Aliases for HIST1H1E Gene
External Ids for HIST1H1E Gene
Previous HGNC Symbols for HIST1H1E Gene
Previous GeneCards Identifiers for HIST1H1E Gene
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H1E Gene
HIST1H1E (Histone Cluster 1 H1 Family Member E) is a Protein Coding gene. Diseases associated with HIST1H1E include Rahman Syndrome and Sotos Syndrome 1. Among its related pathways are E2F mediated regulation of DNA replication and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include chromatin DNA binding. An important paralog of this gene is HIST1H1B.
UniProtKB/Swiss-Prot for HIST1H1E Gene
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).