2TJS4_HUMAN
- A2VBB7_HUMAN
- A2VBX9_HUMAN
- A2VBY0_HUMAN
- A2VBY1_HUMAN
- A2VBZ9_HUMAN
- A2VC07_HUMAN
- A2VC08_HUMAN
- A3EYJ3_HUMAN
- A3EYJ4_HUMAN
- A3F718_HUMAN
- A3F719_HUMAN
- A3F720_HUMAN
- A3F967_HUMAN
- A3FEK4_HUMAN
- A3FEM0_HUMAN
- A3FFS6_HUMAN
- A3FFS7_HUMAN
- A3FG53_HUMAN
- A3FG54_HUMAN
- A3FG55_HUMAN
- A3FG56_HUMAN
- A3FG57_HUMAN
- A3FG58_HUMAN
- A3FG59_HUMAN
- A3FG60_HUMAN
- A3FG61_HUMAN
- A3FG62_HUMAN
- A3FG64_HUMAN
- A3FG65_HUMAN
- A3FG66_HUMAN
- A3FP42_HUMAN
- A3KE32_HUMAN
- A3KLI7_HUMAN
- A3RKJ7_HUMAN
- A3RKJ8_HUMAN
- A3RKK0_HUMAN
- A3RLM7_HUMAN
- A4FRG0_HUMAN
- A4FRG1_HUMAN
- A4FSH4_HUMAN
- A4GWZ2_HUMAN
- A4GX62_HUMAN
- A4L9N8_HUMAN
- A4Q971_HUMAN
- A4Q972_HUMAN
- A4UQL5_HUMAN
- A4URH0_HUMAN
- A4URH7_HUMAN
- A4USG3_HUMAN
- A4USG4_HUMAN
- A4UYK5_HUMAN
- A4ZVL4_HUMAN
- A4ZW43_HUMAN
- A4ZX99_HUMAN
- A4ZY85_HUMAN
- A5A163_HUMAN
- A5A340_HUMAN
- A5A8M8_HUMAN
- A5CLI0_HUMAN
- A5CVD8_HUMAN
- A5H2C3_HUMAN
- A5HC28_HUMAN
- A5HC71_HUMAN
- A5HC72_HUMAN
- A5HC73_HUMAN
- A5HDH5_HUMAN
- A5HDH6_HUMAN
- A5HKN5_HUMAN
- A5HKN6_HUMAN
- A5HM76_HUMAN
- A5HNU4_HUMAN
- A5JSG4_HUMAN
- A5JSG7_HUMAN
- A5LIC1_HUMAN
- A5PHK0_HUMAN
- A5PHP5_HUMAN
- A5PHP6_HUMAN
- A5PHT2_HUMAN
- A5PHT8_HUMAN
- A5PI53_HUMAN
- A5PI54_HUMAN
- A5Z1V7_HUMAN
- A6BML9_HUMAN
- A6H567_HUMAN
- A6H579_HUMAN
- A6H580_HUMAN
- A6MWD8_HUMAN
- A6MWD9_HUMAN
- A6N5Y9_HUMAN
- A6N842_HUMAN
- A6N843_HUMAN
- A6N8I8_HUMAN
- A6Q0R2_HUMAN
- A7E1B6_HUMAN
- A7E1C2_HUMAN
- A7E1C3_HUMAN
- A7L6C1_HUMAN
- A7L6C2_HUMAN
- A7LB38_HUMAN
- A7LB39_HUMAN
- A7MAD9_HUMAN
- A7MAE0_HUMAN
- A7MAK0_HUMAN
- A7MAK1_HUMAN
- A7MAP7_HUMAN
- A7U4Z6_HUMAN
- A7U8S2_HUMAN
- A7U8S3_HUMAN
- A7U8S4_HUMAN
- A7U966_HUMAN
- A7UDB3_HUMAN
- A7UM66_HUMAN
- A7UM83_HUMAN
- A7UM86_HUMAN
- A7UM87_HUMAN
- A7WPI6_HUMAN
- A7WPJ0_HUMAN
- A7WPJ1_HUMAN
- A7XBN0_HUMAN
- A7XBN3_HUMAN
- A7XFV8_HUMAN
- A7XNK1_HUMAN
- A7XPU1_HUMAN
- A8CKI4_HUMAN
- A8D9X9_HUMAN
- A8E0S0_HUMAN
- A8E0Y5_HUMAN
- A8E0Y6_HUMAN
- A8E1W1_HUMAN
- A8KNJ4_HUMAN
- A8R7G2_HUMAN
- A8U3X0_HUMAN
- A8UHA5_HUMAN
- A8VU75_HUMAN
- A8VYQ2_HUMAN
- A8VYQ6_HUMAN
- A8VYR0_HUMAN
- A8VYR4_HUMAN
- A8VYR7_HUMAN
- A8VYR8_HUMAN
- A8VYR9_HUMAN
- A8VYS0_HUMAN
- A8YQE7_HUMAN
- A8YQF0_HUMAN
- A8YQF1_HUMAN
- A8YQG9_HUMAN
- A8YQI3_HUMAN
- A8YQI4_HUMAN
- A8YQI6_HUMAN
- A9J7N0_HUMAN
- A9J7N7_HUMAN
- A9J7P1_HUMAN
- A9J7P3_HUMAN
- A9JIG5_HUMAN
- A9JNR9_HUMAN
- A9JPE7_HUMAN
- A9JPE8_HUMAN
- A9QUT8_HUMAN
- A9QVM5_HUMAN
- A9XFY0_HUMAN
- A9XFY1_HUMAN
- A9XFY2_HUMAN
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