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This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008] See more...
Aliases for HES5 Gene
Aliases for HES5 Gene
External Ids for HES5 Gene
- HGNC: 19764
- Entrez Gene: 388585
- Ensembl: ENSG00000197921
- OMIM: 607348
- UniProtKB: Q5TA89
Previous GeneCards Identifiers for HES5 Gene
- GC01U900022
- GC01M002495
- GC01M002450
- GC01M001739
- GC01M002460
Summaries for HES5 Gene
-
This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]
GeneCards Summary for HES5 Gene
HES5 (Hes Family BHLH Transcription Factor 5) is a Protein Coding gene. Diseases associated with HES5 include Large Intestine Adenoma and Chromosome 1P36 Deletion Syndrome. Among its related pathways are Notch Signaling Pathway (WikiPathways) and Signaling by NOTCH1. Gene Ontology (GO) annotations related to this gene include chromatin binding and protein dimerization activity. An important paralog of this gene is HES4.
UniProtKB/Swiss-Prot Summary for HES5 Gene
-
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).
Additional gene information for HES5 Gene
- Monarch Initiative
- Search for HES5 at DataMed
- Search for HES5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HES5 Gene
Genomics for HES5 Gene
GeneHancer (GH) Regulatory Elements for HES5 Gene
Promoters and enhancers for HES5 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J002522 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 500.7 | +3.5 | 3540 | 7.8 | HNRNPK ZNF217 ZSCAN5C TCF12 NRF1 POLR2G USF1 SP1 FOS SIX5 | PANK4 HES5 lnc-HES5-2 ENSG00000224387 FAAP20 MORN1 MMEL1 ENSG00000272449 | |
| GH01J002531 | Promoter | 0.7 | Ensembl | 500.7 | -0.7 | -738 | 0.4 | MYC CTCF NFIC GATA3 EZH2 HIC1 NFIB VEZF1 MAX ZFX | ENSG00000272449 HES5 MMEL1 AB372649-001 | |
| GH01J001685 | Enhancer | 1 | ENCODE dbSUPER | 5.9 | +843.9 | 843913 | 2.3 | TCF12 FOS CLOCK TEAD1 CTBP1 NCOR1 WT1 ZNF316 MAFF SAP130 | CDK11B HES5 ANKRD65 SLC35E2B piR-35778-001 | |
| GH01J003093 | Enhancer | 0.5 | Ensembl dbSUPER | 5.6 | -563.9 | -563938 | 2 | ZIC2 SPI1 | PRDM16-DT PRDM16 HES5 MIR4251 | |
| GH01J002128 | Enhancer | 0.6 | FANTOM5 CraniofacialAtlas dbSUPER | 2.8 | +402.0 | 402001 | 0.6 | EP300 | HES5 ENSG00000271806 PRKCZ |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HES5 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HES5
- Top Transcription factor binding sites by QIAGEN in the HES5 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- GATA-1
Genomic Locations for HES5 Gene
Genomic Locations for HES5 Gene
- chr1:2,528,745-2,530,263
- (GRCh38/hg38)
- Size:
- 1,519 bases
- Orientation:
- Minus strand
- chr1:2,460,184-2,461,684
- (GRCh37/hg19)
- Size:
- 1,501 bases
- Orientation:
- Minus strand
Genomic View for HES5 Gene
Genes around HES5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.32 by HGNC
- 1p36.32 by Entrez Gene
- 1p36.32 by Ensembl
HES5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HES5 Gene
Proteins for HES5 Gene
-
Protein details for HES5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5TA89-HES5_HUMAN
- Recommended name:
- Transcription factor HES-5
- Protein Accession:
- Q5TA89
- B9DI85
Protein attributes for HES5 Gene
- Size:
- 166 amino acids
- Molecular mass:
- 18226 Da
- Quaternary structure:
-
- Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
Post-translational modifications for HES5 Gene
Other Protein References for HES5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ HES5 Antibody
- Creative Diagnostics Anti-HES5 monoclonal antibody, clone 4C7
- Creative Biolabs Mouse Anti-HES5 Recombinant Antibody (CBFYH-0962)
- Novus Biologicals Antibodies for HES5
-
Abcam antibodies for HES5
- Invitrogen Antibodies for HES5 (AFLGC-HES5)
- antibodies-online: Show 9 available HES5 Antibodies ranked by validation data
- Compare Top HES5 Antibodies
-
Recommended
- 37 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 29 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 22 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for HES5
-
Custom Antibody ServicesProSci Antibodies for HES5
-
Santa Cruz Biotechnology (SCBT) Antibodies for HES5
Protein Products
-
OriGene Purified Proteins for HES5
- Search Origene for MassSpec and Protein Over-expression Lysates for HES5
- Origene Custom Protein Services for HES5
No data available for DME Specific Peptides for HES5 Gene
Domains & Families for HES5 Gene
Gene Families for HES5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HES5 Gene
- Blocks:
-
- Basic helix-loop-helix dimerization domain bHLH
- Orange
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HES5 Gene
- GenScript: Design optimal peptide antigens:
-
- Hairy and enhancer of split 5 (HES5_HUMAN)
- HES5 protein (Q5M8T3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q5TA89UniProtKB/Swiss-Prot:
HES5_HUMAN :- Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
- Domain:
-
- Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
- The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
Function for HES5 Gene
Molecular function for HES5 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).
Phenotypes From GWAS Catalog for HES5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA,ISS | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
Phenotypes for HES5 Gene
- MGI mutant phenotypes for HES5:
-
inferred from 4 alleles
- respiratory system phenotype
- vision/eye phenotype
- nervous system phenotype
- no phenotypic analysis
- taste/olfaction phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- embryo phenotype
- hearing/vestibular/ear phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for HES5:
Animal Models for HES5 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HES5 - Select products 50% OFF >
- * HES5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for HES5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HES5
- genomics-online: gRNA clones - Search for available HES5 gRNA products
- Overview of 102 available HES5 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for HES5
miRNA for HES5 Gene
- miRTarBase miRNAs that target HES5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HES5
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- genomics-online: shRNA clones - Search for available HES5 shRNA products
- Overview of 102 available HES5 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for HES5 - Select products 50% OFF >
- * HES5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HES5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HES5
- genomics-online: cdna clones - Search for available HES5 CDNA products
- Overview of 102 available HES5 gene related products
- orf clones - Search for available HES5 ORF products
- Overview of 102 available HES5 gene related products
Cell Line Products
-
Horizon Cell Lines for HES5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HES5 Gene
Localization for HES5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HES5 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nuclear speckles (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005575 | cellular_component | ND | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for HES5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | Notch Signaling Pathway (WikiPathways) | ||
| 3 | HIV Life Cycle |
.45
|
|
| 4 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
| 5 | Gastric cancer |
.62
|
|
Pathways by source for HES5 Gene
5 BioSystems pathways for HES5 Gene
4 KEGG pathways for HES5 Gene
Interacting Proteins for HES5 Gene
GPS-Prot Interaction Network for HES5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | -- |
| GO:0002062 | NOT chondrocyte differentiation | ISS | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007155 | cell adhesion | IEA,ISS | -- |
| GO:0007219 | Notch signaling pathway | TAS,IEA | -- |
No data available for SIGNOR curated interactions for HES5 Gene
Transcripts for HES5 Gene
mRNA/cDNA for HES5 Gene
- 1 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000378453 1324 bps (ENST00000378453.4)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HES5 - Select products 50% OFF >
- * HES5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HES5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HES5
- genomics-online: gRNA clones - Search for available HES5 gRNA products
- Overview of 102 available HES5 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for HES5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HES5
- Browse OriGene Inhibitory RNA Products For HES5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HES5
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Clone Products
- Applied Biological Materials (abm): Clones for HES5 - Select products 50% OFF >
- * HES5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HES5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HES5
- genomics-online: cdna clones - Search for available HES5 CDNA products
- Overview of 102 available HES5 gene related products
- orf clones - Search for available HES5 ORF products
- Overview of 102 available HES5 gene related products
Relevant External Links for HES5 Gene
- GeneLoc Exon Structure for
- HES5
Expression for HES5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Protoplasmic Astrocyte Cells Neocortex
- Hypothalamus
- Neural Tube (Nervous System)
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- Late Retinal Progenitor Cells Retinal Neuroblastic Layer
- Muller Glia Precursor Cells Inner Nuclear Layer
- Early Retinal Progenitor Cells Retinal Neuroblastic Layer
- Retina
-
Skeletal Muscle (Muscoskeletal System)
- Myoblasts Mandibular Arch Muscles
- Muscle Progenitor Cells Mandibular Arch Muscles
- Myoblasts Hyoid Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Paraxial Mesoderm Cells Paraxial Mesoderm
-
Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Paraxial Mesoderm Cells Paraxial Mesoderm
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
-
Somite (Muscoskeletal System)
- Presomitic Mesoderm Cells Presomitic Mesoderm
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
-
Glial Cells
- Protoplasmic Astrocyte Cells Neocortex
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
- Neural Ectoderm (Nervous System)
- NULL (Uncategorized)
- Oligodendrocytes (Nervous System)
- Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for HES5 Gene
This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.8), Brain - Amygdala (x4.4), and Brain - Hypothalamus (x4.1).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HES5
SOURCE GeneReport for Unigene cluster for HES5 Gene:
Hs.57971mRNA Expression by UniProt/SwissProt for HES5 Gene:
Q5TA89-HES5_HUMAN
Tissue specificity:
Expressed in fetal heart and brain tumors.
Evidence on tissue expression from TISSUES for HES5 Gene
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for HES5
-
OriGene qPCR primer pairs and template standards for HES5
- genomics-online: primer clones - Search for available HES5 Primer products
- Overview of 102 available HES5 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HES5 Gene
Orthologs for HES5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | HES5 31 30 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | HES5 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HES5 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hes5 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Hes5 17 31 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HES5 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HES5 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HES5 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hes5.1 30 |
|
||
| Str.11260 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53782 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100149066 30 |
|
||
| her2 31 |
|
OneToOne | |||
| hes5 30 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Her 31 |
|
OneToMany | |
| E(spl) 31 |
|
OneToMany | |||
| HLHmbeta 31 |
|
OneToMany | |||
| HLHmdelta 31 |
|
OneToMany | |||
| HLHm7 31 |
|
OneToMany | |||
| HLHmgamma 31 |
|
OneToMany | |||
| HLHm5 31 |
|
OneToMany | |||
| HLHm3 31 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | lin-22 31 |
|
OneToOne |
- Species where no ortholog for HES5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for HES5 Gene
- ENSEMBL:
- Gene Tree for HES5 (if available)
- TreeFam:
- Gene Tree for HES5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HES5: view image
Paralogs for HES5 Gene
Variants for HES5 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1 | OTHER | inversion | 15895083 |
| nsv470684 | CNV | loss | 18288195 |
| nsv545076 | CNV | gain | 21841781 |
| nsv545077 | CNV | gain | 21841781 |
| nsv545080 | CNV | loss | 21841781 |
| nsv7171 | OTHER | inversion | 18451855 |
| nsv818222 | CNV | loss | 17921354 |
| nsv823920 | CNV | gain | 20364138 |
| nsv824031 | CNV | gain | 20364138 |
| nsv951557 | CNV | deletion | 24416366 |
Gene Damage Index Score:
1.84;
34.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HES5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HES5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES5 Gene
Disorders for HES5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| large intestine adenoma |
|
|
| chromosome 1p36 deletion syndrome |
|
|
Search HES5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HES5
No data available for UniProtKB/Swiss-Prot and Genatlas for HES5 Gene
Publications for HES5 Gene
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
- Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M … Katoh M (International journal of oncology 2004) 3 4 54
- HES5 promotes cellular proliferation of non-small cell lung cancer through STAT3 signaling. (PMID: 27878283) Gu S … Wu C (Oncology reports 2017) 3 54
- HES5 silencing is an early and recurrent change in prostate tumourigenesis. (PMID: 25560400) Massie CE … Lynch AG (Endocrine-related cancer 2015) 3 54
- HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival in hepatocellular carcinoma. (PMID: 26342546) Zhu G … Cheng C (Experimental and molecular pathology 2015) 3 54
ExternalLinks
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- antibodies-online: Show 9 available HES5 Antibodies ranked by validation data
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- 29 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 22 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for available HES5 related products ranked by validation data
- antibodies-online: Show 5 available HES5 Proteins ranked by validation data
- Compare Top HES5 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for HES5
- Search Santa Cruz Biotechnology (SCBT) for HES5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HES5
- Custom Antibody ServicesProSci Antibodies for HES5
- Search for HES5 Proteins at ProSci
- Horizon Cell Lines for HES5
- genomics-online: cdna clones - Search for available HES5 CDNA products
- Overview of 102 available HES5 gene related products
- orf clones - Search for available HES5 ORF products
- Overview of 102 available HES5 gene related products
- genomics-online: gRNA clones - Search for available HES5 gRNA products
- Overview of 102 available HES5 gene related products
- genomics-online: primer clones - Search for available HES5 Primer products
- Overview of 102 available HES5 gene related products
- genomics-online: shRNA clones - Search for available HES5 shRNA products
- Overview of 102 available HES5 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HES5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HES5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HES5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HES5
- Boster Bio Antibodies for HES5
- Browse Boster Bio ELISA Kits
Sources for HES5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody