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This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two si... See more...
Aliases for HEY2 Gene
Aliases for HEY2 Gene
- Hes Related Family BHLH Transcription Factor With YRPW Motif 2 2 3 5
- BHLHb32 2 3 4
- HERP1 2 3 4
- Hairy/Enhancer-Of-Split Related With YRPW Motif Protein 2 3 4
- Hairy/Enhancer-Of-Split Related With YRPW Motif 2 2 3
- Hairy And Enhancer Of Split-Related Protein 2 3 4
- Class B Basic Helix-Loop-Helix Protein 32 3 4
- Cardiovascular Helix-Loop-Helix Factor 1 3 4
- Hairy-Related Transcription Factor 2 3 4
- HES-Related Repressor Protein 2 3 4
- Protein Gridlock Homolog 3 4
- HESR-2 3 4
- HESR2 2 3
External Ids for HEY2 Gene
- HGNC: 4881
- Entrez Gene: 23493
- Ensembl: ENSG00000135547
- OMIM: 604674
- UniProtKB: Q9UBP5
Previous GeneCards Identifiers for HEY2 Gene
- GC06P125917
- GC06P126003
- GC06P126051
- GC06P126112
- GC06P126068
- GC06P123645
Summaries for HEY2 Gene
-
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for HEY2 Gene
HEY2 (Hes Related Family BHLH Transcription Factor With YRPW Motif 2) is a Protein Coding gene. Diseases associated with HEY2 include Tricuspid Atresia and Chronic Apical Periodontitis. Among its related pathways are Signaling by GPCR and Heart Development. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is HEY1.
UniProtKB/Swiss-Prot Summary for HEY2 Gene
-
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Additional gene information for HEY2 Gene
- HGNC(4881)
- Entrez Gene(23493)
- Ensembl(ENSG00000135547)
- OMIM(604674)
- UniProtKB(Q9UBP5)
- Open Targets Platform(ENSG00000135547)
- Monarch Initiative
- Search for HEY2 at DataMed
- Search for HEY2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HEY2 Gene
Genomics for HEY2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HEY2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HEY2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HEY2
- Top Transcription factor binding sites by QIAGEN in the HEY2 gene promoter:
-
- CREB
- deltaCREB
- HOXA9
- HOXA9B
- Meis-1
- Meis-1a
- MyoD
- MZF-1
- NF-AT1
- Nkx6-1
Genomic Locations for HEY2 Gene
Genomic Locations for HEY2 Gene
- chr6:125,747,639-125,762,243
- (GRCh38/hg38)
- Size:
- 14,605 bases
- Orientation:
- Plus strand
- chr6:126,068,810-126,082,415
- (GRCh37/hg19)
- Size:
- 13,606 bases
- Orientation:
- Plus strand
Genomic View for HEY2 Gene
Genes around HEY2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q22.31 by HGNC
- 6q22.31 by Entrez Gene
- 6q22.31 by Ensembl
HEY2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HEY2 Gene
Proteins for HEY2 Gene
-
Protein details for HEY2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBP5-HEY2_HUMAN
- Recommended name:
- Hairy/enhancer-of-split related with YRPW motif protein 2
- Protein Accession:
- Q9UBP5
Protein attributes for HEY2 Gene
- Size:
- 337 amino acids
- Molecular mass:
- 35808 Da
- Quaternary structure:
-
- May self-associate (By similarity). Interacts with GATA4, HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with ARNT and GATA6.
Post-translational modifications for HEY2 Gene
Other Protein References for HEY2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ HRT2 Antibody
- Creative Diagnostics Anti-HEY2 monoclonal antibody
- Creative Biolabs Mouse Anti-HEY2 Recombinant Antibody (1H10)
- Novus Biologicals Antibodies for HEY2
-
Abcam antibodies for HEY2
- Invitrogen Antibodies for HEY2 (AFLGC-Hey2)
-
Biorbyt antibodies for HEY2
-
Boster Bio Antibodies for HEY2
-
Santa Cruz Biotechnology (SCBT) Antibodies for HEY2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HEY2
- Origene Custom Protein Services for HEY2
-
Abcam proteins for HEY2
No data available for DME Specific Peptides for HEY2 Gene
Domains & Families for HEY2 Gene
Gene Families for HEY2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HEY2 Gene
- InterPro:
- Blocks:
-
- Basic helix-loop-helix dimerization domain bHLH
- Orange
- ProtoNet:
Suggested Antigen Peptide Sequences for HEY2 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein gridlock homolog (HEY2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UBP5- Family:
-
- Belongs to the HEY family.
Function for HEY2 Gene
Molecular function for HEY2 Gene
- UniProtKB/Swiss-Prot Function:
- Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Phenotypes From GWAS Catalog for HEY2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IDA,ISM | 19274049 |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | 16293227 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA,ISS | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for HEY2 Gene
- MGI mutant phenotypes for HEY2:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for HEY2:
Animal Models for HEY2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HEY2 - Select products 50% OFF >
- * HEY2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HEY2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HEY2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEY2
miRNA for HEY2 Gene
- miRTarBase miRNAs that target HEY2
-
- hsa-miR-148b-3p (MIRT019456)
- hsa-miR-128-3p (MIRT022041)
- hsa-miR-181a-5p (MIRT025160)
- hsa-miR-4452 (MIRT445980)
- hsa-miR-6079 (MIRT445981)
- hsa-miR-183-3p (MIRT445982)
- hsa-miR-4635 (MIRT445983)
- hsa-miR-6512-5p (MIRT445984)
- hsa-miR-1264 (MIRT445985)
- hsa-miR-4752 (MIRT710100)
- hsa-miR-6833-5p (MIRT710101)
- hsa-miR-5701 (MIRT710102)
- hsa-miR-4326 (MIRT710103)
- hsa-miR-8056 (MIRT710104)
- hsa-miR-3691-5p (MIRT710105)
- hsa-miR-376c-5p (MIRT710106)
- hsa-miR-376b-5p (MIRT710107)
- hsa-miR-3121-5p (MIRT710108)
- hsa-miR-208b-5p (MIRT710109)
- hsa-miR-208a-5p (MIRT710110)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HEY2
- Browse OriGene Inhibitory RNA Products For HEY2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HEY2
Clone Products
- Applied Biological Materials (abm): Clones for HEY2 - Select products 50% OFF >
- * HEY2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HEY2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HEY2
Cell Line Products
-
Horizon Cell Lines for HEY2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HEY2 Gene
Localization for HEY2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HEY2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Aggresome (2)
- Nuclear bodies (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA,ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,ISS | -- |
| GO:0016580 | colocalizes_with Sin3 complex | IDA | 11486045 |
Pathways & Interactions for HEY2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | Notch Signaling Pathway (WikiPathways) | ||
| 3 | HIV Life Cycle |
.45
|
|
| 4 | Gastric cancer |
.62
|
|
| 5 | PI3K-Akt signaling pathway | ||
Pathways by source for HEY2 Gene
4 BioSystems pathways for HEY2 Gene
4 KEGG pathways for HEY2 Gene
1 GeneGo (Thomson Reuters) pathway for HEY2 Gene
- Development Notch Signaling Pathway
Interacting Proteins for HEY2 Gene
Selected Interacting proteins:
Q9UBP5-HEY2_HUMAN
ENSP00000357348
for HEY2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for HEY2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IMP | 11486045 |
| GO:0001568 | blood vessel development | IEA | -- |
| GO:0001570 | vasculogenesis | IEA,ISS | -- |
| GO:0003150 | muscular septum morphogenesis | IEA,ISS | -- |
| GO:0003151 | outflow tract morphogenesis | IEA,ISS | -- |
Transcripts for HEY2 Gene
mRNA/cDNA for HEY2 Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368364 2626 nts (view in UCSC)
- ENST00000368365 2461 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HEY2 - Select products 50% OFF >
- * HEY2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HEY2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HEY2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HEY2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HEY2
- Browse OriGene Inhibitory RNA Products For HEY2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HEY2
Clone Products
- Applied Biological Materials (abm): Clones for HEY2 - Select products 50% OFF >
- * HEY2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HEY2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HEY2
Relevant External Links for HEY2 Gene
- GeneLoc Exon Structure for
- HEY2
Expression for HEY2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Hypothalamus
- Hippocampus
- Thalamus
- Cerebellum
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Eye (Sensory Organs)
- Late Retinal Progenitor Cells Retinal Neuroblastic Layer
- Muller Glia Precursor Cells Inner Nuclear Layer
- Early Retinal Progenitor Cells Retinal Neuroblastic Layer
- Inner Cell Mass (Early Embryonic Tissues)
-
Pancreas (Endocrine System)
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Adipose (Muscoskeletal System)
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HEY2 Gene
This gene is overexpressed in Artery - Tibial (x11.1), Heart - Left Ventricle (x5.1), and Artery - Coronary (x4.5).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HEY2
SOURCE GeneReport for Unigene cluster for HEY2 Gene:
Hs.144287Evidence on tissue expression from TISSUES for HEY2 Gene
- Heart(4.7)
- Lung(4.5)
- Muscle(2.9)
- Nervous system(2.8)
- Skin(2.7)
- Kidney(2.4)
- Bone marrow(2.3)
- Pancreas(2.2)
- Liver(2.1)
- Eye(2)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for HEY2
-
OriGene qPCR primer pairs and template standards for HEY2
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HEY2 Gene
Orthologs for HEY2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HEY2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | HEY2 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HEY2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HEY2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Hey2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hey2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | HEY2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LOC100858839 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | HEY2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hey2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | hey2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Hey 31 32 |
|
OneToMany |
- Species where no ortholog for HEY2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for HEY2 Gene
- ENSEMBL:
- Gene Tree for HEY2 (if available)
- TreeFam:
- Gene Tree for HEY2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HEY2: view image
Paralogs for HEY2 Gene
Variants for HEY2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HEY2 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708201 | Likely Benign: not provided | 125,759,677(+) | G/A | MISSENSE_VARIANT | |
| 778251 | Benign: not provided | 125,752,066(+) | T/G | SYNONYMOUS_VARIANT | |
| 790587 | Benign: not provided | 125,752,098(+) | A/T | INTRON_VARIANT | |
| rs3734638 | - | p.Val140Met | |||
| rs747221103 | - | p.Thr96Ala |
Residual Variation Intolerance Score:
55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.20;
52.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HEY2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HEY2 Gene
Disorders for HEY2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tricuspid atresia |
|
|
| chronic apical periodontitis |
|
|
| tricuspid valve stenosis |
|
|
| aortic valve disease 1 |
|
|
| proctitis |
|
|
Search HEY2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HEY2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HEY2 Gene
Publications for HEY2 Gene
- HERP, a new primary target of Notch regulated by ligand binding. (PMID: 11486044) Iso T … Hamamori Y (Molecular and cellular biology 2001) 3 4 23
- Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. (PMID: 10415358) Leimeister C … Gessler M (Mechanisms of development 1999) 2 3 4
- Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PMID: 17611704) Katoh M … Katoh M (International journal of oncology 2007) 3 23
- HEY2 mutations in malformed hearts. (PMID: 16329098) Reamon-Buettner SM … Borlak J (Human mutation 2006) 3 4
- CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6. (PMID: 16293227) Shirvani S … Chin MT (Biochemical and biophysical research communications 2006) 3 4
ExternalLinks
Products for HEY2 Gene
- Custom Antibody Services
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- Origene Custom Protein Services for HEY2
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- Browse OriGene Inhibitory RNA Products For HEY2
- OriGene qPCR primer pairs for HEY2
- OriGene qPCR primer pairs and template standards for HEY2
- OriGene CRISPR knockouts for HEY2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HEY2
- Sino Biological Human cDNA Clone for HEY2
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HEY2
- Novus Biologicals proteins and lysates for HEY2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for HEY2
- Abcam proteins for HEY2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for HEY2 (AFLGC-Hey2)
- VectorBuilder Custom and pre-made DNA vectors for HEY2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HEY2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HEY2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HEY2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HEY2
- antibodies-online: Show 18 available HEY2 Antibodies ranked by validation data
- Compare Top HEY2 Antibodies
- antibodies-online: Search results for available HEY2 related products ranked by validation data
- antibodies-online: Show 6 available HEY2 Proteins ranked by validation data
- Compare Top HEY2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for HEY2
- Search Santa Cruz Biotechnology (SCBT) for HEY2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HEY2
- Horizon Cell Lines for HEY2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HEY2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HEY2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HEY2
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- Boster Bio Antibodies for HEY2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for HEY2
Sources for HEY2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
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