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HES2 (Hes Family BHLH Transcription Factor 2) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathway (sino) and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transcription factor binding and double-stranded DNA binding. An important paralog of this gene is HES1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA,IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003690 | double-stranded DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | ISA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PI3K-Akt signaling pathway | ||
2 | Notch Signaling Pathway (sino) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0009952 | anterior/posterior pattern specification | IBA | 21873635 |
GO:0045892 | negative regulation of transcription, DNA-templated | IEA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||
SP3: | |||||||||||||||||||||||
SP4: | |||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||
SP6: | - | - | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HES2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HES2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hes2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hes2 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HES2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HES2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HES2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hes2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | hes2.1 30 31 |
|
OneToMany | |
hes2.2 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | h 31 |
|
ManyToMany | |
Side 31 |
|
ManyToMany | |||
dpn 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2235687 | - |
p.Pro139Ser |
No disorders were found for HES2 Gene.