Aliases for HEY2 Gene
Aliases for HEY2 Gene
- Hes Related Family BHLH Transcription Factor With YRPW Motif 2 2 3 5
- Hairy/Enhancer-Of-Split Related With YRPW Motif 2 2 3
- Hairy And Enhancer Of Split-Related Protein 2 3 4
- Class B Basic Helix-Loop-Helix Protein 32 3 4
- Cardiovascular Helix-Loop-Helix Factor 1 3 4
- Hairy-Related Transcription Factor 2 3 4
- HES-Related Repressor Protein 2 3 4
- Protein Gridlock Homolog 3 4
- BHLHb32 3 4
- HESR-2 3 4
- HERP1 3 4
- HRT-2 3 4
- HCHF1 3 4
External Ids for HEY2 Gene
- HGNC: 4881
- Entrez Gene: 23493
- Ensembl: ENSG00000135547
- OMIM: 604674
- UniProtKB: Q9UBP5
Previous GeneCards Identifiers for HEY2 Gene
- GC06P125917
- GC06P126003
- GC06P126051
- GC06P126112
- GC06P126068
- GC06P123645
Summaries for HEY2 Gene
-
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for HEY2 Gene
HEY2 (Hes Related Family BHLH Transcription Factor With YRPW Motif 2) is a Protein Coding gene. Diseases associated with HEY2 include Tricuspid Valve Stenosis and Tricuspid Atresia. Among its related pathways are Signaling by NOTCH1 and Development NOTCH1-mediated pathway for NF-KB activity modulation. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is HEY1.
UniProtKB/Swiss-Prot for HEY2 Gene
-
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5-CACGTG-3. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Additional gene information for HEY2 Gene
- Monarch Initiative
- Search for HEY2 at DataMed
- Search for HEY2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEY2 Gene
Genomics for HEY2 Gene
GeneHancer (GH) Regulatory Elements for HEY2 Gene
Promoters and enhancers for HEY2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HEY2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for HEY2 Gene
Genomic Locations for HEY2 Gene
- chr6:125,747,664-125,761,271
- (GRCh38/hg38)
- Size:
- 13,608 bases
- Orientation:
- Plus strand
- chr6:126,068,810-126,082,415
- (GRCh37/hg19)
Genomic View for HEY2 Gene
Genes around HEY2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q22.31 by Ensembl
- 6q22.31 by Entrez Gene
- 6q22.31 by HGNC
HEY2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HEY2 Gene
Proteins for HEY2 Gene
-
Protein details for HEY2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBP5-HEY2_HUMAN
- Recommended name:
- Hairy/enhancer-of-split related with YRPW motif protein 2
- Protein Accession:
- Q9UBP5
Protein attributes for HEY2 Gene
- Size:
- 337 amino acids
- Molecular mass:
- 35808 Da
- Quaternary structure:
-
- May self-associate (By similarity). Interacts with GATA4, HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with ARNT and GATA6.
Post-translational modifications for HEY2 Gene
Other Protein References for HEY2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HEY2
-
Abcam antibodies for HEY2
- Invitrogen Antibodies for HEY2
- GeneTex HEY2 antibody for HEY2
-
Santa Cruz Biotechnology (SCBT) Antibodies for HEY2
Protein Products
-
OriGene Purified Proteins for HEY2
- Search Origene for MassSpec and Protein Over-expression Lysates for HEY2
- Origene Custom Protein Services for HEY2
- Search GeneTex for Proteins for HEY2
-
Abcam proteins for HEY2
Assay Products
- antibodies-online: Search results for available HEY2 related products ranked by validation data
No data available for DME Specific Peptides for HEY2 Gene
Domains & Families for HEY2 Gene
Gene Families for HEY2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HEY2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HEY2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UBP5- Family:
-
- Belongs to the HEY family.
Function for HEY2 Gene
Molecular function for HEY2 Gene
- UniProtKB/Swiss-Prot Function:
- Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5-CACGTG-3. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Phenotypes From GWAS Catalog for HEY2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding | IEA,ISS | -- |
| GO:0000988 | transcription factor activity, protein binding | IDA | 21290414 |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | 16293227 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IDA,IEA | 15485867 |
Phenotypes for HEY2 Gene
- MGI mutant phenotypes for HEY2:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for HEY2:
Animal Models for HEY2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HEY2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HEY2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEY2 gene
- Search ViGene Biosciences for HEY2
CRISPR Products
-
OriGene CRISPR knockouts for HEY2
- genomics-online: gRNA clones - Search results for 101 available HEY2 gene related products
- Overview of 101 available HEY2 gene related products
- Applied Biological Materials CRISPR for HEY2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEY2
- GenScript: Design CRISPR guide RNA sequences for HEY2
miRNA for HEY2 Gene
- miRTarBase miRNAs that target HEY2
-
- hsa-mir-148b-3p (MIRT019456)
- hsa-mir-128-3p (MIRT022041)
- hsa-mir-181a-5p (MIRT025160)
- hsa-mir-4452 (MIRT445980)
- hsa-mir-6079 (MIRT445981)
- hsa-mir-183-3p (MIRT445982)
- hsa-mir-4635 (MIRT445983)
- hsa-mir-6512-5p (MIRT445984)
- hsa-mir-1264 (MIRT445985)
- hsa-mir-4752 (MIRT710100)
- hsa-mir-6833-5p (MIRT710101)
- hsa-mir-5701 (MIRT710102)
- hsa-mir-4326 (MIRT710103)
- hsa-mir-8056 (MIRT710104)
- hsa-mir-3691-5p (MIRT710105)
- hsa-mir-376c-5p (MIRT710106)
- hsa-mir-376b-5p (MIRT710107)
- hsa-mir-3121-5p (MIRT710108)
- hsa-mir-208b-5p (MIRT710109)
- hsa-mir-208a-5p (MIRT710110)
miRNA Products
- Search ViGene Biosciences for HEY2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HEY2
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- Overview of 101 available HEY2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HEY2 gene
Clone Products
- Sino Biological Human cDNA Clone for HEY2
- VectorBuilder custom plasmid, inducible vectors for HEY2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HEY2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for HEY2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HEY2
-
ViGene Biosciences adenoviral particle packaged cDNA for HEY2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HEY2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HEY2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HEY2 Gene
Localization for HEY2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HEY2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
- Aggresome (2)
- Nuclear bodies (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,ISS | -- |
| GO:0016580 | colocalizes_with Sin3 complex | IDA | 11486045 |
| GO:0017053 | transcriptional repressor complex | IDA | 11486045 |
Pathways & Interactions for HEY2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | HIV Life Cycle |
.45
|
|
| 3 | Gastric cancer |
.62
|
|
| 4 | PI3K-Akt signaling pathway | ||
| 5 | Pathways in cancer | ||
Pathways by source for HEY2 Gene
4 BioSystems pathways for HEY2 Gene
3 KEGG pathways for HEY2 Gene
1 GeneGo (Thomson Reuters) pathway for HEY2 Gene
Interacting Proteins for HEY2 Gene
Selected Interacting proteins:
Q9UBP5-HEY2_HUMAN
ENSP00000357348
for HEY2 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 11486045 |
| GO:0001568 | blood vessel development | IEA | -- |
| GO:0001570 | vasculogenesis | ISS,IEA | -- |
| GO:0003150 | muscular septum morphogenesis | ISS,IEA | -- |
| GO:0003151 | outflow tract morphogenesis | ISS,IEA | -- |
Transcripts for HEY2 Gene
mRNA/cDNA for HEY2 Gene
- (4) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (52) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HEY2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HEY2
- genomics-online: gRNA clones - Search results for 101 available HEY2 gene related products
- Overview of 101 available HEY2 gene related products
- Applied Biological Materials CRISPR for HEY2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEY2
- GenScript: Design CRISPR guide RNA sequences for HEY2
miRNA Products
- Search ViGene Biosciences for HEY2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HEY2
- Browse OriGene Inhibitory RNA Products For HEY2
- genomics-online: shRNA clones - Search results for 101 available HEY2 gene related products
- Overview of 101 available HEY2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HEY2 gene
Clone Products
- Sino Biological Human cDNA Clone for HEY2
- VectorBuilder custom plasmid, inducible vectors for HEY2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HEY2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for HEY2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HEY2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Pons
- Cerebral Cortex
- Medulla Oblongata
- Amygdala
- Cartilage (Muscoskeletal System)
- Bone (Muscoskeletal System)
-
Eye (Sensory Organs)
- Late Retinal Progenitor Cells Retinal Neuroblastic Layer
- Early Retinal Progenitor Cells Retinal Neuroblastic Layer
- Muller Glia Precursor Cells Inner Nuclear Layer
- Inner Cell Mass (Early Embryonic Tissues)
-
Pancreas (Endocrine System)
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Adipose (Muscoskeletal System)
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HEY2 Gene
This gene is overexpressed in Artery - Tibial (x11.1), Heart - Left Ventricle (x5.1), and Artery - Coronary (x4.5).
NURSA nuclear receptor signaling pathways regulating expression of HEY2 Gene:
HEY2SOURCE GeneReport for Unigene cluster for HEY2 Gene:
Hs.144287Evidence on tissue expression from TISSUES for HEY2 Gene
- Heart(4.6)
- Lung(4.2)
- Muscle(2.4)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for HEY2
-
OriGene qPCR primer pairs and template standards for HEY2
- genomics-online: primer clones - Search results for 101 available HEY2 gene related products
- Overview of 101 available HEY2 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HEY2 Gene
Orthologs for HEY2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HEY2 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HEY2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HEY2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | HEY2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hey2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hey2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HEY2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC100858839 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HEY2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hey2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hey2 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Hey 35 34 |
|
- Species where no ortholog for HEY2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HEY2 Gene
Variants for HEY2 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000054095 | -- | 125,749,026(+) | T/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000261176 | -- | 125,756,126(+) | C/T | intron_variant | |
| rs1000514239 | -- | 125,753,873(+) | C/G | intron_variant | |
| rs1000547136 | -- | 125,753,532(+) | A/G/T | intron_variant | |
| rs1000647912 | -- | 125,757,160(+) | G/A | intron_variant |
Residual Variation Intolerance Score:
55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.20;
52.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HEY2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HEY2 Gene
Disorders for HEY2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tricuspid valve stenosis |
|
|
| tricuspid atresia |
|
|
| labyrinthitis |
|
|
| pediatric ependymoma |
|
|
| tetralogy of fallot |
|
|
Search HEY2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HEY2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HEY2 Gene
Publications for HEY2 Gene
- HERP, a new primary target of Notch regulated by ligand binding. (PMID: 11486044) Iso T … Hamamori Y (Molecular and cellular biology 2001) 3 4 22 58
- Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. (PMID: 10415358) Leimeister C … Gessler M (Mechanisms of development 1999) 2 3 4 58
- Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PMID: 17611704) Katoh M … Katoh M (International journal of oncology 2007) 3 22 58
- CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6. (PMID: 16293227) Shirvani S … Chin MT (Biochemical and biophysical research communications 2006) 3 4 58
- HEY2 mutations in malformed hearts. (PMID: 16329098) Reamon-Buettner SM … Borlak J (Human mutation 2006) 3 4 58
Products for HEY2 Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HEY2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 71 available HEY2 Antibodies ranked by validation data
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- genomics-online: gRNA clones - Search results for 101 available HEY2 gene related products
- Overview of 101 available HEY2 gene related products
- genomics-online: primer clones - Search results for 101 available HEY2 gene related products
- Overview of 101 available HEY2 gene related products
- genomics-online: shRNA clones - Search results for 101 available HEY2 gene related products
- Overview of 101 available HEY2 gene related products
Sources for HEY2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems