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This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodim... See more...
Aliases for HGF Gene
Aliases for HGF Gene
External Ids for HGF Gene
- HGNC: 4893
- Entrez Gene: 3082
- Ensembl: ENSG00000019991
- OMIM: 142409
- UniProtKB: P14210
Previous HGNC Symbols for HGF Gene
- DFNB39
Previous GeneCards Identifiers for HGF Gene
- GC07M079863
- GC07M080926
- GC07M080940
- GC07M080943
- GC07M080976
- GC07M081166
- GC07M081328
- GC07M075935
Summaries for HGF Gene
-
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
GeneCards Summary for HGF Gene
HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include identical protein binding and serine-type endopeptidase activity. An important paralog of this gene is MST1.
UniProtKB/Swiss-Prot Summary for HGF Gene
-
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
-
The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule.
Additional gene information for HGF Gene
- HGNC(4893)
- Entrez Gene(3082)
- Ensembl(ENSG00000019991)
- OMIM(142409)
- UniProtKB(P14210)
- Open Targets Platform(ENSG00000019991)
- Monarch Initiative
- Search for HGF at DataMed
- Search for HGF at HumanCyc
No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HGF Gene
Genomics for HGF Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HGF Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07J081768 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.8 | 779 | 3.3 | PRDM10 MNT CTCF ARID3A BMI1 ZNF335 SPI1 RCOR1 ZNF398 RAD21 | HGF ENSG00000233491 LOC100128317 SEMA3C | |
| GH07J082204 | Enhancer | 0.6 | Ensembl ENCODE | 5.5 | -434.3 | -434344 | 0.8 | BACH1 NFE2 MAFK NFE2L2 BHLHE40 HLF | HGF piR-38351-436 L13714-417 CACNA2D1 | |
| GH07J082212 | Enhancer | 0.2 | ENCODE | 5.6 | -442.3 | -442266 | 1.2 | HGF L13714-417 piR-38351-436 CACNA2D1 | ||
| GH07J081748 | Enhancer | 0.2 | FANTOM5 | 3 | +22.3 | 22276 | 0.3 | HGF ENSG00000233491 LOC100128317 SEMA3C | ||
| GH07J081724 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 0.3 | +45.0 | 44970 | 2.3 | SP1 JUND CEBPB FOS MAFK POLR2A | lnc-CD36-9 LOC100128317 ENSG00000233491 HGF SEMA3C |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HGF on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HGF
- Top Transcription factor binding sites by QIAGEN in the HGF gene promoter:
-
- AP-1
- C/EBPalpha
Genomic Locations for HGF Gene
Genomic Locations for HGF Gene
- chr7:81,699,006-81,770,438
- (GRCh38/hg38)
- Size:
- 71,433 bases
- Orientation:
- Minus strand
- chr7:81,328,322-81,399,754
- (GRCh37/hg19)
- Size:
- 71,433 bases
- Orientation:
- Minus strand
Genomic View for HGF Gene
Genes around HGF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q21.11 by HGNC
- 7q21.11 by Entrez Gene
- 7q21.11 by Ensembl
HGF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HGF Gene
Proteins for HGF Gene
-
Protein details for HGF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14210-HGF_HUMAN
- Recommended name:
- Hepatocyte growth factor
- Protein Accession:
- P14210
- A1L3U6
- Q02935
- Q13494
- Q14519
- Q3KRB2
- Q8TCE2
- Q9BYL9
- Q9BYM0
- Q9UDU6
Protein attributes for HGF Gene
- Size:
- 728 amino acids
- Molecular mass:
- 83134 Da
- Quaternary structure:
-
- Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
- Miscellaneous:
-
- [Isoform 4]: Acts as a competitive antagonist in MET-signaling.
Three dimensional structures from OCA and Proteopedia for HGF Gene
Protein Expression for HGF Gene
Selected DME Specific Peptides for HGF Gene
- P14210:
-
- NYCRNPD
- PWCFTTDP
Post-translational modifications for HGF Gene
Other Protein References for HGF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences HGF / Hepatocyte Growth Factor Antibody (LS-B4657) and HGF / Hepatocyte Growth Factor Antibody (LS-B4957)
- G Biosciences Immunotag™ HGF Antibody
- GeneTex Anti-HGF antibody and Anti-HGF (alpha subunit) antibody
- NSJ Bioreagents Hepatocyte Growth Factor Antibody (HGF)
- Creative Diagnostics Anti-Hepatocyte Growth Factor polyclonal antibody
-
Creative Biolabs
- Recombinant Anti-Human HGF Antibody
- Anti-Human HGF Therapeutic Antibody (Rilotumumab)
- Anti-Human HGF Therapeutic Antibody (Flanvotumab)
- Anti-HGF Therapeutic Antibody (ficlatuzumab)
- Anti-Human HGF/SF Therapeutic Single Domain Antibody (04e09)
- Mouse Anti-HGF (AA 200-494) Recombinant Antibody (CBFYH-1033)
- Mouse Anti-HGF Recombinant Antibody (CBFYH-1014)
- Mouse Anti-HGF Recombinant Antibody (CBFYH-3057)
- Mouse Anti-HGF Recombinant Antibody (CBFYH-1025)
- Mouse Anti-HGF Recombinant Antibody (CBFYH-3056)
- Recombinant Chimeric (mouse/human) Anti-HGF Antibody (chL2G7)
- Recombinant Humanized Anti-HGF Antibody (HuL2G7)
- Afuco™ Anti-HGF ADCC Theraputic Antibody (Rilotumumab), ADCC Enhanced
- Recombinant Mouse Anti-HGF Antibody (HE2B8-4)
- Afuco™ Anti-HGF ADCC Theraputic Antibody (Ficlatuzumab), ADCC Enhanced
- Recombinant Human Anti-HGF Antibody Fab Fragment (HGF13hum5)
- Recombinant Human Anti-HGF Antibody scFv Fragment (LRMR2B8)
- Recombinant Anti-HGF Antibody Fab Fragment (AB012)
- Recombinant Mouse Anti-HGF Antibody Fab Fragment (1A3)
- Afuco™ Anti-HGF ADCC Theraputic Antibody (Flanvotumab), ADCC Enhanced
- Recombinant Humanized Anti-HGF Antibody Fab Fragment (HuL2G7)
- BioLegend HGF Antibody
- Novus Biologicals Antibodies for HGF
-
Abcam antibodies for HGF
- Invitrogen Antibodies for HGF (AFLGC-Hgf)
- antibodies-online: Show 591 available HGF Antibodies ranked by validation data
- Compare Top HGF Antibodies
-
Recommended
- 189 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IEP Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 38 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HGF
- Sino Biological Antibodies for HGF
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HGF
- Origene Custom Protein Services for HGF
- Sino Biological Recombinant Proteins for HGF
- Sino Biological Cell Lysates for HGF
- ProSpec Recombinant Proteins for HGF
- antibodies-online: Show 76 available HGF Proteins ranked by validation data
- Compare Top HGF Proteins
-
Abcam proteins for HGF
Assay Products
- RayBiotech Human HGF ELISA (For Lysates) and Human HGF ELISA
- Novus Biologicals ELISA Kits for HGF
- antibodies-online: Show 142 available HGF Elisa Kits ranked by validation data
- Compare Top HGF Elisa Kits
-
Quality Products:
- ABIN6720511
- ABIN624992
- ABIN414383
- ABIN1115405
- ABIN411278
- ABIN367595
- ABIN491758
- ABIN3032931
- ABIN1380034
- ABIN624993
- ABIN625126
- ABIN365445
- ABIN415597
- ABIN2859322
- ABIN2684466
- ABIN5563534
- ABIN625127
- ABIN1570289
- ABIN1115407
- ABIN5524601
- ABIN1115406
- ABIN416317
- ABIN1889441
- ABIN365554
- ABIN2748164
- ABIN5563535
- ABIN1570290
- ABIN5524603
- ABIN2708645
- ABIN2684468
-
Abcam assays for HGF
Domains & Families for HGF Gene
Gene Families for HGF Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted secreted proteins
Protein Domains for HGF Gene
- InterPro:
- Blocks:
-
- Kringle
- Serine protease, trypsin family
- Chymotrypsin serine protease family (S1) signature
- N/apple PAN
- Apple-like
- ProtoNet:
Suggested Antigen Peptide Sequences for HGF Gene
- GenScript: Design optimal peptide antigens:
-
- Hepatocyte growth factor isoform 6 (C9WSJ4_HUMAN)
- Scatter factor (HGF_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P14210- Family:
-
- Belongs to the peptidase S1 family. Plasminogen subfamily.
Function for HGF Gene
Molecular function for HGF Gene
- UniProtKB/Swiss-Prot Function:
- Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
- GENATLAS Biochemistry:
- hepatocyte growth factor,precursor of chains alpha and beta,expressed in platelets,fibroblast,macrophage,endothelial and smooth muscle cells
Enzyme Numbers (IUBMB) for HGF Gene
LifeMap Function Summary for HGF Gene
During embryonic development, HGF as signaling molecule is secreted from the following cells
- Kidney
- Limb
- Mesoderm
- Liver
It affects the following cells:
- Liver
- Limb
- Somite
- Kidney
HGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Liver
- Skeletal Muscle
- Epithelial Cells
- Pancreas
Phenotypes From GWAS Catalog for HGF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004252 | NOT serine-type endopeptidase activity | IBA,NAS | 2531289 |
| GO:0005515 | protein binding | IPI | 1846706 |
| GO:0008083 | growth factor activity | NAS | 2531289 |
| GO:0042056 | chemoattractant activity | IDA | 21245381 |
| GO:0042802 | identical protein binding | IPI | 17804794 |
Phenotypes for HGF Gene
- MGI mutant phenotypes for HGF:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for HGF:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability
- Decreased HPV16-GFP infection
- Increased centriole number
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HGF - Select products 50% OFF >
- * HGF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HGF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HGF
-
Santa Cruz Biotechnology (SCBT) CRISPR for HGF
miRNA for HGF Gene
- miRTarBase miRNAs that target HGF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HGF
- Browse OriGene Inhibitory RNA Products For HGF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HGF
Clone Products
- Applied Biological Materials (abm): Clones for HGF - Select products 50% OFF >
- * HGF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226277
- MR226277
- MR226277L3
- MR226277L4
- MR228535
- MR230984
- MR231001
- MR231002
- RC213241
- RC213241L3
- RC213241L4
- RC215308
- RC215308L1
- RC215308L2
- RC215308L3
- RC215308L4
- RC215593
- RC215593L1
- RC215593L2
- RC215593L3
- RC215593L4
- RC220421
- RC220421L3
- RC220421L4
- RC223533
- RG213241
- RG215308
- RG215593
- RG220421
- RG223533
- RR213062
- RR213062L3
- RR213062L4
- MR226277L3V
- MR226277L4V
- RC213241L3V
- RC213241L4V
- RC215308L1V
- RC215308L2V
- RC215308L3V
- RC215308L4V
- RC215593L1V
- RC215593L2V
- RC215593L3V
- RC215593L4V
- RC220421L3V
- RC220421L4V
- RR213062L3V
- RR213062L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HGF
- Addgene plasmids for HGF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HGF
Cell Line Products
-
Horizon Cell Lines for HGF
No data available for Transcription Factor Targets and HOMER Transcription for HGF Gene
Localization for HGF Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| nucleus | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
- Centrosome (2)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0016020 | membrane | HDA | 19946888 |
| GO:0031093 | platelet alpha granule lumen | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for HGF Gene
Pathways & Interactions for HGF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 3 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
|
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
| 4 | GAB1 signalosome |
.89
|
|
| 5 | MET promotes cell motility |
.45
|
|
Pathways by source for HGF Gene
13 BioSystems pathways for HGF Gene
77 Reactome pathways for HGF Gene
14 KEGG pathways for HGF Gene
2 GeneGo (Thomson Reuters) pathways for HGF Gene
- Cell adhesion PLAU signaling
- Development HGF signaling pathway
1 R&D Systems pathway for HGF Gene
64 Qiagen pathways for HGF Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
1 Cell Signaling Technology pathway for HGF Gene
Interacting Proteins for HGF Gene
Selected Interacting proteins:
P14210-HGF_HUMAN
ENSP00000222390
for HGF Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for HGF
SIGNOR curated interactions for HGF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000187 | activation of MAPK activity | IEA | -- |
| GO:0000278 | mitotic cell cycle | NAS | 2531289 |
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001837 | epithelial to mesenchymal transition | TAS | 14679171 |
Drugs & Compounds for HGF Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Agonist | Anti-inflammatory glucocorticoid | 2886 | |
| Heparin | Approved, Investigational | Pharma | Antagonist, Target | 1058 | ||
| Bortezomib | Approved, Investigational | Pharma | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 910 | ||
| Dexamethasone acetate | Approved, Investigational, Vet_approved | Pharma | 2886 | |||
| Osimertinib | Approved | Pharma | 144 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Norleual |
|
334994-34-2 |
|
|
||
| PF 04217903 mesylate |
|
956906-93-7 |
|
|
||
| SGX 523 |
|
1022150-57-7 |
|
|
(5) Tocris Compounds for HGF Gene
| Compound | Action | Cas Number |
|---|---|---|
| Norleual | Highly potent HGF/c-MET inhibitor; also AT4 antagonist | 334994-34-2 |
| PF 04217903 mesylate | Highly selective MET inhibitor | 956906-93-7 |
| PHA 665752 | Potent and selective MET inhibitor | 477575-56-7 |
| SGX 523 | Selective and potent c-MET kinase inhibitor | 1022150-57-7 |
| SU 11274 | Selective inhibitor of MET kinase activity | 658084-23-2 |
Drug Products
Transcripts for HGF Gene
mRNA/cDNA for HGF Gene
- 5 REFSEQ mRNAs :
- 25 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000222390 5834 nts (view in UCSC)
- ENST00000354224 1425 nts (view in UCSC)
- ENST00000412881 590 nts (view in UCSC)
- ENST00000421558 545 nts (view in UCSC)
- ENST00000423064 2021 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HGF - Select products 50% OFF >
- * HGF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HGF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HGF
-
Santa Cruz Biotechnology (SCBT) CRISPR for HGF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HGF
- Browse OriGene Inhibitory RNA Products For HGF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HGF
Clone Products
- Applied Biological Materials (abm): Clones for HGF - Select products 50% OFF >
- * HGF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226277
- MR226277
- MR226277L3
- MR226277L4
- MR228535
- MR230984
- MR231001
- MR231002
- RC213241
- RC213241L3
- RC213241L4
- RC215308
- RC215308L1
- RC215308L2
- RC215308L3
- RC215308L4
- RC215593
- RC215593L1
- RC215593L2
- RC215593L3
- RC215593L4
- RC220421
- RC220421L3
- RC220421L4
- RC223533
- RG213241
- RG215308
- RG215593
- RG220421
- RG223533
- RR213062
- RR213062L3
- RR213062L4
- MR226277L3V
- MR226277L4V
- RC213241L3V
- RC213241L4V
- RC215308L1V
- RC215308L2V
- RC215308L3V
- RC215308L4V
- RC215593L1V
- RC215593L2V
- RC215593L3V
- RC215593L4V
- RC220421L3V
- RC220421L4V
- RR213062L3V
- RR213062L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HGF
- Addgene plasmids for HGF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HGF
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for HGF Gene
- GeneLoc Exon Structure for
- HGF
Expression for HGF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
- NULL (Integumentary System)
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
- Septum Transversum Mesenchyme Cells Septum Transversum
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
- Hepatocyte-like cells(Si-Tayeb K et. al. 2010)
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
-
Limb (Muscoskeletal System)
- Progress Zone Cells Limb Bud
-
Cartilage (Muscoskeletal System)
- Progress Zone Cells Limb Bud
-
Lung (Respiratory System)
- Early Lung Mesoderm Cells Lung Mesoderm
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Uncategorized
- Umbilical Cord (Extraembryonic Tissues)
- Trophoblast (Extraembryonic Tissues)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for HGF Gene
This gene is overexpressed in Liver (x5.3).
This gene is overexpressed in Bone marrow mesenchymal stem cell (27.1), Amniocyte (24.6), and Placenta (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HGF Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HGF
SOURCE GeneReport for Unigene cluster for HGF Gene:
Hs.396530Evidence on tissue expression from TISSUES for HGF Gene
- Liver(4.7)
- Blood(4.6)
- Nervous system(4.6)
- Lung(4.6)
- Kidney(3.4)
- Heart(3.3)
- Intestine(3.3)
- Bone marrow(3.2)
- Muscle(3.1)
- Skin(3)
- Spleen(2.8)
- Lymph node(2.8)
- Pancreas(2.8)
- Eye(2.8)
- Stomach(2.7)
- Gall bladder(2.6)
- Bone(2.6)
- Thyroid gland(2.4)
- Adrenal gland(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HGF Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- eye
- head
- inner ear
- middle ear
- outer ear
- skull
General:
- peripheral nerve
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for HGF
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HGF Gene
Orthologs for HGF Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HGF 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HGF 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HGF 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | HGF 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Hgf 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hgf 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | HGF 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HGF 30 |
|
||
| HGF/SF 31 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | HGF 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hgf 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | hgfa 30 31 |
|
OneToMany | |
| HGF (2 of 2) 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Tequila 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | svh-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for HGF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for HGF Gene
- ENSEMBL:
- Gene Tree for HGF (if available)
- TreeFam:
- Gene Tree for HGF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HGF: view image
Paralogs for HGF Gene
(7) SIMAP similar genes for HGF Gene using alignment to 6 proteins:
- HGF_HUMAN
- C9JDP4_HUMAN
- C9JJ35_HUMAN
- C9JS80_HUMAN
- C9WSJ3_HUMAN
- C9WSJ4_HUMAN
Pseudogenes.org Pseudogenes for HGF Gene
Variants for HGF Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HGF Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 667244 | Uncertain Significance: not specified | 81,705,458(-) | C/T | MISSENSE_VARIANT | |
| 667245 | Uncertain Significance: not specified | 81,702,759(-) | T/TA | INTRON_VARIANT | |
| 681499 | Likely Benign: not provided | 81,706,417(-) | C/A | MISSENSE_VARIANT | |
| 682779 | Benign: not provided | 81,707,219(-) | C/A | INTRON_VARIANT | |
| 745720 | Likely Benign: not provided | 81,752,151(-) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1101e201 | CNV | deletion | 23290073 |
| dgv3601n106 | CNV | deletion | 24896259 |
| esv2384607 | CNV | deletion | 18987734 |
| esv2618632 | CNV | deletion | 19546169 |
| esv2734743 | CNV | deletion | 23290073 |
| esv3541994 | CNV | deletion | 23714750 |
| esv3576398 | CNV | gain | 25503493 |
| esv3613890 | CNV | loss | 21293372 |
| esv3613891 | CNV | loss | 21293372 |
| esv3807 | CNV | loss | 18987735 |
| esv8642 | CNV | loss | 19470904 |
| nsv1019753 | CNV | gain | 25217958 |
| nsv1074527 | CNV | deletion | 25765185 |
| nsv1124235 | CNV | deletion | 24896259 |
| nsv1150903 | CNV | deletion | 26484159 |
| nsv366332 | CNV | deletion | 16902084 |
| nsv464609 | CNV | loss | 19166990 |
| nsv607689 | CNV | loss | 21841781 |
| nsv951366 | CNV | duplication | 24416366 |
| nsv955962 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
8.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.03;
50.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HGF Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HGF Gene
Disorders for HGF Gene
(93) MalaCards diseases for HGF Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal recessive 39 |
|
|
| autosomal recessive non-syndromic sensorineural deafness type dfnb |
|
|
| salivary gland carcinoma |
|
|
| obstructive nephropathy |
|
|
| acute kidney failure |
|
Search HGF in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HGF_HUMAN- Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:19576567}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for HGF
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for HGF Gene
Publications for HGF Gene
- Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. (PMID: 19576567) Schultz JM … Morell RJ (American journal of human genetics 2009) 2 3 4
- Family-based association analysis of hepatocyte growth factor (HGF) gene polymorphisms in high myopia. (PMID: 16723436) Han W … Yip SP (Investigative ophthalmology & visual science 2006) 3 23 41
- Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. (PMID: 15167892) Stamos J … Wiesmann C (The EMBO journal 2004) 3 4 23
- Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population. (PMID: 15064106) Takiuchi S … Tomoike H (Atherosclerosis 2004) 3 23 41
- Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution. (PMID: 9817840) Ultsch M … de Vos AM (Structure (London, England : 1993) 1998) 3 4 23
ExternalLinks
Products for HGF Gene
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- MG226277
- MR226277
- MR226277L3
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- RC215308L1V
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- RC215308L4V
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- RC215593L2V
- RC215593L3V
- RC215593L4V
- RC220421L3V
- RC220421L4V
- RR213062L3V
- RR213062L4V
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- Sino Biological Recombinant Proteins for HGF
- Sino Biological Cell Lysates for HGF
- Sino Biological Antibodies for HGF
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HGF
- Novus Biologicals proteins and lysates for HGF
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- Abcam antibodies for HGF
- Abcam proteins for HGF
- Abcam assays for HGF
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- VectorBuilder Custom and pre-made DNA vectors for HGF (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HGF (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HGF (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HGF CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HGF
- Addgene plasmids for HGF
- antibodies-online: Show 591 available HGF Antibodies ranked by validation data
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- Recommended
- 189 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IEP Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 38 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- antibodies-online: Show 142 available HGF Elisa Kits ranked by validation data
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- Quality Products:
- ABIN6720511
- ABIN624992
- ABIN414383
- ABIN1115405
- ABIN411278
- ABIN367595
- ABIN491758
- ABIN3032931
- ABIN1380034
- ABIN624993
- ABIN625126
- ABIN365445
- ABIN415597
- ABIN2859322
- ABIN2684466
- ABIN5563534
- ABIN625127
- ABIN1570289
- ABIN1115407
- ABIN5524601
- ABIN1115406
- ABIN416317
- ABIN1889441
- ABIN365554
- ABIN2748164
- ABIN5563535
- ABIN1570290
- ABIN5524603
- ABIN2708645
- ABIN2684468
- antibodies-online: Show 76 available HGF Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for HGF
- Search Santa Cruz Biotechnology (SCBT) for HGF siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HGF
- Horizon Cell Lines for HGF
- Browse GeneCopoeia Cell Lines
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- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HGF
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Sources for HGF Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pse