Aliases for HEXIM1 Gene
External Ids for HEXIM1 Gene
Previous GeneCards Identifiers for HEXIM1 Gene
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]
GeneCards Summary for HEXIM1 Gene
HEXIM1 (HEXIM P-TEFb Complex Subunit 1) is a Protein Coding gene. Diseases associated with HEXIM1 include Nut Midline Carcinoma. Among its related pathways are Chromatin Regulation / Acetylation and Initiation of transcription and translation elongation at the HIV-1 LTR. Gene Ontology (GO) annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and snRNA binding. An important paralog of this gene is HEXIM2.
UniProtKB/Swiss-Prot Summary for HEXIM1 Gene
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).