Aliases for HILPDA Gene

Aliases for HILPDA Gene

  • Hypoxia Inducible Lipid Droplet Associated 2 3 5
  • HIG2 2 3 4
  • Hypoxia-Inducible Lipid Droplet-Associated Protein 3 4
  • Hypoxia-Inducible Gene 2 Protein 3 4
  • Hypoxia Inducible Gene 2 2 3
  • C7orf68 3 4
  • HIG-2 2 3
  • Hypoxia Inducible Lipid Droplet-Associated 2
  • Chromosome 7 Open Reading Frame 68 2
  • Hypoxia-Inducible Protein 2 3
  • FLJ21076 2
  • HILPDA 5

External Ids for HILPDA Gene

Previous HGNC Symbols for HILPDA Gene

  • C7orf68

Previous GeneCards Identifiers for HILPDA Gene

  • GC07P128109
  • GC07P128112
  • GC07P128115
  • GC07P128117
  • GC07P128123
  • GC07P128461
  • GC07P128523
  • GC07P129015
  • GC07P129069
  • GC07P129113
  • GC07P129281
  • GC07P128541
  • GC07P128560
  • GC07P128576
  • GC07P128593
  • GC07P128607
  • GC07P128629
  • GC07P128751
  • GC07P128941

Summaries for HILPDA Gene

GeneCards Summary for HILPDA Gene

HILPDA (Hypoxia Inducible Lipid Droplet Associated) is a Protein Coding gene. Diseases associated with HILPDA include Hypoxia. Among its related pathways are Metabolism and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

UniProtKB/Swiss-Prot Summary for HILPDA Gene

  • Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.

Additional gene information for HILPDA Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HILPDA Gene

Genomics for HILPDA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HILPDA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HILPDA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HILPDA

Genomic Locations for HILPDA Gene

Genomic Locations for HILPDA Gene
chr7:128,455,830-128,458,418
(GRCh38/hg38)
Size:
2,589 bases
Orientation:
Plus strand
chr7:128,095,884-128,098,472
(GRCh37/hg19)
Size:
2,589 bases
Orientation:
Plus strand

Genomic View for HILPDA Gene

Genes around HILPDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HILPDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HILPDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HILPDA Gene

Proteins for HILPDA Gene

  • Protein details for HILPDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5L2-HLPDA_HUMAN
    Recommended name:
    Hypoxia-inducible lipid droplet-associated protein
    Protein Accession:
    Q9Y5L2
    Secondary Accessions:
    • A4D0Z5
    • Q52LY5
    • Q53HJ7

    Protein attributes for HILPDA Gene

    Size:
    63 amino acids
    Molecular mass:
    6950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HILPDA Gene

Post-translational modifications for HILPDA Gene

  • Glycosylation at Ser44, Thr49, Thr52, Ser60, and Ser62
  • Modification sites at PhosphoSitePlus

Other Protein References for HILPDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HILPDA Gene

Domains & Families for HILPDA Gene

Gene Families for HILPDA Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for HILPDA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HILPDA Gene

GenScript: Design optimal peptide antigens:
  • Hypoxia-inducible gene 2 protein (HIG2_HUMAN)
genes like me logo Genes that share domains with HILPDA: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HILPDA Gene

Function for HILPDA Gene

Molecular function for HILPDA Gene

UniProtKB/Swiss-Prot Function:
Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
UniProtKB/Swiss-Prot Induction:
By hypoxia but highly abundant under normoxic conditions (at protein level).

Gene Ontology (GO) - Molecular Function for HILPDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 15930302
GO:0005515 protein binding IPI 15930302
genes like me logo Genes that share ontologies with HILPDA: view
genes like me logo Genes that share phenotypes with HILPDA: view

Animal Models for HILPDA Gene

MGI Knock Outs for HILPDA:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HILPDA

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HILPDA Gene

Localization for HILPDA Gene

Subcellular locations from UniProtKB/Swiss-Prot for HILPDA Gene

Lipid droplet. Secreted. Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HILPDA gene
Compartment Confidence
extracellular 5
nucleus 4
cytosol 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HILPDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 15930302
GO:0005654 nucleoplasm IDA --
GO:0005811 lipid droplet IBA,IDA 20624928
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HILPDA: view

Pathways & Interactions for HILPDA Gene

PathCards logo

SuperPathways for HILPDA Gene

genes like me logo Genes that share pathways with HILPDA: view

Pathways by source for HILPDA Gene

Gene Ontology (GO) - Biological Process for HILPDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 20624928
GO:0008284 positive regulation of cell proliferation IDA 15930302
GO:0010884 positive regulation of lipid storage IDA 20624928
GO:0034389 lipid droplet organization TAS --
GO:0035425 autocrine signaling IBA,IDA 15930302
genes like me logo Genes that share ontologies with HILPDA: view

No data available for SIGNOR curated interactions for HILPDA Gene

Drugs & Compounds for HILPDA Gene

No Compound Related Data Available

Transcripts for HILPDA Gene

mRNA/cDNA for HILPDA Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HILPDA

Alternative Splicing Database (ASD) splice patterns (SP) for HILPDA Gene

No ASD Table

Relevant External Links for HILPDA Gene

GeneLoc Exon Structure for
HILPDA

Expression for HILPDA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HILPDA Gene

mRNA differential expression in normal tissues according to GTEx for HILPDA Gene

This gene is overexpressed in Whole Blood (x6.5) and Esophagus - Mucosa (x5.3).

Protein differential expression in normal tissues from HIPED for HILPDA Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HILPDA Gene



Protein tissue co-expression partners for HILPDA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HILPDA

SOURCE GeneReport for Unigene cluster for HILPDA Gene:

Hs.706124

mRNA Expression by UniProt/SwissProt for HILPDA Gene:

Q9Y5L2-HLPDA_HUMAN
Tissue specificity: Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level).

Evidence on tissue expression from TISSUES for HILPDA Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with HILPDA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HILPDA Gene

Orthologs for HILPDA Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HILPDA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HILPDA 30 31
  • 99.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hilpda 30
  • 77.78 (n)
Mouse
(Mus musculus)
Mammalia Hilpda 30 17 31
  • 77.78 (n)
OneToOne
Species where no ortholog for HILPDA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for HILPDA Gene

ENSEMBL:
Gene Tree for HILPDA (if available)
TreeFam:
Gene Tree for HILPDA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HILPDA: view image

Paralogs for HILPDA Gene

No data available for Paralogs for HILPDA Gene

Variants for HILPDA Gene

Additional dbSNP identifiers (rs#s) for HILPDA Gene

Structural Variations from Database of Genomic Variants (DGV) for HILPDA Gene

Variant ID Type Subtype PubMed ID
esv3614970 CNV loss 21293372
nsv608401 CNV loss 21841781
nsv831124 CNV gain+loss 17160897

Variation tolerance for HILPDA Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HILPDA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HILPDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HILPDA Gene

Disorders for HILPDA Gene

MalaCards: The human disease database

(1) MalaCards diseases for HILPDA Gene - From: GeneCards

Disorder Aliases PubMed IDs
hypoxia
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with HILPDA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HILPDA Gene

Publications for HILPDA Gene

  1. Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy. (PMID: 15930302) Togashi A … Nakamura Y (Cancer research 2005) 2 3 4 23
  2. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. (PMID: 10690527) Denko N … Giaccia A (Clinical cancer research : an official journal of the American Association for Cancer Research 2000) 2 3 4
  3. Expression of hypoxia-inducible 2 (HIG2) protein in uterine cancer. (PMID: 21614900) Nishimura S … Aoki D (European journal of gynaecological oncology 2011) 3 4
  4. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. (PMID: 20624928) Gimm T … Warnecke C (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010) 3 4
  5. Differential expression of hypoxia-inducible protein 2 among different histological types of epithelial ovarian cancer and in clear cell adenocarcinomas. (PMID: 20134266) Nishimura S … Aoki D (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2010) 3 23

Products for HILPDA Gene

  • Signalway Proteins for HILPDA

Sources for HILPDA Gene