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Aliases for HIST1H4A Gene

Aliases for HIST1H4A Gene

  • Histone Cluster 1 H4 Family Member A 2 3 5
  • H4 Histone Family, Member A 2 3
  • Histone Cluster 1, H4a 2 3
  • Histone 1, H4a 2 3
  • H4FA 3 4
  • Histone H4 3
  • HIST2H4 4
  • H4/A 4
  • H4/B 4
  • H4/C 4
  • H4/D 4
  • H4/E 4
  • H4/G 4
  • H4/H 4
  • H4/I 4
  • H4/J 4
  • H4/K 4
  • H4/M 4
  • H4/N 4
  • H4/O 4
  • H4F2 4
  • H4FB 4
  • H4FC 4
  • H4FD 4
  • H4FE 4
  • H4FG 4
  • H4FH 4
  • H4FI 4
  • H4FJ 4
  • H4FK 4
  • H4FM 4
  • H4FN 4
  • H4FO 4

External Ids for HIST1H4A Gene

Previous HGNC Symbols for HIST1H4A Gene

  • H4FA

Previous GeneCards Identifiers for HIST1H4A Gene

  • GC06P026079
  • GC06P026084
  • GC06P026129
  • GC06P025964

Summaries for HIST1H4A Gene

Entrez Gene Summary for HIST1H4A Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H4A Gene

HIST1H4A (Histone Cluster 1 H4 Family Member A) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include histone binding. An important paralog of this gene is HIST4H4.

UniProtKB/Swiss-Prot for HIST1H4A Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H4A Gene

Additional gene information for HIST1H4A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H4A Gene

Genomics for HIST1H4A Gene

GeneHancer (GH) Regulatory Elements for HIST1H4A Gene

Promoters and enhancers for HIST1H4A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J026120 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.8 +102.3 102295 7.8 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC SSRP1 HIST1H2AC HIST1H2BC PIR32750 PIR33095 PIR44445 ABT1 BTN2A3P HMGN4 BTN2A1 BTN2A2
GH06J025535 Enhancer 0.9 FANTOM5 4.6 -486.1 -486129 0 PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 E2F8 NCOA1 RPL21P68 CARMIL1 CMAHP LOC100533655 HIST1H4A HIST1H3B HIST1H4B HIST1H2AB HIST1H3A GC06M025494
GH06J026019 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 +5.9 5907 16.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 HIST1H3B HIST1H4B HIST1H2AB ABT1 BTN2A1 BTN2A3P HMGN4 BTN2A2 ENSG00000272462 BTN3A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HIST1H4A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIST1H4A gene promoter:
  • Pax-4a
  • Egr-4
  • Pax-5
  • deltaCREB
  • CREB
  • CBF-C
  • CBF-B
  • CBF-A
  • CBF(2)
  • CP1A

Genomic Locations for HIST1H4A Gene

Genomic Locations for HIST1H4A Gene
chr6:26,021,679-26,022,050
(GRCh38/hg38)
Size:
372 bases
Orientation:
Plus strand
chr6:26,021,907-26,022,278
(GRCh37/hg19)
Size:
372 bases
Orientation:
Plus strand

Genomic View for HIST1H4A Gene

Genes around HIST1H4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H4A Gene

Proteins for HIST1H4A Gene

  • Protein details for HIST1H4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62805-H4_HUMAN
    Recommended name:
    Histone H4
    Protein Accession:
    P62805
    Secondary Accessions:
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7
    • A2VCL0
    • P02304
    • P02305
    • Q6DRA9
    • Q6FGB8
    • Q6NWP7

    Protein attributes for HIST1H4A Gene

    Size:
    103 amino acids
    Molecular mass:
    11367 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SequenceCaution:
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
    • Sequence=AAI28106.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIST1H4A Gene

neXtProt entry for HIST1H4A Gene

Post-translational modifications for HIST1H4A Gene

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.
  • Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Sumoylated, which is associated with transcriptional repression.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Butyrylation of histones marks active promoters and competes with histone acetylation.
  • Ubiquitination at isoforms=80, Lys78, isoforms=60, and Lys32
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H4A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H4A Gene

Domains & Families for HIST1H4A Gene

Gene Families for HIST1H4A Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for HIST1H4A Gene

Suggested Antigen Peptide Sequences for HIST1H4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62805

UniProtKB/Swiss-Prot:

H4_HUMAN :
  • Belongs to the histone H4 family.
Family:
  • Belongs to the histone H4 family.
genes like me logo Genes that share domains with HIST1H4A: view

Function for HIST1H4A Gene

Molecular function for HIST1H4A Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for HIST1H4A Gene

Gene Ontology (GO) - Molecular Function for HIST1H4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IBA 3035717
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 9540062
GO:0019904 protein domain specific binding IPI 22368283
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with HIST1H4A: view
genes like me logo Genes that share phenotypes with HIST1H4A: view

Animal Model Products

CRISPR Products

miRNA for HIST1H4A Gene

miRTarBase miRNAs that target HIST1H4A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIST1H4A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H4A Gene

Localization for HIST1H4A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H4A gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HIST1H4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 14718166
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0000786 nucleosome TAS 3035717
GO:0000788 nuclear nucleosome IDA,IBA 20498094
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with HIST1H4A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HIST1H4A Gene

Pathways & Interactions for HIST1H4A Gene

SuperPathways for HIST1H4A Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence (REACTOME)
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST1H4A: view

Interacting Proteins for HIST1H4A Gene

Gene Ontology (GO) - Biological Process for HIST1H4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006334 nucleosome assembly IDA,IBA 20498094
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with HIST1H4A: view

No data available for SIGNOR curated interactions for HIST1H4A Gene

Drugs & Compounds for HIST1H4A Gene

No Compound Related Data Available

Transcripts for HIST1H4A Gene

mRNA/cDNA for HIST1H4A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H4A Gene

Histone cluster 1, H4a:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIST1H4A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H4A Gene

No ASD Table

Relevant External Links for HIST1H4A Gene

GeneLoc Exon Structure for
HIST1H4A
ECgene alternative splicing isoforms for
HIST1H4A

Expression for HIST1H4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H4A Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H4A Gene

This gene is overexpressed in Whole Blood (x4.8) and Brain - Cerebellum (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST1H4A Gene



Protein tissue co-expression partners for HIST1H4A Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST1H4A Gene:

HIST1H4A

SOURCE GeneReport for Unigene cluster for HIST1H4A Gene:

Hs.248178

Evidence on tissue expression from TISSUES for HIST1H4A Gene

  • Liver(4.5)
  • Nervous system(4.4)
  • Eye(4.2)
  • Blood(2.4)
  • Lung(2.2)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with HIST1H4A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H4A Gene

Orthologs for HIST1H4A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H4A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Hist1h4d 16 33
  • 86.73 (n)
rat
(Rattus norvegicus)
Mammalia Hist1h4m 33
  • 85.76 (n)
chimpanzee
(Pan troglodytes)
Mammalia LOC748532 33
  • 84.14 (n)
cow
(Bos Taurus)
Mammalia LOC516742 33
  • 83.17 (n)
chicken
(Gallus gallus)
Aves HIST1H46L5 33
  • 87.06 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495257 33
  • 80.26 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100005308 33
  • 80.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta His4:CG33887 33
  • 80.58 (n)
worm
(Caenorhabditis elegans)
Secernentea his-67 33
  • 76.7 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2281 33
rice
(Oryza sativa)
Liliopsida Os07g0549900 33
  • 83.5 (n)
Species where no ortholog for HIST1H4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST1H4A Gene

ENSEMBL:
Gene Tree for HIST1H4A (if available)
TreeFam:
Gene Tree for HIST1H4A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HIST1H4A: view image

Paralogs for HIST1H4A Gene

(3) SIMAP similar genes for HIST1H4A Gene using alignment to 1 proteins:

  • H4_HUMAN
genes like me logo Genes that share paralogs with HIST1H4A: view

Variants for HIST1H4A Gene

Sequence variations from dbSNP and Humsavar for HIST1H4A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs747622981 A breast cancer sample p.Glu64Gln
rs1001751186 -- 26,021,009(+) G/A upstream_transcript_variant
rs1003023837 -- 26,021,387(+) A/G upstream_transcript_variant
rs1004059208 -- 26,021,135(+) G/T upstream_transcript_variant
rs1004310398 -- 26,021,224(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HIST1H4A Gene

Variant ID Type Subtype PubMed ID
nsv509122 CNV insertion 20534489
nsv428137 CNV loss 18775914
nsv1023453 CNV gain 25217958
dgv5926n100 CNV gain 25217958

Variation tolerance for HIST1H4A Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIST1H4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H4A Gene

Disorders for HIST1H4A Gene

UniProtKB/Swiss-Prot

H4_HUMAN
  • Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. {ECO:0000269 PubMed:12414651}.

Additional Disease Information for HIST1H4A

No disorders were found for HIST1H4A Gene.

No data available for MalaCards and Genatlas for HIST1H4A Gene

Publications for HIST1H4A Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 58
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W … Doenecke D (Genomics 1997) 2 3 4 58
  3. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PMID: 19818714) Yan Q … Shipp MA (Molecular cell 2009) 3 4 58
  4. SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20. (PMID: 15964846) Yin Y … Zhu G (The Journal of biological chemistry 2005) 3 4 58
  5. Histone sumoylation is associated with transcriptional repression. (PMID: 14578449) Shiio Y … Eisenman RN (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58

Products for HIST1H4A Gene

Sources for HIST1H4A Gene

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