Aliases for HES2 Gene

Aliases for HES2 Gene

  • Hes Family BHLH Transcription Factor 2 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 40 3 4
  • Hairy And Enhancer Of Split 2 3 4
  • Transcription Factor HES-2 3 4
  • BHLHb40 3 4
  • Hairy And Enhancer Of Split 2 (Drosophila) 2
  • BHLHB40 4

External Ids for HES2 Gene

Previous GeneCards Identifiers for HES2 Gene

  • GC01M006049
  • GC01M006281
  • GC01U900784
  • GC01M006183
  • GC01M006406
  • GC01M005622
  • GC01M006472

Summaries for HES2 Gene

GeneCards Summary for HES2 Gene

HES2 (Hes Family BHLH Transcription Factor 2) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transcription factor binding and double-stranded DNA binding. An important paralog of this gene is HES4.

UniProtKB/Swiss-Prot Summary for HES2 Gene

  • Transcriptional repressor of genes that require a bHLH protein for their transcription.

Additional gene information for HES2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HES2 Gene

Genomics for HES2 Gene

GeneHancer (GH) Regulatory Elements for HES2 Gene

Promoters and enhancers for HES2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J006418 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 500.4 +5.2 5153 1.8 HNRNPK NRF1 ZIC2 POLR2A ZBTB10 ZNF423 ZBTB26 KLF4 EZH2 NR2F2 HES2 THAP3 NOL9 ZBTB48 LOC102724450 RNF207 RPL22 PHF13 ESPN ACOT7
GH01J006424 Promoter 1.3 EPDnew Ensembl 500.7 -0.3 -331 1.2 ZFX ZNF423 ZBTB26 CTBP1 MYC EZH2 SIN3A KDM5B KLF9 ZNF282 ESPN HES2 THAP3 LOC102724450 RNF207 RPL22 ACOT7 MIR4252
GH01J006422 Promoter/Enhancer 1.2 Ensembl ENCODE 500.7 +1.2 1150 1.6 CTCF ZNF639 ZIC2 ZNF423 GABPA ZBTB26 TRIM28 TARDBP REST RFX1 ESPN HES2 PHF13 NOL9 LOC102724450 RNF207 RPL22 THAP3 ACOT7 lnc-ACOT7-3
GH01J006299 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 2.1 +122.9 122875 5.2 REST MXI1 BCL11A TCF12 CTCF FOS POLR2A BATF RCOR1 SMARCA4 ESPN ACOT7 ZBTB48 PLEKHG5 GPR153 HES2 THAP3 NPHP4 piR-56759-001 lnc-GPR153-1
GH01J006412 Promoter/Enhancer 1.2 Ensembl ENCODE 0.4 +9.7 9672 4.3 CTCF MYC USF1 SP1 ZIC2 ZNF423 TRIM22 TEAD1 SMC3 MXI1 RF00017-020 lnc-ACOT7-3 ESPN RNF207 HES3 ICMT LINC00337 PLEKHG5 LOC102724450 RPL22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HES2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HES2

Top Transcription factor binding sites by QIAGEN in the HES2 gene promoter:
  • AhR
  • AREB6
  • Arnt
  • c-Myc
  • E47
  • LCR-F1
  • Max
  • N-Myc
  • Pax-4a

Genomic Locations for HES2 Gene

Genomic Locations for HES2 Gene
chr1:6,412,418-6,424,670
(GRCh38/hg38)
Size:
12,253 bases
Orientation:
Minus strand
chr1:6,472,478-6,484,730
(GRCh37/hg19)
Size:
12,253 bases
Orientation:
Minus strand

Genomic View for HES2 Gene

Genes around HES2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES2 Gene

Proteins for HES2 Gene

  • Protein details for HES2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y543-HES2_HUMAN
    Recommended name:
    Transcription factor HES-2
    Protein Accession:
    Q9Y543
    Secondary Accessions:
    • A2RTZ9
    • Q96EN4
    • Q9Y542

    Protein attributes for HES2 Gene

    Size:
    173 amino acids
    Molecular mass:
    18470 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

    Alternative splice isoforms for HES2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HES2 Gene

Post-translational modifications for HES2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HES2 Gene

No data available for DME Specific Peptides for HES2 Gene

Domains & Families for HES2 Gene

Gene Families for HES2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HES2 Gene

Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
  • Orange
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HES2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ33803 fis, clone CTONG2000561, highly similar to Transcription factor HES-2 (A2RTZ9_HUMAN)
  • Hairy and enhancer of split 2 (HES2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y543

UniProtKB/Swiss-Prot:

HES2_HUMAN :
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
Domain:
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
genes like me logo Genes that share domains with HES2: view

Function for HES2 Gene

Molecular function for HES2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription.

Gene Ontology (GO) - Molecular Function for HES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA,IBA 21873635
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with HES2: view
genes like me logo Genes that share phenotypes with HES2: view

Animal Model Products

Clone Products

  • Addgene plasmids for HES2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HES2 Gene

Localization for HES2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HES2 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for HES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with HES2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HES2 Gene

Pathways & Interactions for HES2 Gene

PathCards logo

SuperPathways for HES2 Gene

SuperPathway Contained pathways
1 PI3K-Akt signaling pathway
genes like me logo Genes that share pathways with HES2: view

Pathways by source for HES2 Gene

1 KEGG pathway for HES2 Gene

Gene Ontology (GO) - Biological Process for HES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009952 anterior/posterior pattern specification IBA 21873635
GO:0030154 cell differentiation IBA 21873635
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HES2: view

No data available for SIGNOR curated interactions for HES2 Gene

Drugs & Compounds for HES2 Gene

No Compound Related Data Available

Transcripts for HES2 Gene

mRNA/cDNA for HES2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for HES2

Alternative Splicing Database (ASD) splice patterns (SP) for HES2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b
SP1: - -
SP2: - - - - - - -
SP3:
SP4:
SP5: -
SP6: - - - - -

Relevant External Links for HES2 Gene

GeneLoc Exon Structure for
HES2

Expression for HES2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HES2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HES2 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.1), Vagina (x8.2), Skin - Not Sun Exposed (Suprapubic) (x7.5), Skin - Sun Exposed (Lower leg) (x6.8), and Cervix - Ectocervix (x4.4).

Protein differential expression in normal tissues from HIPED for HES2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HES2 Gene



Protein tissue co-expression partners for HES2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HES2

SOURCE GeneReport for Unigene cluster for HES2 Gene:

Hs.118727

mRNA Expression by UniProt/SwissProt for HES2 Gene:

Q9Y543-HES2_HUMAN
Tissue specificity: Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.

Evidence on tissue expression from TISSUES for HES2 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with HES2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HES2 Gene

Orthologs for HES2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HES2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HES2 31 30
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HES2 31 30
  • 82.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hes2 30
  • 81.36 (n)
mouse
(Mus musculus)
Mammalia Hes2 17 31 30
  • 81.33 (n)
dog
(Canis familiaris)
Mammalia HES2 31 30
  • 80.81 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HES2 31
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HES2 31
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 35 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hes2 30
  • 60.47 (n)
zebrafish
(Danio rerio)
Actinopterygii hes2.1 31 30
  • 58.1 (n)
OneToMany
hes2.2 31
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta h 31
  • 18 (a)
ManyToMany
Side 31
  • 13 (a)
ManyToMany
dpn 31
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 18 (a)
OneToOne
Species where no ortholog for HES2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES2 Gene

ENSEMBL:
Gene Tree for HES2 (if available)
TreeFam:
Gene Tree for HES2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HES2: view image

Paralogs for HES2 Gene

Paralogs for HES2 Gene

(3) SIMAP similar genes for HES2 Gene using alignment to 3 proteins:

  • HES2_HUMAN
  • K7EJN2_HUMAN
  • K7EJQ0_HUMAN
genes like me logo Genes that share paralogs with HES2: view

Variants for HES2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HES2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2235687 - p.Pro139Ser

Additional dbSNP identifiers (rs#s) for HES2 Gene

Structural Variations from Database of Genomic Variants (DGV) for HES2 Gene

Variant ID Type Subtype PubMed ID
dgv2n27 CNV loss 19166990
dgv80n54 CNV loss 21841781
esv25412 CNV gain+loss 19812545
nsv1009548 CNV loss 25217958
nsv508836 CNV insertion 20534489
nsv545240 CNV loss 21841781
nsv7880 CNV gain+loss 18304495
nsv954048 CNV deletion 24416366

Variation tolerance for HES2 Gene

Gene Damage Index Score: 3.36; 53.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HES2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HES2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES2 Gene

Disorders for HES2 Gene

Additional Disease Information for HES2

No disorders were found for HES2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HES2 Gene

Publications for HES2 Gene

  1. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M … Katoh M (International journal of oncology 2004) 2 3 4 23 54
  2. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. (PMID: 17611704) Katoh M … Katoh M (International journal of oncology 2007) 3 23 54
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for HES2 Gene

Sources for HES2 Gene