Aliases for HES4 Gene

Aliases for HES4 Gene

  • Hes Family BHLH Transcription Factor 4 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 42 3 4
  • Hairy And Enhancer Of Split 4 3 4
  • Transcription Factor HES-4 3 4
  • BHLH Factor Hes4 3 4
  • BHLHb42 3 4
  • HHES4 3 4
  • Hairy And Enhancer Of Split 4 (Drosophila) 2
  • BHLHB42 4

External Ids for HES4 Gene

Previous GeneCards Identifiers for HES4 Gene

  • GC01M000974
  • GC01M000924
  • GC01M000206
  • GC01M001000

Summaries for HES4 Gene

GeneCards Summary for HES4 Gene

HES4 (Hes Family BHLH Transcription Factor 4) is a Protein Coding gene. Diseases associated with HES4 include Trichuriasis and Chromosome 1P36 Deletion Syndrome. Among its related pathways are PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transcription factor binding and protein dimerization activity. An important paralog of this gene is HES1.

UniProtKB/Swiss-Prot Summary for HES4 Gene

  • Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity).

Additional gene information for HES4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HES4 Gene

Genomics for HES4 Gene

GeneHancer (GH) Regulatory Elements for HES4 Gene

Promoters and enhancers for HES4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HES4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HES4

Top Transcription factor binding sites by QIAGEN in the HES4 gene promoter:
  • CREB
  • deltaCREB
  • MyoD
  • p53

Genomic Locations for HES4 Gene

Genomic Locations for HES4 Gene
chr1:998,962-1,001,285
(GRCh38/hg38)
Size:
2,324 bases
Orientation:
Minus strand
chr1:934,342-935,552
(GRCh37/hg19)
Size:
1,211 bases
Orientation:
Minus strand

Genomic View for HES4 Gene

Genes around HES4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES4 Gene

Proteins for HES4 Gene

  • Protein details for HES4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCC6-HES4_HUMAN
    Recommended name:
    Transcription factor HES-4
    Protein Accession:
    Q9HCC6
    Secondary Accessions:
    • Q5SVA5

    Protein attributes for HES4 Gene

    Size:
    221 amino acids
    Molecular mass:
    23523 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

neXtProt entry for HES4 Gene

Post-translational modifications for HES4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HES4 Gene

No data available for DME Specific Peptides for HES4 Gene

Domains & Families for HES4 Gene

Gene Families for HES4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HES4 Gene

Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
  • Orange
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HES4 Gene

GenScript: Design optimal peptide antigens:
  • bHLH factor Hes4 (HES4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HCC6

UniProtKB/Swiss-Prot:

HES4_HUMAN :
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
Domain:
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
genes like me logo Genes that share domains with HES4: view

Function for HES4 Gene

Molecular function for HES4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity).

Phenotypes From GWAS Catalog for HES4 Gene

Gene Ontology (GO) - Molecular Function for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0008134 transcription factor binding NAS 17611704
genes like me logo Genes that share ontologies with HES4: view
genes like me logo Genes that share phenotypes with HES4: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for HES4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HES4 Gene

Localization for HES4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HES4 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with HES4: view

Pathways & Interactions for HES4 Gene

PathCards logo

SuperPathways for HES4 Gene

SuperPathway Contained pathways
1 PI3K-Akt signaling pathway
genes like me logo Genes that share pathways with HES4: view

Pathways by source for HES4 Gene

1 KEGG pathway for HES4 Gene

Gene Ontology (GO) - Biological Process for HES4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0009952 anterior/posterior pattern specification IBA 21873635
genes like me logo Genes that share ontologies with HES4: view

No data available for SIGNOR curated interactions for HES4 Gene

Drugs & Compounds for HES4 Gene

No Compound Related Data Available

Transcripts for HES4 Gene

mRNA/cDNA for HES4 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for HES4

Alternative Splicing Database (ASD) splice patterns (SP) for HES4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for HES4 Gene

GeneLoc Exon Structure for
HES4

Expression for HES4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HES4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HES4

SOURCE GeneReport for Unigene cluster for HES4 Gene:

Hs.154029

Evidence on tissue expression from TISSUES for HES4 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with HES4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HES4 Gene

Orthologs for HES4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HES4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
OneToMany
-- 31
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HES4 31
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HES4 31
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HES4 31
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 24 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 38 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 49 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii her6 31
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta h 31
  • 25 (a)
ManyToMany
dpn 31
  • 22 (a)
ManyToMany
Side 31
  • 16 (a)
ManyToMany
Species where no ortholog for HES4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES4 Gene

ENSEMBL:
Gene Tree for HES4 (if available)
TreeFam:
Gene Tree for HES4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HES4: view image

Paralogs for HES4 Gene

Paralogs for HES4 Gene

(4) SIMAP similar genes for HES4 Gene using alignment to 3 proteins:

  • HES4_HUMAN
  • D6REB3_HUMAN
  • E9PB28_HUMAN
genes like me logo Genes that share paralogs with HES4: view

Variants for HES4 Gene

Additional dbSNP identifiers (rs#s) for HES4 Gene

Structural Variations from Database of Genomic Variants (DGV) for HES4 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
dgv5n100 CNV gain 25217958
esv2762302 CNV gain 21179565
nsv1013524 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv428334 CNV gain 18775914
nsv482937 CNV loss 15286789
nsv517709 CNV gain+loss 19592680
nsv544895 CNV loss 21841781
nsv827252 CNV gain 20364138
nsv832980 CNV gain 17160897
nsv950451 CNV deletion 24416366

Variation tolerance for HES4 Gene

Gene Damage Index Score: 7.83; 83.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HES4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HES4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HES4 Gene

Disorders for HES4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HES4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
trichuriasis
  • infection by trichuris trichura
chromosome 1p36 deletion syndrome
  • monosomy 1p36 syndrome
distal arthrogryposis
  • freeman-sheldon syndrome
- elite association - COSMIC cancer census association via MalaCards
Search HES4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HES4

genes like me logo Genes that share disorders with HES4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HES4 Gene

Publications for HES4 Gene

  1. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. (PMID: 11260262) Bessho Y … Kageyama R (Genes to cells : devoted to molecular & cellular mechanisms 2001) 2 3 4 54
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M … Katoh M (International journal of oncology 2004) 2 3 54
  5. Hes4: A potential prognostic biomarker for newly diagnosed patients with high-grade osteosarcoma. (PMID: 27786411) McManus M … Schadler K (Pediatric blood & cancer 2017) 3 54

Products for HES4 Gene

Sources for HES4 Gene