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HES3 (Hes Family BHLH Transcription Factor 3) is a Protein Coding gene. Diseases associated with HES3 include Chromosome 1P36 Deletion Syndrome. Among its related pathways are Notch Signaling Pathway (sino) and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transcription factor binding and protein dimerization activity. An important paralog of this gene is HES1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0008134 | transcription factor binding | NAS | 17611704 |
GO:0046983 | protein dimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | ISA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PI3K-Akt signaling pathway | ||
2 | Notch Signaling Pathway (sino) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0007219 | Notch signaling pathway | IBA | 21873635 |
GO:0009952 | anterior/posterior pattern specification | IBA | 21873635 |
GO:0045665 | negative regulation of neuron differentiation | IBA | 21873635 |
GO:0045892 | negative regulation of transcription, DNA-templated | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HES3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HES3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HES3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Hes3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hes3 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hes3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | her3 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
chromosome 1p36 deletion syndrome |
|
|