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The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
HIRIP3 (HIRA Interacting Protein 3) is a Protein Coding gene. Diseases associated with HIRIP3 include Chromosome 16P12.2-P11.2 Deletion Syndrome, 7.1- To 8.7-Mb and Schizophrenia 3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 9710638 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS,IDA | 17391060 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006333 | chromatin assembly or disassembly | TAS | 9710638 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||||||||||||||
SP10: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HIRIP3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HIRIP3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HIRIP3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hirip3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hirip3 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HIRIP3 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HIRIP3 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | hirip3 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11643314 | - | p.Gly521Trp | |||
rs35431046 | - | p.Ala496Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3638378 | CNV | loss | 21293372 |
esv997840 | CNV | deletion | 20482838 |
Disorder | Aliases | PubMed IDs |
---|---|---|
chromosome 16p12.2-p11.2 deletion syndrome, 7.1- to 8.7-mb |
|
|
schizophrenia 3 |
|
|
endocardial fibroelastosis |
|
|
autism |
|
|