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Aliases for HIST1H4H Gene

Aliases for HIST1H4H Gene

  • Histone Cluster 1 H4 Family Member H 2 3 5
  • H4 Histone Family, Member H 2 3
  • Histone Cluster 1, H4h 2 3
  • Histone 1, H4h 2 3
  • H4/H 3 4
  • H4FH 3 4
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • Histone H4 3
  • HIST2H4 4
  • H4FA 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/G 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FG 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4

External Ids for HIST1H4H Gene

Previous HGNC Symbols for HIST1H4H Gene

  • H4FH

Previous GeneCards Identifiers for HIST1H4H Gene

  • GC06M026339
  • GC06M026389
  • GC06M026281
  • GC06M026228
  • GC06M026293
  • GC06M026457
  • GC06M026480
  • GC06M026499
  • GC06M026525
  • GC06M026560
  • GC06M026589

Summaries for HIST1H4H Gene

Entrez Gene Summary for HIST1H4H Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H4H Gene

HIST1H4H (Histone Cluster 1 H4 Family Member H) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include histone binding. An important paralog of this gene is HIST1H4K.

UniProtKB/Swiss-Prot for HIST1H4H Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H4H Gene

Additional gene information for HIST1H4H Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4H Gene

Genomics for HIST1H4H Gene

GeneHancer (GH) Regulatory Elements for HIST1H4H Gene

Promoters and enhancers for HIST1H4H Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I026283 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 556.1 +0.5 531 3.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 HIST1H4H PIR54542 PIR40221 LOC105374985 PIR50839 TRX-CAT1-2 ABT1 HMGN4 BTN2A3P BTN2A1
GH06I026309 Enhancer 1.5 Ensembl ENCODE dbSUPER 19.7 -26.2 -26203 4.9 MLX YBX1 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 NFYC MEF2D GC06M026658 TRQ-TTG3-1 TRQ-TTG3-2 TRS-TGA3-1 TRX-CAT1-3 ABT1 ZNF322 BTN2A2 BTN2A1 BTN3A2
GH06I026327 Enhancer 1.5 Ensembl ENCODE dbSUPER 19.2 -42.5 -42489 2.3 SMAD1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B ZNF766 ZNF213 E2F8 ZNF207 GC06P027057 PIR51941 TRR-ACG1-1 TRS-AGA2-1 BTN3A2 HIST1H4H ZNF322 LOC102724851 HMGN4 BTN1A1
GH06I026248 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.2 +30.3 30268 12.9 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A IRF4 YY1 HIST1H2BH HIST1H3F LOC105374986 ABT1 HMGN4 BTN2A1 BTN2A3P HIST1H3E BTN2A2 ZNF322
GH06I026193 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.6 +84.8 84846 14.6 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000282988 HIST1H2AD HIST1H2BF HIST1H3D HIST1H4E RPS10P1 ABT1 HMGN4 BTN2A3P BTN2A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HIST1H4H on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIST1H4H gene promoter:

Genomic Locations for HIST1H4H Gene

Genomic Locations for HIST1H4H Gene
chr6:26,277,609-26,285,638
(GRCh38/hg38)
Size:
8,030 bases
Orientation:
Minus strand
chr6:26,281,283-26,285,762
(GRCh37/hg19)

Genomic View for HIST1H4H Gene

Genes around HIST1H4H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H4H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H4H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4H Gene

Proteins for HIST1H4H Gene

  • Protein details for HIST1H4H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST1H4H Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST1H4H Gene

neXtProt entry for HIST1H4H Gene

Post-translational modifications for HIST1H4H Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Butyrylation of histones marks active promoters and competes with histone acetylation.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and isoforms=80

Other Protein References for HIST1H4H Gene

No data available for DME Specific Peptides for HIST1H4H Gene

Domains & Families for HIST1H4H Gene

Gene Families for HIST1H4H Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for HIST1H4H Gene

Suggested Antigen Peptide Sequences for HIST1H4H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST1H4H: view

Function for HIST1H4H Gene

Molecular function for HIST1H4H Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for HIST1H4H Gene

Gene Ontology (GO) - Molecular Function for HIST1H4H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IBA 3035717
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with HIST1H4H: view

Phenotypes for HIST1H4H Gene

GenomeRNAi human phenotypes for HIST1H4H:
genes like me logo Genes that share phenotypes with HIST1H4H: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4H Gene

Localization for HIST1H4H Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H4H gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HIST1H4H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region IDA,HDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IBA,IDA 20498094
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with HIST1H4H: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HIST1H4H Gene

Pathways & Interactions for HIST1H4H Gene

SuperPathways for HIST1H4H Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST1H4H: view

Interacting Proteins for HIST1H4H Gene

Selected Interacting proteins: P62805-H4_HUMAN for HIST1H4H Gene via MINT UniProtKB IID

Symbol External ID(s) Details
TP53BP1
KDM4A
BRD2
COPRS
PHF20

Gene Ontology (GO) - Biological Process for HIST1H4H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IDA,IBA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with HIST1H4H: view

No data available for SIGNOR curated interactions for HIST1H4H Gene

Drugs & Compounds for HIST1H4H Gene

No Compound Related Data Available

Transcripts for HIST1H4H Gene

mRNA/cDNA for HIST1H4H Gene

Unigene Clusters for HIST1H4H Gene

Histone cluster 1, H4h:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4H Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2:
SP3: - -

Relevant External Links for HIST1H4H Gene

GeneLoc Exon Structure for
HIST1H4H
ECgene alternative splicing isoforms for
HIST1H4H

Expression for HIST1H4H Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H4H Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H4H Gene

This gene is overexpressed in Muscle - Skeletal (x7.2) and Whole Blood (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST1H4H Gene



Protein tissue co-expression partners for HIST1H4H Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST1H4H Gene:

HIST1H4H

SOURCE GeneReport for Unigene cluster for HIST1H4H Gene:

Hs.591790

Evidence on tissue expression from TISSUES for HIST1H4H Gene

  • Nervous system(4.6)
  • Liver(4.5)
  • Eye(4.2)
  • Intestine(2.8)
  • Lung(2.6)
  • Blood(2.4)
  • Kidney(2.4)
  • Muscle(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with HIST1H4H: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H4H Gene

Orthologs for HIST1H4H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H4H Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 34
  • 100 (a)
ManyToMany
LOC528329 33
  • 84.14 (n)
mouse
(Mus musculus)
Mammalia Hist1h4f 34
  • 100 (a)
OneToOne
Hist1h4k 33 16
  • 83.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC748525 33
  • 83.82 (n)
rat
(Rattus norvegicus)
Mammalia RGD1562378 33
  • 82.85 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733031 33
  • 79.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia h4-A 33
zebrafish
(Danio rerio)
Actinopterygii HIST1H4H 34
  • 100 (a)
OneToMany
LOC101886781 33
  • 82.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33909 33
  • 80.26 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012586 33
  • 79.94 (n)
worm
(Caenorhabditis elegans)
Secernentea his-46 33
  • 77.35 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHF1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G53730 33
  • 74.43 (n)
rice
(Oryza sativa)
Liliopsida Os02g0684500 33
  • 77.99 (n)
Species where no ortholog for HIST1H4H was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • fila