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Aliases for HIST1H4C Gene

Aliases for HIST1H4C Gene

  • Histone Cluster 1 H4 Family Member C 2 3 5
  • H4 Histone Family, Member G 2 3
  • Histone Cluster 1, H4c 2 3
  • Histone 1, H4c 2 3
  • H4/G 3 4
  • H4FG 3 4
  • HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 4
  • Histone H4 3
  • DJ221C16.1 3
  • HIST2H4 4
  • H4FA 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4

External Ids for HIST1H4C Gene

Previous HGNC Symbols for HIST1H4C Gene

  • H4FG

Previous GeneCards Identifiers for HIST1H4C Gene

  • GC06P026161
  • GC06P026212
  • GC06P026104
  • GC06P026048
  • GC06P026109
  • GC06P026119
  • GC06P026122
  • GC06P026379
  • GC06P026469
  • GC06P026517
  • GC06P026815

Summaries for HIST1H4C Gene

Entrez Gene Summary for HIST1H4C Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H4C Gene

HIST1H4C (Histone Cluster 1 H4 Family Member C) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include histone binding. An important paralog of this gene is HIST1H4H.

UniProtKB/Swiss-Prot for HIST1H4C Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H4C Gene

Additional gene information for HIST1H4C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4C Gene

Genomics for HIST1H4C Gene

GeneHancer (GH) Regulatory Elements for HIST1H4C Gene

Promoters and enhancers for HIST1H4C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I026102 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.4 374 3.6 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GC06P026112 HIST1H4C PIR33351 PIR50904 ENSG00000272462 ABT1 HMGN4 BTN2A1 BTN2A3P BTN2A2
GH06I026101 Enhancer 0.4 ENCODE 550.8 -1.8 -1841 0.1 HMBOX1 PRDM10 PRDM1 HIST1H4C GC06P026096 GC06P025915
GH06I026019 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -76.3 -76290 16.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 HIST1H3A HIST1H3B HIST1H4B HIST1H2AB HIST1H4A ABT1 HMGN4 BTN2A1 BTN2A3P BTN2A2
GH06I026248 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 9.7 +151.5 151494 12.9 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A IRF4 YY1 HIST1H2BH HIST1H3F LOC105374986 ABT1 HMGN4 BTN2A1 BTN2A3P HIST1H3E BTN2A2 ZNF322
GH06I026193 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 9.3 +96.9 96916 14.6 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000282988 HIST1H2AD HIST1H2BF HIST1H3D HIST1H4E RPS10P1 ABT1 HMGN4 BTN2A3P BTN2A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HIST1H4C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIST1H4C gene promoter:

Genomic Locations for HIST1H4C Gene

Genomic Locations for HIST1H4C Gene
chr6:26,103,876-26,104,337
(GRCh38/hg38)
Size:
462 bases
Orientation:
Plus strand
chr6:26,104,104-26,104,565
(GRCh37/hg19)

Genomic View for HIST1H4C Gene

Genes around HIST1H4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4C Gene

Proteins for HIST1H4C Gene

  • Protein details for HIST1H4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST1H4C Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST1H4C Gene

neXtProt entry for HIST1H4C Gene

Post-translational modifications for HIST1H4C Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Butyrylation of histones marks active promoters and competes with histone acetylation.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Sumoylated, which is associated with transcriptional repression.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Ubiquitination at isoforms=32, isoforms=60, posLast=7878, and isoforms=80

Other Protein References for HIST1H4C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H4C Gene

Domains & Families for HIST1H4C Gene

Gene Families for HIST1H4C Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for HIST1H4C Gene

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST1H4C: view

No data available for Suggested Antigen Peptide Sequences for HIST1H4C Gene

Function for HIST1H4C Gene

Molecular function for HIST1H4C Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for HIST1H4C Gene

Gene Ontology (GO) - Molecular Function for HIST1H4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA,TAS 3035717
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with HIST1H4C: view

Phenotypes for HIST1H4C Gene

GenomeRNAi human phenotypes for HIST1H4C:
genes like me logo Genes that share phenotypes with HIST1H4C: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4C Gene

Localization for HIST1H4C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H4C gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HIST1H4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region IDA,HDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IDA,IBA 20498094
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with HIST1H4C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HIST1H4C Gene

Pathways & Interactions for HIST1H4C Gene

SuperPathways for HIST1H4C Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST1H4C: view

Interacting Proteins for HIST1H4C Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367034%0d%0a9606.ENSP00000336868%0d%0a9606.ENSP00000358151%0d%0a9606.ENSP00000350580%0d%0a9606.ENSP00000349430%0d%0a9606.ENSP00000274764%0d%0a
Selected Interacting proteins: P62805-H4_HUMAN ENSP00000367034 for HIST1H4C Gene via MINT UniProtKB STRING IID

Symbol External ID(s) Details
TP53BP1
KDM4A
BRD2
YWHAZ
SMARCA5

Gene Ontology (GO) - Biological Process for HIST1H4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IDA,IBA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with HIST1H4C: view

No data available for SIGNOR curated interactions for HIST1H4C Gene

Drugs & Compounds for HIST1H4C Gene

No Compound Related Data Available

Transcripts for HIST1H4C Gene

mRNA/cDNA for HIST1H4C Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(545) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H4C Gene

Histone cluster 1, H4c:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4C Gene

No ASD Table

Relevant External Links for HIST1H4C Gene

GeneLoc Exon Structure for
HIST1H4C
ECgene alternative splicing isoforms for
HIST1H4C

Expression for HIST1H4C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H4C Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H4C Gene

This gene is overexpressed in Whole Blood (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H4C Gene



Protein tissue co-expression partners for HIST1H4C Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST1H4C Gene:

HIST1H4C

SOURCE GeneReport for Unigene cluster for HIST1H4C Gene:

Hs.46423

Evidence on tissue expression from TISSUES for HIST1H4C Gene

  • Liver(5)
  • Blood(4.9)
  • Nervous system(4.5)
  • Eye(4.2)
  • Intestine(2.3)
  • Kidney(2.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with HIST1H4C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H4C Gene

Orthologs for HIST1H4C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H4C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HIST1H4C 34
  • 100 (a)
OneToOne
LOC100855431 33
  • 77.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 100 (a)
ManyToMany
-- 34
  • 100 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToMany
LOC465305 33
  • 81.88 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912489 33
  • 82.2 (n)
mouse
(Mus musculus)
Mammalia Hist2h4 33 16 34
  • 79.94 (n)
cow
(Bos Taurus)
Mammalia LOC526789 33
  • 79.61 (n)
chicken
(Gallus gallus)
Aves H4-I 34
  • 100 (a)
OneToMany
HIST1H46L6 33
  • 79.94 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia hist1h4a 33
  • 80.58 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-113a14.26 34
  • 100 (a)
ManyToMany
si:dkey-261m9.9 34
  • 100 (a)
ManyToMany
si:ch211-113a14.17 33
  • 77.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33897 33
  • 78.32 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003909 33
  • 77.67 (n)
worm
(Caenorhabditis elegans)
Secernentea his-38 33
  • 77.02 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HHF1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G46320 33
  • 73.14 (n)
soybean
(Glycine max)
eudicotyledons Gma.15752 33
rice
(Oryza sativa)
Liliopsida Os09g0433600 33
  • 77.35 (n)
Species where no ortholog for HIST1H4C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST1H4C Gene

ENSEMBL:
Gene Tree for HIST1H4C (if available)
TreeFam:
Gene Tree for HIST1H4C (if available)

Paralogs for HIST1H4C Gene

(3) SIMAP similar genes for HIST1H4C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H4C: view

Variants for HIST1H4C Gene

Sequence variations from dbSNP and Humsavar for HIST1H4C Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000465875 -- 26,102,150(+) C/G upstream_transcript_variant
rs1001321460 -- 26,103,229(+) AAGAGT/AAGAGTAAGAGT upstream_transcript_variant
rs1001469277 -- 26,103,639(+) C/G upstream_transcript_variant
rs1001605230 -- 26,103,891(+) G/A upstream_transcript_variant
rs1002513130 -- 26,104,364(+) G/A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HIST1H4C Gene

Variant ID Type Subtype PubMed ID
dgv5926n100 CNV gain 25217958
esv3608393 CNV gain 21293372
nsv1023453 CNV gain 25217958
nsv428137 CNV loss 18775914

Variation tolerance for HIST1H4C Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIST1H4C Gene

Human Gene Mutation Database (HGMD)
HIST1H4C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4C Gene

Disorders for HIST1H4C Gene

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.

Additional Disease Information for HIST1H4C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HIST1H4C Gene.

No data available for MalaCards and Genatlas for HIST1H4C Gene

Publications for HIST1H4C Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 58
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W … Doenecke D (Genomics 1997) 2 3 4 58
  3. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E … Dorak MT (Molecular human reproduction 2010) 3 44 58
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  5. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 3 4 58

Products for HIST1H4C Gene