Aliases for HIC1 Gene
Aliases for HIC1 Gene
External Ids for HIC1 Gene
- HGNC: 4909
- Entrez Gene: 3090
- Ensembl: ENSG00000177374
- OMIM: 603825
- UniProtKB: Q14526
Previous GeneCards Identifiers for HIC1 Gene
- GC17P002266
- GC17P002300
- GC17P001910
- GC17P002166
- GC17P001906
- GC17P001905
- GC17P001958
- GC17P001964
- GC17P001967
- GC17P001973
Summaries for HIC1 Gene
-
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]
GeneCards Summary for HIC1 Gene
HIC1 (HIC ZBTB Transcriptional Repressor 1) is a Protein Coding gene. Diseases associated with HIC1 include Miller-Dieker Lissencephaly Syndrome and Medulloblastoma. Among its related pathways are Direct p53 effectors and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and histone deacetylase binding. An important paralog of this gene is HIC2.
UniProtKB/Swiss-Prot for HIC1 Gene
-
Transcriptional repressor. Recognizes and binds to the consensus sequence 5-[CG]NG[CG]GGGCA[CA]CC-3. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.
Additional gene information for HIC1 Gene
- Monarch Initiative
- Search for HIC1 at DataMed
- Search for HIC1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIC1 Gene
Genomics for HIC1 Gene
GeneHancer (GH) Regulatory Elements for HIC1 Gene
Promoters and enhancers for HIC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HIC1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HIC1 gene promoter:
-
- Max
- AP-2alphaA
- AP-2alpha
- AP-4
- GATA-2
- CP2
- AP-2beta
Regulatory Element Products
Genomic Locations for HIC1 Gene
Genomic Locations for HIC1 Gene
- chr17:2,054,154-2,063,241
- (GRCh38/hg38)
- Size:
- 9,088 bases
- Orientation:
- Plus strand
- chr17:1,957,448-1,962,981
- (GRCh37/hg19)
- Size:
- 5,534 bases
- Orientation:
- Plus strand
Genomic View for HIC1 Gene
Genes around HIC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.3 by Entrez Gene
- 17p13.3 by HGNC
- 17p13.3 by Ensembl
HIC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIC1 Gene
Proteins for HIC1 Gene
-
Protein details for HIC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14526-HIC1_HUMAN
- Recommended name:
- Hypermethylated in cancer 1 protein
- Protein Accession:
- Q14526
- D3DTI4
Protein attributes for HIC1 Gene
- Size:
- 733 amino acids
- Molecular mass:
- 76508 Da
- Quaternary structure:
-
- Self-associates. Interacts with HIC2. Interacts with CTBP1 and CTBP2. Interacts with TCF7L2 and ARID1A. Interacts with MTA1 and MBD3; indicative for an association with the NuRD complex.
- Miscellaneous:
-
- The HIC1 gene is frequently found epigenetically silenced or deleted in different types of solid tumors.
Protein Expression for HIC1 Gene
Post-translational modifications for HIC1 Gene
- Acetylated on several residues, including Lys-333. Lys-333 is deacetylated by SIRT1.
- Sumoylated on Lys-333 by a PIAS family member, which enhances interaction with MTA1, positively regulates transcriptional repression activity and is enhanced by HDAC4.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for HIC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HIC1
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- Invitrogen Antibodies for HIC1
- GeneTex HIC1 Antibody for HIC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HIC1
Protein Products
-
OriGene Purified Proteins for HIC1
- Search Origene for MassSpec and Protein Over-expression Lysates for HIC1
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- Search GeneTex for Proteins for HIC1
Assay Products
No data available for DME Specific Peptides for HIC1 Gene
Domains & Families for HIC1 Gene
Gene Families for HIC1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HIC1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIC1 Gene
Graphical View of Domain Structure for InterPro Entry
Q14526UniProtKB/Swiss-Prot:
HIC1_HUMAN :- The BTB domain inhibits the binding to a single consensus binding site, but mediates cooperative binding to multiple binding sites.
- Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
- Domain:
-
- The BTB domain inhibits the binding to a single consensus binding site, but mediates cooperative binding to multiple binding sites.
- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
Function for HIC1 Gene
Molecular function for HIC1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor. Recognizes and binds to the consensus sequence 5-[CG]NG[CG]GGGCA[CA]CC-3. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.
- GENATLAS Biochemistry:
- zinc finger transcription factor gene,ubiquitously expressed in mesenchyme of the sclerotomes,lateral body wall,limb and craniofacial region,hypermethylated and underexpressed in tumor,deleted in the Miller-Dieker syndrome,putatively involved in the pathogenesis as suggested by the developmental defects observed in Hic1 deficient mice
Phenotypes From GWAS Catalog for HIC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 15231840 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | TAS | 7585125 |
Phenotypes for HIC1 Gene
- MGI mutant phenotypes for HIC1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for HIC1:
-
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased ID2::GFP protein expression
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased viability after Maraba virus infection
Animal Models for HIC1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIC1
-
CRISPR Products
-
OriGene CRISPR knockouts for HIC1
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- genomics-online: gRNA clones - Search results for 83 available HIC1 gene related products
- Overview of 83 available HIC1 gene related products
- Applied Biological Materials CRISPR for HIC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIC1
- GenScript: Design CRISPR guide RNA sequences for HIC1
miRNA for HIC1 Gene
- miRTarBase miRNAs that target HIC1
-
- hsa-mir-335-5p (MIRT017725)
- hsa-mir-3175 (MIRT286061)
- hsa-mir-6777-5p (MIRT286071)
- hsa-mir-6889-5p (MIRT286073)
- hsa-mir-4749-5p (MIRT487220)
- hsa-mir-4706 (MIRT487221)
- hsa-mir-18a-3p (MIRT487222)
- hsa-mir-324-3p (MIRT487223)
- hsa-mir-1913 (MIRT487224)
- hsa-mir-4781-5p (MIRT487226)
- hsa-mir-19b-3p (MIRT727500)
- hsa-mir-19a-3p (MIRT727501)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HIC1
- Browse OriGene Inhibitory RNA Products For HIC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIC1
- genomics-online: shRNA clones - Search results for 83 available HIC1 gene related products
- Overview of 83 available HIC1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for HIC1
- VectorBuilder custom plasmid, inducible vectors for HIC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HIC1
- Applied Biological Materials Clones for HIC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HIC1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HIC1 Gene
Localization for HIC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIC1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISS | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for HIC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Direct p53 effectors | ||
| 2 | E2F transcription factor network | ||
Pathways by source for HIC1 Gene
2 BioSystems pathways for HIC1 Gene
Interacting Proteins for HIC1 Gene
Selected Interacting proteins:
Q14526-HIC1_HUMAN
ENSP00000314080
for HIC1 Gene via
IID
STRING
MINT
UniProtKB
GPS-Prot Interaction Network for HIC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 7585125 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | IDA | 16269335 |
No data available for SIGNOR curated interactions for HIC1 Gene
Transcripts for HIC1 Gene
mRNA/cDNA for HIC1 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (23) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000322941 3053 bps (uc010cjy.4)
- ENST00000399849 3156 bps (uc002ftz.5)
- ENST00000571875 812 bps (uc059zkw.1)
- ENST00000571990 654 bps (uc059zkx.1)
- ENST00000574370 1134 bps (uc059zkv.1)
Unigene Clusters for HIC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HIC1
- genomics-online: gRNA clones - Search results for 83 available HIC1 gene related products
- Overview of 83 available HIC1 gene related products
- Applied Biological Materials CRISPR for HIC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIC1
- GenScript: Design CRISPR guide RNA sequences for HIC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HIC1
- Browse OriGene Inhibitory RNA Products For HIC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIC1
- genomics-online: shRNA clones - Search results for 83 available HIC1 gene related products
- Overview of 83 available HIC1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for HIC1
- VectorBuilder custom plasmid, inducible vectors for HIC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HIC1
- Applied Biological Materials Clones for HIC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HIC1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
This gene is overexpressed in Adipocyte (22.9), Fetal ovary (21.4), Fetal gut (13.0), and Fetal testis (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIC1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HIC1 Gene:
HIC1SOURCE GeneReport for Unigene cluster for HIC1 Gene:
Hs.72956mRNA Expression by UniProt/SwissProt for HIC1 Gene:
Q14526-HIC1_HUMAN
Tissue specificity:
Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and ovary. Expression is absent or decreased in many tumor cells.
Evidence on tissue expression from TISSUES for HIC1 Gene
- Liver(4.2)
- Nervous system(4.1)
- Lung(3.2)
- Pancreas(2.9)
- Intestine(2.8)
- Eye(2.4)
- Thyroid gland(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HIC1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- chin
- cranial nerve
- ear
- epiglottis
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- outer ear
- pharynx
- skull
- tooth
Thorax:
- bronchus
- heart
- lung
- trachea
Abdomen:
- abdominal wall
- biliary tract
- duodenum
- intestine
- kidney
- large intestine
- liver
- pancreas
- small intestine
- stomach
Pelvis:
- pelvis
- placenta
- testicle
- uterus
Limb:
- digit
- finger
- foot
- hand
- lower limb
- toe
- upper limb
General:
- blood
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
Primer Products
-
OriGene qPCR primer pairs for HIC1
- genomics-online: primer clones - Search results for 83 available HIC1 gene related products
- Overview of 83 available HIC1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for HIC1 Gene
Orthologs for HIC1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIC1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HIC1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HIC1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | LOC100912068 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Hic1 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HIC1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HIC1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HIC1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hic1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hic1 34 33 |
|
OneToOne |
- Species where no ortholog for HIC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for HIC1 Gene
- ENSEMBL:
- Gene Tree for HIC1 (if available)
- TreeFam:
- Gene Tree for HIC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HIC1: view image
Paralogs for HIC1 Gene
Paralogs for HIC1 Gene
(29) SIMAP similar genes for HIC1 Gene using alignment to 7 proteins:
- HIC1_HUMAN
- A0MA52_HUMAN
- A0PJI1_HUMAN
- I3L388_HUMAN
- K7ENQ1_HUMAN
- Q70SM2_HUMAN
- V9GYA4_HUMAN
Variants for HIC1 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000073456 | -- | 2,059,894(+) | G/A | downstream_transcript_variant | |
| rs1000699005 | -- | 2,055,477(+) | G/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000831836 | -- | 2,053,382(+) | G/A | upstream_transcript_variant | |
| rs1001134941 | -- | 2,053,477(+) | C/T | upstream_transcript_variant | |
| rs1001281747 | -- | 2,057,841(+) | C/A | coding_sequence_variant, missense_variant |
Gene Damage Index Score:
3.55;
55.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HIC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIC1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIC1 Gene
Disorders for HIC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| miller-dieker lissencephaly syndrome |
|
|
| medulloblastoma |
|
|
| spinal cord ependymoma |
|
|
Search HIC1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HIC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HIC1 Gene
Publications for HIC1 Gene
- Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1). (PMID: 19525223) Van Rechem C … Leprince D (The Journal of biological chemistry 2009) 3 4 22 58
- An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. (PMID: 17283066) Stankovic-Valentin N … Leprince D (Molecular and cellular biology 2007) 3 4 22 58
- HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. (PMID: 16724116) Valenta T … Korinek V (The EMBO journal 2006) 3 4 22 58
- A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. (PMID: 16762039) Stankovic-Valentin N … Leprince D (The FEBS journal 2006) 3 4 22 58
- The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. (PMID: 15231840) Pinte S … Leprince D (The Journal of biological chemistry 2004) 3 4 22 58
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- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HIC1
- Novus Biologicals proteins for HIC1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for HIC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIC1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 81 available HIC1 Antibodies ranked by validation data
- Compare Top HIC1 Antibodies
- antibodies-online: Search results for 3 available HIC1 Elisa Kits ranked by validation data
- Compare Top HIC1 Elisa Kits
- antibodies-online: Search results for 4 available HIC1 Proteins ranked by validation data
- Compare Top HIC1 Proteins
- GeneTex HIC1 Antibody for HIC1
- Search GeneTex for Proteins for HIC1
- Santa Cruz Biotechnology (SCBT) Antibodies for HIC1
- Search Santa Cruz Biotechnology (SCBT) for HIC1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIC1
- Horizon Cell Lines for HIC1
- genomics-online: cdna clones - Search results for 83 available HIC1 gene related products
- Overview of 83 available HIC1 gene related products
- orf clones - Search results for 83 available HIC1 gene related products
- Overview of 83 available HIC1 gene related products
- genomics-online: gRNA clones - Search results for 83 available HIC1 gene related products
- Overview of 83 available HIC1 gene related products
- genomics-online: primer clones - Search results for 83 available HIC1 gene related products
- Overview of 83 available HIC1 gene related products
- genomics-online: shRNA clones - Search results for 83 available HIC1 gene related products
- Overview of 83 available HIC1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HIC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HIC1
- GeneCopoeia miRNA 3'UTR Target clone products for HIC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIC1
Sources for HIC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt