Aliases for HIPK3 Gene
External Ids for HIPK3 Gene
Previous GeneCards Identifiers for HIPK3 Gene
GeneCards Summary for HIPK3 Gene
HIPK3 (Homeodomain Interacting Protein Kinase 3) is a Protein Coding gene. Diseases associated with HIPK3 include Amyotrophic Lateral Sclerosis 1. Among its related pathways are Cellular senescence (KEGG). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is HIPK2.
UniProtKB/Swiss-Prot Summary for HIPK3 Gene
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).