Aliases for HIF1A Gene
Aliases for HIF1A Gene
- Hypoxia Inducible Factor 1 Alpha Subunit 2 3 5
- Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) 2 3
- Class E Basic Helix-Loop-Helix Protein 78 3 4
- Basic-Helix-Loop-Helix-PAS Protein MOP1 3 4
- PAS Domain-Containing Protein 8 3 4
- Member Of PAS Protein 1 3 4
- HIF-1-Alpha 3 4
- HIF1-ALPHA 3 4
- BHLHe78 3 4
- PASD8 3 4
- MOP1 3 4
External Ids for HIF1A Gene
- HGNC: 4910
- Entrez Gene: 3091
- Ensembl: ENSG00000100644
- OMIM: 603348
- UniProtKB: Q16665
Previous GeneCards Identifiers for HIF1A Gene
- GC14P059488
- GC14P055956
- GC14P060152
- GC14P061231
- GC14P062162
- GC14P042326
Summaries for HIF1A Gene
-
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
GeneCards Summary for HIF1A Gene
HIF1A (Hypoxia Inducible Factor 1 Alpha Subunit) is a Protein Coding gene. Diseases associated with HIF1A include Hypoxia and Retinal Ischemia. Among its related pathways are Mitophagy - animal and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is EPAS1.
UniProtKB/Swiss-Prot for HIF1A Gene
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Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5-[AG]CGTG-3 within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
-
Hypoxia Inducible Factors (HIFs) are transcription factors that are activated in response to decreased oxygen availability in the cellular environment. They influence cell metabolism, cell survival and angiogenesis to maintain biological homeostasis.
Additional gene information for HIF1A Gene
- Monarch Initiative
- Search for HIF1A at DataMed
- Search for HIF1A at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIF1A Gene
Genomics for HIF1A Gene
GeneHancer (GH) Regulatory Elements for HIF1A Gene
Promoters and enhancers for HIF1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HIF1A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HIF1A gene promoter:
Regulatory Element Products
Genomic Locations for HIF1A Gene
Genomic Locations for HIF1A Gene
- chr14:61,695,401-61,748,259
- (GRCh38/hg38)
- Size:
- 52,859 bases
- Orientation:
- Plus strand
- chr14:62,162,119-62,214,977
- (GRCh37/hg19)
Genomic View for HIF1A Gene
Genes around HIF1A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q23.2 by Ensembl
- 14q23.2 by Entrez Gene
- 14q23.2 by HGNC
HIF1A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIF1A Gene
Proteins for HIF1A Gene
-
Protein details for HIF1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16665-HIF1A_HUMAN
- Recommended name:
- Hypoxia-inducible factor 1-alpha
- Protein Accession:
- Q16665
- C0LZJ3
- Q53XP6
- Q96PT9
- Q9UPB1
Protein attributes for HIF1A Gene
- Size:
- 826 amino acids
- Molecular mass:
- 92670 Da
- Quaternary structure:
-
- Interacts with the HIF1A beta/ARNT subunit; heterodimerization is required for DNA binding. Interacts with COPS5; the interaction increases the transcriptional activity of HIF1A through increased stability (By similarity). Interacts with EP300 (via TAZ-type 1 domains); the interaction is stimulated in response to hypoxia and inhibited by CITED2. Interacts with CREBBP (via TAZ-type 1 domains). Interacts with NCOA1, NCOA2, APEX and HSP90. Interacts (hydroxylated within the ODD domain) with VHLL (via beta domain); the interaction, leads to polyubiquitination and subsequent HIF1A proteasomal degradation. During hypoxia, sumoylated HIF1A also binds VHL; the interaction promotes the ubiquitination of HIF1A. Interacts with SENP1; the interaction desumoylates HIF1A resulting in stabilization and activation of transcription. Interacts (Via the ODD domain) with ARD1A; the interaction appears not to acetylate HIF1A nor have any affect on protein stability, during hypoxia. Interacts with RWDD3; the interaction enhances HIF1A sumoylation. Interacts with TSGA10 (By similarity). Interacts with HIF3A (By similarity). Interacts with RORA (via the DNA binding domain); the interaction enhances HIF1A transcription under hypoxia through increasing protein stability. Interaction with PSMA7 inhibits the transactivation activity of HIF1A under both normoxic and hypoxia-mimicking conditions. Interacts with USP20. Interacts with RACK1; promotes HIF1A ubiquitination and proteasome-mediated degradation. Interacts (via N-terminus) with USP19. Interacts with SIRT2. Interacts (deacetylated form) with EGLN1. Interacts with CBFA2T3. Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842).
Three dimensional structures from OCA and Proteopedia for HIF1A Gene
Post-translational modifications for HIF1A Gene
- Acetylation of Lys-532 by ARD1 increases interaction with VHL and stimulates subsequent proteasomal degradation (PubMed:12464182). Deacetylation of Lys-709 by SIRT2 increases its interaction with and hydroxylation by EGLN1 thereby inactivating HIF1A activity by inducing its proteasomal degradation (PubMed:24681946).
- In normoxia, is hydroxylated on Pro-402 and Pro-564 in the oxygen-dependent degradation domain (ODD) by EGLN1/PHD2 and EGLN2/PHD1 (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). EGLN3/PHD3 has also been shown to hydroxylate Pro-564 (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). Deubiquitinated by USP20 (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). In normoxia, is hydroxylated on Asn-803 by HIF1AN, thus abrogating interaction with CREBBP and EP300 and preventing transcriptional activation (PubMed:12080085). This hydroxylation is inhibited by the Cu/Zn-chelator, Clioquinol (PubMed:12080085). Repressed by iron ion, via Fe(2+) prolyl hydroxylase (PHD) enzymes-mediated hydroxylation and subsequent proteasomal degradation (PubMed:28296633).
- Polyubiquitinated; in normoxia, following hydroxylation and interaction with VHL. Lys-532 appears to be the principal site of ubiquitination. Clioquinol, the Cu/Zn-chelator, inhibits ubiquitination through preventing hydroxylation at Asn-803. Ubiquitinated by a CUL2-based E3 ligase.
- Requires phosphorylation for DNA-binding. Phosphorylation at Ser-247 by CSNK1D/CK1 represses kinase activity and impairs ARNT binding. Phosphorylation by GSK3-beta and PLK3 promote degradation by the proteasome.
- S-nitrosylation of Cys-800 may be responsible for increased recruitment of p300 coactivator necessary for transcriptional activity of HIF-1 complex.
- Sumoylated; with SUMO1 under hypoxia. Sumoylation is enhanced through interaction with RWDD3. Both sumoylation and desumoylation seem to be involved in the regulation of its stability during hypoxia. Sumoylation can promote either its stabilization or its VHL-dependent degradation by promoting hydroxyproline-independent HIF1A-VHL complex binding, thus leading to HIF1A ubiquitination and proteasomal degradation. Desumoylation by SENP1 increases its stability amd transcriptional activity. There is a disaccord between various publications on the effect of sumoylation and desumoylation on its stability and transcriptional activity.
- The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains.
- Ubiquitination at isoforms=2, 3185, isoforms=2, 3251, posLast=297297, isoforms=2, 3377, isoforms=2, 3532, posLast=538538, and isoforms=2, 3547
Other Protein References for HIF1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for HIF1A (HIF-1 alpha)
- Cell Signaling Technology (CST) Antibodies for HIF1A (HIF1A)
-
Custom Antibody ServicesOriGene Antibodies for HIF1A
- TA351581
- TA336766
- TA336765
- TA336764
- TA336763
- TA336704
- TA336484
- TA336308
- TA336260
- TA335200
- TA332405
- TA329159
- TA326476
- TA325528
- TA324790
- TA319212
- TA309691
- TA309690
- TA309689
- DM311P
- DM311-05
- DM311
- AP54987SU-N
- AP54986SU-N
- AP23253PU-N
- AP20633PU-N
- AP14543PU-N
- AM50284PU-T
- AM50284PU-S
- AM50284PU-N
- AM06608SU-N
- Novus Biologicals Antibodies for HIF1A
-
Abcam antibodies for HIF1A
-
Cloud-Clone Corp. Antibodies for HIF1A
- Invitrogen Antibodies for HIF1A
- antibodies-online: Search results for 666 available HIF1A Antibodies ranked by validation data
- Compare Top HIF1A Antibodies
-
Recommended
- 1 PLA Antibody (anti-rat)
- 2 IP Antibodies (anti-rat)
- 6 IHC Antibodies (anti-rat)
- 6 FACS Antibodies (anti-rat)
- 11 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 190 WB Antibodies (anti-rat)
- 1 PLA Antibody (anti-human)
- 2 IF/ICC Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 13 IHC Antibodies (anti-human)
- 21 IHC (p) Antibodies (anti-human)
- 27 IF Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 460 WB Antibodies (anti-human)
- 1 PLA Antibody (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 12 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 23 FACS Antibodies (anti-mouse)
- 221 WB Antibodies (anti-mouse)
- GeneTex HIF1A antibody for HIF1A
-
Santa Cruz Biotechnology (SCBT) Antibodies for HIF1A
- Sino Biological Antibodies for HIF1A
Protein Products
-
OriGene Purified Proteins for HIF1A
- Search Origene for MassSpec and Protein Over-expression Lysates for HIF1A
- Origene Custom Protein Services for HIF1A
- Sino Biological Recombinant Proteins for HIF1A
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for HIF1A
-
Cloud-Clone Corp. Proteins for HIF1A
- Search GeneTex for Proteins for HIF1A
-
Abcam proteins for HIF1A
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for HIF1A (HIF-1 alpha)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for HIF1A (HIF1A)
- antibodies-online: Search results for 81 available HIF1A Elisa Kits ranked by validation data
- Compare Top HIF1A Elisa Kits
-
Recommended
- 2 Wild boar (Sus scrofa) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 17 Rat (Rattus) ELISA Kits
- 8 Rabbit ELISA Kits
- 10 Pig (Porcine) ELISA Kits
- 19 Mouse (Murine) ELISA Kits
- 2 Monkey ELISA Kits
- 23 Human ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 1 Guinea Pig ELISA Kit
- 1 Goat ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 2 Cow (Bovine) ELISA Kits
- 2 Chicken ELISA Kits
-
Abcam assays for HIF1A
No data available for DME Specific Peptides for HIF1A Gene
Domains & Families for HIF1A Gene
Gene Families for HIF1A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HIF1A Gene
Suggested Antigen Peptide Sequences for HIF1A Gene
Graphical View of Domain Structure for InterPro Entry
Q16665UniProtKB/Swiss-Prot:
HIF1A_HUMAN :- Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID).
- Domain:
-
- Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID).
Function for HIF1A Gene
Molecular function for HIF1A Gene
- GENATLAS Biochemistry:
- hypoxia-inducible factor 1,alpha subunit,complexing with HIF2A and HIF2B (ANRT) for activation of genes involved in metabolism,angiogenesis,erythropoiesis and glycolysis through the recruitement of the CBP/p300 co-activator,rapidly degraded by proteasome under normoxic conditions,binding to VHL,involved (essential) in cardiovascular development and systemic 02 homeostasis
- UniProtKB/Swiss-Prot Function:
- Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5-[AG]CGTG-3 within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
- UniProtKB/Swiss-Prot Induction:
- Under reduced oxygen tension. Induced also by various receptor-mediated factors such as growth factors, cytokines, and circulatory factors such as PDGF, EGF, FGF2, IGF2, TGFB1, HGF, TNF, IL1B/interleukin-1 beta, angiotensin-2 and thrombin. However, this induction is less intense than that stimulated by hypoxia. Repressed by HIPK2 and LIMD1.
Phenotypes From GWAS Catalog for HIF1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IDA | 25043030 |
| GO:0000989 | transcription factor activity, transcription factor binding | IDA | 22735262 |
| GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding | IEA | -- |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IMP | 24983504 |
Phenotypes for HIF1A Gene
- MGI mutant phenotypes for HIF1A:
-
inferred from 12 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for HIF1A:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased cell death HMECs cells
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased shRNA abundance
- Decreased caspase 3/7 activity
Animal Models for HIF1A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIF1A
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HIF1A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIF1A gene
- Search ViGene Biosciences for HIF1A
CRISPR Products
-
OriGene CRISPR knockouts for HIF1A
- genomics-online: gRNA clones - Search results for available HIF1A gene related products
- Applied Biological Materials CRISPR for HIF1A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIF1A
- GenScript: Design CRISPR guide RNA sequences for HIF1A
miRNA for HIF1A Gene
- miRTarBase miRNAs that target HIF1A
-
- hsa-mir-20a-5p (MIRT000002)
- hsa-mir-519c-3p (MIRT000496)
- hsa-mir-20b-5p (MIRT000498)
- hsa-mir-107 (MIRT004487)
- hsa-mir-18a-5p (MIRT004587)
- hsa-mir-17-5p (MIRT004588)
- hsa-mir-424-5p (MIRT005926)
- hsa-mir-199a-5p (MIRT006138)
- hsa-mir-138-5p (MIRT006744)
- hsa-mir-199b-5p (MIRT007022)
- hsa-mir-33a-5p (MIRT028216)
- hsa-mir-106b-3p (MIRT038587)
- hsa-let-7b-5p (MIRT051936)
- bta-mir-31 (MIRT053898)
- hsa-mir-210-3p (MIRT054349)
- hsa-mir-3121-3p (MIRT070721)
- hsa-mir-3668 (MIRT070723)
- hsa-mir-6815-3p (MIRT070728)
- hsa-mir-589-3p (MIRT070730)
- hsa-mir-889-3p (MIRT070731)
- hsa-mir-935 (MIRT070733)
- hsa-mir-1910-3p (MIRT070734)
- hsa-mir-3074-3p (MIRT070735)
- hsa-mir-5094 (MIRT070737)
- hsa-mir-6511a-5p (MIRT070739)
- hsa-mir-6755-5p (MIRT070740)
- hsa-mir-6806-5p (MIRT070741)
- hsa-mir-93-5p (MIRT070742)
- hsa-mir-106a-5p (MIRT070743)
- hsa-mir-106b-5p (MIRT070745)
- hsa-mir-519d-3p (MIRT070750)
- hsa-mir-4282 (MIRT070774)
- hsa-mir-8055 (MIRT138601)
- hsa-mir-153-5p (MIRT191495)
- hsa-mir-18b-5p (MIRT191496)
- hsa-mir-3662 (MIRT191501)
- hsa-mir-4735-3p (MIRT191502)
- hsa-mir-576-3p (MIRT191510)
- hsa-mir-151a-3p (MIRT279526)
- hsa-mir-5681b (MIRT279539)
- hsa-mir-155-5p (MIRT398178)
- hsa-mir-5692a (MIRT398180)
- hsa-mir-22-3p (MIRT437403)
- hsa-mir-21-5p (MIRT437916)
- hsa-mir-5089-3p (MIRT536880)
- hsa-mir-4662a-5p (MIRT536881)
- hsa-mir-1322 (MIRT536882)
- hsa-mir-509-5p (MIRT547974)
- hsa-mir-509-3-5p (MIRT547975)
- hsa-mir-4418 (MIRT547976)
- hsa-mir-6807-3p (MIRT547977)
- hsa-mir-217 (MIRT547978)
- hsa-mir-4799-5p (MIRT547979)
- hsa-mir-4463 (MIRT547980)
- hsa-mir-4499 (MIRT547981)
- hsa-mir-329-5p (MIRT557309)
- hsa-mir-4748 (MIRT557310)
- hsa-mir-4464 (MIRT557311)
- hsa-mir-449c-5p (MIRT557312)
- hsa-mir-34b-5p (MIRT557313)
- hsa-mir-2682-5p (MIRT557314)
- hsa-mir-940 (MIRT557315)
- hsa-mir-6893-5p (MIRT557316)
- hsa-mir-6808-5p (MIRT557317)
- hsa-mir-106a-3p (MIRT557318)
- hsa-mir-299-5p (MIRT557319)
- hsa-mir-4470 (MIRT702956)
- hsa-mir-4487 (MIRT702957)
- hsa-mir-558 (MIRT702958)
- hsa-mir-3160-3p (MIRT702959)
- hsa-mir-3128 (MIRT702960)
- hsa-mir-625-3p (MIRT702961)
- hsa-mir-548ah-5p (MIRT702962)
- hsa-mir-3609 (MIRT702963)
- hsa-mir-494-3p (MIRT702964)
- hsa-mir-142-5p (MIRT731348)
- hsa-mir-27a-3p (MIRT731838)
- hsa-mir-433-3p (MIRT731849)
- mmu-mir-18a-5p (MIRT731915)
- hsa-mir-429 (MIRT732516)
- hsa-mir-338-3p (MIRT733004)
- hsa-mir-186-5p (MIRT733159)
- bta-mir-155 (MIRT733508)
- bta-mir-199a-5p (MIRT733509)
- hsa-mir-138-1-3p (MIRT733856)
- hsa-mir-145-5p (MIRT734225)
- hsa-mir-200c-5p (MIRT734294)
- hsa-mir-497-3p (MIRT734722)
Targeted motifs for HIF1A Gene
HOMER Transcription Factor Regulatory Elements motif HIF1A
- Consensus sequence: TACGTGCV Submotif: canonical Cell Type: MCF7 GEO ID: GSE28352
miRNA Products
- Search ViGene Biosciences for HIF1A
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for HIF1A
- Browse OriGene Inhibitory RNA Products For HIF1A
- genomics-online: shRNA clones - Search results for available HIF1A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HIF1A gene
Clone Products
-
OriGene ORF clones in human for HIF1A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIF1A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HIF1A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIF1A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HIF1A
- genomics-online: cdna clones - Search results for available HIF1A gene related products
- orf clones - Search results for available HIF1A gene related products
- Applied Biological Materials Clones for HIF1A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HIF1A
-
ViGene Biosciences adenoviral particle packaged cDNA for HIF1A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIF1A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIF1A gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for HIF1A Gene
Localization for HIF1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIF1A Gene
- Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (PubMed:9822602). {ECO:0000250 UniProtKB:Q61221}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Nuclear bodies (3)
- Nucleoplasm (3)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 8089148 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IPI | 9576906 |
| GO:0005737 | cytoplasm | IEA,IDA | 19651758 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for HIF1A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 2 | HIF Repressor Pathways | ||
| 3 | Signaling by NOTCH1 | ||
| 4 | Signaling by PTK6 |
.01
|
|
| 5 | Notch signaling pathway (KEGG) | ||
Pathways by source for HIF1A Gene
1 Sino Biological pathway for HIF1A Gene
2 GeneTex pathways for HIF1A Gene
2 Cell Signaling Technology pathways for HIF1A Gene
17 BioSystems pathways for HIF1A Gene
23 Reactome pathways for HIF1A Gene
11 KEGG pathways for HIF1A Gene
3 GeneGo (Thomson Reuters) pathways for HIF1A Gene
3 R&D Systems pathways for HIF1A Gene
5 Qiagen pathways for HIF1A Gene
Interacting Proteins for HIF1A Gene
Selected Interacting proteins:
ENSP00000338018
Q16665-HIF1A_HUMAN
for HIF1A Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for HIF1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001568 | blood vessel development | IEA | -- |
| GO:0001666 | response to hypoxia | IEA,IMP | 12411310 |
| GO:0001755 | neural crest cell migration | IEA | -- |
| GO:0001837 | epithelial to mesenchymal transition | IEA,ISS | 18037992 |
Drugs & Compounds for HIF1A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Nitroglycerin | Approved, Investigational | Pharma | inhibitor, stimulator | 179 | ||
| Carvedilol | Approved, Investigational | Pharma | Antagonist, Target, modulator | 173 | ||
| Axitinib | Approved, Investigational | Pharma | Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 116 | ||
| Everolimus | Approved | Pharma | mTOR inhibitor, mTOR Inhibitors, Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors | 2011 | ||
| Sorafenib | Approved, Investigational | Pharma | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 717 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| TC-S 7009 |
|
1422955-31-4 |
|
|
(4) Tocris Compounds for HIF1A Gene
| Compound | Action | Cas Number |
|---|---|---|
| Echinomycin | Highly potent and selective HIF-1alpha inhibitor | 512-64-1 |
| KC7F2 | HIF-1alpha inhibitor; down-regulates HIF-1alpha protein synthesis | 927822-86-4 |
| ML 228 | HIF pathway activator | 1357171-62-0 |
| TC-S 7009 | High affinity and selective HIF-2alpha inhibitor | 1422955-31-4 |
(11) ApexBio Compounds for HIF1A Gene
| Compound | Action | Cas Number |
|---|---|---|
| BAY 87-2243 | HIF-1 inhibitor,potent and selective | 1227158-85-1 |
| Chetomin | A4505 inhibitor | 1403-36-7 |
| DMOG | Competitive HIF-PH inhibitor, cell-permeable | 89464-63-1 |
| FG-4592 (ASP1517) | HIF prolyl-hydroxylase inhibitor | 808118-40-3 |
| IOX2(Glycine) | HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor | 931398-72-0 |
| KC7F2 | HIF-1α inhibitor | 927822-86-4 |
| ML 228 | HIF pathway activator | 1357171-62-0 |
| Molidustat (BAY85-3934) | Novel HIF-PH inhibitor | 1154028-82-6 |
| PX 12 | Trx-1 inhibitor | 141400-58-0 |
| PX-478 2HCl | HIF-1α inhibitor | 685898-44-6 |
| YC 1 | inhibitor of HIF-1α | 170632-47-0 |
Transcripts for HIF1A Gene
mRNA/cDNA for HIF1A Gene
- (3) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIF1A Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIF1A
- genomics-online: gRNA clones - Search results for available HIF1A gene related products
- Applied Biological Materials CRISPR for HIF1A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIF1A
- GenScript: Design CRISPR guide RNA sequences for HIF1A
miRNA Products
- Search ViGene Biosciences for HIF1A
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for HIF1A
- Browse OriGene Inhibitory RNA Products For HIF1A
- genomics-online: shRNA clones - Search results for available HIF1A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HIF1A gene
Clone Products
-
OriGene ORF clones in human for HIF1A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIF1A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HIF1A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIF1A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HIF1A
- genomics-online: cdna clones - Search results for available HIF1A gene related products
- orf clones - Search results for available HIF1A gene related products
- Applied Biological Materials Clones for HIF1A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||
| SP4: |
Expression for HIF1A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells
- Bone (Muscoskeletal System)
- Brain (Nervous System)
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
NURSA nuclear receptor signaling pathways regulating expression of HIF1A Gene:
HIF1ASOURCE GeneReport for Unigene cluster for HIF1A Gene:
Hs.597216mRNA Expression by UniProt/SwissProt for HIF1A Gene:
Q16665-HIF1A_HUMAN
Tissue specificity:
Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
Evidence on tissue expression from TISSUES for HIF1A Gene
- Nervous system(4.9)
- Liver(4.6)
- Lung(4.3)
- Kidney(3.8)
- Skin(3.6)
- Heart(3.5)
- Intestine(3.5)
- Blood(3.2)
- Bone marrow(3.2)
- Muscle(3)
- Lymph node(2.8)
- Adrenal gland(2.7)
- Spleen(2.7)
- Pancreas(2.6)
- Eye(2.5)
- Stomach(2.2)
- Gall bladder(2.1)
- Thyroid gland(2.1)
- Bone(2)
Primer Products
-
OriGene qPCR primer pairs for HIF1A
-
OriGene qPCR primer pairs and template standards for HIF1A
- genomics-online: primer clones - Search results for available HIF1A gene related products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIF1A Gene
Orthologs for HIF1A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIF1A 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | HIF1A 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HIF1A 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hif1a 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hif1a 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HIF1A 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HIF1A 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HIF1A 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HIF1A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.10694 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | hif1a-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hif1ab 33 34 |
|
||
| zgc55405 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8039 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | sima 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | hif-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for HIF1A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HIF1A Gene
Paralogs for HIF1A Gene
(4) SIMAP similar genes for HIF1A Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for HIF1A Gene
Variants for HIF1A Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920781 | uncertain-significance, Malignant tumor of prostate | 61,727,582(+) | G/A | coding_sequence_variant, missense_variant | |
| rs142325668 | uncertain-significance, not specified | 61,741,130(+) | C/G | coding_sequence_variant, missense_variant | |
| rs1000043301 | -- | 61,735,471(+) | C/A/T | intron_variant | |
| rs1000117098 | -- | 61,741,812(+) | A/C | intron_variant | |
| rs1000126254 | -- | 61,695,702(+) | C/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv952848 | CNV | duplication | 24416366 |
| nsv564884 | CNV | loss | 21841781 |
| nsv1300 | CNV | deletion | 18451855 |
| nsv1131145 | CNV | deletion | 24896259 |
| dgv3721n54 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
5.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.30;
70.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HIF1A Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIF1A Gene
Disorders for HIF1A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypoxia |
|
|
| retinal ischemia |
|
|
| renal clear cell carcinoma |
|
|
| fumarate hydratase deficiency |
|
|
| transitional meningioma |
|
|
Search HIF1A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HIF1A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HIF1A Gene
Publications for HIF1A Gene
- Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes. (PMID: 18785001) Schneider BP … Sledge GW (Breast cancer research and treatment 2009) 3 22 44 58
- Non-synonymous sequence variants within the oxygen-dependent degradation domain of the HIF1A gene are not associated with pre-eclampsia in the Finnish population. (PMID: 18980686) Heino S … Laivuori H (BMC medical genetics 2008) 3 22 44 58
- C2028T polymorphism in exon 12 and dinucleotide repeat polymorphism in intron 13 of the HIF-1alpha gene define HIF-1alpha protein expression in non-small cell lung cancer. (PMID: 16837101) Koukourakis MI … Sivridis E (Lung cancer (Amsterdam, Netherlands) 2006) 3 22 44 58
- VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha. (PMID: 15776016) Li Z … Wu G (EMBO reports 2005) 3 4 22 58
- Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha. (PMID: 16288748) Arnesen T … Lillehaug JR (FEBS letters 2005) 3 4 22 58
Products for HIF1A Gene
- R&D Systems Antibodies for HIF1A (HIF-1 alpha)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for HIF1A (HIF-1 alpha)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HIF1A
- AM06608SU-N
- AM50284PU-N
- AM50284PU-S
- AM50284PU-T
- AP14543PU-N
- AP20633PU-N
- AP23253PU-N
- AP54986SU-N
- AP54987SU-N
- DM311
- DM311-05
- DM311P
- TA309689
- TA309690
- TA309691
- TA319212
- TA324790
- TA325528
- TA326476
- TA329159
- TA332405
- TA335200
- TA336260
- TA336308
- TA336484
- TA336704
- TA336763
- TA336764
- TA336765
- TA336766
- TA351581
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HIF1A
- Search Origene for MassSpec and Protein Over-expression Lysates for HIF1A
- Origene Custom Protein Services for HIF1A
- Origene shrna and RNAi products in human, mouse, rat for HIF1A
- Browse OriGene Inhibitory RNA Products For HIF1A
- OriGene qPCR primer pairs and template standards for HIF1A
- OriGene qPCR primer pairs for HIF1A
- OriGene CRISPR knockouts for HIF1A
- OriGene ORF clones in human for HIF1A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HIF1A
- GenScript: Next-day shipping of latest version cDNA ORF clones for HIF1A in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HIF1A
- GenScript Custom Assay Services for HIF1A
- GenScript Custom overexpressing Cell Line Services for HIF1A
- GenScript: Design CRISPR guide RNA sequences for HIF1A
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HIF1A
- Cell Signaling Technology (CST) Antibodies for HIF1A (HIF1A)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for HIF1A (HIF1A)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for HIF1A
- Sino Biological Recombinant Proteins for HIF1A
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for HIF1A
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for HIF1A
- Novus Biologicals lysates and proteins for HIF1A
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for HIF1A
- Abcam proteins for HIF1A
- Abcam assays for HIF1A
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for HIF1A
- Cloud-Clone Corp. Antibodies for HIF1A
- Cloud-Clone Corp. Proteins for HIF1A
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for HIF1A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for HIF1A
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIF1A
- VectorBuilder custom plasmid, inducible vectors for HIF1A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIF1A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HIF1A
- antibodies-online: Search results for 666 available HIF1A Antibodies ranked by validation data
- Compare Top HIF1A Antibodies
- Recommended
- 221 WB Antibodies (anti-mouse)
- 23 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 12 IHC (p) Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 1 PLA Antibody (anti-mouse)
- 460 WB Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 27 IF Antibodies (anti-human)
- 21 IHC (p) Antibodies (anti-human)
- 13 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 2 IF/ICC Antibodies (anti-human)
- 1 PLA Antibody (anti-human)
- 190 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 11 IHC (p) Antibodies (anti-rat)
- 6 FACS Antibodies (anti-rat)
- 6 IHC Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 PLA Antibody (anti-rat)
- antibodies-online: Search results for 81 available HIF1A Elisa Kits ranked by validation data
- Compare Top HIF1A Elisa Kits
- Recommended
- 2 Chicken ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 1 Dog (Canine) ELISA Kit
- 1 Goat ELISA Kit
- 1 Guinea Pig ELISA Kit
- 1 Horse (Equine) ELISA Kit
- 23 Human ELISA Kits
- 2 Monkey ELISA Kits
- 19 Mouse (Murine) ELISA Kits
- 10 Pig (Porcine) ELISA Kits
- 8 Rabbit ELISA Kits
- 17 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
- antibodies-online: Search results for 50 available HIF1A Proteins ranked by validation data
- Compare Top HIF1A Proteins
- GeneTex HIF1A antibody for HIF1A
- Search GeneTex for Proteins for HIF1A
- ViGene Biosciences adenoviral particle packaged cDNA for HIF1A gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIF1A gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIF1A gene
- Search ViGene Biosciences for HIF1A
- Santa Cruz Biotechnology (SCBT) Antibodies for HIF1A
- Search Santa Cruz Biotechnology (SCBT) for HIF1A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIF1A
- Horizon Cell Lines for HIF1A
- genomics-online: cdna clones - Search results for available HIF1A gene related products
- orf clones - Search results for available HIF1A gene related products
- genomics-online: gRNA clones - Search results for available HIF1A gene related products
- genomics-online: primer clones - Search results for available HIF1A gene related products
- genomics-online: shRNA clones - Search results for available HIF1A gene related products
Sources for HIF1A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148)