Aliases for HK3 Gene
External Ids for HK3 Gene
Previous GeneCards Identifiers for HK3 Gene
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
GeneCards Summary for HK3 Gene
HK3 (Hexokinase 3) is a Protein Coding gene. Among its related pathways are Galactose metabolism and Central carbon metabolism in cancer. Gene Ontology (GO) annotations related to this gene include enzyme binding and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is HK2.
UniProtKB/Swiss-Prot Summary for HK3 Gene
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:8717435). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435).