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This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodim... See more...
Aliases for HGF Gene
Aliases for HGF Gene
External Ids for HGF Gene
- HGNC: 4893
- NCBI Entrez Gene: 3082
- Ensembl: ENSG00000019991
- OMIM®: 142409
- UniProtKB/Swiss-Prot: P14210
Previous HGNC Symbols for HGF Gene
- DFNB39
Previous GeneCards Identifiers for HGF Gene
- GC07M079863
- GC07M080926
- GC07M080940
- GC07M080943
- GC07M080976
- GC07M081166
- GC07M081328
- GC07M075935
Summaries for HGF Gene
-
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
GeneCards Summary for HGF Gene
HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are RET signaling and Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include identical protein binding and serine-type endopeptidase activity. An important paralog of this gene is MST1.
UniProtKB/Swiss-Prot Summary for HGF Gene
-
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
-
The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule.
Additional gene information for HGF Gene
No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HGF Gene
Genomics for HGF Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HGF Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07J081768 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | +0.8 | 779 | 3.3 | RAD21 SPI1 BMI1 ZNF398 ARID3A MNT TAF1 CTCF PRDM10 ZNF335 | HGF LOC100128317 lnc-CD36-9 SEMA3C | |
| GH07J082204 | Enhancer | 0.6 | Ensembl ENCODE | 5.5 | -434.3 | -434344 | 0.8 | NFE2 BHLHE40 NFE2L2 MAFK BACH1 HLF | HGF piR-38351-436 L13714-422 HSALNG0059259 CACNA2D1 | |
| GH07J082212 | Enhancer | 0.2 | ENCODE | 5.6 | -442.3 | -442266 | 1.2 | HGF L13714-422 piR-38351-436 HSALNG0059259 CACNA2D1 | ||
| GH07J081748 | Enhancer | 0.2 | FANTOM5 | 3 | +22.3 | 22276 | 0.3 | HGF LOC100128317 lnc-CD36-9 SEMA3C | ||
| GH07J081724 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 0.3 | +45.0 | 44970 | 2.3 | JUND CEBPB MAFK POLR2A EP300 FOS | LOC100128317 lnc-CD36-9 HGF SEMA3C |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HGF on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HGF
- Top Transcription factor binding sites by QIAGEN in the HGF gene promoter:
-
- AP-1
- C/EBPalpha
Genomic Locations for HGF Gene
Latest Assembly
- chr7:81,699,006-81,770,438
- (GRCh38/hg38)
- Size:
- 71,433 bases
- Orientation:
- Minus strand
Previous Assembly
- chr7:81,328,326-81,399,363
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 71,038 bases
- Orientation:
- Minus strand
Genomic View for HGF Gene
Genes around HGF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q21.11 by HGNC
- 7q21.11 by Entrez Gene
- 7q21.11 by Ensembl
HGF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HGF Gene
Proteins for HGF Gene
-
Protein details for HGF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14210-HGF_HUMAN
- Recommended name:
- Hepatocyte growth factor
- Protein Accession:
- P14210
- A1L3U6
- Q02935
- Q13494
- Q14519
- Q3KRB2
- Q8TCE2
- Q9BYL9
- Q9BYM0
- Q9UDU6
Protein attributes for HGF Gene
- Size:
- 728 amino acids
- Molecular mass:
- 83134 Da
- Quaternary structure:
-
- Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
- Miscellaneous:
-
- [Isoform 4]: Acts as a competitive antagonist in MET-signaling.
Three dimensional structures from OCA and Proteopedia for HGF Gene
Protein Expression for HGF Gene
Selected DME Specific Peptides for HGF Gene
- P14210:
-
- NYCRNPD
- PWCFTTDP
Post-translational modifications for HGF Gene
Other Protein References for HGF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences HGF / Hepatocyte Growth Factor Antibody (LS-B4657) and HGF / Hepatocyte Growth Factor Antibody (LS-B4957)
- G Biosciences Immunotag™ HGF Antibody
- GeneTex Anti-HGF antibody and Anti-HGF (alpha subunit) antibody
- NSJ Bioreagents Hepatocyte Growth Factor Antibody (HGF)
- BioLegend HGF Antibody
- Novus Biologicals Antibodies for HGF
-
Abcam antibodies for HGF
- Invitrogen Antibodies for HGF (AFLGC-Hgf)
- antibodies-online: Show 591 available HGF Antibodies ranked by validation data
- Compare Top HGF Antibodies
-
Recommended
- 189 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IEP Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 38 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HGF
- Sino Biological Antibodies for HGF
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for HGF
- Origene Custom Protein Services for HGF
- Sino Biological Recombinant Proteins for HGF
- Sino Biological Cell Lysates for HGF
- ProSpec Recombinant Proteins for HGF
- antibodies-online: Show 76 available HGF Proteins ranked by validation data
- Compare Top HGF Proteins
-
Abcam proteins for HGF
Assay products for research
- RayBiotech Human HGF ELISA (For Lysates) and Human HGF ELISA
- antibodies-online: Show 142 available HGF Elisa Kits ranked by validation data
- Compare Top HGF Elisa Kits
-
Quality Products:
- ABIN6720511
- ABIN624992
- ABIN414383
- ABIN1115405
- ABIN411278
- ABIN367595
- ABIN491758
- ABIN3032931
- ABIN1380034
- ABIN624993
- ABIN625126
- ABIN365445
- ABIN415597
- ABIN2859322
- ABIN2684466
- ABIN5563534
- ABIN625127
- ABIN1570289
- ABIN1115407
- ABIN5524601
- ABIN1115406
- ABIN416317
- ABIN1889441
- ABIN365554
- ABIN2748164
- ABIN5563535
- ABIN1570290
- ABIN5524603
- ABIN2708645
- ABIN2684468
-
Abcam assays for HGF
- Sino Biological Assays for HGF
Domains & Families for HGF Gene
Gene Families for HGF Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted secreted proteins
Protein Domains for HGF Gene
- InterPro:
- Blocks:
-
- Kringle
- Serine protease, trypsin family
- Chymotrypsin serine protease family (S1) signature
- N/apple PAN
- Apple-like
Suggested Antigen Peptide Sequences for HGF Gene
- GenScript: Design optimal peptide antigens:
-
- Hepatocyte growth factor isoform 6 (C9WSJ4_HUMAN)
- Scatter factor (HGF_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P14210- Family:
-
- Belongs to the peptidase S1 family. Plasminogen subfamily.
Function for HGF Gene
Molecular function for HGF Gene
- UniProtKB/Swiss-Prot Function:
- Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
- GENATLAS Biochemistry:
- hepatocyte growth factor,precursor of chains alpha and beta,expressed in platelets,fibroblast,macrophage,endothelial and smooth muscle cells
Enzyme Numbers (IUBMB) for HGF Gene
LifeMap Function Summary for HGF Gene
During embryonic development, HGF as signaling molecule is secreted from the following cells
- Kidney
- Limb
- Mesoderm
- Liver
It affects the following cells:
- Liver
- Limb
- Somite
- Kidney
HGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Liver
- Skeletal Muscle
- Epithelial Cells
- Pancreas
Phenotypes From GWAS Catalog for HGF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004252 | NOT serine-type endopeptidase activity | IBA,NAS | 2531289 |
| GO:0005515 | protein binding | IPI | 1846706 |
| GO:0008083 | growth factor activity | NAS | 2531289 |
| GO:0042056 | chemoattractant activity | IDA | 21245381 |
| GO:0042802 | identical protein binding | IPI | 17804794 |
Phenotypes for HGF Gene
- MGI mutant phenotypes for HGF:
-
inferred from 6 alleles
- nervous system phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- embryo phenotype
- pigmentation phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for HGF:
-
- shRNA abundance <= 50%
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased centriole number
- Decreased viability
- Decreased HPV16-GFP infection
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HGF - Starting at $85 >
- * HGF CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HGF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HGF
-
Santa Cruz Biotechnology (SCBT) CRISPR for HGF
miRNA for HGF Gene
- miRTarBase miRNAs that target HGF
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HGF
- Browse OriGene Inhibitory RNA Products For HGF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HGF
Clone products for research
- Applied Biological Materials (abm): Clones for HGF - Starting at $45 >
- * HGF as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG226277
- MR226277
- MR226277L3
- MR226277L4
- MR228535
- MR230984
- MR231001
- MR231002
- RC213241
- RC213241L3
- RC213241L4
- RC215308
- RC215308L1
- RC215308L2
- RC215308L3
- RC215308L4
- RC215593
- RC215593L1
- RC215593L2
- RC215593L3
- RC215593L4
- RC220421
- RC220421L3
- RC220421L4
- RC223533
- RG213241
- RG215308
- RG215593
- RG220421
- RG223533
- RR213062
- RR213062L3
- RR213062L4
- MR226277L3V
- MR226277L4V
- RC213241L3V
- RC213241L4V
- RC215308L1V
- RC215308L2V
- RC215308L3V
- RC215308L4V
- RC215593L1V
- RC215593L2V
- RC215593L3V
- RC215593L4V
- RC220421L3V
- RC220421L4V
- RR213062L3V
- RR213062L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HGF
- Addgene plasmids for HGF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HGF
Cell Lines for research
-
Horizon Cell Lines for HGF
No data available for Transcription Factor Targets and HOMER Transcription for HGF Gene
Localization for HGF Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| nucleus | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0016020 | membrane | HDA | 19946888 |
| GO:0031093 | platelet alpha granule lumen | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for HGF Gene
Pathways & Interactions for HGF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 3 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
|
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
| 4 | PI3K/AKT activation |
.89
|
|
| 5 | MET promotes cell motility |
.45
|
|
Pathways by source for HGF Gene
13 BioSystems pathways for HGF Gene
77 Reactome pathways for HGF Gene
15 KEGG pathways for HGF Gene
2 GeneGo (Thomson Reuters) pathways for HGF Gene
- Cell adhesion PLAU signaling
- Development HGF signaling pathway
1 R&D Systems pathway for HGF Gene
64 Qiagen pathways for HGF Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
1 Cell Signaling Technology pathway for HGF Gene
Interacting Proteins for HGF Gene
Selected Interacting proteins:
P14210-HGF_HUMAN
ENSP00000222390
for HGF Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for HGF
SIGNOR curated interactions for HGF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000187 | activation of MAPK activity | IEA | -- |
| GO:0000278 | mitotic cell cycle | NAS | 2531289 |
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001837 | epithelial to mesenchymal transition | TAS | 14679171 |
Drugs & Compounds for HGF Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Anti-inflammatory glucocorticoid | 3149 | ||
| Heparin | Approved, Investigational | Pharma | Target | 1160 | ||
| Bortezomib | Approved, Investigational | Pharma | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 933 | ||
| Dexamethasone acetate | Approved, Investigational, Vet_approved | Pharma | 3149 | |||
| Osimertinib | Approved | Pharma | 174 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Norleual |
|
334994-34-2 |
|
|
||
| PF 04217903 mesylate |
|
956906-93-7 |
|
|
||
| SGX 523 |
|
1022150-57-7 |
|
|
(5) Tocris Compounds for HGF Gene
| Compound | Action | Cas Number |
|---|---|---|
| Norleual | Highly potent HGF/c-MET inhibitor; also AT4 antagonist | 334994-34-2 |
| PF 04217903 mesylate | Highly selective MET inhibitor | 956906-93-7 |
| PHA 665752 | Potent and selective MET inhibitor | 477575-56-7 |
| SGX 523 | Selective and potent c-MET kinase inhibitor | 1022150-57-7 |
| SU 11274 | Selective inhibitor of MET kinase activity | 658084-23-2 |
Drug products for research
Transcripts for HGF Gene
mRNA/cDNA for HGF Gene
- 5 REFSEQ mRNAs :
- 25 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000222390 5834 nts (view in UCSC)
- ENST00000354224 1425 nts (view in UCSC)
- ENST00000412881 590 nts (view in UCSC)
- ENST00000421558 545 nts (view in UCSC)
- ENST00000423064 2021 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HGF - Starting at $85 >
- * HGF CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HGF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HGF
-
Santa Cruz Biotechnology (SCBT) CRISPR for HGF
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HGF
- Browse OriGene Inhibitory RNA Products For HGF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HGF
Clone products for research
- Applied Biological Materials (abm): Clones for HGF - Starting at $45 >
- * HGF as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG226277
- MR226277
- MR226277L3
- MR226277L4
- MR228535
- MR230984
- MR231001
- MR231002
- RC213241
- RC213241L3
- RC213241L4
- RC215308
- RC215308L1
- RC215308L2
- RC215308L3
- RC215308L4
- RC215593
- RC215593L1
- RC215593L2
- RC215593L3
- RC215593L4
- RC220421
- RC220421L3
- RC220421L4
- RC223533
- RG213241
- RG215308
- RG215593
- RG220421
- RG223533
- RR213062
- RR213062L3
- RR213062L4
- MR226277L3V
- MR226277L4V
- RC213241L3V
- RC213241L4V
- RC215308L1V
- RC215308L2V
- RC215308L3V
- RC215308L4V
- RC215593L1V
- RC215593L2V
- RC215593L3V
- RC215593L4V
- RC220421L3V
- RC220421L4V
- RR213062L3V
- RR213062L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HGF
- Addgene plasmids for HGF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HGF
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for HGF Gene
- GeneLoc Exon Structure for
- HGF
Expression for HGF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
- NULL (Integumentary System)
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
- Septum Transversum Mesenchyme Cells Septum Transversum
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
- Hepatocyte-like cells(Si-Tayeb K et. al. 2010)
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
-
Limb (Muscoskeletal System)
- Progress Zone Cells Limb Bud
-
Cartilage (Muscoskeletal System)
- Progress Zone Cells Limb Bud
-
Lung (Respiratory System)
- Early Lung Mesoderm Cells Lung Mesoderm
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Uncategorized
- Umbilical Cord (Extraembryonic Tissues)
- Trophoblast (Extraembryonic Tissues)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for HGF Gene
This gene is overexpressed in Liver (x5.3).
This gene is overexpressed in Bone marrow mesenchymal stem cell (27.1), Amniocyte (24.6), and Placenta (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HGF Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HGF
SOURCE GeneReport for Unigene cluster for HGF Gene:
Hs.396530Evidence on tissue expression from TISSUES for HGF Gene
- Liver(4.7)
- Nervous system(4.6)
- Lung(4.6)
- Blood(4.5)
- Intestine(3.1)
- Kidney(3.1)
- Heart(3)
- Bone marrow(2.9)
- Muscle(2.8)
- Skin(2.7)
- Spleen(2.6)
- Lymph node(2.6)
- Stomach(2.5)
- Pancreas(2.5)
- Eye(2.5)
- Gall bladder(2.4)
- Bone(2.3)
- Adrenal gland(2.3)
- Thyroid gland(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HGF Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- eye
- head
- inner ear
- middle ear
- outer ear
- skull
General:
- peripheral nerve
- peripheral nervous system
Primer products for research
-
OriGene qPCR primer pairs for HGF
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HGF Gene
Orthologs for HGF Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HGF 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HGF 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HGF 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | HGF 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Hgf 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hgf 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | HGF 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HGF 29 |
|
||
| HGF/SF 30 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | HGF 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hgf 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | hgfa 29 30 |
|
OneToMany | |
| HGF (2 of 2) 30 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Tequila 30 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | svh-1 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany |
- Species where no ortholog for HGF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for HGF Gene
- ENSEMBL:
- Gene Tree for HGF (if available)
- TreeFam:
- Gene Tree for HGF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HGF: view image
- Alliance of Genome Resources:
- Additional Orthologs for HGF
Paralogs for HGF Gene
(7) SIMAP similar genes for HGF Gene using alignment to 6 proteins:
- HGF_HUMAN
- C9JDP4_HUMAN
- C9JJ35_HUMAN
- C9JS80_HUMAN
- C9WSJ3_HUMAN
- C9WSJ4_HUMAN
Pseudogenes.org Pseudogenes for HGF Gene
Variants for HGF Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HGF Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 930004 | Uncertain Significance: not specified | 81,743,464(-) |
C/G NM_000601.6(HGF):c.754G>C (p.Asp252His) |
MISSENSE | |
| 995374 | Uncertain Significance: not provided | 81,717,342(-) |
G/A NM_000601.6(HGF):c.1295C>T (p.Ala432Val) |
MISSENSE | |
| rs1363809103 | Uncertain Significance: not specified | 81,702,759(-) |
T/TA NM_000601.6(HGF):c.2011-3dup |
INTRON | |
| rs137853235 | Pathogenic: Deafness, autosomal recessive 39 | 81,752,250(-) |
C/T NM_000601.6(HGF):c.495G>A (p.Ser165=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs138548003 | Likely Benign: not provided | 81,706,340(-) |
G/A NM_000601.6(HGF):c.1704C>T (p.Ser568=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1101e201 | CNV | deletion | 23290073 |
| dgv3601n106 | CNV | deletion | 24896259 |
| esv2384607 | CNV | deletion | 18987734 |
| esv2618632 | CNV | deletion | 19546169 |
| esv2734743 | CNV | deletion | 23290073 |
| esv3541994 | CNV | deletion | 23714750 |
| esv3576398 | CNV | gain | 25503493 |
| esv3613890 | CNV | loss | 21293372 |
| esv3613891 | CNV | loss | 21293372 |
| esv3807 | CNV | loss | 18987735 |
| esv8642 | CNV | loss | 19470904 |
| nsv1019753 | CNV | gain | 25217958 |
| nsv1074527 | CNV | deletion | 25765185 |
| nsv1124235 | CNV | deletion | 24896259 |
| nsv1150903 | CNV | deletion | 26484159 |
| nsv366332 | CNV | deletion | 16902084 |
| nsv464609 | CNV | loss | 19166990 |
| nsv607689 | CNV | loss | 21841781 |
| nsv951366 | CNV | duplication | 24416366 |
| nsv955962 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
8.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.03;
50.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HGF Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HGF Gene
Disorders for HGF Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal recessive 39 |
|
|
| autosomal recessive non-syndromic sensorineural deafness type dfnb |
|
|
| salivary gland carcinoma |
|
|
| obstructive nephropathy |
|
|
| acute kidney failure |
|
|
Search HGF in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HGF_HUMAN- Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:19576567}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for HGF
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for HGF Gene
Publications for HGF Gene
- Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. (PMID: 19576567) Schultz JM … Morell RJ (American journal of human genetics 2009) 2 3 4 72
- Family-based association analysis of hepatocyte growth factor (HGF) gene polymorphisms in high myopia. (PMID: 16723436) Han W … Yip SP (Investigative ophthalmology & visual science 2006) 3 22 40
- Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. (PMID: 15167892) Stamos J … Wiesmann C (The EMBO journal 2004) 3 4 22
- Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population. (PMID: 15064106) Takiuchi S … Tomoike H (Atherosclerosis 2004) 3 22 40
- The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. (PMID: 9493272) Zhou H … Byrd RA (Structure (London, England : 1993) 1998) 3 4 22
ExternalLinks
Products for HGF Gene
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- OriGene qPCR primer pairs for HGF
- OriGene CRISPR knockouts for HGF
- MG226277
- MR226277
- MR226277L3
- MR226277L4
- MR228535
- MR230984
- MR231001
- MR231002
- RC213241
- RC213241L3
- RC213241L4
- RC215308
- RC215308L1
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- RC215308L3
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- RC215593
- RC215593L1
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- RR213062
- RR213062L3
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- MR226277L3V
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- RC213241L3V
- RC213241L4V
- RC215308L1V
- RC215308L2V
- RC215308L3V
- RC215308L4V
- RC215593L1V
- RC215593L2V
- RC215593L3V
- RC215593L4V
- RC220421L3V
- RC220421L4V
- RR213062L3V
- RR213062L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HGF
- Sino Biological Human cDNA Clone for HGF
- Sino Biological Recombinant Proteins for HGF
- Sino Biological Cell Lysates for HGF
- Sino Biological Antibodies for HGF
- Sino Biological Assays for HGF
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HGF
- Novus Biologicals proteins and lysates for HGF
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for HGF
- Abcam proteins for HGF
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- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for HGF (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HGF (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HGF (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HGF CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HGF
- Addgene plasmids for HGF
- antibodies-online: Show 591 available HGF Antibodies ranked by validation data
- Compare Top HGF Antibodies
- Recommended
- 189 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IEP Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 38 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- antibodies-online: Show 142 available HGF Elisa Kits ranked by validation data
- Compare Top HGF Elisa Kits
- Quality Products:
- ABIN6720511
- ABIN624992
- ABIN414383
- ABIN1115405
- ABIN411278
- ABIN367595
- ABIN491758
- ABIN3032931
- ABIN1380034
- ABIN624993
- ABIN625126
- ABIN365445
- ABIN415597
- ABIN2859322
- ABIN2684466
- ABIN5563534
- ABIN625127
- ABIN1570289
- ABIN1115407
- ABIN5524601
- ABIN1115406
- ABIN416317
- ABIN1889441
- ABIN365554
- ABIN2748164
- ABIN5563535
- ABIN1570290
- ABIN5524603
- ABIN2708645
- ABIN2684468
- antibodies-online: Show 76 available HGF Proteins ranked by validation data
- Compare Top HGF Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for HGF
- Search Santa Cruz Biotechnology (SCBT) for HGF siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HGF
- Horizon Cell Lines for HGF
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HGF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HGF
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HGF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HGF
Sources for HGF Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51)