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Aliases for HIGD1B Gene

Aliases for HIGD1B Gene

  • HIG1 Hypoxia Inducible Domain Family Member 1B 2 3 5
  • HIG1 Hypoxia Inducible Domain Family, Member 1B 2
  • HIG1 Domain Family, Member 1B 2
  • HIG1 Domain Family Member 1B 3
  • Protein CLST 11240 4
  • CLST11240-15 3
  • CLST11240 3

External Ids for HIGD1B Gene

Previous GeneCards Identifiers for HIGD1B Gene

  • GC17P040281
  • GC17P042925
  • GC17P038690

Summaries for HIGD1B Gene

Entrez Gene Summary for HIGD1B Gene

  • This gene encodes a member of the hypoxia inducible gene 1 (HIG1) domain family. The encoded protein is localized to the cell membrane and has been linked to tumorigenesis and the progression of pituitary adenomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for HIGD1B Gene

HIGD1B (HIG1 Hypoxia Inducible Domain Family Member 1B) is a Protein Coding gene. Diseases associated with HIGD1B include Hypoxia. An important paralog of this gene is HIGD1C.

Additional gene information for HIGD1B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIGD1B Gene

Genomics for HIGD1B Gene

GeneHancer (GH) Regulatory Elements for HIGD1B Gene

Promoters and enhancers for HIGD1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J044842 Enhancer 0.8 Ensembl ENCODE 650.7 -1.3 -1268 3.1 EBF1 MEF2B ZNF664 MEF2D PCBP2 ZBTB48 PRDM10 ZBTB20 HIGD1B EFTUD2 FAM187A ENSG00000224505 TMUB2 ASB16-AS1 GFAP C1QL1 MEIOC ENSG00000267505
GH17J044847 Promoter 0.7 EPDnew 650.7 +3.1 3079 0.1 POLR2A PRDM10 HIGD1B GC17P044850
GH17J044846 Promoter 0.5 EPDnew 650.7 +1.5 1495 0.1 HIGD1B GFAP C1QL1 GC17P044850
GH17J044818 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.7 -24.4 -24420 3.4 ARNT ZNF493 ZFP64 FEZF1 ZNF2 ZNF121 ZNF213 KLF7 FOS ZNF202 UBTF ASB16-AS1 TMUB2 GJC1 MPP2 GPATCH8 ENSG00000266918 ENSG00000260793 EFTUD2 HIGD1B
GH17J044781 Enhancer 0.9 Ensembl ENCODE dbSUPER 12 -62.6 -62620 1.7 KLF1 IKZF1 GLIS1 ZNF341 REST GABPA ZNF18 ADAM11 DBF4B GJC1 HIGD1B FAM187A CCDC103 EFTUD2 GFAP MEIOC C1QL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HIGD1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIGD1B gene promoter:
  • RORalpha1
  • AP-4
  • AML1a
  • Pbx1a
  • Ik-2
  • Bach1
  • GATA-1
  • GATA-2
  • GATA-3
  • HOXA5

Genomic Locations for HIGD1B Gene

Genomic Locations for HIGD1B Gene
5,666 bases
Plus strand
4,128 bases
Plus strand

Genomic View for HIGD1B Gene

Genes around HIGD1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIGD1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIGD1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIGD1B Gene

Proteins for HIGD1B Gene

  • Protein details for HIGD1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HIG1 domain family member 1B
    Protein Accession:
    Secondary Accessions:
    • D3DX57
    • Q9P297

    Protein attributes for HIGD1B Gene

    99 amino acids
    Molecular mass:
    11058 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HIGD1B Gene

neXtProt entry for HIGD1B Gene

Post-translational modifications for HIGD1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HIGD1B Gene

Domains & Families for HIGD1B Gene

Gene Families for HIGD1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for HIGD1B Gene


Suggested Antigen Peptide Sequences for HIGD1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HIGD1B: view

No data available for UniProtKB/Swiss-Prot for HIGD1B Gene

Function for HIGD1B Gene

genes like me logo Genes that share phenotypes with HIGD1B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HIGD1B Gene

Localization for HIGD1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIGD1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIGD1B gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for HIGD1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HIGD1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HIGD1B Gene

Pathways & Interactions for HIGD1B Gene

SuperPathways for HIGD1B Gene

No Data Available

Interacting Proteins for HIGD1B Gene

Selected Interacting proteins: Q9P298-HIG1B_HUMAN for HIGD1B Gene via IID

Gene Ontology (GO) - Biological Process for HIGD1B Gene


No data available for Pathways by source and SIGNOR curated interactions for HIGD1B Gene

Drugs & Compounds for HIGD1B Gene

No Compound Related Data Available

Transcripts for HIGD1B Gene

Unigene Clusters for HIGD1B Gene

HIG1 hypoxia inducible domain family, member 1B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIGD1B Gene

No ASD Table

Relevant External Links for HIGD1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIGD1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIGD1B Gene

mRNA differential expression in normal tissues according to GTEx for HIGD1B Gene

This gene is overexpressed in Heart - Left Ventricle (x4.4) and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for HIGD1B Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIGD1B Gene

Protein tissue co-expression partners for HIGD1B Gene

NURSA nuclear receptor signaling pathways regulating expression of HIGD1B Gene:


SOURCE GeneReport for Unigene cluster for HIGD1B Gene:

genes like me logo Genes that share expression patterns with HIGD1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIGD1B Gene

Orthologs for HIGD1B Gene

This gene was present in the common ancestor of animals.

Orthologs for HIGD1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HIGD1B 34 33
  • 98.99 (n)
(Canis familiaris)
Mammalia HIGD1B 34 33
  • 85.86 (n)
(Bos Taurus)
Mammalia HIGD1B 34 33
  • 85.86 (n)
(Rattus norvegicus)
Mammalia Higd1b 33
  • 83.16 (n)
(Mus musculus)
Mammalia Higd1b 16 34 33
  • 82.99 (n)
(Monodelphis domestica)
Mammalia HIGD1B 34
  • 53 (a)
(Anolis carolinensis)
Reptilia HIGD1B 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia higd1b 33
  • 57.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11825 34
  • 21 (a)
Species where no ortholog for HIGD1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIGD1B Gene

Gene Tree for HIGD1B (if available)
Gene Tree for HIGD1B (if available)
Evolutionary constrained regions (ECRs) for HIGD1B: view image

Paralogs for HIGD1B Gene

Paralogs for HIGD1B Gene

(4) SIMAP similar genes for HIGD1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HIGD1B: view

Variants for HIGD1B Gene

Sequence variations from dbSNP and Humsavar for HIGD1B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000030781 -- 44,844,887(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000111504 -- 44,848,487(+) A/C intron_variant
rs1001732173 -- 44,843,360(+) A/T upstream_transcript_variant
rs1002014366 -- 44,847,593(+) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002163240 -- 44,843,678(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HIGD1B Gene

Variant ID Type Subtype PubMed ID
esv2715966 CNV deletion 23290073
nsv1118596 CNV duplication 24896259
nsv1146669 OTHER inversion 26484159

Variation tolerance for HIGD1B Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.32; 76.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIGD1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIGD1B Gene

Disorders for HIGD1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for HIGD1B Gene - From: GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HIGD1B

genes like me logo Genes that share disorders with HIGD1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HIGD1B Gene

Publications for HIGD1B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PMID: 22609626) Klammt C … Choe S (Nature methods 2012) 4 58
  4. Analysis of differential gene expression in plurihormonal pituitary adenomas using bead-based fiber-optic arrays. (PMID: 22588334) Jiang Z … Zhang Y (Journal of neuro-oncology 2012) 3 58
  5. Analysis of differential gene expression by bead-based fiber-optic array in nonfunctioning pituitary adenomas. (PMID: 21351040) Jiang Z … Zhang Y (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2011) 3 58

Products for HIGD1B Gene

Sources for HIGD1B Gene

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