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Aliases for HIST2H3PS2 Gene

Aliases for HIST2H3PS2 Gene

  • Histone Cluster 2 H3 Pseudogene 2 2 3 3 5
  • Histone 2, H3, Pseudogene 2 2 3
  • Histone Cluster 2, H3, Pseudogene 2 2
  • P06 3

External Ids for HIST2H3PS2 Gene

Previous GeneCards Identifiers for HIST2H3PS2 Gene

  • GC01M147666
  • GC01M147671
  • GC01M149400

Summaries for HIST2H3PS2 Gene

Entrez Gene Summary for HIST2H3PS2 Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. [provided by RefSeq, Sep 2017]

GeneCards Summary for HIST2H3PS2 Gene

HIST2H3PS2 (Histone Cluster 2 H3 Pseudogene 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H3E.

Gene Wiki entry for HIST2H3PS2 Gene

Additional gene information for HIST2H3PS2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H3PS2 Gene

Genomics for HIST2H3PS2 Gene

GeneHancer (GH) Regulatory Elements for HIST2H3PS2 Gene

Promoters and enhancers for HIST2H3PS2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J143903 Promoter/Enhancer 0.8 Ensembl ENCODE 650.7 +1.0 968 3.2 ZBTB33 ENSG00000273213 GC01P143907 HIST2H2BB HIST2H3PS2 LOC105371209 PIR31911 GC01P143904
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HIST2H3PS2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HIST2H3PS2 Gene

Genomic Locations for HIST2H3PS2 Gene
457 bases
Minus strand
412 bases
Minus strand

Genomic View for HIST2H3PS2 Gene

Genes around HIST2H3PS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST2H3PS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST2H3PS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H3PS2 Gene

Proteins for HIST2H3PS2 Gene

  • Protein details for HIST2H3PS2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Histone H3
    Protein Accession:

    Protein attributes for HIST2H3PS2 Gene

    136 amino acids
    Molecular mass:
    15430 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST2H3PS2 Gene

neXtProt entry for HIST2H3PS2 Gene

Post-translational modifications for HIST2H3PS2 Gene

No Post-translational modifications

Other Protein References for HIST2H3PS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST2H3PS2 Gene

Domains & Families for HIST2H3PS2 Gene

Gene Families for HIST2H3PS2 Gene

  • Belongs to the histone H3 family.
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HIST2H3PS2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HIST2H3PS2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HIST2H3PS2 Gene

Function for HIST2H3PS2 Gene

Gene Ontology (GO) - Molecular Function for HIST2H3PS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0031492 nucleosomal DNA binding IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST2H3PS2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIST2H3PS2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HIST2H3PS2 Gene

Localization for HIST2H3PS2 Gene

Gene Ontology (GO) - Cellular Components for HIST2H3PS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with HIST2H3PS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HIST2H3PS2 Gene

Pathways & Interactions for HIST2H3PS2 Gene

SuperPathways for HIST2H3PS2 Gene

No Data Available

Interacting Proteins for HIST2H3PS2 Gene

Gene Ontology (GO) - Biological Process for HIST2H3PS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IBA --
genes like me logo Genes that share ontologies with HIST2H3PS2: view

No data available for Pathways by source and SIGNOR curated interactions for HIST2H3PS2 Gene

Drugs & Compounds for HIST2H3PS2 Gene

No Compound Related Data Available

Transcripts for HIST2H3PS2 Gene

mRNA/cDNA for HIST2H3PS2 Gene

(2) REFSEQ mRNAs :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIST2H3PS2

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H3PS2 Gene

No ASD Table

Relevant External Links for HIST2H3PS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIST2H3PS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST2H3PS2 Gene

mRNA expression in normal human tissues for HIST2H3PS2 Gene

Protein differential expression in normal tissues from HIPED for HIST2H3PS2 Gene

This gene is overexpressed in CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for HIST2H3PS2 Gene

Protein tissue co-expression partners for HIST2H3PS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST2H3PS2 Gene:

genes like me logo Genes that share expression patterns with HIST2H3PS2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H3PS2 Gene

Orthologs for HIST2H3PS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HIST2H3PS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 34
  • 97 (a)
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
(Mus musculus)
Mammalia Hist2h3c1 34
  • 97 (a)
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia HIST2H3PS2 34
  • 91 (a)
(Gallus gallus)
Aves H3-I 34
  • 97 (a)
(Anolis carolinensis)
Reptilia HIST2H3PS2 34
  • 97 (a)
(Danio rerio)
Actinopterygii HIST2H3PS2 (1 of 2) 34
  • 97 (a)
hist2h3c 34
  • 97 (a)
fruit fly
(Drosophila melanogaster)
Insecta His3:CG33833 34
  • 97 (a)
His3:CG33851 34
  • 97 (a)
(Caenorhabditis elegans)
Secernentea his-13 34
  • 95 (a)
his-42 34
  • 95 (a)
his-9 34
  • 95 (a)
his-17 34
  • 95 (a)
his-45 34
  • 95 (a)
his-6 34
  • 95 (a)
his-55 34
  • 95 (a)
his-32 34
  • 95 (a)
his-63 34
  • 95 (a)
his-40 34
  • 95 (a)
his-59 34
  • 95 (a)
his-27 34
  • 95 (a)
his-25 34
  • 95 (a)
his-49 34
  • 95 (a)
his-2 34
  • 95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 97 (a)
Species where no ortholog for HIST2H3PS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HIST2H3PS2 Gene

Gene Tree for HIST2H3PS2 (if available)
Gene Tree for HIST2H3PS2 (if available)
Evolutionary constrained regions (ECRs) for HIST2H3PS2: view image

Paralogs for HIST2H3PS2 Gene

(18) SIMAP similar genes for HIST2H3PS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST2H3PS2: view

Variants for HIST2H3PS2 Gene

Variation tolerance for HIST2H3PS2 Gene

Gene Damage Index Score: 2.86; 48.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIST2H3PS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for HIST2H3PS2 Gene

Disorders for HIST2H3PS2 Gene

No disorders were found for HIST2H3PS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for HIST2H3PS2 Gene

Publications for HIST2H3PS2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. The human histone H3 complement anno 2011. (PMID: 21782046) Ederveen TH … Logie C (Biochimica et biophysica acta 2011) 3 58

Products for HIST2H3PS2 Gene

Sources for HIST2H3PS2 Gene

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