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Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
HK3 (Hexokinase 3) is a Protein Coding gene. Among its related pathways are Galactose metabolism and Central carbon metabolism in cancer. Gene Ontology (GO) annotations related to this gene include enzyme binding and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is HK2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003824 | catalytic activity | IEA | -- |
GO:0004340 | glucokinase activity | IBA,ISS | -- |
GO:0004396 | hexokinase activity | IEA,IDA | 8717435 |
GO:0005515 | protein binding | IPI | 32296183 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005739 | mitochondrion | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0034774 | secretory granule lumen | TAS | -- |
GO:1904813 | ficolin-1-rich granule lumen | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Galactose metabolism |
Galactose metabolism
.38
|
Glycogen metabolism
.01
|
2 | Glucose metabolism |
Glycolysis and gluconeogenesis (short map)
.58
.52
|
.01
|
3 | Innate Immune System |
.61
|
|
4 | Metabolism |
.40
|
|
5 | Hexose transport |
.85
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001678 | cellular glucose homeostasis | IEA,IBA | 21873635 |
GO:0005975 | carbohydrate metabolic process | IEA | -- |
GO:0006002 | fructose 6-phosphate metabolic process | ISS | -- |
GO:0006096 | glycolytic process | IEA,IBA | 21873635 |
GO:0008152 | metabolic process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
58-64-0 |
|
|||
alpha-D-Glucose |
|
492-62-6 |
|
|||
Beta-D-Fructose 6-phosphate |
|
|
||||
dADP |
|
2793-06-8 |
|
|||
D-Fructose |
|
53188-23-1 |
|
Compound | Action | Cas Number |
---|---|---|
Lonidamine | 50264-69-2 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HK3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HK3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HK3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Hk3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hk3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | HK3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HK3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HK3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HK3 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Hex-C 31 32 |
|
ManyToMany | |
Hex-A 31 32 |
|
ManyToMany | |||
Hex-t2 31 32 |
|
ManyToMany | |||
Hex-t1 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | H25P06.1 32 |
|
|
|
F14B4.2 31 32 |
|
OneToMany | |||
Y77E11A.1 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | EMI2 31 |
|
ManyToMany | |
GLK1 31 |
|
ManyToMany | |||
HXK1 31 33 |
|
ManyToMany | |||
HXK2 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11095 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs112160979 | Benign: not provided | 176,889,667(-) |
C/T NM_002115.3(HK3):c.708G>A (p.Pro236=) |
SYNONYMOUS | |
rs114856191 | Likely Benign: not provided | 176,884,090(-) |
G/A NM_002115.3(HK3):c.1902C>T (p.Cys634=) |
SYNONYMOUS | |
rs1204803991 | Likely Benign: not provided | 176,887,345(-) |
G/A NM_002115.3(HK3):c.1601-8C>T |
INTRON | |
rs199663371 | Likely Benign: not provided | 176,891,149(-) |
G/A NM_002115.3(HK3):c.302C>T (p.Ala101Val) |
MISSENSE | |
rs35610191 | Not Provided: not provided. - | 176,889,454(-) |
C/Tp.Gly281Arg NM_002115.3(HK3):c.841G>A (p.Gly281Arg) |
MISSENSE |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10180n54 | CNV | loss | 21841781 |
dgv10181n54 | CNV | loss | 21841781 |
dgv362n21 | CNV | loss | 19592680 |
dgv732n27 | CNV | loss | 19166990 |
esv3306603 | CNV | mobile element insertion | 20981092 |
esv3308925 | CNV | mobile element insertion | 20981092 |
esv3326187 | CNV | insertion | 20981092 |
esv3332381 | CNV | insertion | 20981092 |
esv3575904 | CNV | gain | 25503493 |
nsv462562 | CNV | loss | 19166990 |
nsv519416 | CNV | gain | 19592680 |
nsv600353 | CNV | loss | 21841781 |
nsv950724 | CNV | deletion | 24416366 |
No disorders were found for HK3 Gene.