HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. T... See more...

Aliases for HLA-A Gene

Aliases for HLA-A Gene

  • Major Histocompatibility Complex, Class I, A 2 3 5
  • HLA Class I Histocompatibility Antigen, A-1 Alpha Chain 3 4
  • HLAA 3 4
  • HLA Class I Histocompatibility Antigen, A-10 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-28 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-11 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-23 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-24 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-25 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-26 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-29 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-30 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-31 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-32 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-33 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-34 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-36 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-43 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-66 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-68 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-69 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-74 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-80 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-9 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-2 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-3 Alpha Chain 4
  • MHC Class I Antigen HLA-A Heavy Chain 3
  • Human Leukocyte Antigen A*01 4
  • Human Leukocyte Antigen A*02 4
  • Human Leukocyte Antigen A*03 4
  • Leukocyte Antigen Class I-A 3
  • MHC Class I Antigen A*11 4
  • MHC Class I Antigen A*23 4
  • MHC Class I Antigen A*24 4
  • MHC Class I Antigen A*25 4
  • MHC Class I Antigen A*26 4
  • MHC Class I Antigen A*29 4
  • MHC Class I Antigen A*30 4
  • MHC Class I Antigen A*31 4
  • MHC Class I Antigen A*32 4
  • MHC Class I Antigen A*33 4
  • MHC Class I Antigen A*34 4
  • MHC Class I Antigen A*36 4
  • MHC Class I Antigen A*43 4
  • MHC Class I Antigen A*66 4
  • MHC Class I Antigen A*68 4
  • MHC Class I Antigen A*69 4
  • MHC Class I Antigen A*74 4
  • MHC Class I Antigen A*80 4
  • HLA-A*01 4
  • HLA-A*02 4
  • HLA-A*03 4
  • Aw-19 4
  • Aw-24 4
  • Aw-33 4
  • Aw-34 4
  • Aw-36 4
  • Aw-43 4
  • Aw-66 4
  • Aw-68 4
  • Aw-69 4
  • Aw-74 4
  • Aw-80 4

External Ids for HLA-A Gene

Previous GeneCards Identifiers for HLA-A Gene

  • GC06P029953
  • GC06P029626
  • GC06P029902
  • GC06P030016
  • GC06P030019
  • GC06P030020
  • GC06P029916
  • GC06P029918
  • GC06P029921
  • GC06P029933
  • GC06P029949
  • GC06P030186
  • GC06P030205
  • GC06P030244
  • GC06P032253
  • GC06P032430
  • GC06P030355
  • GC06P030504
  • GC06P030707
  • GC06P030868
  • GC06P031028
  • GC06P031179
  • GC06P031361
  • GC06P031772

Summaries for HLA-A Gene

Entrez Gene Summary for HLA-A Gene

  • HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-A Gene

HLA-A (Major Histocompatibility Complex, Class I, A) is a Protein Coding gene. Diseases associated with HLA-A include Severe Cutaneous Adverse Reaction and Birdshot Chorioretinopathy. Among its related pathways are Phagosome and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include peptide antigen binding. An important paralog of this gene is HLA-B.

UniProtKB/Swiss-Prot Summary for HLA-A Gene

  • Antigen-presenting major histocompatibility complex class I (MHCI) molecule, HLA-A*01 serotype. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A*01-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:19177349, PubMed:26758806, PubMed:24395804). May also present self-peptides, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17189421, PubMed:20364150). Can bind different peptides that share a common structural motif defined by the nature of the peptide anchor residues. HLA-A*01:01 presents a restricted peptide repertoire including viral epitopes derived from IAV NP/nucleoprotein (CTELKLSDY), IAV PB1/polymerase basic protein 1 (VSDGGPNLY), HAdV-11 capsid L3/hexon protein (LTDLGQNLLY) as well as tumor peptide antigens including MAGE1 (EADPTGHSY), MAGEA3 (EVDPIGHLY) and WT1 (TSEKRPFMCAY), all having in common a canonical motif with a negatively charged Asp or Glu residue at position 3 and a Tyr anchor residue at C-terminal (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:20364150, PubMed:25880248, PubMed:30530481, PubMed:24395804, PubMed:26758806). A number of HLA-A*01:01-restricted peptides carry a post-translational modification with oxidation and N-terminal acetylation being the most frequent (PubMed:25880248). Fails to present highly immunogenic peptides from the EBV latent antigens (PubMed:18779413).
  • Antigen-presenting major histocompatibility complex class I (MHCI) molecule, HLA-A*02 serotype. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A*02-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:7694806, PubMed:2784196, PubMed:12138174, PubMed:12796775, PubMed:28250417, PubMed:8906788, PubMed:19542454, PubMed:20619457). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7935798). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 11 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome (PubMed:17079320, PubMed:26929325). Can bind different peptides that share a common structural motif defined by the nature of the peptide anchor residues (PubMed:7935798, PubMed:8906788, PubMed:8805302, PubMed:8630735, PubMed:22245737). HLA-A*02:01, a major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at C-terminal anchors (PubMed:12796775, PubMed:8805302, PubMed:8630735, PubMed:9177355, PubMed:20619457, PubMed:18275829, PubMed:28250417, PubMed:7694806, PubMed:8906788, PubMed:11502003, PubMed:19542454, PubMed:12138174).
  • Antigen-presenting major histocompatibility complex class I (MHCI) molecule, HLA-A*03 serotype. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A*03-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:2456340, PubMed:7504010, PubMed:7679507, PubMed:9862734, PubMed:19543285, PubMed:21943705). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 11 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome (PubMed:27049119). Can bind different peptides that share a common structural motif defined by the nature of the peptide anchor residues. HLA-A*03:01 presents viral epitopes derived from IAV NP (ILRGSVAHK), HIV-1 nef (QVPLRPMTYK), HIV-1 gag-pol (AIFQSSMTK) as well tumor peptide antigens including PMEL (LIYRRRLMK), NODAL (HAYIQSLLK), TRP-2 (RMYNMVPFF), all having in common hydrophobic amino acids at position 2 and LYS or ARG anchor residues at C-terminal (PubMed:7504010, PubMed:7679507, PubMed:9862734, PubMed:19543285, PubMed:21943705). May also display spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119).

Gene Wiki entry for HLA-A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HLA-A Gene

Genomics for HLA-A Gene

GeneHancer (GH) Regulatory Elements for HLA-A Gene

Promoters and enhancers for HLA-A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLA-A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HLA-A gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • MyoD
  • NF-kappaB1

Genomic Locations for HLA-A Gene

Genomic Locations for HLA-A Gene
chr6:29,941,260-29,945,884
(GRCh38/hg38)
Size:
4,625 bases
Orientation:
Plus strand
chr6:29,909,037-29,913,661
(GRCh37/hg19)
Size:
4,625 bases
Orientation:
Plus strand

Genomic View for HLA-A Gene

Genes around HLA-A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-A Gene

  • Protein details for HLA-A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01892-1A02_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, A-2 alpha chain
    Protein Accession:
    P01892
    Secondary Accessions:
    • O19619
    • P06338
    • P10313
    • P30444
    • P30445
    • P30446
    • P30514
    • Q29680
    • Q29837
    • Q29899
    • Q95352
    • Q95380
    • Q9TPX8
    • Q9TPX9
    • Q9TPY0
    • Q9TQH5
    • Q9TQI3

    Protein attributes for HLA-A Gene

    Size:
    365 amino acids
    Molecular mass:
    40922 Da
    Quaternary structure:
    • Heterotrimer that consists of an alpha chain HLA-A*02, a beta chain B2M and a peptide (peptide-HLA-A*02-B2M) (PubMed:8805302, PubMed:7694806, PubMed:7935798, PubMed:9177355, PubMed:18275829, PubMed:22245737, PubMed:28250417, PubMed:11502003). Early in biogenesis, HLA-A*02-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR (PubMed:21263072). Interacts with TAP1-TAP2 transporter via TAPBP; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:8805302, PubMed:8630735, PubMed:21263072). Interacts with TAPBPL; TAPBPL binds peptide-free HLA-A*02-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange for higher affinity peptides (PubMed:26869717). Only optimally assembled peptide-HLA-A*02-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. HLA-A*02 (via polymorphic alpha-1 and alpha-2 domains) interacts with antigen-specific TCR (via CDR3 domains) (PubMed:22245737, PubMed:12796775, PubMed:18275829). One HLA-A*02 molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction insures peptide-HLA-A*02-B2M recognition by CD8-positive T cells only (PubMed:9177355, PubMed:2784196).
    • (Microbial infection) Interacts with HHV-8 MIR1 protein.
    • (Microbial infection) Interacts with HTLV-1 accessory protein p12I.
    SequenceCaution:
    • Sequence=CAA41022.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown extensively.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HLA-A Gene

neXtProt entry for HLA-A Gene

Post-translational modifications for HLA-A Gene

Other Protein References for HLA-A Gene

Antibody Products

No data available for DME Specific Peptides for HLA-A Gene

Domains & Families for HLA-A Gene

Gene Families for HLA-A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for HLA-A Gene

GenScript: Design optimal peptide antigens:
  • MHC class I antigen A*1 (1A01_HUMAN)
  • MHC class I antigen A*2 (1A02_HUMAN)
  • MHC class I antigen A*3 (1A03_HUMAN)
  • MHC class I antigen A*11 (1A11_HUMAN)
  • MHC class I antigen A*23 (1A23_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30443

UniProtKB/Swiss-Prot:

1A23_HUMAN :
  • The alpha-1 domain is a structural part of the peptide-binding cleft.
  • Belongs to the MHC class I family.
Domain:
  • The alpha-1 domain is a structural part of the peptide-binding cleft.
  • The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:19177349, PubMed:26758806, PubMed:24395804). Mediates the interaction with TAP1-TAP2 complex (By similarity).
  • The alpha-3 Ig-like domain mediates the interaction with CD8 coreceptor.
  • The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:7694806, PubMed:8906788, PubMed:2784196, PubMed:28250417, PubMed:22245737, PubMed:19542454, PubMed:20619457). Mediates the interaction with TAP1-TAP2 complex (PubMed:8805302).
  • The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:21543847, PubMed:21943705). Mediates the interaction with TAP1-TAP2 complex (By similarity).
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-A: view

Function for HLA-A Gene

Molecular function for HLA-A Gene

UniProtKB/Swiss-Prot Function:
Antigen-presenting major histocompatibility complex class I (MHCI) molecule, HLA-A*01 serotype. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A*01-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:19177349, PubMed:26758806, PubMed:24395804). May also present self-peptides, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17189421, PubMed:20364150). Can bind different peptides that share a common structural motif defined by the nature of the peptide anchor residues. HLA-A*01:01 presents a restricted peptide repertoire including viral epitopes derived from IAV NP/nucleoprotein (CTELKLSDY), IAV PB1/polymerase basic protein 1 (VSDGGPNLY), HAdV-11 capsid L3/hexon protein (LTDLGQNLLY) as well as tumor peptide antigens including MAGE1 (EADPTGHSY), MAGEA3 (EVDPIGHLY) and WT1 (TSEKRPFMCAY), all having in common a canonical motif with a negatively charged Asp or Glu residue at position 3 and a Tyr anchor residue at C-terminal (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:20364150, PubMed:25880248, PubMed:30530481, PubMed:24395804, PubMed:26758806). A number of HLA-A*01:01-restricted peptides carry a post-translational modification with oxidation and N-terminal acetylation being the most frequent (PubMed:25880248). Fails to present highly immunogenic peptides from the EBV latent antigens (PubMed:18779413).
UniProtKB/Swiss-Prot Function:
Antigen-presenting major histocompatibility complex class I (MHCI) molecule, HLA-A*02 serotype. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A*02-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:7694806, PubMed:2784196, PubMed:12138174, PubMed:12796775, PubMed:28250417, PubMed:8906788, PubMed:19542454, PubMed:20619457). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7935798). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 11 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome (PubMed:17079320, PubMed:26929325). Can bind different peptides that share a common structural motif defined by the nature of the peptide anchor residues (PubMed:7935798, PubMed:8906788, PubMed:8805302, PubMed:8630735, PubMed:22245737). HLA-A*02:01, a major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at C-terminal anchors (PubMed:12796775, PubMed:8805302, PubMed:8630735, PubMed:9177355, PubMed:20619457, PubMed:18275829, PubMed:28250417, PubMed:7694806, PubMed:8906788, PubMed:11502003, PubMed:19542454, PubMed:12138174).
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG, and proinflammatory cytokines IL1B and TNF.
UniProtKB/Swiss-Prot Function:
Antigen-presenting major histocompatibility complex class I (MHCI) molecule, HLA-A*03 serotype. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A*03-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:2456340, PubMed:7504010, PubMed:7679507, PubMed:9862734, PubMed:19543285, PubMed:21943705). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 11 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome (PubMed:27049119). Can bind different peptides that share a common structural motif defined by the nature of the peptide anchor residues. HLA-A*03:01 presents viral epitopes derived from IAV NP (ILRGSVAHK), HIV-1 nef (QVPLRPMTYK), HIV-1 gag-pol (AIFQSSMTK) as well tumor peptide antigens including PMEL (LIYRRRLMK), NODAL (HAYIQSLLK), TRP-2 (RMYNMVPFF), all having in common hydrophobic amino acids at position 2 and LYS or ARG anchor residues at C-terminal (PubMed:7504010, PubMed:7679507, PubMed:9862734, PubMed:19543285, PubMed:21943705). May also display spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119).
UniProtKB/Swiss-Prot Function:
Involved in the presentation of foreign antigens to the immune system.
GENATLAS Biochemistry:
HLA-A,alpha chain,44kDa,class Ia ,ubiquitously expressed,except central nervous system,placenta,sperm cells (see MHC1)

Phenotypes From GWAS Catalog for HLA-A Gene

Gene Ontology (GO) - Molecular Function for HLA-A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005102 signaling receptor binding IBA 21873635
GO:0005515 protein binding IPI 23401559
GO:0030881 beta-2-microglobulin binding ISS --
GO:0042605 peptide antigen binding ISS --
genes like me logo Genes that share ontologies with HLA-A: view
genes like me logo Genes that share phenotypes with HLA-A: view

Human Phenotype Ontology for HLA-A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for HLA-A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-A Gene

Localization for HLA-A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
golgi apparatus 5
extracellular 4
endosome 4
cytoskeleton 1
nucleus 1
cytosol 1
mitochondrion 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HLA-A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus ISS --
genes like me logo Genes that share ontologies with HLA-A: view

Pathways & Interactions for HLA-A Gene

genes like me logo Genes that share pathways with HLA-A: view