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Aliases for HILS1 Gene

Aliases for HILS1 Gene

  • Histone Linker H1 Domain, Spermatid-Specific 1 (Pseudogene) 2 3 5
  • Spermatid-Specific Linker Histone H1-Like Protein 3
  • Histone Linker H1 Domain, Spermatid-Specific 1 2
  • H1.9 3

External Ids for HILS1 Gene

Previous GeneCards Identifiers for HILS1 Gene

  • GC17U900024
  • GC17M048723
  • GC17M045603
  • GC17M048248
  • GC17M043617

Summaries for HILS1 Gene

Entrez Gene Summary for HILS1 Gene

  • This locus is the ortholog of a mouse protein-coding gene that displays characteristics of a linker histone and is expressed in nuclei of late maturing spermatids. The human locus is expressed; however, the open reading frame has been disrupted by a frameshift so it is unlikely to encode a functional protein. [provided by RefSeq, Oct 2008]

GeneCards Summary for HILS1 Gene

HILS1 (Histone Linker H1 Domain, Spermatid-Specific 1 (Pseudogene)) is a Pseudogene. Among its related pathways are Transcription_CREM signaling in testis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and histone binding.

UniProtKB/Swiss-Prot for HILS1 Gene

  • DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.

Additional gene information for HILS1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HILS1 Gene

Genomics for HILS1 Gene

GeneHancer (GH) Regulatory Elements for HILS1 Gene

Promoters and enhancers for HILS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I050171 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.1 -11.3 -11344 42 CLOCK DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D COL1A1 SGCA ENSG00000262837 LUC7L3 TMEM92-AS1 TMEM92 XYLT2 ZNF652 PPP1R9B FLJ45513
GH17I050288 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -108.6 -108643 3.5 BATF BRCA1 RAD21 ZBTB40 RFX5 ZNF335 ZNF766 ZNF416 RCOR1 FOS TMEM92-AS1 KAT7 COL1A1 HILS1 SGCA ENSG00000253730 MBTD1 DLX3 ENSG00000248172 PPP1R9B
GH17I050099 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.2 +79.6 79576 3.6 ATF1 FOXA2 MLX ARID4B ETS1 YY1 ZNF766 GLIS2 SP3 RXRA ENSG00000250282 PDK2 ENSG00000262837 ENSG00000253730 SGCA HILS1 SAMD14 PICART1 ENSG00000275025
GH17I050107 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.1 +70.5 70457 6.4 ELF3 ARID4B KLF17 THRB ZNF48 RAD21 ZBTB40 TCF12 EGR1 FOS PDK2 ENSG00000253730 SGCA HILS1 ENSG00000248172 DLX3 SAMD14 ACSF2 CHAD PICART1
GH17I050216 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.6 -38.7 -38652 6.9 FOXA2 ARID4B YY1 SCRT2 ATF7 FOS IKZF2 RXRA USF2 CEBPB TMEM92 TMEM92-AS1 HILS1 SGCA ENSG00000253730 SAMD14 PDK2 ENSG00000250282 ACSF2 CHAD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HILS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HILS1 gene promoter:

Genomic Locations for HILS1 Gene

Genomic Locations for HILS1 Gene
chr17:50,171,428-50,181,178
(GRCh38/hg38)
Size:
9,751 bases
Orientation:
Minus strand
chr17:48,248,789-48,258,539
(GRCh37/hg19)

Genomic View for HILS1 Gene

Genes around HILS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HILS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HILS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HILS1 Gene

Proteins for HILS1 Gene

  • Protein details for HILS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60008-HILS1_HUMAN
    Recommended name:
    Spermatid-specific linker histone H1-like protein
    Protein Accession:
    P60008

    Protein attributes for HILS1 Gene

    Size:
    231 amino acids
    Molecular mass:
    25632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HILS1 Gene

Post-translational modifications for HILS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HILS1 Gene

Domains & Families for HILS1 Gene

Protein Domains for HILS1 Gene

Suggested Antigen Peptide Sequences for HILS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60008

UniProtKB/Swiss-Prot:

HILS1_HUMAN :
  • Belongs to the histone H1/H5 family.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HILS1: view

No data available for Gene Families for HILS1 Gene

Function for HILS1 Gene

Molecular function for HILS1 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.

Phenotypes From GWAS Catalog for HILS1 Gene

Gene Ontology (GO) - Molecular Function for HILS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IDA 12920187
GO:0003677 DNA binding IEA --
GO:0042393 histone binding IDA 12920187
genes like me logo Genes that share ontologies with HILS1: view
genes like me logo Genes that share phenotypes with HILS1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HILS1 Gene

Localization for HILS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HILS1 Gene

Nucleus. Chromosome.

Gene Ontology (GO) - Cellular Components for HILS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IDA 12920187
GO:0001673 male germ cell nucleus IDA 12920187
genes like me logo Genes that share ontologies with HILS1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HILS1 Gene

Pathways & Interactions for HILS1 Gene

genes like me logo Genes that share pathways with HILS1: view

Pathways by source for HILS1 Gene

1 GeneGo (Thomson Reuters) pathway for HILS1 Gene

Interacting Proteins for HILS1 Gene

Gene Ontology (GO) - Biological Process for HILS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0006338 chromatin remodeling NAS 12920187
GO:0006342 chromatin silencing IDA 12920187
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 12920187
genes like me logo Genes that share ontologies with HILS1: view

No data available for SIGNOR curated interactions for HILS1 Gene

Drugs & Compounds for HILS1 Gene

(1) Additional Compounds for HILS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HILS1: view

Transcripts for HILS1 Gene

mRNA/cDNA for HILS1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HILS1 Gene

Histone linker H1 domain, spermatid-specific 1, pseudogene:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HILS1 Gene

No ASD Table

Relevant External Links for HILS1 Gene

GeneLoc Exon Structure for
HILS1
ECgene alternative splicing isoforms for
HILS1

Expression for HILS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HILS1 Gene

mRNA differential expression in normal tissues according to GTEx for HILS1 Gene

This gene is overexpressed in Testis (x8.4) and Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for HILS1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HILS1 Gene



Protein tissue co-expression partners for HILS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HILS1 Gene:

HILS1

SOURCE GeneReport for Unigene cluster for HILS1 Gene:

Hs.25934

mRNA Expression by UniProt/SwissProt for HILS1 Gene:

P60008-HILS1_HUMAN
Tissue specificity: Expressed exclusively in the testis.
genes like me logo Genes that share expression patterns with HILS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HILS1 Gene

Orthologs for HILS1 Gene

Evolution for HILS1 Gene

ENSEMBL:
Gene Tree for HILS1 (if available)
TreeFam:
Gene Tree for HILS1 (if available)

No data available for Orthologs for HILS1 Gene

Paralogs for HILS1 Gene

No data available for Paralogs for HILS1 Gene

Variants for HILS1 Gene

Sequence variations from dbSNP and Humsavar for HILS1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000084672 -- 50,174,040(-) T/C upstream_transcript_variant
rs1001862771 -- 50,173,378(-) T/C upstream_transcript_variant
rs1002158074 -- 50,172,431(-) C/T non_coding_transcript_variant
rs1002485317 -- 50,171,256(-) C/A/T downstream_transcript_variant
rs1003100139 -- 50,171,715(-) G/A non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HILS1 Gene

Variant ID Type Subtype PubMed ID
nsv507842 OTHER sequence alteration 20534489
nsv952339 CNV deletion 24416366

Additional Variant Information for HILS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HILS1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HILS1 Gene

Disorders for HILS1 Gene

Additional Disease Information for HILS1

No disorders were found for HILS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HILS1 Gene

Publications for HILS1 Gene

  1. HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis. (PMID: 12920187) Yan W … Matzuk MM (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 22 58
  2. Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. (PMID: 17852044) Jedrzejczak P … Jagodzinski PP (Archives of andrology 2007) 3 22 58
  3. Isolation and characterization of a novel cDNA encoding a DNA-binding protein (Hils1) specifically expressed in testicular haploid germ cells. (PMID: 14636221) Iguchi N … Nishimune Y (International journal of andrology 2003) 3 22 58
  4. Role of H1 linker histones in mammalian development and stem cell differentiation. (PMID: 26689747) Pan C … Fan Y (Biochimica et biophysica acta 2016) 3 58
  5. Mapping of post-translational modifications of spermatid-specific linker histone H1-like protein, HILS1. (PMID: 26257145) Mishra LN … Rao SM (Journal of proteomics 2015) 3 58

Products for HILS1 Gene

Sources for HILS1 Gene

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