Aliases for HIST1H4J Gene
External Ids for HIST1H4J Gene
Previous HGNC Symbols for HIST1H4J Gene
Previous GeneCards Identifiers for HIST1H4J Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H4J Gene
HIST1H4J (Histone Cluster 1 H4 Family Member J) is a Protein Coding gene. Diseases associated with HIST1H4J include Alpha-Thalassemia/Mental Retardation Syndrome, X-Linked. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include histone binding. An important paralog of this gene is HIST1H4C.
UniProtKB/Swiss-Prot for HIST1H4J Gene
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.