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Aliases for HGF Gene

Aliases for HGF Gene

  • Hepatocyte Growth Factor 2 3 5
  • Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor) 2 3
  • Fibroblast-Derived Tumor Cytotoxic Factor 2 3
  • Lung Fibroblast-Derived Mitogen 2 3
  • Hepatopoietin-A 3 4
  • Scatter Factor 2 4
  • HPTA 3 4
  • SF 3 4
  • Deafness, Autosomal Recessive 39 2
  • Hepatopoietin A 2
  • EC 56
  • EC 3.4.21 56
  • DFNB39 3
  • F-TCF 3
  • HGFB 3

External Ids for HGF Gene

Previous HGNC Symbols for HGF Gene

  • DFNB39

Previous GeneCards Identifiers for HGF Gene

  • GC07M079863
  • GC07M080926
  • GC07M080940
  • GC07M080943
  • GC07M080976
  • GC07M081166
  • GC07M081328
  • GC07M075935

Summaries for HGF Gene

Entrez Gene Summary for HGF Gene

  • This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

CIViC summary for HGF Gene

GeneCards Summary for HGF Gene

HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are RET signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include identical protein binding and serine-type endopeptidase activity. An important paralog of this gene is MST1.

UniProtKB/Swiss-Prot for HGF Gene

  • Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Tocris Summary for HGF Gene

  • The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule.

Gene Wiki entry for HGF Gene

Additional gene information for HGF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HGF Gene

Genomics for HGF Gene

GeneHancer (GH) Regulatory Elements for HGF Gene

Promoters and enhancers for HGF Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I081768 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +0.7 747 3.3 ZNF335 CTCF TAF1 RCOR1 ZNF398 MNT BMI1 HGF LOC100128317
GH07I082204 Enhancer 0.7 Ensembl ENCODE 5.5 -434.3 -434308 0.8 HLF BACH1 NFE2 NFE2L2 HGF GC07P082036 GC07M082379 CACNA2D1
GH07I082212 Enhancer 0.2 ENCODE 5.6 -442.3 -442266 1.2 HGF GC07P082036 GC07M082379 CACNA2D1
GH07I081748 Enhancer 0.2 FANTOM5 2.9 +22.3 22276 0.3 HGF LOC100128317
GH07I081845 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.2 -75.9 -75895 1.7 EBF1 FEZF1 BATF IRF4 POLR2A NR2F1 DPF2 ELF1 ZNF843 NR2F2 HGF GC07M081947
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HGF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HGF gene promoter:

Genomic Locations for HGF Gene

Genomic Locations for HGF Gene
71,433 bases
Minus strand

Genomic View for HGF Gene

Genes around HGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HGF Gene

Proteins for HGF Gene

  • Protein details for HGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatocyte growth factor
    Protein Accession:
    Secondary Accessions:
    • A1L3U6
    • Q02935
    • Q13494
    • Q14519
    • Q3KRB2
    • Q8TCE2
    • Q9BYL9
    • Q9BYM0
    • Q9UDU6

    Protein attributes for HGF Gene

    728 amino acids
    Molecular mass:
    83134 Da
    Quaternary structure:
    • Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.

    Three dimensional structures from OCA and Proteopedia for HGF Gene

    Alternative splice isoforms for HGF Gene

neXtProt entry for HGF Gene

Selected DME Specific Peptides for HGF Gene


Post-translational modifications for HGF Gene

  • Glycosylation at isoforms=3294, posLast=402402, isoforms=3476, isoforms=3566, and isoforms=3653
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for HGF

Domains & Families for HGF Gene

Gene Families for HGF Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for HGF Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family. Plasminogen subfamily.
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
genes like me logo Genes that share domains with HGF: view

Function for HGF Gene

Molecular function for HGF Gene

GENATLAS Biochemistry:
hepatocyte growth factor,precursor of chains alpha and beta,expressed in platelets,fibroblast,macrophage,endothelial and smooth muscle cells
UniProtKB/Swiss-Prot Function:
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Enzyme Numbers (IUBMB) for HGF Gene

LifeMap Function Summary for HGF Gene

Phenotypes From GWAS Catalog for HGF Gene

Gene Ontology (GO) - Molecular Function for HGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 NOT serine-type endopeptidase activity NAS 2531289
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 1846706
GO:0008083 growth factor activity NAS 2531289
genes like me logo Genes that share ontologies with HGF: view
genes like me logo Genes that share phenotypes with HGF: view

Human Phenotype Ontology for HGF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HGF Gene

MGI Knock Outs for HGF:

Clone Products

  • Addgene plasmids for HGF

No data available for Transcription Factor Targets and HOMER Transcription for HGF Gene

Localization for HGF Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HGF gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
mitochondrion 1
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0016020 membrane HDA,IDA 19946888
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with HGF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HGF Gene

Pathways & Interactions for HGF Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PEDF Induced Signaling
4 PI3K/AKT activation
5 MET promotes cell motility
genes like me logo Genes that share pathways with HGF: view

SIGNOR curated interactions for HGF Gene


Gene Ontology (GO) - Biological Process for HGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IEA --
GO:0000278 mitotic cell cycle NAS 2531289
GO:0000902 cell morphogenesis IEA --
GO:0001837 epithelial to mesenchymal transition TAS 14679171
genes like me logo Genes that share ontologies with HGF: view

Drugs & Compounds for HGF Gene

(121) Drugs for HGF Gene - From: DrugBank, ClinicalTrials, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist 2314
Heparin Approved, Investigational Pharma Antagonist, Target 905,282
Bortezomib Approved, Investigational Pharma Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
Phenytoin Approved, Vet_approved Pharma Pore Blocker 79
N,O6-Disulfo-Glucosamine Experimental Pharma Target 0

(58) Additional Compounds for HGF Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PF 04217903 mesylate

(5) Tocris Compounds for HGF Gene

Compound Action Cas Number
Norleual Highly potent HGF/c-MET inhibitor; also AT4 antagonist 334994-34-2
PF 04217903 mesylate Highly selective MET inhibitor 956906-93-7
PHA 665752 Potent and selective MET inhibitor 477575-56-7
SGX 523 Selective and potent c-MET kinase inhibitor 1022150-57-7
SU 11274 Selective inhibitor of MET kinase activity 658084-23-2
genes like me logo Genes that share compounds with HGF: view

Transcripts for HGF Gene

Unigene Clusters for HGF Gene

Hepatocyte growth factor (hepapoietin A; scatter factor):
Representative Sequences:

Clone Products

  • Addgene plasmids for HGF

Alternative Splicing Database (ASD) splice patterns (SP) for HGF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -

Relevant External Links for HGF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HGF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HGF Gene

This gene is overexpressed in Liver (x5.3).

Protein differential expression in normal tissues from HIPED for HGF Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (27.1), Amniocyte (24.6), and Placenta (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HGF Gene

NURSA nuclear receptor signaling pathways regulating expression of HGF Gene:


SOURCE GeneReport for Unigene cluster for HGF Gene:


Evidence on tissue expression from TISSUES for HGF Gene

  • Liver(4.7)
  • Blood(4.5)
  • Lung(4.5)
  • Nervous system(4.5)
  • Kidney(3.1)
  • Heart(2.8)
  • Intestine(2.7)
  • Bone marrow(2.6)
  • Muscle(2.5)
  • Skin(2.3)
  • Eye(2.2)
  • Stomach(2.2)
  • Lymph node(2)
  • Pancreas(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HGF Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • nervous
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • head
  • inner ear
  • middle ear
  • outer ear
  • skull
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with HGF: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HGF Gene

Orthologs for HGF Gene

This gene was present in the common ancestor of animals.

Orthologs for HGF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HGF 33 34
  • 99.91 (n)
(Bos Taurus)
Mammalia HGF 33 34
  • 92.76 (n)
(Canis familiaris)
Mammalia HGF 33 34
  • 92.49 (n)
(Monodelphis domestica)
Mammalia HGF 34
  • 89 (a)
(Mus musculus)
Mammalia Hgf 33 16 34
  • 88.51 (n)
(Rattus norvegicus)
Mammalia Hgf 33
  • 88.09 (n)
(Ornithorhynchus anatinus)
Mammalia HGF 34
  • 80 (a)
(Gallus gallus)
Aves HGF 33
  • 76.87 (n)
  • 75 (a)
(Anolis carolinensis)
Reptilia HGF 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hgf 33
  • 70.63 (n)
(Danio rerio)
Actinopterygii hgfa 33 34
  • 55.29 (n)
HGF (2 of 2) 34
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tequila 34
  • 5 (a)
(Caenorhabditis elegans)
Secernentea svh-1 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
-- 34
  • 18 (a)
Species where no ortholog for HGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HGF Gene

Gene Tree for HGF (if available)
Gene Tree for HGF (if available)

Paralogs for HGF Gene

Paralogs for HGF Gene

(7) SIMAP similar genes for HGF Gene using alignment to 6 proteins: Pseudogenes for HGF Gene

genes like me logo Genes that share paralogs with HGF: view

Variants for HGF Gene

Sequence variations from dbSNP and Humsavar for HGF Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs137853235 pathogenic, Deafness, autosomal recessive 39 81,752,250(-) C/T coding_sequence_variant, intron_variant, synonymous_variant
rs142045938 likely-benign, uncertain-significance, not specified, Nonsyndromic Hearing Loss, Mixed 81,757,200(-) T/C coding_sequence_variant, synonymous_variant
rs150267054 uncertain-significance, Nonsyndromic Hearing Loss, Mixed 81,762,824(-) G/A coding_sequence_variant, missense_variant
rs1800793 benign, likely-benign, not specified, Nonsyndromic Hearing Loss, Mixed 81,717,369(-) T/A/C genic_downstream_transcript_variant, intron_variant
rs182057547 uncertain-significance, Nonsyndromic Hearing Loss, Mixed 81,702,185(-) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HGF Gene

Variant ID Type Subtype PubMed ID
dgv1101e201 CNV deletion 23290073
dgv3601n106 CNV deletion 24896259
esv2384607 CNV deletion 18987734
esv2618632 CNV deletion 19546169
esv2734743 CNV deletion 23290073
esv3541994 CNV deletion 23714750
esv3576398 CNV gain 25503493
esv3613890 CNV loss 21293372
esv3613891 CNV loss 21293372
esv3807 CNV loss 18987735
esv8642 CNV loss 19470904
nsv1019753 CNV gain 25217958
nsv1074527 CNV deletion 25765185
nsv1124235 CNV deletion 24896259
nsv1150903 CNV deletion 26484159
nsv366332 CNV deletion 16902084
nsv464609 CNV loss 19166990
nsv607689 CNV loss 21841781
nsv951366 CNV duplication 24416366
nsv955962 CNV deletion 24416366

Variation tolerance for HGF Gene

Residual Variation Intolerance Score: 8.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HGF Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HGF Gene

Disorders for HGF Gene

MalaCards: The human disease database

(48) MalaCards diseases for HGF Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 39
  • dfnb39
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
acute kidney failure
  • acute renal failure
acute liver failure
  • acute hepatic failure
familial progressive hyperpigmentation
  • melanosis universalis hereditaria
- elite association - COSMIC cancer census association via MalaCards
Search HGF in MalaCards View complete list of genes associated with diseases


  • Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:19576567}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for HGF

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HGF: view

No data available for Genatlas for HGF Gene

Publications for HGF Gene

  1. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. (PMID: 19576567) Schultz JM … Morell RJ (American journal of human genetics 2009) 2 3 4 58
  2. Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. (PMID: 15167892) Stamos J … Wiesmann C (The EMBO journal 2004) 3 4 22 58
  3. The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. (PMID: 9493272) Zhou H … Byrd RA (Structure (London, England : 1993) 1998) 3 4 22 58
  4. Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution. (PMID: 9817840) Ultsch M … de Vos AM (Structure (London, England : 1993) 1998) 3 4 22 58
  5. Organization of the human hepatocyte growth factor-encoding gene. (PMID: 1831432) Seki T … Shimizu S (Gene 1991) 3 4 22 58

Products for HGF Gene

  • Addgene plasmids for HGF