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Aliases for HIST2H4A Gene

Aliases for HIST2H4A Gene

  • Histone Cluster 2 H4 Family Member A 2 3 5
  • Histone Cluster 2, H4a 2 3
  • H4 Histone, Family 2 2 3
  • Histone 2, H4a 2 3
  • HIST2H4 3 4
  • H4/N 3 4
  • H4F2 3 4
  • H4FN 3 4
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • H4 Histone Family, Member N 3
  • Histone IV, Family 2 3
  • Histone 2, H4 2
  • Histone H4 3
  • FO108 3
  • H4FA 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/G 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/O 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FG 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FO 4
  • H4 3

External Ids for HIST2H4A Gene

Previous HGNC Symbols for HIST2H4A Gene

  • H4F2
  • H4FN
  • HIST2H4
  • H4/n

Previous GeneCards Identifiers for HIST2H4A Gene

  • GC01P148070
  • GC01M121215

Summaries for HIST2H4A Gene

Entrez Gene Summary for HIST2H4A Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST2H4A Gene

HIST2H4A (Histone Cluster 2 H4 Family Member A) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include histone binding. An important paralog of this gene is HIST1H4D.

UniProtKB/Swiss-Prot for HIST2H4A Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST2H4A Gene

Additional gene information for HIST2H4A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H4A Gene

Genomics for HIST2H4A Gene

GeneHancer (GH) Regulatory Elements for HIST2H4A Gene

Promoters and enhancers for HIST2H4A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I149831 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 550.8 +0.0 44 3 GC01M149831 HIST2H4A HIST2H3C
GH01I149835 Enhancer 0.4 Ensembl dbSUPER 0.8 +2.8 2844 0.6 HIST2H4A HIST2H3C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HIST2H4A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIST2H4A gene promoter:

Genomic Locations for HIST2H4A Gene

Genomic Locations for HIST2H4A Gene
chr1:149,832,657-149,839,767
(GRCh38/hg38)
Size:
7,111 bases
Orientation:
Plus strand
chr1:149,804,221-149,811,339
(GRCh37/hg19)

Genomic View for HIST2H4A Gene

Genes around HIST2H4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST2H4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST2H4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H4A Gene

Proteins for HIST2H4A Gene

  • Protein details for HIST2H4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST2H4A Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST2H4A Gene

neXtProt entry for HIST2H4A Gene

Post-translational modifications for HIST2H4A Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Butyrylation of histones marks active promoters and competes with histone acetylation.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and isoforms=80
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST2H4A Gene

No data available for DME Specific Peptides for HIST2H4A Gene

Domains & Families for HIST2H4A Gene

Gene Families for HIST2H4A Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for HIST2H4A Gene

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST2H4A: view

No data available for Suggested Antigen Peptide Sequences for HIST2H4A Gene

Function for HIST2H4A Gene

Molecular function for HIST2H4A Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Ontology (GO) - Molecular Function for HIST2H4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA,TAS 3035717
GO:0003723 RNA binding IDA,HDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with HIST2H4A: view

Phenotypes for HIST2H4A Gene

genes like me logo Genes that share phenotypes with HIST2H4A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST2H4A Gene

Localization for HIST2H4A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST2H4A gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HIST2H4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region HDA,IDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IBA,IDA 20498094
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with HIST2H4A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HIST2H4A Gene

Pathways & Interactions for HIST2H4A Gene

SuperPathways for HIST2H4A Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST2H4A: view

Interacting Proteins for HIST2H4A Gene

Selected Interacting proteins: P62805-H4_HUMAN for HIST2H4A Gene via MINT UniProtKB IID

Symbol External ID(s) Details
TP53BP1
KDM4A
BRD2
COPRS
PHF20

Gene Ontology (GO) - Biological Process for HIST2H4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IDA,IBA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with HIST2H4A: view

No data available for SIGNOR curated interactions for HIST2H4A Gene

Drugs & Compounds for HIST2H4A Gene

No Compound Related Data Available

Transcripts for HIST2H4A Gene

mRNA/cDNA for HIST2H4A Gene

Unigene Clusters for HIST2H4A Gene

Histone cluster 2, H4a:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H4A Gene

No ASD Table

Relevant External Links for HIST2H4A Gene

GeneLoc Exon Structure for
HIST2H4A
ECgene alternative splicing isoforms for
HIST2H4A

Expression for HIST2H4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST2H4A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST2H4A Gene



Protein tissue co-expression partners for HIST2H4A Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST2H4A Gene:

HIST2H4A

SOURCE GeneReport for Unigene cluster for HIST2H4A Gene:

Hs.655235

Evidence on tissue expression from TISSUES for HIST2H4A Gene

  • Liver(4.5)
  • Nervous system(4.4)
  • Eye(4.2)
  • Blood(2.4)
  • Lung(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with HIST2H4A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H4A Gene

Orthologs for HIST2H4A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST2H4A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Hist1h4b 33 16
  • 86.41 (n)
dog
(Canis familiaris)
Mammalia LOC486670 33
  • 85.11 (n)
chimpanzee
(Pan troglodytes)
Mammalia LOC736707 33
  • 84.79 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912564 33
  • 83.5 (n)
cow
(Bos Taurus)
Mammalia H4 33
  • 83.17 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734147 33
  • 81.88 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101884830 33
  • 81.55 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005026 33
  • 82.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33905 33
  • 77.02 (n)
worm
(Caenorhabditis elegans)
Secernentea his-64 33
  • 77.99 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07820 33
  • 77.35 (n)
rice
(Oryza sativa)
Liliopsida Os04g0583600 33
  • 82.2 (n)
Species where no ortholog for HIST2H4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST2H4A Gene

ENSEMBL:
Gene Tree for HIST2H4A (if available)
TreeFam:
Gene Tree for HIST2H4A (if available)

Paralogs for HIST2H4A Gene

(3) SIMAP similar genes for HIST2H4A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST2H4A: view

Variants for HIST2H4A Gene

Sequence variations from dbSNP and Humsavar for HIST2H4A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs9436039 -- 149,833,520(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HIST2H4A Gene

Variant ID Type Subtype PubMed ID
esv1007634 OTHER inversion 20482838
nsv46 OTHER inversion 15895083
nsv469694 CNV loss 16826518
nsv499132 OTHER inversion 21111241
nsv547843 CNV loss 21841781
nsv7182 OTHER inversion 18451855
nsv824564 CNV gain 20364138
nsv831503 CNV gain 17160897
nsv831525 CNV gain 17160897
nsv946379 CNV duplication 23825009
nsv946381 CNV duplication 23825009

Additional Variant Information for HIST2H4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST2H4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HIST2H4A Gene

Disorders for HIST2H4A Gene

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.

Additional Disease Information for HIST2H4A

No disorders were found for HIST2H4A Gene.

No data available for MalaCards and Genatlas for HIST2H4A Gene

Publications for HIST2H4A Gene

  1. Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad CD … Stein GS (Gene 2004) 2 3 4 58
  2. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U … Nick H (Science (New York, N.Y.) 1987) 2 3 4 58
  3. Structure and in vitro transcription of a human H4 histone gene. (PMID: 6314274) Sierra F … Stein J (Nucleic acids research 1983) 2 3 4 58
  4. Human PAD4 regulates histone arginine methylation levels via demethylimination. (PMID: 15345777) Wang Y … Coonrod SA (Science (New York, N.Y.) 2004) 3 4 58
  5. Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. (PMID: 12556504) Hovhannisyan H … Stein JL (Molecular and cellular biology 2003) 3 22 58

Products for HIST2H4A Gene

Sources for HIST2H4A Gene

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