HIF1A Gene (Protein Coding)

Hypoxia Inducible Factor 1 Subunit Alpha

GCID:: GC14P061695

GIFtS:: 47

Genes Participants

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other ... See more...

Aliases for HIF1A Gene

Hypoxia Inducible Factor 1 Subunit Alpha ² ³ ⁵
BHLHe78 ² ³ ⁴
PASD8 ² ³ ⁴
MOP1 ² ³ ⁴
Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) ² ³
Class E Basic Helix-Loop-Helix Protein 78 ³ ⁴
Basic-Helix-Loop-Helix-PAS Protein MOP1 ³ ⁴
Hypoxia-Inducible Factor 1-Alpha ³ ⁴
PAS Domain-Containing Protein 8 ³ ⁴
Member Of PAS Protein 1 ³ ⁴
HIF-1-Alpha ³ ⁴
HIF-1alpha ² ³

HIF1 ² ³
Hypoxia-Inducible Factor 1 Alpha Isoform I.3 ³
Hypoxia Inducible Factor 1 Alpha Subunit ³
Hypoxia-Inducible Factor1alpha ³
Member Of PAS Superfamily 1 ³
ARNT Interacting Protein ³
ARNT-Interacting Protein ⁴
HIF1-ALPHA ³
HIF1-Alpha ⁴
BHLHE78 ⁴
HIF-1A ³
HIF1A ⁵

External Ids for HIF1A Gene

HGNC: 4910
Entrez Gene: 3091
Ensembl: ENSG00000100644
OMIM: 603348
UniProtKB: Q16665

Previous GeneCards Identifiers for HIF1A Gene

GC14P059488
GC14P055956
GC14P060152
GC14P061231
GC14P062162
GC14P042326

Search aliases for HIF1A gene in PubMed and other databases

Summaries for HIF1A Gene

Entrez Gene Summary for HIF1A Gene

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

CIViC Summary for HIF1A Gene

GeneCards Summary for HIF1A Gene

HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Hypoxia and Retinal Ischemia. Among its related pathways are Signaling by PTK6 and HIF1Alpha Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is EPAS1.

UniProtKB/Swiss-Prot Summary for HIF1A Gene

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
- HIF1A_HUMAN,Q16665

Tocris Summary for HIF1A Gene

Hypoxia Inducible Factors (HIFs) are transcription factors that are activated in response to decreased oxygen availability in the cellular environment. They influence cell metabolism, cell survival and angiogenesis to maintain biological homeostasis.

Gene Wiki entry for HIF1A Gene

Additional gene information for HIF1A Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HIF1A Gene

Genomics for HIF1A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data

Request up-to-date GeneHancer data

Promoters and enhancers for HIF1A Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH14J061694	Promoter/Enhancer	2.2	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	600.7	+3.4	3388	9.4	SP1 CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 LEF1 IKZF1 ZNF692	HIF1A HIF1A-AS1 lnc-SNAPC1-4 ENSG00000232774 SNAPC1 RF00449
GH14J061551	Promoter/Enhancer	2.4	EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	23	-130.8	-130820	27.2	CEBPG HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 SOX13	LINC01303 HIF1A TRMT5 SLC38A6 SIX4 ENSG00000232774 HIF1A-AS3 FLJ22447 NONHSAG015175.2 ENSG00000258989
GH14J061468	Promoter/Enhancer	1.9	FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	23.3	-217.9	-217870	17.7	CREB1 GATAD2A CTCF ZNF629 PRDM10 REST ZNF512 RCOR2 BACH1 TARDBP	HIF1A LINC01303 ENSG00000232774 SNAPC1 HIF1A-AS1 PRKCH ENSG00000258989 piR-57133-155 TMEM30B
GH14J061465	Promoter/Enhancer	1.6	FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	20.6	-228.9	-228902	2.8	TEAD4 CEBPA SCRT2 SOX13 CEBPB SP1 NR3C1 CHD2 USF1 FOS	HIF1A LINC01303 PRKCH ENSG00000258989 piR-57133-155 TMEM30B
GH14J061489	Enhancer	1.2	FANTOM5 ENCODE dbSUPER	23.2	-203.9	-203931	5.2	IKZF1 FOXA1 SP1 CEBPA SOX13 ETS1 JUND FOXA2 FOS JUN	HIF1A ENSG00000232774 LINC01303 PRKCH ENSG00000258989 piR-57133-155 TMEM30B

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HIF1A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HIF1A

Top Transcription factor binding sites by QIAGEN in the HIF1A gene promoter:

AML1a

Genomic Locations for HIF1A Gene

chr14:61,695,513-61,748,259: (GRCh38/hg38)

Size:: 52,747 bases
Orientation:: Plus strand

chr14:62,162,119-62,214,977: (GRCh37/hg19)

Size:: 52,859 bases
Orientation:: Plus strand

Genomic View for HIF1A Gene

Genes around HIF1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

14q23.2 by HGNC
14q23.2 by Entrez Gene
14q23.2 by Ensembl

HIF1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for HIF1A Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HIF1A Gene

NC_000014.9

Proteins for HIF1A Gene

Protein details for HIF1A Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

Q16665-HIF1A_HUMAN

Recommended name:

Hypoxia-inducible factor 1-alpha

Protein Accession:

Q16665

Secondary Accessions:
- C0LZJ3
- Q53XP6
- Q96PT9
- Q9UPB1
Protein attributes for HIF1A Gene
Size:

826 amino acids

Molecular mass:

92670 Da
Quaternary structure:
Interacts with the ARNT; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:10944113, PubMed:20699359). Interacts with COPS5; the interaction increases the transcriptional activity of HIF1A through increased stability (By similarity). Interacts with EP300 (via TAZ-type 1 domains); the interaction is stimulated in response to hypoxia and inhibited by CITED2. Interacts with CREBBP (via TAZ-type 1 domains). Interacts with NCOA1, NCOA2, APEX and HSP90. Interacts (hydroxylated within the ODD domain) with VHLL (via beta domain); the interaction, leads to polyubiquitination and subsequent HIF1A proteasomal degradation. During hypoxia, sumoylated HIF1A also binds VHL; the interaction promotes the ubiquitination of HIF1A. Interacts with SENP1; the interaction desumoylates HIF1A resulting in stabilization and activation of transcription. Interacts (Via the ODD domain) with ARD1A; the interaction appears not to acetylate HIF1A nor have any affect on protein stability, during hypoxia. Interacts with RWDD3; the interaction enhances HIF1A sumoylation. Interacts with TSGA10 (By similarity). Interacts with HIF3A (By similarity). Interacts with RORA (via the DNA binding domain); the interaction enhances HIF1A transcription under hypoxia through increasing protein stability. Interaction with PSMA7 inhibits the transactivation activity of HIF1A under both normoxic and hypoxia-mimicking conditions. Interacts with USP20. Interacts with RACK1; promotes HIF1A ubiquitination and proteasome-mediated degradation. Interacts (via N-terminus) with USP19. Interacts with SIRT2. Interacts (deacetylated form) with EGLN1. Interacts with CBFA2T3. Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842).
Miscellaneous:
[Isoform 3]: Up-regulated in peripheral T-lymphocytes after T-cell receptor stimulation. Highest expression in peripheral blood leukocytes and thymus.
Three dimensional structures from OCA and Proteopedia for HIF1A Gene
- 1D7G (3D)
- 1H2K (3D)
- 1H2L (3D)
- 1H2M (3D)
- 1L3E (3D)
- 1L8C (3D)
Alternative splice isoforms for HIF1A Gene
UniProtKB/Swiss-Prot:
Q16665-1

Q16665-2

Q16665-3

neXtProt entry for HIF1A Gene

Post-translational modifications for HIF1A Gene

S-nitrosylation of Cys-800 may be responsible for increased recruitment of p300 coactivator necessary for transcriptional activity of HIF-1 complex.
- Q16665-HIF1A_HUMAN
Requires phosphorylation for DNA-binding. Phosphorylation at Ser-247 by CSNK1D/CK1 represses kinase activity and impairs ARNT binding. Phosphorylation by GSK3-beta and PLK3 promote degradation by the proteasome.
- Q16665-HIF1A_HUMAN
Sumoylated; with SUMO1 under hypoxia. Sumoylation is enhanced through interaction with RWDD3. Both sumoylation and desumoylation seem to be involved in the regulation of its stability during hypoxia. Sumoylation can promote either its stabilization or its VHL-dependent degradation by promoting hydroxyproline-independent HIF1A-VHL complex binding, thus leading to HIF1A ubiquitination and proteasomal degradation. Desumoylation by SENP1 increases its stability amd transcriptional activity. There is a disaccord between various publications on the effect of sumoylation and desumoylation on its stability and transcriptional activity.
- Q16665-HIF1A_HUMAN
Acetylation of Lys-532 by ARD1 increases interaction with VHL and stimulates subsequent proteasomal degradation (PubMed:12464182). Deacetylation of Lys-709 by SIRT2 increases its interaction with and hydroxylation by EGLN1 thereby inactivating HIF1A activity by inducing its proteasomal degradation (PubMed:24681946).
- Q16665-HIF1A_HUMAN
Polyubiquitinated; in normoxia, following hydroxylation and interaction with VHL. Lys-532 appears to be the principal site of ubiquitination. Clioquinol, the Cu/Zn-chelator, inhibits ubiquitination through preventing hydroxylation at Asn-803. Ubiquitinated by a CUL2-based E3 ligase.
- Q16665-HIF1A_HUMAN
In normoxia, is hydroxylated on Pro-402 and Pro-564 in the oxygen-dependent degradation domain (ODD) by EGLN1/PHD2 and EGLN2/PHD1 (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). EGLN3/PHD3 has also been shown to hydroxylate Pro-564 (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). Deubiquitinated by USP20 (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). In normoxia, is hydroxylated on Asn-803 by HIF1AN, thus abrogating interaction with CREBBP and EP300 and preventing transcriptional activation (PubMed:12080085). This hydroxylation is inhibited by the Cu/Zn-chelator, Clioquinol (PubMed:12080085). Repressed by iron ion, via Fe(2+) prolyl hydroxylase (PHD) enzymes-mediated hydroxylation and subsequent proteasomal degradation (PubMed:28296633).
- Q16665-HIF1A_HUMAN
The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains.
- Q16665-HIF1A_HUMAN
Ubiquitination at Lys185, Lys251, Lys297, Lys377, Lys532, Lys538, Lys547, and Lys709
- NX_Q16665 (NX_Q16665-1)
Modification sites at PhosphoSitePlus
- Q16665

Other Protein References for HIF1A Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

LifeSpan BioSciences HIF1A / HIF1 Alpha Antibody (LS-B495) and HIF1A / HIF1 Alpha Antibody (LS-B1503)

G Biosciences Immunotag™ HIF1A Antibody

NSJ Bioreagents HIF1A Antibody / HIF-1 alpha (Recombinant Rabbit Monoclonal)

Creative Diagnostics Mouse anti-Human Hypoxia-Inducible Factor-1 alpha Monoclonal antibody [clone PA13]

Creative Biolabs

HUABIO HIF1 alpha Antibody (ER1802-41) and HIF-1 alpha Antibody (R1510-5)

BioLegend

GeneTex Anti-HIF1 alpha antibody [GT10211] and Anti-HIF1 alpha antibody

Human/Mouse/Rat HIF-1 alpha/HIF1A Antibody (MAB1536)

OriGene Antibodies for HIF1A
- AB0070-100
- AB0112-200
- AM06608SU-N
- AM50284PU-S
- AM50284PU-T
- AP14543PU-N
- AP20633PU-N
- AP23253PU-N
- AP54986SU-N
- AP54987SU-N
- TA309689
- TA309690
- TA309691
- TA319212
- TA319213
- TA324790
- TA325528
- TA326476
- TA329159
- TA335200
- TA336260
- TA336308
- TA336484
- TA336704
- TA336763
- TA336764
- TA336765
- TA336766
- TA351581
- TA354706
- TA811847
- TA811847S
Custom Antibody Services

Novus Biologicals Antibodies for HIF1A

Abcam antibodies for HIF1A
- HIF-1 alpha

Invitrogen Antibodies for HIF1A (AFLGC-HIF1A)

Biorbyt antibodies for HIF1A
- orb161305
- orb99244
- orb12588
- orb131775
- orb511147
- orb241896
- orb216126
- orb38479

Boster Bio Antibodies for HIF1A
- A00013-1
- PB9129
- PB9253
- M00013-1
- M00013-2

Santa Cruz Biotechnology (SCBT) Antibodies for HIF1A

Sino Biological Antibodies for HIF1A

Protein Products

RayBiotech

Creative Biomart Recombinant Human Neutrophil Cytosolic Factor 1, His-tagged

OriGene Purified Proteins for HIF1A
Search Origene for MassSpec and Protein Over-expression Lysates for HIF1A
Origene Custom Protein Services for HIF1A

Novus Biologicals proteins and lysates for HIF1A

Sino Biological Recombinant Proteins for HIF1A
Browse Sino Biological Cell Lysates

ProSpec Recombinant Proteins for HIF1A

antibodies-online: Show 45 available HIF1A Proteins ranked by validation data
Compare Top HIF1A Proteins

Signalway Proteins for HIF1A
- AP72194
- AP78664
- GP11622
- GP12301
- GP12302
- GP12303

Search for HIF1A Proteins at ProSci

Abcam proteins for HIF1A
- HIF-1 alpha

Assay Products

G Biosciences Immunotag™ Human HIF1A (Hypoxia-inducible factor 1-alpha ) ELISA and Immunotag™ Hypoxia-inducible factor 1-alpha ELISA Kit

RayBiotech

Creative Diagnostics HIF1A (Human) ELISA Kit

Human/Mouse Total HIF-1 alpha/HIF1A DuoSet IC ELISA (DYC1935-2)

Browse Boster Bio ELISA Kits

Signalway ELISA kits for HIF1A
- EK2257
- EK14474

Abcam assays for HIF1A
- HIF-1 alpha

Browse Sino Biological Assays

No data available for DME Specific Peptides for HIF1A Gene

Domains & Families for HIF1A Gene

Gene Families for HIF1A Gene

HGNC:

Basic helix-loop-helix proteins

Human Protein Atlas (HPA):

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Protein Domains for HIF1A Gene

InterPro:

Blocks:

PAS domain
Basic helix-loop-helix dimerization domain bHLH
PAS fold-3
Hypoxia-inducible factor-1 alpha signature

ProtoNet:

Q16665

Suggested Antigen Peptide Sequences for HIF1A Gene

GenScript: Design optimal peptide antigens:

cDNA FLJ57096, highly similar to Hypoxia-inducible factor 1 alpha (B4E2U7_HUMAN)
Hypoxia-inducible factor 1, alpha subunit, variant K12NR (D0VY79_HUMAN)
PAS domain-containing protein 8 (HIF1A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16665

UniProtKB/Swiss-Prot:

HIF1A_HUMAN :

Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID).

Domain:

Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID).

Function for HIF1A Gene

Molecular function for HIF1A Gene

UniProtKB/Swiss-Prot Function:

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

HIF1A_HUMAN,Q16665

UniProtKB/Swiss-Prot Induction:

Under reduced oxygen tension. Induced also by various receptor-mediated factors such as growth factors, cytokines, and circulatory factors such as PDGF, EGF, FGF2, IGF2, TGFB1, HGF, TNF, IL1B/interleukin-1 beta, angiotensin-2 and thrombin. However, this induction is less intense than that stimulated by hypoxia. Repressed by HIPK2 and LIMD1.

HIF1A_HUMAN,Q16665

GENATLAS Biochemistry:

hypoxia-inducible factor 1,alpha subunit,complexing with HIF2A and HIF2B (ANRT) for activation of genes involved in metabolism,angiogenesis,erythropoiesis and glycolysis through the recruitement of the CBP/p300 co-activator,rapidly degraded by proteasome under normoxic conditions,binding to VHL,involved (essential) in cardiovascular development and systemic 02 homeostasis

HIF1A

Phenotypes From GWAS Catalog for HIF1A Gene

Gene Ontology (GO) - Molecular Function for HIF1A Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA	19782034
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IEA	--
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA,ISM	19274049
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA,IMP	24983504
GO:0002039	p53 binding	IPI	15629713

Phenotypes for HIF1A Gene

MGI mutant phenotypes for HIF1A:

inferred from 12 alleles

GenomeRNAi human phenotypes for HIF1A:

Animal Models for HIF1A Gene

MGI Knock Outs for HIF1A:

Hif1a ^{Hif1a<tm1.1Stom>}
Hif1a ^{Hif1a<tm1Jhu>}
Hif1a ^{Hif1a<tm1Pec>}
Hif1a ^{Hif1a<tm1Rsjo>}
Hif1a ^{Hif1a<tm1Mcs>}
Hif1a ^{Hif1a<tm1.1Mcs>}
Hif1a ^{Hif1a<tm2Rsjo>}
Hif1a ^{Hif1a<tm3.1Rsjo>}

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for HIF1A - Select products 50% OFF >
* HIF1A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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OriGene CRISPR knockouts for HIF1A
- GA102107
- GA201899
- KN202461
- KN202461BN
- KN202461LP
- KN202461RB
- KN307708
- KN307708BN
- KN307708LP
- KN307708RB
- KN402461
- KN507708

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HIF1A

Santa Cruz Biotechnology (SCBT) CRISPR for HIF1A

miRNA for HIF1A Gene

miRTarBase miRNAs that target HIF1A

Targeted motifs for HIF1A Gene

HOMER Transcription Factor Regulatory Elements motif HIF1A

Consensus sequence: TACGTGCV Submotif: canonical Cell Type: MCF7 GEO ID: GSE28352

miRNA Products

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Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for HIF1A
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Search Santa Cruz Biotechnology (SCBT) for HIF1A siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for HIF1A - Select products 50% OFF >
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OriGene clones in human,mouse,rat for HIF1A
- SC213108
- SC214052
- MC221924
- RN210999
- SC119189
- SC127304
- SC331945
OriGene ORF clones in human,mouse,rat for HIF1A
- MG210895
- MR210895
- MR210895L1
- MR210895L2
- MR210895L3
- MR210895L4
- RC202461
- RC202461L1
- RC202461L2
- RC202461L3
- RC202461L4
- RC218966
- RC218966L1
- RC218966L2
- RC218966L3
- RC218966L4
- RC234963
- RG202461
- RG218966
- RG234963
- RR210999
- RR210999L3
- RR210999L4
- MR210895L1V
- MR210895L2V
- MR210895L3V
- MR210895L4V
- RC202461L1V
- RC202461L2V
- RC202461L3V
- RC202461L4V
- RC218966L1V
- RC218966L2V
- RC218966L3V
- RC218966L4V
- RR210999L3V
- RR210999L4V
- RC402570
- RC402571
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for HIF1A

Addgene plasmids for HIF1A

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Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for HIF1A

Browse GeneCopoeia Cell Lines

VectorBuilder Stable cell line generation for HIF1A

Horizon Cell Lines for HIF1A
- HIF1A knockout cell line
- HIF1A knockout cell line

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for HIF1A Gene

Localization for HIF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIF1A Gene

Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (PubMed:9822602). {ECO:0000250 UniProtKB:Q61221}.

Q16665-HIF1A_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	5
plasma membrane	3
extracellular	3
cytoskeleton	3
mitochondrion	3
endoplasmic reticulum	3
lysosome	3
peroxisome	2
endosome	2
golgi apparatus	2

Subcellular locations from the

Human Protein Atlas (HPA)

Nucleoplasm (4)
Nuclear bodies (3)
Plasma membrane (3)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for HIF1A Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IDA,ISA	--
GO:0005623	cell	IEA	--
GO:0005634	nucleus	IBA,IDA	8089148
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	IPI	9576906

Pathways & Interactions for HIF1A Gene

SuperPathways for HIF1A Gene

	SuperPathway	Contained pathways
1	Regulation of activated PAK-2p34 by proteasome mediated degradation	Cellular response to hypoxia .87 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha .87	Regulation of Hypoxia-inducible Factor (HIF) by oxygen .87 Regulation of gene expression by Hypoxia-inducible Factor .01
2	HIF Repressors	HIF Enhancers .38 HIF Repressors .38	Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha .01
3	Signaling by NOTCH1	Signaling by NOTCH1 .78 NOTCH1 Intracellular Domain Regulates Transcription .68	Signaling by NOTCH .65
4	Signaling by PTK6	Signaling by PTK6 .40 PTK6 Expression .01	PTK6 promotes HIF1A stabilization .01
5	Notch Signaling Pathway (WikiPathways)	Notch Signaling Pathway .41	Notch Signaling Pathways .31

Pathways by source for HIF1A Gene

1 Sino Biological pathway for HIF1A Gene

P53 Pathway

17 BioSystems pathways for HIF1A Gene

23 Reactome pathways for HIF1A Gene

12 KEGG pathways for HIF1A Gene

3 GeneGo (Thomson Reuters) pathways for HIF1A Gene

Development_Leptin signaling via JAK/STAT and MAPK cascades
Transcription Ligand-dependent activation of the ESR1/SP pathway
Transcription Receptor-mediated HIF regulation

3 R&D Systems pathways for HIF1A Gene

5 Qiagen pathways for HIF1A Gene

HIF1Alpha Pathway
ILK Signaling
Molecular Mechanisms of Cancer
mTOR Pathway
p53 Signaling

2 Cell Signaling Technology pathways for HIF1A Gene

2 GeneTex pathways for HIF1A Gene

Interacting Proteins for HIF1A Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: Q16665-HIF1A_HUMAN ENSP00000437955 for HIF1A Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
CREBBP	Q92793 ⁴ ²⁰ ¹²⁶ ENSP00000262367 ²¹	EBI-447269, EBI-81215 MINT-4652920 STRING: ENSP00000262367 IID: # exp=13 # pred=3
EGLN1	Q9GZT9 ⁴ ²⁰ ¹²⁶ ENSP00000355601 ²¹	EBI-447269, EBI-1174818 MINT-1957554 STRING: ENSP00000355601 IID: # exp=14 # pred=3
EGLN2	Q96KS0 ⁴ ²⁰ ¹²⁶ ENSP00000469686 ²¹	EBI-447269, EBI-726614 MINT-1957493 STRING: ENSP00000469686 IID: # exp=7 # pred=3
EGLN3	Q9H6Z9 ⁴ ²⁰ ¹²⁶ ENSP00000250457 ²¹	EBI-447269, EBI-1175354 MINT-1957585 STRING: ENSP00000250457 IID: # exp=10 # pred=3
EP300	Q09472 ⁴ ²⁰ ¹²⁶ ENSP00000263253 ²¹	EBI-447269, EBI-447295 MINT-4652938 STRING: ENSP00000263253 IID: # exp=38 # pred=5

GPS-Prot Interaction Network for HIF1A

SIGNOR curated interactions for HIF1A Gene

Activates:

Is activated by:

Is inactivated by:

Other effect:

CSNK2A1

Gene Ontology (GO) - Biological Process for HIF1A Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001568	blood vessel development	IEA	--
GO:0001666	response to hypoxia	IEA,IMP	12411310
GO:0001755	neural crest cell migration	IEA	--
GO:0001837	epithelial to mesenchymal transition	IEA,ISS	18037992

Drugs & Compounds for HIF1A Gene

(104) Drugs for HIF1A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, Tocris, and Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Nitroglycerin	Approved, Investigational	MalaCards Medline Plus	Pharma	inhibitor, stimulator		229
Carvedilol	Approved, Investigational	MalaCards Medline Plus	Pharma	Antagonist, Target, modulator		199
Hydralazine	Approved	MalaCards Medline Plus	Pharma	Target, inducer		57
Axitinib	Approved, Investigational	MalaCards Medline Plus	Pharma		Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors	144
Sorafenib	Approved, Investigational	MalaCards Medline Plus	Pharma		Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors	779

(52) Additional Compounds for HIF1A Gene - From: Novoseek and Tocris

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs
TC-S 7009			MalaCards Medline Plus	1422955-31-4

(4) Tocris Compounds for HIF1A Gene

Compound	Action	Cas Number
Echinomycin	Highly potent and selective HIF-1alpha inhibitor	512-64-1
KC7F2	HIF-1alpha inhibitor; down-regulates HIF-1alpha protein synthesis	927822-86-4
ML 228	HIF pathway activator	1357171-62-0
TC-S 7009	High affinity and selective HIF-2alpha inhibitor	1422955-31-4

(11) ApexBio Compounds for HIF1A Gene

Compound	Action	Cas Number
BAY 87-2243	HIF-1 inhibitor,potent and selective	1227158-85-1
Chetomin	A4505 inhibitor	1403-36-7
DMOG	Competitive HIF-PH inhibitor, cell-permeable	89464-63-1
FG-4592 (ASP1517)	HIF prolyl-hydroxylase inhibitor	808118-40-3
IOX2(Glycine)	HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor	931398-72-0
KC7F2	HIF-1α inhibitor	927822-86-4
ML 228	HIF pathway activator	1357171-62-0
Molidustat (BAY85-3934)	Novel HIF-PH inhibitor	1154028-82-6
PX 12	Trx-1 inhibitor	141400-58-0
PX-478 2HCl	HIF-1α inhibitor	685898-44-6
YC 1	inhibitor of HIF-1α	170632-47-0

Drug Products

RayBiotech

Creative Biomart Recombinant Human Neutrophil Cytosolic Factor 1, His-tagged

Tocris compounds for HIF1A

ApexBio compounds for HIF1A

Transcripts for HIF1A Gene