Aliases for HIF1AN Gene

Aliases for HIF1AN Gene

  • Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor 2 3 5
  • FIH1 2 3 4
  • Hypoxia-Inducible Factor Asparagine Hydroxylase 3 4
  • Hypoxia-Inducible Factor 1-Alpha Inhibitor 3 4
  • Peptide-Aspartate Beta-Dioxygenase 2 3
  • Factor Inhibiting HIF-1 3 4
  • FIH-1 3 4
  • Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor 3
  • Factor Inhibiting HIF1 3
  • DKFZp762F1811 2
  • EC 1.14.11.30 4
  • EC 1.14.11.n4 4
  • FLJ20615 2
  • FLJ22027 2
  • HIF1AN 5

External Ids for HIF1AN Gene

Previous GeneCards Identifiers for HIF1AN Gene

  • GC10P101188
  • GC10P101529
  • GC10P102420
  • GC10P101960
  • GC10P102285
  • GC10P095924

Summaries for HIF1AN Gene

GeneCards Summary for HIF1AN Gene

HIF1AN (Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor) is a Protein Coding gene. Diseases associated with HIF1AN include Hypoxia and Familial Isolated Hypoparathyroidism. Among its related pathways are HIF1Alpha Pathway and HIF Repressors. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. An important paralog of this gene is HSPBAP1.

UniProtKB/Swiss-Prot Summary for HIF1AN Gene

  • Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

Gene Wiki entry for HIF1AN Gene

Additional gene information for HIF1AN Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HIF1AN Gene

Genomics for HIF1AN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HIF1AN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HIF1AN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HIF1AN

Top Transcription factor binding sites by QIAGEN in the HIF1AN gene promoter:
  • c-Myc
  • CUTL1
  • E47
  • IRF-7A
  • Max
  • MIF-1
  • RP58
  • SRF
  • SRF (504 AA)
  • Tal-1beta

Genomic Locations for HIF1AN Gene

Genomic Locations for HIF1AN Gene
chr10:100,529,072-100,559,998
(GRCh38/hg38)
Size:
30,927 bases
Orientation:
Plus strand
chr10:102,288,829-102,319,755
(GRCh37/hg19)
Size:
30,927 bases
Orientation:
Plus strand

Genomic View for HIF1AN Gene

Genes around HIF1AN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIF1AN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIF1AN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIF1AN Gene

Proteins for HIF1AN Gene

  • Protein details for HIF1AN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWT6-HIF1N_HUMAN
    Recommended name:
    Hypoxia-inducible factor 1-alpha inhibitor
    Protein Accession:
    Q9NWT6
    Secondary Accessions:
    • D3DR69
    • Q5W147
    • Q969Q7
    • Q9NPV5

    Protein attributes for HIF1AN Gene

    Size:
    349 amino acids
    Molecular mass:
    40285 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Homodimer; homodimerization is essential for catalytic activity. Interacts with VHL and HIF1A. Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA. Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4. Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A. Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4 (By similarity). Interacts with UBE3A. Interacts with ANKS3 (By similarity). Interacts with NECAB3; the interaction is indirect and seems to be mediated by APBA3.

    Three dimensional structures from OCA and Proteopedia for HIF1AN Gene

neXtProt entry for HIF1AN Gene

Post-translational modifications for HIF1AN Gene

  • Ubiquitination at Lys115 and Lys131
  • Modification sites at PhosphoSitePlus

Other Protein References for HIF1AN Gene

Antibody Products

No data available for DME Specific Peptides for HIF1AN Gene

Domains & Families for HIF1AN Gene

Gene Families for HIF1AN Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HIF1AN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HIF1AN Gene

GenScript: Design optimal peptide antigens:
  • Hypoxia-inducible factor asparagine hydroxylase (HIF1N_HUMAN)
genes like me logo Genes that share domains with HIF1AN: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HIF1AN Gene

Function for HIF1AN Gene

Molecular function for HIF1AN Gene

UniProtKB/Swiss-Prot Function:
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate; Xref=Rhea:RHEA:54268, Rhea:RHEA-COMP:13833, Rhea:RHEA-COMP:13834, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50347, ChEBI:CHEBI:138107; EC=1.14.11.30; Evidence={ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:14701857, ECO:0000269|PubMed:17573339};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate; Xref=Rhea:RHEA:54264, Rhea:RHEA-COMP:13836, Rhea:RHEA-COMP:13837, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29979, ChEBI:CHEBI:30031, ChEBI:CHEBI:138021; EC=1.14.11.n4; Evidence={ECO:0000269|PubMed:21251231};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate; Xref=Rhea:RHEA:54272, Rhea:RHEA-COMP:13838, Rhea:RHEA-COMP:13839, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:50347, ChEBI:CHEBI:138107; EC=1.14.11.n4; Evidence={ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate; Xref=Rhea:RHEA:54280, Rhea:RHEA-COMP:13843, Rhea:RHEA-COMP:13844, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29961, ChEBI:CHEBI:30031, ChEBI:CHEBI:138111; EC=1.14.11.n4; Evidence={ECO:0000269|PubMed:21177872};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=100 uM for HIF1A (788-822) peptide {ECO:0000269|PubMed:14701857}; KM=160 uM for HIF2A (832-866) peptide {ECO:0000269|PubMed:14701857}; KM=0.5 uM for Fe(2+) {ECO:0000269|PubMed:14701857}; KM=25 uM for 2-oxoglutarate {ECO:0000269|PubMed:14701857}; KM=260 uM for ascorbate {ECO:0000269|PubMed:14701857}; KM=90 uM for O(2) {ECO:0000269|PubMed:14701857}; Note=The kinetic constants are determined for the recombinant FLAG-His-tagged protein.;

Enzyme Numbers (IUBMB) for HIF1AN Gene

Phenotypes From GWAS Catalog for HIF1AN Gene

Gene Ontology (GO) - Molecular Function for HIF1AN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005112 Notch binding IPI 17573339
GO:0005506 iron ion binding IDA --
GO:0005515 protein binding IPI 11641274
GO:0008198 ferrous iron binding IDA 12446723
GO:0008270 zinc ion binding IDA 12446723
genes like me logo Genes that share ontologies with HIF1AN: view
genes like me logo Genes that share phenotypes with HIF1AN: view

Animal Models for HIF1AN Gene

MGI Knock Outs for HIF1AN:

Animal Model Products

CRISPR Products

miRNA for HIF1AN Gene

miRTarBase miRNAs that target HIF1AN

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIF1AN

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIF1AN Gene

Localization for HIF1AN Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIF1AN Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIF1AN gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HIF1AN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 colocalizes_with nucleus IEA,IDA 18299578
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IDA 14734545
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA,IDA 19726677
genes like me logo Genes that share ontologies with HIF1AN: view

Pathways & Interactions for HIF1AN Gene

genes like me logo Genes that share pathways with HIF1AN: view

SIGNOR curated interactions for HIF1AN Gene

Inactivates:

Gene Ontology (GO) - Biological Process for HIF1AN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036138 peptidyl-histidine hydroxylation IBA,IDA 21251231
GO:0042264 peptidyl-aspartic acid hydroxylation IDA 21177872
GO:0042265 peptidyl-asparagine hydroxylation IBA,IMP 19245366
GO:0045663 positive regulation of myoblast differentiation IDA 18299578
GO:0045746 negative regulation of Notch signaling pathway IDA 18299578
genes like me logo Genes that share ontologies with HIF1AN: view

Drugs & Compounds for HIF1AN Gene

(14) Drugs for HIF1AN Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Iron Approved, Experimental Pharma 1560
Succinic acid Approved Nutra Agonist, Full agonist 0
D-tartaric acid Experimental Pharma Target 0

(1) Additional Compounds for HIF1AN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for HIF1AN Gene

Compound Action Cas Number
BAY 87-2243 HIF-1 inhibitor,potent and selective 1227158-85-1
genes like me logo Genes that share compounds with HIF1AN: view

Drug Products

Transcripts for HIF1AN Gene

mRNA/cDNA for HIF1AN Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIF1AN

Alternative Splicing Database (ASD) splice patterns (SP) for HIF1AN Gene

No ASD Table

Relevant External Links for HIF1AN Gene

GeneLoc Exon Structure for
HIF1AN

Expression for HIF1AN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HIF1AN Gene

mRNA differential expression in normal tissues according to GTEx for HIF1AN Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for HIF1AN Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.5) and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIF1AN Gene



Protein tissue co-expression partners for HIF1AN Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HIF1AN

SOURCE GeneReport for Unigene cluster for HIF1AN Gene:

Hs.500788

Evidence on tissue expression from TISSUES for HIF1AN Gene

  • Nervous system(4.7)
  • Muscle(4.5)
  • Kidney(2.7)
  • Heart(2.6)
  • Skin(2.4)
  • Intestine(2.3)
  • Blood(2.2)
  • Liver(2.2)
  • Bone marrow(2.1)
  • Lymph node(2)
  • Spleen(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with HIF1AN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIF1AN Gene

Orthologs for HIF1AN Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIF1AN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HIF1AN 30 31
  • 99.81 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HIF1AN 30 31
  • 94.46 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HIF1AN 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia HIF1AN 30 31
  • 93.87 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Hif1an 30 17 31
  • 91.12 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hif1an 30
  • 91.12 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia HIF1AN 31
  • 90 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HIF1AN 30 31
  • 80.83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HIF1AN 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hif1an 30
  • 77.44 (n)
MGC76135 30
Zebrafish
(Danio rerio)
Actinopterygii hif1an 30 31
  • 75.08 (n)
OneToOne
Dr.13371 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 57 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.13324 30
Species where no ortholog for HIF1AN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HIF1AN Gene

ENSEMBL:
Gene Tree for HIF1AN (if available)
TreeFam:
Gene Tree for HIF1AN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HIF1AN: view image

Paralogs for HIF1AN Gene

Paralogs for HIF1AN Gene

genes like me logo Genes that share paralogs with HIF1AN: view

Variants for HIF1AN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HIF1AN Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs2295778 - p.Pro41Ala

Additional dbSNP identifiers (rs#s) for HIF1AN Gene

Structural Variations from Database of Genomic Variants (DGV) for HIF1AN Gene

Variant ID Type Subtype PubMed ID
dgv277e212 CNV loss 25503493
esv2759779 CNV gain+loss 17122850
nsv7519 CNV insertion 18451855
nsv831962 CNV gain 17160897
nsv831963 CNV loss 17160897

Variation tolerance for HIF1AN Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIF1AN Gene

Human Gene Mutation Database (HGMD)
HIF1AN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIF1AN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIF1AN Gene

Disorders for HIF1AN Gene

MalaCards: The human disease database

(5) MalaCards diseases for HIF1AN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypoxia
familial isolated hypoparathyroidism
  • fih
parathyroid gland disease
  • disease of parathyroid glands
acute mountain sickness
  • altitude anoxia
renal cell carcinoma, nonpapillary
  • rcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HIF1AN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HIF1AN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HIF1AN Gene

Publications for HIF1AN Gene

  1. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. (PMID: 11641274) Mahon PC … Semenza GL (Genes & development 2001) 2 3 4 23
  2. Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1. (PMID: 19726677) Sakamoto T … Seiki M (The Journal of biological chemistry 2009) 3 4 23
  3. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. (PMID: 18299578) Zheng X … Poellinger L (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 23
  4. Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. (PMID: 14734545) Linke S … Peet DJ (The Journal of biological chemistry 2004) 3 4 23
  5. Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau. (PMID: 12482756) Lee C … Ryu SE (The Journal of biological chemistry 2003) 3 4 23

Products for HIF1AN Gene

Sources for HIF1AN Gene