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Aliases for HIST1H4L Gene

Aliases for HIST1H4L Gene

  • Histone Cluster 1 H4 Family Member L 2 3 5
  • H4 Histone Family, Member K 2 3
  • Histone Cluster 1, H4l 2 3
  • Histone 1, H4l 2 3
  • H4/K 3 4
  • H4FK 3 4
  • Histone H4 3
  • HIST2H4 4
  • H4.K 3
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/G 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FA 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FG 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FM 4
  • H4FN 4
  • H4FO 4

External Ids for HIST1H4L Gene

Previous HGNC Symbols for HIST1H4L Gene

  • H4FK

Previous GeneCards Identifiers for HIST1H4L Gene

  • GC06M027900
  • GC06M027948
  • GC06M027842
  • GC06M027650
  • GC06M027848
  • GC06M027853
  • GC06M027917
  • GC06M027940
  • GC06M027962
  • GC06M027985
  • GC06M027994
  • GC06M028011
  • GC06M028030
  • GC06M028052
  • GC06M028074
  • GC06M028100

Summaries for HIST1H4L Gene

Entrez Gene Summary for HIST1H4L Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H4L Gene

HIST1H4L (Histone Cluster 1 H4 Family Member L) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include histone binding. An important paralog of this gene is HIST1H4B.

UniProtKB/Swiss-Prot for HIST1H4L Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H4L Gene

Additional gene information for HIST1H4L Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4L Gene

Genomics for HIST1H4L Gene

GeneHancer (GH) Regulatory Elements for HIST1H4L Gene

Promoters and enhancers for HIST1H4L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J027821 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.7 +49.6 49606 4.6 HDGF HNRNPUL1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A YY1 POLR2B GC06P027825 HIST1H4J HIST1H2BN ZKSCAN4 ZSCAN9 ZKSCAN8 ZSCAN12 ZKSCAN3 HIST1H3J HIST1H1B
GH06J027834 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.6 +36.2 36218 6.4 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 SP3 NFYC MEF2D HIST1H2BN HIST1H2AK GC06M027849 ZKSCAN3 ZKSCAN4 ZKSCAN8 ZSCAN9 ZSCAN12 HNRNPA1P1 HIST1H2BPS2
GH06J027771 Enhancer 1.5 FANTOM5 Ensembl ENCODE 10.4 +100.3 100273 2.6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 PIR59721 ZKSCAN4 ZSCAN12 ZSCAN9 ZKSCAN3 ZKSCAN8 ZNF603P HIST1H4L ZNF391 ZSCAN26
GH06J027157 Enhancer 1.3 Ensembl ENCODE 9.6 +715.7 715675 1.7 HDGF FOXA2 ARNT SIN3A YBX1 ZNF2 ZNF766 ZNF213 E2F8 ZNF207 GC06P027255 TRH-GTG1-5 ABT1 BTN2A3P ZKSCAN8 HMGN4 BTN3A2 BTN2A2 BTN2A1 ZNF322
GH06J027887 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 3.7 -20.0 -19970 11.9 ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 NFYC SSRP1 ZNF610 RCOR2 HIST1H2AM HIST1H2BO HIST1H3J GC06M028139 PIR50251 PIR61297 PIR62073 PIR45952 ZKSCAN8 ZKSCAN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HIST1H4L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIST1H4L gene promoter:
  • Egr-3
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F
  • E47
  • Tal-1
  • Brachyury

Genomic Locations for HIST1H4L Gene

Genomic Locations for HIST1H4L Gene
chr6:27,873,148-27,873,511
(GRCh38/hg38)
Size:
364 bases
Orientation:
Minus strand
chr6:27,840,926-27,841,289
(GRCh37/hg19)
Size:
364 bases
Orientation:
Minus strand

Genomic View for HIST1H4L Gene

Genes around HIST1H4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4L Gene

Proteins for HIST1H4L Gene

  • Protein details for HIST1H4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST1H4L Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST1H4L Gene

neXtProt entry for HIST1H4L Gene

Post-translational modifications for HIST1H4L Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Sumoylated, which is associated with transcriptional repression.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Butyrylation of histones marks active promoters and competes with histone acetylation.
  • Ubiquitination at isoforms=80, Lys78, isoforms=60, and Lys32
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H4L Gene

Domains & Families for HIST1H4L Gene

Gene Families for HIST1H4L Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for HIST1H4L Gene

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST1H4L: view

No data available for Suggested Antigen Peptide Sequences for HIST1H4L Gene

Function for HIST1H4L Gene

Molecular function for HIST1H4L Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for HIST1H4L Gene

Gene Ontology (GO) - Molecular Function for HIST1H4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IBA 3035717
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with HIST1H4L: view
genes like me logo Genes that share phenotypes with HIST1H4L: view

Animal Model Products

CRISPR Products

miRNA for HIST1H4L Gene

miRTarBase miRNAs that target HIST1H4L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIST1H4L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4L Gene

Localization for HIST1H4L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H4L gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HIST1H4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IBA,IDA 20498094
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with HIST1H4L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HIST1H4L Gene

Pathways & Interactions for HIST1H4L Gene

SuperPathways for HIST1H4L Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST1H4L: view

Interacting Proteins for HIST1H4L Gene

Gene Ontology (GO) - Biological Process for HIST1H4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IDA,IBA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with HIST1H4L: view

No data available for SIGNOR curated interactions for HIST1H4L Gene

Drugs & Compounds for HIST1H4L Gene

No Compound Related Data Available

Transcripts for HIST1H4L Gene

mRNA/cDNA for HIST1H4L Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H4L Gene

Histone cluster 1, H4l:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIST1H4L

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4L Gene

No ASD Table

Relevant External Links for HIST1H4L Gene

GeneLoc Exon Structure for
HIST1H4L
ECgene alternative splicing isoforms for
HIST1H4L

Expression for HIST1H4L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST1H4L Gene



Protein tissue co-expression partners for HIST1H4L Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST1H4L Gene:

HIST1H4L

SOURCE GeneReport for Unigene cluster for HIST1H4L Gene:

Hs.533295

Evidence on tissue expression from TISSUES for HIST1H4L Gene

  • Liver(4.5)
  • Nervous system(4.4)
  • Eye(4.2)
  • Intestine(2.9)
  • Blood(2.4)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with HIST1H4L: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H4L Gene

Orthologs for HIST1H4L Gene

This gene was present in the common ancestor of animals.

Orthologs for HIST1H4L Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC488260 33
  • 87.7 (n)
mouse
(Mus musculus)
Mammalia Hist1h4n 16 33
  • 87.06 (n)
chimpanzee
(Pan troglodytes)
Mammalia LOC735611 33
  • 85.44 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912290 33
  • 83.82 (n)
cow
(Bos Taurus)
Mammalia LOC530773 33
  • 82.2 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485962 33
  • 80.58 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882398 33
  • 79.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta His4r 33
  • 77.67 (n)
Species where no ortholog for HIST1H4L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H4L Gene

ENSEMBL:
Gene Tree for HIST1H4L (if available)
TreeFam:
Gene Tree for HIST1H4L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HIST1H4L: view image

Paralogs for HIST1H4L Gene

(3) SIMAP similar genes for HIST1H4L Gene using alignment to 1 proteins:

  • H4_HUMAN
genes like me logo Genes that share paralogs with HIST1H4L: view

Variants for HIST1H4L Gene

Sequence variations from dbSNP and Humsavar for HIST1H4L Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000243106 -- 27,873,406(-) G/T coding_sequence_variant, synonymous_variant
rs1000531261 -- 27,873,562(-) A/C upstream_transcript_variant
rs1001126506 -- 27,875,091(-) T/C upstream_transcript_variant
rs1002291307 -- 27,873,086(-) A/G downstream_transcript_variant
rs1002355328 -- 27,872,666(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HIST1H4L Gene

Variant ID Type Subtype PubMed ID
nsv601208 CNV loss 21841781

Variation tolerance for HIST1H4L Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIST1H4L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4L Gene

Disorders for HIST1H4L Gene

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.

Additional Disease Information for HIST1H4L

No disorders were found for HIST1H4L Gene.

No data available for MalaCards and Genatlas for HIST1H4L Gene

Publications for HIST1H4L Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 58
  2. Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PMID: 9031620) Albig W … Doenecke D (Gene 1997) 2 3 4 58
  3. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 2 3 4 58
  4. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U … Nick H (Science (New York, N.Y.) 1987) 3 4 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

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Sources for HIST1H4L Gene

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