Aliases for HKDC1 Gene
External Ids for HKDC1 Gene
Previous GeneCards Identifiers for HKDC1 Gene
This gene encodes a member of the hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma. [provided by RefSeq, Sep 2016]
GeneCards Summary for HKDC1 Gene
HKDC1 (Hexokinase Domain Containing 1) is a Protein Coding gene. Diseases associated with HKDC1 include Orofacial Cleft 1 and Gestational Diabetes. Among its related pathways are Galactose metabolism and Carbon metabolism. Gene Ontology (GO) annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and glucokinase activity. An important paralog of this gene is HK1.
UniProtKB/Swiss-Prot Summary for HKDC1 Gene
Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (PubMed:30517626). Has low glucose phosphorylating activity compared to other hexokinases (PubMed:30517626). Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity).