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Aliases for HGS Gene

Aliases for HGS Gene

  • Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate 2 3 3 5
  • Protein Pp110 3 4
  • HRS 3 4
  • Human Growth Factor-Regulated Tyrosine Kinase Substrate 3
  • Hrs 4

External Ids for HGS Gene

Previous GeneCards Identifiers for HGS Gene

  • GC17U990142
  • GC17P080211
  • GC17P080346
  • GC17P077261
  • GC17P079651
  • GC17P075097

Summaries for HGS Gene

Entrez Gene Summary for HGS Gene

  • The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

GeneCards Summary for HGS Gene

HGS (Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate) is a Protein Coding gene. Among its related pathways are EGF/EGFR Signaling Pathway and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is ANKFY1.

UniProtKB/Swiss-Prot for HGS Gene

  • Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

Gene Wiki entry for HGS Gene

Additional gene information for HGS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HGS Gene

Genomics for HGS Gene

GeneHancer (GH) Regulatory Elements for HGS Gene

Promoters and enhancers for HGS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J081682 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 661.2 +0.8 828 3.5 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF213 ARL16 HGS ALYREF FOXK2 LOC105371942 CCDC137 PDE6G NPLOC4 TSPAN10 P4HB
GH17J081681 Enhancer 0.6 ENCODE 650.7 -1.7 -1690 0.9 ZBTB8A ZIC2 OSR2 GLIS2 ZNF629 GLIS1 ZNF600 ZBTB17 ZNF423 SP7 HGS PIR45047 ARL16 NPLOC4 TSPAN10 GCGR MCRIP1 PPP1R27 ANAPC11 ALYREF
GH17J081864 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 59.7 +185.6 185617 8.9 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ARHGDIA ENSG00000262413 HGS TBCD ENSG00000260563 NARF-IT1 TEPSIN CEP131 FAAP100 ENSG00000262652
GH17J081700 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 52.6 +19.5 19464 4.2 HDGF CLOCK MLX ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 POLR2B ENSG00000262049 ENSG00000262660 MRPL12 ARL16 HGS FAAP100 CEP131 ENSG00000260563 TEPSIN NARF-IT1
GH17J082291 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 47.6 +615.3 615307 14.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 CSNK1D ENSG00000260563 NARF-IT1 HGS ENSG00000262652 ARL2BPP9 ALYREF FAAP100 TEX19 DUS1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HGS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HGS gene promoter:
  • ATF6
  • AP-4
  • AML1a
  • Lmo2
  • CP2
  • C/EBPalpha
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for HGS Gene

Genomic Locations for HGS Gene
chr17:81,683,326-81,703,138
(GRCh38/hg38)
Size:
19,813 bases
Orientation:
Plus strand
chr17:79,650,356-79,670,168
(GRCh37/hg19)
Size:
19,813 bases
Orientation:
Plus strand

Genomic View for HGS Gene

Genes around HGS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HGS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HGS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HGS Gene

Proteins for HGS Gene

  • Protein details for HGS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14964-HGS_HUMAN
    Recommended name:
    Hepatocyte growth factor-regulated tyrosine kinase substrate
    Protein Accession:
    O14964
    Secondary Accessions:
    • Q9NR36

    Protein attributes for HGS Gene

    Size:
    777 amino acids
    Molecular mass:
    86192 Da
    Quaternary structure:
    • Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 (or probably STAM) and EPS15 (PubMed:12551915). Interacts with STAM (PubMed:9407053). Interacts with STAM2 (By similarity). Interacts with EPS15; the interaction is direct, calcium-dependent and inhibited by SNAP25 (By similarity). Identified in a complex with STAM and LITAF (PubMed:23166352). Found in a complex with STAM and E3 ligase ITCH and DTX3L (PubMed:24790097). Interacts with E3 ligase DTX3L; the interaction brings together STAM and HSG, promotes their recruitment to early endosomes and decreases STAM and HGS ubiquitination by ITCH (PubMed:24790097). Interacts with NF2; the interaction is direct (PubMed:10861283). Interacts with ubiquitin; the interaction is direct (By similarity). Interacts with VPS37C (PubMed:15509564). Interacts with SMAD1, SMAD2 and SMAD3 (By similarity). Interacts with TSG101; the interaction mediates the association with the ESCRT-I complex (PubMed:21070952). Interacts with SNAP25; the interaction is direct and decreases with addition of increasing concentrations of free calcium (By similarity). Interacts with SNX1; the interaction is direct (By similarity). Component of a 550 kDa membrane complex at least composed of HGS and SNX1 but excluding EGFR (By similarity). Interacts with TRAK1 (PubMed:18675823). Interacts with TRAK2 (By similarity). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3 (PubMed:15772161). Interacts (via UIM domain) with UBQLN1 (via ubiquitin-like domain) (By similarity). Interacts with ARRDC3 (PubMed:23208550). Identified in a complex containing at least ARRDC4, AVPR2 and HGS (PubMed:23236378). Interacts with LAPTM4B; promotes HGS ubiquitination (PubMed:25588945).

    Three dimensional structures from OCA and Proteopedia for HGS Gene

    Alternative splice isoforms for HGS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HGS Gene

Post-translational modifications for HGS Gene

  • Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.
  • Ubiquitinated (PubMed:25588945). Ubiquitinated by ITCH (PubMed:14602072, PubMed:24790097).
  • Ubiquitination at isoforms=551, isoforms=513, isoforms=2473, isoforms=2251, Lys207, Lys202, Lys192, Lys136, isoforms=2126, isoforms=297, Lys93, and isoforms=286
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HGS Gene

Domains & Families for HGS Gene

Gene Families for HGS Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HGS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14964

UniProtKB/Swiss-Prot:

HGS_HUMAN :
  • Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix.
Domain:
  • Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix.
  • The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.
genes like me logo Genes that share domains with HGS: view

Function for HGS Gene

Molecular function for HGS Gene

UniProtKB/Swiss-Prot Function:
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
GENATLAS Biochemistry:
hepatocyte growth factor-regulated tyrosine kinase substrate,inhibiting the cytokine cell growth function induced by STAM

Phenotypes From GWAS Catalog for HGS Gene

Gene Ontology (GO) - Molecular Function for HGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10861283
GO:0016301 kinase activity IEA --
GO:0019904 protein domain specific binding IPI 11984006
GO:0044389 ubiquitin-like protein ligase binding IPI 24790097
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HGS: view
genes like me logo Genes that share phenotypes with HGS: view

Animal Models for HGS Gene

MGI Knock Outs for HGS:
  • Hgs Hgs<tm1Sor>
  • Hgs Hgs<tm1a(EUCOMM)Wtsi>
  • Hgs Hgs<tm1Sug>

Clone Products

  • Addgene plasmids for HGS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HGS Gene

Localization for HGS Gene

Subcellular locations from UniProtKB/Swiss-Prot for HGS Gene

Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane; Peripheral membrane protein. Note=Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments. {ECO:0000269 PubMed:16159959}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HGS gene
Compartment Confidence
extracellular 5
cytosol 5
lysosome 5
endosome 5
plasma membrane 2
nucleus 2
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endosomes (4)
  • Cytosol (3)
  • Lysosomes (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005764 lysosome IDA --
GO:0005768 endosome IDA 15611048
GO:0005769 early endosome IDA 10861283
genes like me logo Genes that share ontologies with HGS: view

Pathways & Interactions for HGS Gene

genes like me logo Genes that share pathways with HGS: view

SIGNOR curated interactions for HGS Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for HGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006622 protein targeting to lysosome IMP 18767904
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction TAS 9407053
GO:0008285 negative regulation of cell proliferation TAS 9407053
GO:0010324 membrane invagination IMP 18767904
genes like me logo Genes that share ontologies with HGS: view

Drugs & Compounds for HGS Gene

(8) Drugs for HGS Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citric Acid Approved, Vet_approved Nutra Agonist, Activator, Target 1243

(6) Additional Compounds for HGS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HGS: view

Transcripts for HGS Gene

Unigene Clusters for HGS Gene

Hepatocyte growth factor-regulated tyrosine kinase substrate:
Representative Sequences:

Clone Products

  • Addgene plasmids for HGS

Alternative Splicing Database (ASD) splice patterns (SP) for HGS Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 18b · 18c ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c · 24d
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10: -
SP11:

Relevant External Links for HGS Gene

GeneLoc Exon Structure for
HGS
ECgene alternative splicing isoforms for
HGS

Expression for HGS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HGS Gene

Protein differential expression in normal tissues from HIPED for HGS Gene

This gene is overexpressed in Heart (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HGS Gene



Protein tissue co-expression partners for HGS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HGS Gene:

HGS

SOURCE GeneReport for Unigene cluster for HGS Gene:

Hs.661056

mRNA Expression by UniProt/SwissProt for HGS Gene:

O14964-HGS_HUMAN
Tissue specificity: Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for HGS Gene

  • Skin(4.7)
  • Nervous system(4.7)
  • Liver(4.4)
  • Eye(2.2)
  • Kidney(2.2)
  • Blood(2.1)
  • Heart(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with HGS: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HGS Gene

Orthologs for HGS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HGS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HGS 34 33
  • 98.96 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HGS 34
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HGS 34 33
  • 88.06 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HGS 34 33
  • 87.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hgs 16 34 33
  • 86.98 (n)
rat
(Rattus norvegicus)
Mammalia Hgs 33
  • 86.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HGS 34 33
  • 79.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HGS 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hgs 33
  • 73.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68804 33
zebrafish
(Danio rerio)
Actinopterygii hgs 34 33
  • 78.62 (n)
OneToOne
wufi34f05 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008887 33
  • 61.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hrs 34 35 33
  • 58.71 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hgrs-1 34 33
  • 46.77 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS27 36 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToOne
Species where no ortholog for HGS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HGS Gene

ENSEMBL:
Gene Tree for HGS (if available)
TreeFam:
Gene Tree for HGS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HGS: view image

Paralogs for HGS Gene

Paralogs for HGS Gene

(3) SIMAP similar genes for HGS Gene using alignment to 8 proteins:

  • HGS_HUMAN
  • I3L165_HUMAN
  • I3L1E3_HUMAN
  • I3L1F1_HUMAN
  • I3L1P5_HUMAN
  • I3L2H4_HUMAN
  • I3L326_HUMAN
  • I3L346_HUMAN
genes like me logo Genes that share paralogs with HGS: view

Variants for HGS Gene

Sequence variations from dbSNP and Humsavar for HGS Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs863223352 likely-pathogenic, Childhood-Onset Schizophrenia 81,683,794(+) C/A upstream_transcript_variant
rs1000299525 -- 81,700,930(+) C/T intron_variant
rs1000633808 -- 81,699,617(+) G/A intron_variant
rs1000782977 -- 81,697,574(+) G/C intron_variant
rs1000835485 -- 81,697,421(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HGS Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV gain+loss 19812545
nsv1113896 CNV deletion 24896259
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv828128 CNV loss 20364138
nsv952390 CNV deletion 24416366

Variation tolerance for HGS Gene

Residual Variation Intolerance Score: 6.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HGS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HGS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HGS Gene

Disorders for HGS Gene

Additional Disease Information for HGS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HGS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HGS Gene

Publications for HGS Gene

  1. Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17. (PMID: 9630564) Lu L … Kitamura N (Gene 1998) 2 3 4 22 58
  2. Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. (PMID: 9407053) Asao H … Sugamura K (The Journal of biological chemistry 1997) 2 3 4 22 58
  3. Hybrid structural model of the complete human ESCRT-0 complex. (PMID: 19278655) Ren X … Hurley JH (Structure (London, England : 1993) 2009) 3 4 22 58
  4. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PMID: 12551915) Bache KG … Stenmark H (The Journal of biological chemistry 2003) 3 4 22 58
  5. HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. (PMID: 12900394) Pornillos O … Sundquist WI (The Journal of cell biology 2003) 3 4 22 58

Products for HGS Gene

Sources for HGS Gene