Aliases for HHEX Gene
External Ids for HHEX Gene
Previous HGNC Symbols for HHEX Gene
Previous GeneCards Identifiers for HHEX Gene
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for HHEX Gene
HHEX (Hematopoietically Expressed Homeobox) is a Protein Coding gene. Diseases associated with HHEX include Acute Myeloid Leukemia With T(8;21)(Q22;Q22) Translocation and Maturity-Onset Diabetes Of The Young. Among its related pathways are Transcriptional misregulation in cancer and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding.
UniProtKB/Swiss-Prot Summary for HHEX Gene
Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). May play a role in hematopoietic differentiation (PubMed:8096636).