Aliases for HIVEP1 Gene
External Ids for HIVEP1 Gene
Previous HGNC Symbols for HIVEP1 Gene
Previous GeneCards Identifiers for HIVEP1 Gene
This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011]
GeneCards Summary for HIVEP1 Gene
HIVEP1 (Human Immunodeficiency Virus Type I Enhancer Binding Protein 1) is a Protein Coding gene. Diseases associated with HIVEP1 include Visual Epilepsy and Attention Deficit-Hyperactivity Disorder. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is HIVEP3.
UniProtKB/Swiss-Prot for HIVEP1 Gene
This protein specifically binds to the DNA sequence 5-GGGACTTTCC-3 which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.