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Aliases for HKR1 Gene

Aliases for HKR1 Gene

  • HKR1, GLI-Kruppel Zinc Finger Family Member 2 3 5
  • Zinc Finger Protein 875 3 4
  • Oncogene HKR1 2 3
  • ZNF875 3 4
  • Krueppel-Related Zinc Finger Protein 1 3
  • GLI-Kruppel Family Member HKR1 2
  • Protein HKR1 4

External Ids for HKR1 Gene

Previous GeneCards Identifiers for HKR1 Gene

  • GC19U990048
  • GC19P042484
  • GC19P042517
  • GC19P037825
  • GC19P034275
  • GC19P037803

Summaries for HKR1 Gene

GeneCards Summary for HKR1 Gene

HKR1 (HKR1, GLI-Kruppel Zinc Finger Family Member) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF133.

UniProtKB/Swiss-Prot for HKR1 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for HKR1 Gene

Additional gene information for HKR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HKR1 Gene

Genomics for HKR1 Gene

GeneHancer (GH) Regulatory Elements for HKR1 Gene

Promoters and enhancers for HKR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J037333 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.3 +22.0 21987 1.7 PKNOX1 ATF1 SIN3A ZNF2 IRF4 BRCA1 ETS1 GLIS2 ELK1 ZNF143 HKR1 ZNF383 ZNF793 ZNF850 ZNF345 ZNF527 ZNF567 ZNF540 ZNF571 ENSG00000267682
GH19J037312 Promoter/Enhancer 1.2 Ensembl ENCODE 669.5 0.0 -37 1.3 MXI1 PKNOX1 SAP130 ZNF133 BMI1 ZNF335 E2F1 RBAK ZNF600 KLF8 HKR1 ZNF527 ZNF567 ZNF383 ZNF345 ENSG00000267682 ZNF850 ZNF793 ZNF571 ZNF573
GH19J037346 Promoter 0.7 EPDnew 654.6 +33.5 33469 0.1 ZNF610 ZIC2 HKR1 ZNF527 ENSG00000267682
GH19J037593 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 164.6 +281.9 281864 2.2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF213 ZNF571 ZNF540 ZNF567 ZNF527 ZNF345 ZNF383 HKR1 ZFP30 ZNF850 ZNF607
GH19J037653 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 159.8 +342.5 342463 3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 ZNF571 ZFP30 ZNF567 ZNF345 ZNF527 ZNF383 HKR1 ZNF850 ZNF790 ZNF607
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HKR1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HKR1 Gene

Genomic Locations for HKR1 Gene
chr19:37,312,837-37,369,365
(GRCh38/hg38)
Size:
56,529 bases
Orientation:
Plus strand
chr19:37,803,739-37,860,267
(GRCh37/hg19)
Size:
56,529 bases
Orientation:
Plus strand

Genomic View for HKR1 Gene

Genes around HKR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HKR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HKR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HKR1 Gene

Proteins for HKR1 Gene

  • Protein details for HKR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10072-HKR1_HUMAN
    Recommended name:
    Krueppel-related zinc finger protein 1
    Protein Accession:
    P10072
    Secondary Accessions:
    • A8MRS7
    • Q6PJD0
    • Q9BSW9
    • Q9UM09

    Protein attributes for HKR1 Gene

    Size:
    659 amino acids
    Molecular mass:
    75128 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86058.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HKR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HKR1 Gene

Post-translational modifications for HKR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HKR1 Gene

Domains & Families for HKR1 Gene

Gene Families for HKR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HKR1 Gene

Suggested Antigen Peptide Sequences for HKR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10072

UniProtKB/Swiss-Prot:

HKR1_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with HKR1: view

Function for HKR1 Gene

Molecular function for HKR1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
GLI-Kruppel family member HKR1

Phenotypes From GWAS Catalog for HKR1 Gene

Gene Ontology (GO) - Molecular Function for HKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0043565 sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HKR1: view
genes like me logo Genes that share phenotypes with HKR1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HKR1 Gene

Localization for HKR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HKR1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HKR1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Mitochondria (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HKR1: view

Pathways & Interactions for HKR1 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with HKR1: view

Pathways by source for HKR1 Gene

2 Reactome pathways for HKR1 Gene

Gene Ontology (GO) - Biological Process for HKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 2850480
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development NAS 2850480
genes like me logo Genes that share ontologies with HKR1: view

No data available for SIGNOR curated interactions for HKR1 Gene

Drugs & Compounds for HKR1 Gene

No Compound Related Data Available

Transcripts for HKR1 Gene

Unigene Clusters for HKR1 Gene

HKR1, GLI-Kruppel zinc finger family member:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HKR1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - -
SP12: - -
SP13: - - -

ExUns: 11h · 11i · 11j · 11k
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for HKR1 Gene

GeneLoc Exon Structure for
HKR1
ECgene alternative splicing isoforms for
HKR1

Expression for HKR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HKR1 Gene

Protein differential expression in normal tissues from HIPED for HKR1 Gene

This gene is overexpressed in Islet of Langerhans (34.7) and Breast (34.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HKR1 Gene



Protein tissue co-expression partners for HKR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HKR1 Gene:

HKR1

SOURCE GeneReport for Unigene cluster for HKR1 Gene:

Hs.657027

Evidence on tissue expression from TISSUES for HKR1 Gene

  • Nervous system(3.8)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with HKR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HKR1 Gene

Orthologs for HKR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HKR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HKR1 34 33
  • 98.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HKR1 34 33
  • 86.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HKR1 33
  • 82.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TDA9 36
Species where no ortholog for HKR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HKR1 Gene

ENSEMBL:
Gene Tree for HKR1 (if available)
TreeFam:
Gene Tree for HKR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HKR1: view image

Paralogs for HKR1 Gene

Paralogs for HKR1 Gene

(604) SIMAP similar genes for HKR1 Gene using alignment to 16 proteins:

  • HKR1_HUMAN
  • F5H6A5_HUMAN
  • K7EJS1_HUMAN
  • K7EL05_HUMAN
  • K7EL22_HUMAN
  • K7EL36_HUMAN
  • K7EM51_HUMAN
  • K7EME6_HUMAN
  • K7EMG8_HUMAN
  • K7EMJ9_HUMAN
  • K7ENA5_HUMAN
  • K7EPW3_HUMAN
  • K7EQG8_HUMAN
  • K7ERA5_HUMAN
  • K7ES32_HUMAN
  • Q7Z6E1_HUMAN
genes like me logo Genes that share paralogs with HKR1: view

Variants for HKR1 Gene

Sequence variations from dbSNP and Humsavar for HKR1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000052138 -- 37,336,560(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000110173 -- 37,338,279(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000212088 -- 37,353,030(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000225887 -- 37,338,045(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000249682 -- 37,343,586(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HKR1 Gene

Variant ID Type Subtype PubMed ID
esv2758759 CNV loss 17122850
nsv9718 CNV loss 18304495

Variation tolerance for HKR1 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.38; 90.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HKR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HKR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HKR1 Gene

Disorders for HKR1 Gene

Additional Disease Information for HKR1

No disorders were found for HKR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HKR1 Gene

Publications for HKR1 Gene

  1. The Krüppel-type zinc finger family gene, HKR1, is induced in lung cancer by exposure to platinum drugs. (PMID: 9813242) Oguri T … Watanabe H (Gene 1998) 2 3 4 58
  2. The GLI-Kruppel family of human genes. (PMID: 2850480) Ruppert JM … Vogelstein B (Molecular and cellular biology 1988) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase. (PMID: 26787842) Nishimura A … Tatebayashi K (Molecular and cellular biology 2016) 3 58
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58

Products for HKR1 Gene

Sources for HKR1 Gene

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