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Aliases for HIST2H2BD Gene

Aliases for HIST2H2BD Gene

  • Histone Cluster 2 H2B Family Member D (Pseudogene) 2 3 5
  • Histone Cluster 2, H2bd (Pseudogene) 2 3
  • H2B Histone Family, Member O 2 3
  • Histone 2, H2bd 2 3
  • Putative Histone H2B Type 2-D 4
  • H2B/O 3
  • H2B/S 3
  • H2BFO 3

External Ids for HIST2H2BD Gene

Previous HGNC Symbols for HIST2H2BD Gene

  • H2BFO

Previous GeneCards Identifiers for HIST2H2BD Gene

  • GC01U900037
  • GC01P148081
  • GC01P149814
  • GC01M121204
  • GC01P149846
  • GC01P149882
  • GC01P149847
  • GC01P149848
  • GC01P149849
  • GC01P149850
  • GC01P149860
  • GC01P149869
  • GC01P149872
  • GC01P149878

Summaries for HIST2H2BD Gene

Entrez Gene Summary for HIST2H2BD Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is found in a histone cluster on chromosome 1. [provided by RefSeq, Oct 2015]

GeneCards Summary for HIST2H2BD Gene

HIST2H2BD (Histone Cluster 2 H2B Family Member D (Pseudogene)) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for HIST2H2BD Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Additional gene information for HIST2H2BD Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST2H2BD Gene

Genomics for HIST2H2BD Gene

GeneHancer (GH) Regulatory Elements for HIST2H2BD Gene

Promoters and enhancers for HIST2H2BD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HIST2H2BD on UCSC Golden Path with GeneCards custom track

Genomic Locations for HIST2H2BD Gene

Genomic Locations for HIST2H2BD Gene
chr1:149,842,875-149,846,486
(GRCh38/hg38)
Size:
3,612 bases
Orientation:
Plus strand
chr1:149,814,587-149,815,100
(GRCh37/hg19)
Size:
514 bases
Orientation:
Plus strand

Genomic View for HIST2H2BD Gene

Genes around HIST2H2BD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST2H2BD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST2H2BD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST2H2BD Gene

Proteins for HIST2H2BD Gene

  • Protein details for HIST2H2BD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DRA6-H2B2D_HUMAN
    Recommended name:
    Putative histone H2B type 2-D
    Protein Accession:
    Q6DRA6

    Protein attributes for HIST2H2BD Gene

    Size:
    164 amino acids
    Molecular mass:
    18018 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    Miscellaneous:
    • The mouse orthologous protein seems not to exist.

neXtProt entry for HIST2H2BD Gene

Post-translational modifications for HIST2H2BD Gene

  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HIST2H2BD Gene

Domains & Families for HIST2H2BD Gene

Gene Families for HIST2H2BD Gene

HGNC:

Protein Domains for HIST2H2BD Gene

Suggested Antigen Peptide Sequences for HIST2H2BD Gene

GenScript: Design optimal peptide antigens:
  • Putative histone H2B type 2-D (H2B2D_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6DRA6

UniProtKB/Swiss-Prot:

H2B2D_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST2H2BD: view

Function for HIST2H2BD Gene

Molecular function for HIST2H2BD Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for HIST2H2BD Gene

Gene Ontology (GO) - Molecular Function for HIST2H2BD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA 21873635
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST2H2BD: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HIST2H2BD Gene

Localization for HIST2H2BD Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST2H2BD Gene

Nucleus. Chromosome.

Gene Ontology (GO) - Cellular Components for HIST2H2BD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HIST2H2BD: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HIST2H2BD Gene

Pathways & Interactions for HIST2H2BD Gene

PathCards logo

SuperPathways for HIST2H2BD Gene

No Data Available

Interacting Proteins for HIST2H2BD Gene

Selected Interacting proteins: Q6DRA6-H2B2D_HUMAN for HIST2H2BD Gene via IID

Symbol External ID(s) Details
CBX5

Gene Ontology (GO) - Biological Process for HIST2H2BD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IBA 21873635
genes like me logo Genes that share ontologies with HIST2H2BD: view

No data available for Pathways by source and SIGNOR curated interactions for HIST2H2BD Gene

Drugs & Compounds for HIST2H2BD Gene

No Compound Related Data Available

Transcripts for HIST2H2BD Gene

mRNA/cDNA for HIST2H2BD Gene

(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST2H2BD Gene

No ASD Table

Relevant External Links for HIST2H2BD Gene

GeneLoc Exon Structure for
HIST2H2BD
ECgene alternative splicing isoforms for
HIST2H2BD

Expression for HIST2H2BD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST2H2BD Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST2H2BD Gene:

HIST2H2BD
genes like me logo Genes that share expression patterns with HIST2H2BD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST2H2BD Gene

Orthologs for HIST2H2BD Gene

Evolution for HIST2H2BD Gene

ENSEMBL:
Gene Tree for HIST2H2BD (if available)
TreeFam:
Gene Tree for HIST2H2BD (if available)

No data available for Orthologs for HIST2H2BD Gene

Paralogs for HIST2H2BD Gene

genes like me logo Genes that share paralogs with HIST2H2BD: view

No data available for Paralogs for HIST2H2BD Gene

Variants for HIST2H2BD Gene

Additional Variant Information for HIST2H2BD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST2H2BD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for HIST2H2BD Gene

Disorders for HIST2H2BD Gene

Additional Disease Information for HIST2H2BD

No disorders were found for HIST2H2BD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST2H2BD Gene

Publications for HIST2H2BD Gene

  1. Functional characterization of a human histone gene cluster duplication. (PMID: 15527963) Braastad CD … Stein GS (Gene 2004) 2 3 4 58
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 58
  3. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F … Kasprzak KS (Molecular and cellular biochemistry 2005) 3 4 58
  4. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung WL … Allis CD (Cell 2003) 3 4 58
  5. Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters. (PMID: 27105113) Goudarzi A … Khochbin S (Molecular cell 2016) 4 58

Products for HIST2H2BD Gene

Sources for HIST2H2BD Gene

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