Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008] See more...

Aliases for HINT2 Gene

Aliases for HINT2 Gene

  • Histidine Triad Nucleotide Binding Protein 2 2 3 5
  • Histidine Triad Nucleotide-Binding Protein 2, Mitochondrial 3 4
  • PKCI-1-Related HIT Protein 3 4
  • HIT-17kDa 3 4
  • HINT-2 3 4
  • HINT-3 3 4
  • Protein Kinase C Inhibitor-2 3
  • EC 3.-.-.- 4
  • HIT-17 3
  • HINT2 5

External Ids for HINT2 Gene

Previous GeneCards Identifiers for HINT2 Gene

  • GC09M036125
  • GC09M035982
  • GC09M035802

Summaries for HINT2 Gene

Entrez Gene Summary for HINT2 Gene

  • Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HINT2 Gene

HINT2 (Histidine Triad Nucleotide Binding Protein 2) is a Protein Coding gene. Diseases associated with HINT2 include Substernal Goiter and Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include nucleotide binding and hydrolase activity. An important paralog of this gene is HINT1.

UniProtKB/Swiss-Prot Summary for HINT2 Gene

  • Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.

Additional gene information for HINT2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HINT2 Gene

Genomics for HINT2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HINT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HINT2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HINT2

Top Transcription factor binding sites by QIAGEN in the HINT2 gene promoter:
  • AREB6
  • Egr-3
  • Evi-1
  • HNF-1
  • HNF-1A
  • Lmo2
  • Oct-B1
  • oct-B2
  • oct-B3

Genomic Locations for HINT2 Gene

Genomic Locations for HINT2 Gene
chr9:35,812,960-35,815,479
(GRCh38/hg38)
Size:
2,520 bases
Orientation:
Minus strand
chr9:35,812,957-35,815,351
(GRCh37/hg19)
Size:
2,395 bases
Orientation:
Minus strand

Genomic View for HINT2 Gene

Genes around HINT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HINT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HINT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HINT2 Gene

Proteins for HINT2 Gene

  • Protein details for HINT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX68-HINT2_HUMAN
    Recommended name:
    Histidine triad nucleotide-binding protein 2, mitochondrial
    Protein Accession:
    Q9BX68
    Secondary Accessions:
    • Q5TCW3

    Protein attributes for HINT2 Gene

    Size:
    163 amino acids
    Molecular mass:
    17162 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HINT2 Gene

neXtProt entry for HINT2 Gene

Post-translational modifications for HINT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HINT2 Gene

No data available for DME Specific Peptides for HINT2 Gene

Domains & Families for HINT2 Gene

Gene Families for HINT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HINT2 Gene

InterPro:
Blocks:
  • Histidine triad (HIT) protein
ProtoNet:

Suggested Antigen Peptide Sequences for HINT2 Gene

GenScript: Design optimal peptide antigens:
  • PKCI-1-related HIT protein (HINT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BX68

UniProtKB/Swiss-Prot:

HINT2_HUMAN :
  • Belongs to the HINT family.
Family:
  • Belongs to the HINT family.
genes like me logo Genes that share domains with HINT2: view

Function for HINT2 Gene

Molecular function for HINT2 Gene

UniProtKB/Swiss-Prot Function:
Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=128 uM for adenosine 5'-O-p-nitrophenylphosphoramidate {ECO:0000269|PubMed:16762638};

Enzyme Numbers (IUBMB) for HINT2 Gene

Phenotypes From GWAS Catalog for HINT2 Gene

Gene Ontology (GO) - Molecular Function for HINT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003824 catalytic activity IEA --
GO:0016787 hydrolase activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with HINT2: view
genes like me logo Genes that share phenotypes with HINT2: view

Animal Models for HINT2 Gene

MGI Knock Outs for HINT2:

Animal Model Products

CRISPR Products

miRNA for HINT2 Gene

miRTarBase miRNAs that target HINT2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HINT2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HINT2 Gene

Localization for HINT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HINT2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HINT2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HINT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion ISS --
genes like me logo Genes that share ontologies with HINT2: view

Pathways & Interactions for HINT2 Gene

PathCards logo

SuperPathways for HINT2 Gene

No Data Available

Interacting Proteins for HINT2 Gene

Gene Ontology (GO) - Biological Process for HINT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006694 steroid biosynthetic process IEA --
GO:0006915 apoptotic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:2000757 negative regulation of peptidyl-lysine acetylation IEA --
genes like me logo Genes that share ontologies with HINT2: view

No data available for Pathways by source and SIGNOR curated interactions for HINT2 Gene

Drugs & Compounds for HINT2 Gene

No Compound Related Data Available

Transcripts for HINT2 Gene

mRNA/cDNA for HINT2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HINT2

Alternative Splicing Database (ASD) splice patterns (SP) for HINT2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - -
SP2: -
SP3:
SP4: - -
SP5:
SP6: -

Relevant External Links for HINT2 Gene

GeneLoc Exon Structure for
HINT2

Expression for HINT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HINT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HINT2 Gene

This gene is overexpressed in Liver, secretome (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HINT2 Gene



Protein tissue co-expression partners for HINT2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HINT2

SOURCE GeneReport for Unigene cluster for HINT2 Gene:

Hs.70573

mRNA Expression by UniProt/SwissProt for HINT2 Gene:

Q9BX68-HINT2_HUMAN
Tissue specificity: High expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.

Evidence on tissue expression from TISSUES for HINT2 Gene

  • Liver(4.5)
  • Kidney(4.5)
  • Pancreas(4.3)
  • Muscle(2.7)
  • Heart(2.5)
  • Skin(2.3)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with HINT2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HINT2 Gene

Orthologs for HINT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HINT2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HINT2 30 31
  • 99.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HINT2 30 31
  • 90.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HINT2 30 31
  • 89.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hint2 30
  • 86.25 (n)
Mouse
(Mus musculus)
Mammalia Hint2 30 17 31
  • 85.55 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HINT2 31
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100859112 30
  • 68.14 (n)
HINT2 31
  • 65 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HINT2 31
  • 72 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii hint2 30 31
  • 64.86 (n)
OneToOne
Dr.16548 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG2862 31 32
  • 51 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F21C3.3 32
  • 55 (a)
hint-1 31
  • 52 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons HINT 2 30
  • 57.72 (n)
Corn
(Zea mays)
Liliopsida Zm.2313 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1686 31
  • 50 (a)
OneToOne
Species where no ortholog for HINT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for HINT2 Gene

ENSEMBL:
Gene Tree for HINT2 (if available)
TreeFam:
Gene Tree for HINT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HINT2: view image

Paralogs for HINT2 Gene

Paralogs for HINT2 Gene

(2) SIMAP similar genes for HINT2 Gene using alignment to 1 proteins:

  • HINT2_HUMAN

Pseudogenes.org Pseudogenes for HINT2 Gene

genes like me logo Genes that share paralogs with HINT2: view

Variants for HINT2 Gene

Additional dbSNP identifiers (rs#s) for HINT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for HINT2 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259

Variation tolerance for HINT2 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HINT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HINT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HINT2 Gene

Disorders for HINT2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HINT2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
substernal goiter
  • retrosternal thyroid goiter
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search HINT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HINT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HINT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HINT2 Gene

Publications for HINT2 Gene

  1. Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily. (PMID: 23659632) Maize KM … Finzel BC (The FEBS journal 2013) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  3. Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis. (PMID: 18653718) Lenglet S … Rossier MF (Endocrinology 2008) 3 4
  4. Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. (PMID: 16762638) Martin J … Dufour JF (Gastroenterology 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for HINT2 Gene

  • Signalway Proteins for HINT2

Sources for HINT2 Gene