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Aliases for HIST1H4K Gene

Aliases for HIST1H4K Gene

  • Histone Cluster 1 H4 Family Member K 2 3 5
  • H4 Histone Family, Member D 2 3
  • Histone Cluster 1, H4k 2 3
  • Histone 1, H4k 2 3
  • H4/D 3 4
  • H4FD 3 4
  • DJ160A22.1 3
  • Histone H4 3
  • H4F2iii 3
  • HIST2H4 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/E 4
  • H4/G 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FA 4
  • H4FB 4
  • H4FC 4
  • H4FE 4
  • H4FG 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4

External Ids for HIST1H4K Gene

Previous HGNC Symbols for HIST1H4K Gene

  • H4FD

Previous GeneCards Identifiers for HIST1H4K Gene

  • GC06M027856
  • GC06M027906
  • GC06M027798
  • GC06M027606
  • GC06M027843

Summaries for HIST1H4K Gene

Entrez Gene Summary for HIST1H4K Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H4K Gene

HIST1H4K (Histone Cluster 1 H4 Family Member K) is a Protein Coding gene. Among its related pathways are Meiosis and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include histone binding. An important paralog of this gene is HIST1H4E.

UniProtKB/Swiss-Prot for HIST1H4K Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H4K Gene

Additional gene information for HIST1H4K Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4K Gene

Genomics for HIST1H4K Gene

GeneHancer (GH) Regulatory Elements for HIST1H4K Gene

Promoters and enhancers for HIST1H4K Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HIST1H4K on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIST1H4K gene promoter:
  • AML1a
  • Arnt
  • CREB
  • CUTL1
  • deltaCREB
  • E47
  • FOXO4
  • HEN1
  • SEF-1 (1)
  • XBP-1

Genomic Locations for HIST1H4K Gene

Genomic Locations for HIST1H4K Gene
chr6:27,831,174-27,831,527
(GRCh38/hg38)
Size:
354 bases
Orientation:
Minus strand
chr6:27,798,952-27,799,305
(GRCh37/hg19)
Size:
354 bases
Orientation:
Minus strand

Genomic View for HIST1H4K Gene

Genes around HIST1H4K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H4K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H4K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4K Gene

Proteins for HIST1H4K Gene

  • Protein details for HIST1H4K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST1H4K Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST1H4K Gene

neXtProt entry for HIST1H4K Gene

Post-translational modifications for HIST1H4K Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Sumoylated, which is associated with transcriptional repression.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Butyrylation of histones marks active promoters and competes with histone acetylation.
  • Ubiquitination at isoforms=60, posLast=8080, isoforms=32, and isoforms=78
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H4K Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H4K Gene

Domains & Families for HIST1H4K Gene

Gene Families for HIST1H4K Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for HIST1H4K Gene

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST1H4K: view

No data available for Suggested Antigen Peptide Sequences for HIST1H4K Gene

Function for HIST1H4K Gene

Molecular function for HIST1H4K Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for HIST1H4K Gene

Gene Ontology (GO) - Molecular Function for HIST1H4K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IBA 3035717
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H4K: view
genes like me logo Genes that share phenotypes with HIST1H4K: view

Animal Model Products

CRISPR Products

miRNA for HIST1H4K Gene

miRTarBase miRNAs that target HIST1H4K

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIST1H4K

Clone Products

  • Applied Biological Materials (abm): Clones for HIST1H4K - Now 50% OFF >
  • * HIST1H4K as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * HIST1H4K tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4K Gene

Localization for HIST1H4K Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H4K Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H4K gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HIST1H4K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IDA 20498094
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with HIST1H4K: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HIST1H4K Gene

Pathways & Interactions for HIST1H4K Gene

PathCards logo

SuperPathways for HIST1H4K Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST1H4K: view

Gene Ontology (GO) - Biological Process for HIST1H4K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IDA,IBA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with HIST1H4K: view

No data available for SIGNOR curated interactions for HIST1H4K Gene

Drugs & Compounds for HIST1H4K Gene

No Compound Related Data Available

Transcripts for HIST1H4K Gene

mRNA/cDNA for HIST1H4K Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for HIST1H4K Gene

Histone cluster 1, H4k:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIST1H4K

Clone Products

  • Applied Biological Materials (abm): Clones for HIST1H4K - Now 50% OFF >
  • * HIST1H4K as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * HIST1H4K tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4K Gene

No ASD Table

Relevant External Links for HIST1H4K Gene

GeneLoc Exon Structure for
HIST1H4K
ECgene alternative splicing isoforms for
HIST1H4K

Expression for HIST1H4K Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H4K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H4K Gene

This gene is overexpressed in Whole Blood (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST1H4K Gene



Protein tissue co-expression partners for HIST1H4K Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST1H4K Gene:

HIST1H4K

SOURCE GeneReport for Unigene cluster for HIST1H4K Gene:

Hs.528055

Evidence on tissue expression from TISSUES for HIST1H4K Gene

  • Liver(4.5)
  • Nervous system(4.4)
  • Eye(4.2)
  • Blood(2.4)
  • Lung(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with HIST1H4K: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H4K Gene

Orthologs for HIST1H4K Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H4K Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Hist1h4j 17 34
  • 89.97 (n)
rat
(Rattus norvegicus)
Mammalia LOC102551184 34
  • 89 (n)
cow
(Bos Taurus)
Mammalia LOC518961 34
  • 84.79 (n)
chimpanzee
(Pan troglodytes)
Mammalia LOC462494 34
  • 83.82 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492878 34
  • 84.79 (n)
Str.1273 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.17431 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-113a14.21 34
  • 83.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012558 34
  • 80.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33895 34
  • 78.64 (n)
worm
(Caenorhabditis elegans)
Secernentea his-18 34
  • 76.7 (n)
rice
(Oryza sativa)
Liliopsida Os.12348 34
wheat
(Triticum aestivum)
Liliopsida Ta.25145 34
corn
(Zea mays)
Liliopsida Zm.15826 34
barley
(Hordeum vulgare)
Liliopsida Hv.12211 34
Species where no ortholog for HIST1H4K was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HIST1H4K Gene

ENSEMBL:
Gene Tree for HIST1H4K (if available)
TreeFam:
Gene Tree for HIST1H4K (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HIST1H4K: view image

Paralogs for HIST1H4K Gene

(3) SIMAP similar genes for HIST1H4K Gene using alignment to 1 proteins:

  • H4_HUMAN
genes like me logo Genes that share paralogs with HIST1H4K: view

Variants for HIST1H4K Gene

Sequence variations from dbSNP and Humsavar for HIST1H4K Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000417404 -- 27,832,970(-) G/A upstream_transcript_variant
rs1002338811 -- 27,831,117(-) A/G downstream_transcript_variant
rs1004408119 -- 27,831,024(-) T/C/G downstream_transcript_variant
rs1004740740 -- 27,831,107(-) A/G downstream_transcript_variant
rs1006324171 -- 27,831,974(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HIST1H4K Gene

Variant ID Type Subtype PubMed ID
esv3608441 CNV gain 21293372

Variation tolerance for HIST1H4K Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIST1H4K Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H4K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4K Gene

Disorders for HIST1H4K Gene

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.

Additional Disease Information for HIST1H4K

No disorders were found for HIST1H4K Gene.

No data available for MalaCards and Genatlas for HIST1H4K Gene

Publications for HIST1H4K Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 58
  2. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 2 3 4 58
  3. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. (PMID: 3035717) Pauli U … Nick H (Science (New York, N.Y.) 1987) 3 4 58
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3 58
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 58

Products for HIST1H4K Gene

Sources for HIST1H4K Gene

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